ORF name SGD name Neural network output Fourier score in list of Known genes in list of Zhao genes in list of Spellman genes in list of Cho genes SGD Gene Description YIL169C 0.98 2.8 C YNL322C KRE1 0.98 1.7 cell wall beta-glucan assembly YJL078C PRY3 0.98 5.5 S C "Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein." YOR009W TIR4 0.98 1.0 YDL038C 0.98 5.3 YOL155C 0.97 3.0 C YJR151C DAN4 0.97 1.3 Delayed Anaerobic Gene YOL030W GAS5 0.97 4.1 Z S Hypothetical ORF YLR286C CTS1 0.97 9.3 K S C Endochitinase YOR220W 0.97 2.5 YNR044W AGA1 0.97 6.5 K S anchorage subunit of a-agglutinin YGR023W MTL1 0.97 1.8 Mid-Two Like 1 YMR317W 0.97 2.1 YCR089W FIG2 0.97 3.4 "Factor-Induced Gene 2: expression is induced by the mating pheromones, a and alpha factor; required for efficient mating" YLR194C 0.96 5.4 S YIL011W TIR3 0.96 2.6 S TIP1-related YGR161C 0.96 2.4 YBR067C TIP1 0.96 5.9 K Z S C cold- and heat-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YNL327W EGT2 0.96 8.7 K S "cell-cycle regulation protein, may be involved in the correct timing of cell separation after cytokinesis" YLR332W MID2 0.96 1.5 Protein required for mating YNR067C DSE4 0.96 6.3 S C Daughter Specific Expression 4 YOR382W FIT2 0.96 1.8 "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YLR390W-A CCW14 0.96 2.7 Secretory Stress Response protein YHR143W DSE2 0.96 7.3 S Daugher Specific Expression 2 YFR054C 0.96 1.6 YDL211C 0.96 3.3 S YLR353W BUD8 0.96 4.2 Z S C marks and directs bud emergence to the distal pole of diploid cells YNL283C WSC2 0.95 5.8 Z S cell wall integrity and stress response component 2 YDR349C YPS7 0.95 1.4 Gpi-anchored aspartic protease (Yapsin 7) YHR212C 0.95 0.8 YOL105C WSC3 0.95 1.2 cell wall integrity and stress response component 3 YIL117C PRM5 0.95 3.7 S pheromone-regulated membrane protein YDR534C FIT1 0.95 1.5 "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YIR016W 0.95 0.8 YDR055W PST1 0.95 5.5 S Protoplasts-secreted YLR120C YPS1 0.95 1.8 Gpi-anchored aspartic protease (Yapsin 1) YGL028C SCW11 0.95 8.2 S C Soluble Cell Wall protein YDR451C YHP1 0.95 5.3 S C YJL158C CIS3 0.94 4.7 S cik1 suppressor YJR004C SAG1 0.94 3.8 S alpha-agglutinin YNL176C 0.94 3.7 Z S C YGL035C MIG1 0.94 1.1 Transcription factor involved in glucose repression YOR383C FIT3 0.94 2.0 S "FIT1, FIT2, and FIT3 code for mannoproteins that are incorporated into the cell wall via glycosylphosphatidylinositol anchors." YMR307W GAS1 0.94 5.6 K S Glycophospholipid-anchored surface protein YDL136W RPL35B 0.94 2.3 Homology to rat L35 YDL191W RPL35A 0.94 2.0 Homology to rat L35 YMR233W TRI1 0.94 0.8 Topoisomerase 1 and RAD52 epistasis group Interactions YBR130C SHE3 0.94 1.9 Z cytoplasmic protein involved in mother-specific HO expression YOR279C RFM1 0.94 0.8 Repression Factor of MSE YNL074C MLF3 0.94 0.8 Protein of unknown function YLR121C YPS3 0.94 5.5 S C Gpi-anchored aspartic protease (Yapsin 3) YGL056C SDS23 0.94 1.0 homolog of pombe SDS23; localizes to spindle pole body