ORF name SGD name Neural network output Fourier score in list of Known genes in list of Zhao genes in list of Spellman genes in list of Cho genes SGD Gene Description YIL169C 0.98 2.8 C Protein of unknown function YNL322C KRE1 0.98 1.7 cell wall beta-glucan assembly YJL078C PRY3 0.98 5.5 S C "Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein." YDL038C 0.98 5.3 Protein of unknown function YOR009W TIR4 0.98 1.0 Protein of unknown function YJR151C DAN4 0.97 1.3 Delayed Anaerobic Gene YOL155C 0.97 3.0 C Protein of unknown function YLR286C CTS1 0.97 9.3 K S C Endochitinase YOL030W GAS5 0.97 4.1 Z S Hypothetical ORF YOR220W 0.97 2.5 Protein of unknown function YNR044W AGA1 0.97 6.5 K S anchorage subunit of a-agglutinin YGR023W MTL1 0.97 1.8 Mid-Two Like 1 YMR317W 0.97 2.1 Protein of unknown function YCR089W FIG2 0.97 3.4 "Factor-Induced Gene 2: expression is induced by the mating pheromones, a and alpha factor; required for efficient mating" YLR194C 0.96 5.4 S Protein of unknown function YIL011W TIR3 0.96 2.6 S TIP1-related YGR161C 0.96 2.4 Protein of unknown function YBR067C TIP1 0.96 5.9 K Z S C cold- and heat-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YNL327W EGT2 0.96 8.7 K S "cell-cycle regulation protein, may be involved in the correct timing of cell separation after cytokinesis" YLR332W MID2 0.96 1.5 Protein required for mating YNR067C DSE4 0.96 6.3 S C Daughter Specific Expression 4 YOR382W FIT2 0.96 1.8 "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YLR390W-A CCW14 0.96 2.7 Secretory Stress Response protein YHR143W DSE2 0.96 7.3 S Daugher Specific Expression 2 YFR054C 0.96 1.6 Protein of unknown function YDL211C 0.96 3.3 S Protein of unknown function YLR353W BUD8 0.96 4.2 Z S C marks and directs bud emergence to the distal pole of diploid cells YNL283C WSC2 0.95 5.8 Z S cell wall integrity and stress response component 2 YDR349C YPS7 0.95 1.4 Gpi-anchored aspartic protease (Yapsin 7) YHR212C 0.95 0.8 Protein of unknown function YOL105C WSC3 0.95 1.2 cell wall integrity and stress response component 3 YIL117C PRM5 0.95 3.7 S pheromone-regulated membrane protein YDR534C FIT1 0.95 1.5 "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YIR016W 0.95 0.8 Protein of unknown function YDR055W PST1 0.95 5.5 S Protoplasts-secreted YLR120C YPS1 0.95 1.8 Gpi-anchored aspartic protease (Yapsin 1) YGL028C SCW11 0.95 8.2 S C Soluble Cell Wall protein YDR451C YHP1 0.95 5.3 S C Protein of unknown function YJL158C CIS3 0.94 4.7 S cik1 suppressor YJR004C SAG1 0.94 3.8 S alpha-agglutinin YNL176C 0.94 3.7 Z S C Protein of unknown function YGL035C MIG1 0.94 1.1 Transcription factor involved in glucose repression YOR383C FIT3 0.94 2.0 S "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YMR307W GAS1 0.94 5.6 K S Glycophospholipid-anchored surface protein YDL191W RPL35A 0.94 2.0 Homology to rat L35 YDL136W RPL35B 0.94 2.3 Homology to rat L35 YMR233W TRI1 0.94 0.8 Topoisomerase 1 and RAD52 epistasis group Interactions YBR130C SHE3 0.94 1.9 Z cytoplasmic protein involved in mother-specific HO expression YOR279C RFM1 0.94 0.8 Repression Factor of MSE YNL074C MLF3 0.94 0.8 Protein of unknown function YLR121C YPS3 0.94 5.5 S C Gpi-anchored aspartic protease (Yapsin 3) YGL056C SDS23 0.94 1.0 homolog of pombe SDS23; localizes to spindle pole body YEL040W UTR2 0.93 2.7 S (alias: Congo Red Hypersensitivity) YOR247W SRL1 0.93 4.8 S Suppressor of Rad53 null Lethality YER028C 0.93 1.8 Protein of unknown function YNL053W MSG5 0.93 2.5 C Tyrosine protein phosphatase involved in adaptation response to pheromone