SignalP - 4.1

Signal peptide and cleavage sites in gram+, gram- and eukaryotic amino acid sequences

SignalP 4.1 server predicts the presence and location of signal peptide cleavage sites in amino acid sequences from different organisms: Gram-positive prokaryotes, Gram-negative prokaryotes, and eukaryotes. The method incorporates a prediction of cleavage sites and a signal peptide/non-signal peptide prediction based on a combination of several artificial neural networks.

A book chapter on SignalP 4.1 has been published:

Predicting Secretory Proteins with SignalP
Henrik Nielsen
In Kihara, D (ed): Protein Function Prediction (Methods in Molecular Biology vol. 1611) pp. 59-73, Springer 2017.
doi: 10.1007/978-1-4939-7015-5_6
PMID: 28451972

NOTE (added May 2018): Remember, the presence or absence of a signal peptide is not the whole story about the localization of a protein!
If you want to find out more about the sorting of your eukaryotic proteins, try the protein subcellular localization predictor DeepLoc.

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