YEL040W UTR2 0.93 2.7 S (alias: Congo Red Hypersensitivity) YOR247W SRL1 0.93 4.8 S Suppressor of Rad53 null Lethality YER028C 0.93 1.8 YNL053W MSG5 0.93 2.5 C Tyrosine protein phosphatase involved in adaptation response to pheromone YGL032C AGA2 0.93 4.1 S adhesion subunit of a-agglutinin YOR010C TIR2 0.93 1.6 cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins YDR439W LRS4 0.93 1.2 Loss of rDNA silencing YKR092C SRP40 0.93 1.9 Suppressor of mutant AC40 subunit of RNA polymerase I and III (high serine) YLR457C NBP1 0.93 2.9 S C Nap1p Binding Protein YJL053W PEP8 0.93 1.0 Plays a role in delivery of proteins to the vacuole YGL003C CDH1 0.93 1.5 CDC20 homolog 1 YNL042W BOP3 0.92 2.3 bypass of PAM1 YLR040C 0.92 2.6 S YHR214W 0.92 2.3 YAR066W 0.92 1.7 YIL123W SIM1 0.92 6.0 Z S (putative) invovled in control of DNA replication YFR022W 0.92 2.2 YPL014W 0.92 3.5 S C YPR171W 0.92 1.1 YOR233W KIN4 0.92 2.1 protein kinase YPL155C KIP2 0.92 3.3 Z S kinesin-related protein YML041C VPS71 0.92 0.9 YKL079W SMY1 0.92 2.0 "not believed to act as a kinesin, colocalizes with Myo2p" YGR035C 0.92 4.5 S C YJR150C DAN1 0.92 2.6 Delayed Anaerobic YNR014W 0.92 1.8 YLR394W CST9 0.92 1.5 Chromosome STability; involved in meiotic chromosome synapsis YIR019C MUC1 0.92 1.5 Required for invasion and pseudohyphae formation in response to nitrogen starvation YLR265C NEJ1 0.92 0.9 Nonhomologous End-Joining regulator 1; Repressed by MAT heterozygosity; Interacts with Lif1p in a yeast two-hybrid assay YKR102W FLO10 0.92 1.9 Protein with similarity to flocculation protein Flo1p YDR447C RPS17B 0.92 1.3 Homology to rat ribosomal protein S17 YLR042C 0.91 1.6 YKR091W SRL3 0.91 3.0 S Suppressor of Rad53 null Lethality YNL078W NIS1 0.91 5.3 S C YDR420W HKR1 0.91 1.3 cell surface protein that may regulate cell wall beta-glucan synthesis and bud site selection; Hanenula mrakii killer toxin-resistance protein YGL162W SUT1 0.91 3.0 S Involved in sterol uptake YOR019W 0.91 0.8 YKR010C TOF2 0.91 4.2 Z S C topoisomerase I interacting factor 2 YBR162C TOS1 0.91 2.6 Target of SBF YDL129W 0.91 1.6 YGR074W SMD1 0.91 1.7 "Homolog of human core snRNP protein D1, involved in snRNA maturation" YMR188C 0.91 2.1 YMR268C PRP24 0.91 1.1 U4/U6 snRNA-associated splicing factor YGL259W YPS5 0.91 2.4 Gpi-anchored aspartic protease (Yapsin 5) YGR091W PRP31 0.90 0.9 pre-mRNA splicing protein YGR014W MSB2 0.90 3.7 Z S putative integral membrane protein YER011W TIR1 0.90 2.4 K Cold-shock induced protein of the Srp1p/Tip1p family of serine-alanine-rich proteins. Encodes a stress-response cell wall mannoprotein and this gene is downregulated at acidic pH. YAL065C 0.90 2.0 YBR203W 0.90 1.7 YOR372C NDD1 0.90 2.8 Z S Nuclear Division Defective 1 YCL063W 0.90 4.1 S C YOL036W 0.90 1.0 YGR279C SCW4 0.90 4.2 S C Soluble Cell Wall protein YLR313C SPH1 0.90 5.9 Z S C SPa2-Homolog; protein involved in shmoo formation and required for bipolar bud site selection (GB:AF008236). YDR277C MTH1 0.90 1.6 C Negative