YGL032C AGA2 0.93 4.1 S adhesion subunit of a-agglutinin YOR010C TIR2 0.93 1.6 cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YDR439W LRS4 0.93 1.2 Loss of rDNA silencing YKR092C SRP40 0.93 1.9 Suppressor of mutant AC40 subunit of RNA polymerase I and III (high serine) YLR457C NBP1 0.93 2.9 S C Nap1p Binding Protein YJL053W PEP8 0.93 1.0 Plays a role in delivery of proteins to the vacuole YGL003C CDH1 0.93 1.5 CDC20 homolog 1 YNL042W BOP3 0.92 2.3 bypass of PAM1 YLR040C 0.92 2.6 S Protein of unknown function YHR214W 0.92 2.3 Protein of unknown function YAR066W 0.92 1.7 Protein of unknown function YIL123W SIM1 0.92 6.0 Z S (putative) invovled in control of DNA replication YFR022W 0.92 2.2 Protein of unknown function YPL014W 0.92 3.5 S C Protein of unknown function YPR171W 0.92 1.1 Protein of unknown function YOR233W KIN4 0.92 2.1 protein kinase YPL155C KIP2 0.92 3.3 Z S kinesin-related protein YML041C VPS71 0.92 0.9 Protein of unknown function YKL079W SMY1 0.92 2.0 "not believed to act as a kinesin, colocalizes with Myo2p" YGR035C 0.92 4.5 S C Protein of unknown function YJR150C DAN1 0.92 2.6 Delayed Anaerobic YNR014W 0.92 1.8 Protein of unknown function YLR394W CST9 0.92 1.5 Chromosome STability; involved in meiotic chromosome synapsis YIR019C MUC1 0.92 1.5 Required for invasion and pseudohyphae formation in response to nitrogen starvation YLR265C NEJ1 0.92 0.9 Nonhomologous End-Joining regulator 1; Repressed by MAT heterozygosity; Interacts with Lif1p in a yeast two-hybrid assay YKR102W FLO10 0.92 1.9 Protein with similarity to flocculation protein Flo1p YDR447C RPS17B 0.92 1.3 Homology to rat ribosomal protein S17 YLR042C 0.91 1.6 Protein of unknown function YKR091W SRL3 0.91 3.0 S Suppressor of Rad53 null Lethality YNL078W NIS1 0.91 5.3 S C Protein of unknown function YDR420W HKR1 0.91 1.3 cell surface protein that may regulate cell wall beta-glucan synthesis and bud site selection; Hanenula mrakii killer toxin-resistance protein YGL162W SUT1 0.91 3.0 S Involved in sterol uptake YOR019W 0.91 0.8 Protein of unknown function YKR010C TOF2 0.91 4.2 Z S C topoisomerase I interacting factor 2 YBR162C TOS1 0.91 2.6 Target of SBF YDL129W 0.91 1.6 Protein of unknown function YGR074W SMD1 0.91 1.7 "Homolog of human core snRNP protein D1, involved in snRNA maturation" YMR188C 0.91 2.1 Protein of unknown function YMR268C PRP24 0.91 1.1 U4/U6 snRNA-associated splicing factor YGL259W YPS5 0.91 2.4 Gpi-anchored aspartic protease (Yapsin 5) YGR091W PRP31 0.90 0.9 pre-mRNA splicing protein YGR014W MSB2 0.90 3.7 Z S putative integral membrane protein YER011W TIR1 0.90 2.4 K Cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins. Encodes a stress-response cell wall mannoprotein and this gene is downregulated at acidic pH. YAL065C 0.90 2.0 Protein of unknown function YBR203W 0.90 1.7 Protein of unknown function YOR372C NDD1 0.90 2.8 Z S Nuclear Division Defective 1 YCL063W 0.90 4.1 S C Protein of unknown function YOL036W 0.90 1.0 Protein of unknown function YGR279C SCW4 0.90 4.2 S C Soluble Cell Wall protein YLR313C SPH1 0.90 5.9 Z S C SPa2-Homolog; protein involved in shmoo formation and required for bipolar bud site selection (GB:AF008236). YDR277C MTH1 0.90 1.6 C Negative regulator of HXT gene expression YDR169C STB3 0.90 1.7 binds Sin3p in two-hybrid assay YDL028C MPS1 0.90 1.8 Required for spindle pole body duplication and a mitotic checkpoint function. YHR004C NEM1 0.90 0.8 Nuclear Envelope Morphology YDR223W 0.90 1.0 Protein of unknown function YOR324C 0.90 3.3 S Protein of unknown function YHR211W FLO5 0.90 