MHCMotifDecon-1.0 is a supervised method for motif deconvolution of MHC peptidome data. The method uses MHC binding predictions from NetMHCpan-4.1 (for MHC class I) and NetMHCIIpan-4.1 (for MHC class II) to deconvolute and assign likely MHC restriction elements to MHC peptidome data.
In the deconvolution, MS co-immunoprecipitated contaminants are identified and placed in a trash bin.