regulator of HXT gene expression YDR169C STB3 0.90 1.7 binds Sin3p in two-hybrid assay YDL028C MPS1 0.90 1.8 Required for spindle pole body duplication and a mitotic checkpoint function. YHR004C NEM1 0.90 0.8 Nuclear Envelope Morphology YDR223W 0.90 1.0 YOR324C 0.90 3.3 S YHR211W FLO5 0.90 0.8 FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determined flocculation. YLR094C GIS3 0.90 1.6 GIG3 suppressor YOL060C MAM3 0.90 1.4 putative hemolysin-like protein with three transmembrane domains YDL194W SNF3 0.90 1.3 glucose sensor YJR115W 0.90 0.8 YML109W ZDS2 0.90 2.7 S C multicopy suppressor of a sin4 defect YDR077W SED1 0.90 3.7 K S putative cell surface glycoprotein YDR200C VPS64 0.90 1.7 YDR144C MKC7 0.89 2.0 S protease involved in protein processing that shares functions with Yap3 and Kex2 YDR507C GIN4 0.89 4.5 S C Growth inhibitory gene YBR215W HPC2 0.89 1.1 Protein required for normal cell-cycle regulation of histone gene transcription YJL160C 0.89 2.0 YOR023C AHC1 0.89 1.7 S Ada Histone acetyltransferase complex component YDL127W PCL2 0.89 6.6 K Z S C Interacts with cyclin-dependent kinase PHO85 to form kinase complex with G1-periodic activity involved in cell cycle progression YKL006C-A SFT1 0.89 1.1 Required for transport of proteins between an early and a later golgi compartment. possible NSF attachment protein receptor (V-SNARE) YOR058C ASE1 0.89 4.5 K Z S C essential for anaphase spindle elongation YGR079W 0.89 1.1 YJL128C PBS2 0.89 1.1 "Involved in osmoregulation, member of the HOG1 mitogen-activated protein kinase (MAPK) cascade" YDL048C STP4 0.89 3.3 S C Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YDR524C AGE1 0.89 1.1 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector YDR379W RGA2 0.89 1.6 "contains a Rho-GAP domain and two LIM domains, similar to Rga1p and all known Rho-GAPs" YPL070W 0.89 1.1 YBR156C SLI15 0.89 1.9 C Mitotic spindle protein involved in chromosome segregation. YDL197C ASF2 0.89 4.1 K Z S C anti-silencing protein that causes depression of silent loci when overexpressed YOR288C MPD1 0.89 2.0 Disulfide isomerase related protein YPR023C EAF3 0.89 1.3 Esa1p-Associated Factor YDR422C SIP1 0.89 1.2 SNF1 protein kinase substrate YBR214W SDS24 0.89 1.8 "Similar to S. pombe SDS23, suppresses DIS2, localized to the nucleus" YHR096C HXT5 0.89 2.3 Member of superfamily of monosaccharide transporters YDR528W HLR1 0.89 4.5 Z S LRE1 homolog YOR014W RTS1 0.89 1.1 B-type regulatory subunit of protein phosphatase 2A (PP2A) YOR008C SLG1 0.89 1.3 cell wall integrity and stress response component 1 YPR075C OPY2 0.88 3.4 S imparts Far- phenotype YOL070C 0.88 3.4 S C YKL175W ZRT3 0.88 1.8 YBR142W MAK5 0.88 1.7 Necessary for maintenance of dsRNA killer plasmids. Is predicted to encode an DEAD-box RNA helicase YPR083W MDM36 0.88 1.6 Mitochondrial Distribution and Morphology YGL113W SLD3 0.88 0.9 synthetic lethality with dpb11-1; Sld3p interacts with Cdc45 and is required for initiation of DNA replication. YNR039C