0.8 FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determined flocculation. YLR094C GIS3 0.90 1.6 GIG3 suppressor YOL060C MAM3 0.90 1.4 putative hemolysin-like protein with three transmembrane domains YDL194W SNF3 0.90 1.3 glucose sensor YJR115W 0.90 0.8 Protein of unknown function YML109W ZDS2 0.90 2.7 S C multicopy suppressor of a sin4 defect YDR077W SED1 0.90 3.7 K S putative cell surface glycoprotein YDR200C VPS64 0.90 1.7 Protein of unknown function YDR144C MKC7 0.89 2.0 S protease involved in protein processing that shares functions with Yap3 and Kex2 YDR507C GIN4 0.89 4.5 S C Growth inhibitory gene YBR215W HPC2 0.89 1.1 Protein required for normal cell-cycle regulation of histone gene transcription YJL160C 0.89 2.0 Protein of unknown function YOR023C AHC1 0.89 1.7 S Ada Histone acetyltransferase complex component YDL127W PCL2 0.89 6.6 K Z S C Interacts with cyclin-dependent kinase PHO85 to form kinase complex with G1-periodic activity involved in cell cycle progression YKL006C-A SFT1 0.89 1.1 Required for transport of proteins between an early and a later golgi compartment. possible NSF attachment protein receptor (V-SNARE) YOR058C ASE1 0.89 4.5 K Z S C essential for anaphase spindle elongation YGR079W 0.89 1.1 Protein of unknown function YJL128C PBS2 0.89 1.1 "Involved in osmoregulation, member of the HOG1 mitogen-activated protein kinase (MAPK) cascade" YDL048C STP4 0.89 3.3 S C Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YDR524C AGE1 0.89 1.1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector YDR379W RGA2 0.89 1.6 "contains a Rho-GAP domain and two LIM domains, similar to Rga1p and all known Rho-GAPs" YPL070W 0.89 1.1 Protein of unknown function YBR156C SLI15 0.89 1.9 C Mitotic spindle protein involved in chromosome segregation. YDL197C ASF2 0.89 4.1 K Z S C anti-silencing protein that causes depression of silent loci when overexpressed YOR288C MPD1 0.89 2.0 Disulfide isomerase related protein YPR023C EAF3 0.89 1.3 Esa1p-Associated Factor YDR422C SIP1 0.89 1.2 SNF1 protein kinase substrate YBR214W SDS24 0.89 1.8 "Similar to S. pombe SDS23, suppresses DIS2, localized to the nucleus" YHR096C HXT5 0.89 2.3 Member of superfamily of monosaccharide transporters YDR528W HLR1 0.89 4.5 Z S LRE1 homolog YOR014W RTS1 0.89 1.1 B-type regulatory subunit of protein phosphatase 2A (PP2A) YOR008C SLG1 0.89 1.3 cell wall integrity and stress response component 1 YPR075C OPY2 0.88 3.4 S imparts Far- phenotype YOL070C 0.88 3.4 S C Protein of unknown function YKL175W ZRT3 0.88 1.8 Protein of unknown function YBR142W MAK5 0.88 1.7 Necessary for maintenance of dsRNA killer plasmids. Is predicted to encode an DEAD-box RNA helicase YPR083W MDM36 0.88 1.6 Mitochondrial Distribution and Morphology YGL113W SLD3 0.88 0.9 synthetic lethality with dpb11-1; Sld3p interacts with Cdc45 and is required for initiation of DNA replication. YNR039C ZRG17 0.88 1.0 zinc-regulated gene YNL096C RPS7B 0.88 0.9 Homology to human S7 and Xenopus S8 YIL015W BAR1 0.88 1.1 extracellular protease synthesized in a-cells that cleaves and inactivates alpha factor YGL209W MIG2 0.88 2.8 S "Involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter" YKR045C 0.88 1.0 Protein of unknown function YBR119W MUD1 0.88 1.1 U1 snRNP A protein YDL037C 0.88 8.3 S Protein of unknown function YOL091W SPO21 0.88 2.0 sporulation defective YLL021W SPA2 0.88 2.3 C spindle pole antigen YDR309C GIC2 0.88 4.2 K S C Gtpase-interacting component 2 YBR255W 0.88 1.3 Protein of unknown function YGR027C RPS25A 0.88 0.9 Homology to rat S25 YDR436W PPZ2 