MHCcluster - 2.0

MHC clustring based on binding specififcity

The MHC genomic region in most species is extremely polymorphic. The distinct specificity of the majority of the MHC molecules remains uncharacterized. The MHCcluster is a tool to functionally cluster MHC class I molecules (MHCI) based on their predicted binding specificity. The tool provides highly intuitive heat-map and graphical tree-based visualizations of the functional relationship between MHC class I and class II variants.

For MHC class I, peptide binding predictions are made using NetMHCpan-2.8 PMID 19002680.
For MHC class II, peptide binding predictions are made using NetMHCIIpan-3.2 PMID 21073747.

Note, the predictions used by MHCCluster are generated using NetMHCpan-2.8 (class I) and NetMHGCIIpan-3.2 (class II). These tools are outdated, and the accuracy of the prediction motifs should be taken with caution, in perticular for HLA-C and HLA-II


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