ZRG17 0.88 1.0 zinc-regulated gene YNL096C RPS7B 0.88 0.9 Homology to human S7 and Xenopus S8 YIL015W BAR1 0.88 1.1 extracellular protease synthesized in a-cells that cleaves and inactivates alpha factor YGL209W MIG2 0.88 2.8 S "Involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter" YKR045C 0.88 1.0 YBR119W MUD1 0.88 1.1 U1 snRNP A protein YDL037C 0.88 8.3 S YOL091W SPO21 0.88 2.0 sporulation defective YLL021W SPA2 0.88 2.3 C spindle pole antigen YDR309C GIC2 0.88 4.2 K S C Gtpase-interacting component 2 YBR255W 0.88 1.3 YGR027C RPS25A 0.88 0.9 Homology to rat S25 YDR436W PPZ2 0.88 1.6 serine-threonine phosphatase Z YLR003C 0.88 1.4 YNL272C SEC2 0.88 2.1 C Protein with coiled-coil domain essential for vesicular transport YLL038C ENT4 0.88 1.5 epsin N-terminal homology-containing protein YBL031W SHE1 0.88 2.1 Product of gene unknown YPR056W TFB4 0.88 1.3 "RNA polymerase transcription initiation TFIIH (factor b), 37 kDa subunit" YJR021C REC107 0.88 1.2 meiotic recombination protein YHR049C-A 0.88 1.1 YOL012C HTZ1 0.88 3.5 Z S C Histone-related protein that can suppress histone H4 point mutation YOR018W ROD1 0.88 3.2 Z S "Resistance to o-dinitrobenzene, calcium, and zinc" YGL171W ROK1 0.88 1.1 contains domains found in the DEAD protein family of ATP-dependent RNA helicases; high-copy suppressor of kem1 null mutant YDR227W SIR4 0.87 1.4 "Sir4 binding to Rap1 initiates the sequential association of Sir and other proteins, allowing the subsequent spreading of heterochromatin proteins along the chromosome." YOR355W GDS1 0.87 2.3 S involved in nuclear control of mitochondria YOR295W UAF30 0.87 1.0 Topoisomerase 1 and RAD52 epistasis group Interactions YLR031W 0.87 1.4 YPL158C 0.87 6.1 S C YPL039W 0.87 0.9 YLR333C RPS25B 0.87 1.3 Homology to rat S25; belongs to the S25E family of ribosomal proteins YGR068C 0.87 1.7 YKL176C LST4 0.87 1.1 required for amino acid permease transport from the Golgi to the cell surface. involved in regulated secretion/recycling of nitrogen regulated permeases. YNL269W 0.87 2.1 YKR019C IRS4 0.87 1.0 Increased rDNA silencing YLR035C MLH2 0.87 1.6 Mutl Homolog YKL108W SLD2 0.87 5.4 Z S C Synthetically lethal with dpb11-1; required for DNA replication YDL239C ADY3 0.87 2.7 Accumulation of dyads YHL031C GOS1 0.87 1.3 SNARE protein with a C-terminal membrane anchor
GOlgi Snare YPL074W YTA6 0.87 2.4 Member of CDC48/PAS1/SEC18 family of ATPases YDL074C BRE1 0.87 1.3 putative coiled-coil protein with RING-finger and myosin-like domains YCR067C SED4 0.87 1.2 "Sed4p is an integral ER membrane protein, which, along along with its close homolog, Sec12p, is involved in vesicle formation at the ER" YKL198C PTK1 0.87 0.9 Putative serine/threonine protein kinase YAL041W CDC24 0.87 1.2 calcium-binding protein involved in bud emergence and schmooing YJL051W 0.87 6.1 Z S C YDR285W ZIP1 0.87 2.0 "Synaptonemal complex protein, component of the central element" YGR166W KRE11 0.87 1.1 Involved in biosynthetic pathway for cell