0.88 1.6 serine-threonine phosphatase Z YLR003C 0.88 1.4 Protein of unknown function YNL272C SEC2 0.88 2.1 C Protein with coiled-coil domain essential for vesicular transport YLL038C ENT4 0.88 1.5 epsin N-terminal homology-containing protein YBL031W SHE1 0.88 2.1 Product of gene unknown YPR056W TFB4 0.88 1.3 "RNA polymerase transcription initiation TFIIH (factor b), 37 kDa subunit" YJR021C REC107 0.88 1.2 meiotic recombination protein YHR049C-A 0.88 1.1 Protein of unknown function YOL012C HTZ1 0.88 3.5 Z S C Histone-related protein that can suppress histone H4 point mutation YOR018W ROD1 0.88 3.2 Z S "Resistance to o-dinitrobenzene, calcium, and zinc" YGL171W ROK1 0.88 1.1 contains domains found in the DEAD protein family of ATP-dependent RNA helicases; high-copy suppressor of kem1 null mutant YDR227W SIR4 0.87 1.4 "Sir4 binding to Rap1 initiates the sequential association of Sir and other proteins, allowing the subsequent spreading of heterochromatin proteins along the chromosome." YOR355W GDS1 0.87 2.3 S involved in nuclear control of mitochondria YOR295W UAF30 0.87 1.0 Topoisomerase 1 and RAD52 epistasis group Interactions YLR031W 0.87 1.4 Protein of unknown function YPL158C 0.87 6.1 S C Protein of unknown function YPL039W 0.87 0.9 Protein of unknown function YLR333C RPS25B 0.87 1.3 Homology to rat S25; belongs to the S25E family of ribosomal proteins YGR068C 0.87 1.7 Protein of unknown function YKL176C LST4 0.87 1.1 required for amino acid permease transport from the Golgi to the cell surface. involved in regulated secretion/recycling of nitrogen regulated permeases. YNL269W 0.87 2.1 Protein of unknown function YKR019C IRS4 0.87 1.0 Increased rDNA silencing YLR035C MLH2 0.87 1.6 Mutl Homolog YKL108W SLD2 0.87 5.4 Z S C Synthetically lethal with dpb11-1; required for DNA replication YDL239C ADY3 0.87 2.7 Accumulation of dyads YHL031C GOS1 0.87 1.3 SNARE protein with a C-terminal membrane anchor
GOlgi Snare YPL074W YTA6 0.87 2.4 Member of CDC48/PAS1/SEC18 family of ATPases YDL074C BRE1 0.87 1.3 putative coiled-coil protein with RING-finger and myosin-like domains YCR067C SED4 0.87 1.2 "Sed4p is an integral ER membrane protein, which, along along with its close homolog, Sec12p, is involved in vesicle formation at the ER" YKL198C PTK1 0.87 0.9 Putative serine/threonine protein kinase YAL041W CDC24 0.87 1.2 calcium-binding protein involved in bud emergence and schmooing YJL051W 0.87 6.1 Z S C Protein of unknown function YDR285W ZIP1 0.87 2.0 "Synaptonemal complex protein, component of the central element" YGR166W KRE11 0.87 1.1 Involved in biosynthetic pathway for cell wall beta-glucans YKR005C 0.87 1.6 Protein of unknown function YNL002C RLP7 0.87 1.6 "Significant sequence similarity to RPL7B, but neither can functionally replace the other. Does not correspond to any ribosomal component identified so far, based on its biochemical features" YOR359W VTS1 0.87 1.1 vti1-2 suppressor YPL066W 0.87 1.4 C Protein of unknown function YMR081C ISF1 0.87 1.2 "May regulate NAM7 function, possibly at level of mRNA turnover" YDR116C 0.87 1.7 Protein of unknown function YCR048W ARE1 0.87 1.9 Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) YOL100W PKH2 0.87 1.9 Pkb-activating Kinase Homologue YDL179W PCL9 0.86 1.9 K S C PHO85 cyclin YER064C 0.86 1.9 Protein of unknown function YKL011C CCE1 0.86 1.8 cruciform cutting endonuclease YJL215C 0.86 2.6 Protein of unknown function YLR409C UTP21 0.86 1.1 Protein required for cell viability YAL028W 0.86 2.1 Protein of unknown function YGR283C 0.86 1.3 Protein of unknown function