NetTurnP - 1.0

Amino acid predection in β-turns and β-turn types in proteins

Beta-turns are the most common type of non-repetitive structures, and constitute on average 25% of the residues in all protein chains. The formation of Beta-turns plays an important role in protein folding, protein stability and molecular recognition processes. A high correlation between the tendency for a sequence to form a Beta-turn and the proteins reactivity to antipeptide antibodies has been discovered, and furthermore it has been shown that there is an overrepresentation of Beta-turns in B-cell epitopes. In the area of protein-protein interactions, the formation of Beta-turns types I and II has been indicated to be essential for high-affinity binding to SH2-domains.
NetTurnP predicts if an amino acid is located in a Beta-turn or not. Optional, NetTurnP is also able to predict the nine Beta-turn subtypes.


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