wall beta-glucans YKR005C 0.87 1.6 YNL002C RLP7 0.87 1.6 "Significant sequence similarity to RPL7B, but neither can functionally replace the other. Does not correspond to any ribosomal component identified so far, based on its biochemical features" YOR359W VTS1 0.87 1.1 vti1-2 suppressor YPL066W 0.87 1.4 C YMR081C ISF1 0.87 1.2 "May regulate NAM7 function, possibly at level of mRNA turnover" YDR116C 0.87 1.7 YCR048W ARE1 0.87 1.9 Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) YOL100W PKH2 0.87 1.9 Pkb-activating Kinase Homologue YDL179W PCL9 0.86 1.9 K S C PHO85 cyclin YER064C 0.86 1.9 YKL011C CCE1 0.86 1.8 cruciform cutting endonuclease YJL215C 0.86 2.6 YLR409C UTP21 0.86 1.1 Protein required for cell viability YAL028W 0.86 2.1 YGR283C 0.86 1.3 YPR065W ROX1 0.86 1.8 The ROX1 gene encodes a heme-induced repressor of hypoxic genes in yeast. YKL065C YET1 0.86 2.1 S Yeast homolog of human BAP31 protein YHR188C GPI16 0.86 1.7 Glycosyl Phosphatidyl Inositol 16 YNL233W BNI4 0.86 4.6 Z S C bud neck involved YDR544C 0.86 1.9 YOL001W PHO80 0.86 1.0 Negative regulator of PHO81 and PHO5 YMR305C SCW10 0.86 4.9 S Soluble Cell Wall protein YNL234W 0.86 1.1 YKL064W MNR2 0.86 1.1 Product of gene unknown YOR264W DSE3 0.86 2.6 S C Daughter Specific Expression 3 YOR353C SOG2 0.86 1.3 Protein required for cell viability YCR030C SYP1 0.86 1.7 Suppressor of Yeast Profilin deletion YDL105W QRI2 0.86 2.9 S C Product of gene unknown YBR065C ECM2 0.86 0.9 C ExtraCellular Mutant YGL046W 0.86 1.2 YJR134C SGM1 0.86 1.7 involved in carbohydrate metabolism YCL027W FUS1 0.86 3.9 K S cell-surface protein required for cell fusion YLR319C BUD6 0.86 1.0 actin interacting rotein YGL134W PCL10 0.86 1.8 PHO85 cyclin YJL076W NET1 0.86 1.8 Nucleolar protein involved in exit from mitosis YER114C BOI2 0.86 1.9 "Protein which binds Bem1p and contains a proline-rich sequence, an SH3 domain, and a pleckstrin homology domain" YIL016W SNL1 0.86 0.9 Suppressor of nup116-C lethal. Snl1p is the first Bag domain protein identified in S. cerevisiae. YBL054W 0.86 1.8 YOR050C 0.86 1.8 YKR044W UIP5 0.86 1.8 Ulp1 Interacting Protein 5 YIL147C SLN1 0.86 1.0 Synthetic lethal of N-end rule YDR194C MSS116 0.85 1.8 Mitochondrial RNA helicase of the DEAD box family YDR130C FIN1 0.85 3.5 S Cell cycle-dependent filament between nuclei YBL009W 0.85 3.6 Z S YKL049C CSE4 0.85 2.2 C Required for proper kinetochore function; may be involved in assembly of a CEN-specific chromatin structure YDR184C ATC1 0.85 0.9 "interacts with AIP3, localized to the nucleus" YMR291W 0.85 2.4 YOL108C INO4 0.85 1.3 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis YBR102C EXO84 0.85 0.9 exocyst complex component; homolog in rat brain called rExo84.
pre-mRNA splicing factor. YOR198C BFR1 0.85 1.1 Multicopy suppressor of BFA (Brefeldin A)-induced lethality; implicated in secretion and nuclear segregation YPR141C KAR3 0.85 3.6 K S C kinesin-like nuclear fusion protein YER129W PAK1 0.85 0.9 high copy suppressor of temperature sensitive cdc17 (DNA polymerase alpha) mutations YIL146C ECM37 0.85 1.1 ExtraCellular Mutant YNL183C NPR1 0.85 1.2 Stablizes several nutrient transporters by antagonizing a ubiquitin-mediated protein degradation pathway. YPL137C 0.85 1.6 YBR250W 0.85 1.0 YPL202C AFT2 0.85 1.3 Activator of Iron (Fe) Transcription YPL081W RPS9A 0.85 1.0 Homology to rat S9 and E.coli S4 YDR464W SPP41 0.85 1.3 C appears to control expression of spliceosome components PRP4 and PRP3 YGL081W 0.85 1.0 YDR363W ESC2 0.85 1.7 Establishes Silent Chromatin YDR386W MUS81 0.85 1.6 Mms and UV Sensitive; Mus81p and Rad54p are found together in a complex from whole-cell extracts YDR243C PRP28 0.85 1.5 Required for the first step of splicing in vitro YBR260C RGD1 0.85 1.0 Related GAP Domain YBR189W RPS9B 0.85 2.1 Homology to rat S9 and E. coli S4 YMR019W STB4 0.85 1.2 binds Sin3p in two-hybrid assay YNL267W PIK1 0.85 0.9 "catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokineses through the actin cytoskeleton" YJL103C 0.85 1.7 C YGR272C 0.85 1.2 YIL056W 0.85 2.9 Z S YBR078W ECM33 0.85 3.2 ExtraCellular Mutant YPR015C 0.85 2.1 YPL269W KAR9 0.85 3.4 S cortical protein required for cytoplasmic microtubule orientation; localizes to the tip of shmoo projections and to the tip of budding cells in a cell-cycle dependent manner YNL197C WHI3 0.84 4.2 Z S Protein involved in regulation of cell size YER040W GLN3 0.84 0.9 Regulates glutamine-repressible gene products YPR095C SYT1 0.84 0.8 Suppressor of Ypt3 YMR153W NUP53 0.84 1.0 Component of karyopherin docking complex of the nuclear pore complex YOR227W 0.84 2.1 YGR113W DAM1 0.84 2.9 S Duo1 And Mps1 interacting. Localized to intranuclear spindles and spindle pole bodies. YDR103W STE5 0.84 1.0 Protein of the pheromone pathway YPR115W 0.84 1.1 YDR304C CPR5 0.84 1.2 "Cyclophilin D, Peptidyl-prolyl cis-trans isomerase D" YHR103W SBE22 0.84 1.3 functionally redundant and similar in structure to SBE2 YDR295C PLO2 0.84 0.9 Ploidy-related. Shares homology with PLO1 YGR225W AMA1 0.84 1.0 "Required for sporulation, highly induced during sporulation; activator of meiotic anaphase promoting complex" YPR124W CTR1 0.84 2.7 "High affinity copper transporter into the cell, probable integral membrane protein" YLR325C RPL38 0.84 1.3 Homology to rat L38 YDR216W ADR1 0.84 1.3 Positive transcriptional regulator of ADH2 and peroxisomal protein genes YLR453C RIF2 0.84 1.2 Rap1p-Interacting Factor 2; interacts with the c-terminus of Rap1p and with Rif1p; has functional similarities with Rif1p; Rif2p and Rif1p have synergistic effects on telomere length and chromosome loss YGR237C 0.84 1.6 YDR370C 0.84 1.0 YHR094C HXT1 0.84 1.9 S High-affinity hexose (glucose) transporter YGL143C MRF1 0.84 1.1 Mitochondrial polypeptide chain release factor YKR037C SPC34 0.84 2.7 S Spindle Pole Component of molecular weight 34 kDa YMR102C 0.84 1.7 YKL020C SPT23 0.84 1.0 Dosage dependent suppressor of Ty-induced promoter mutations. Homolog of Mga2. Spt23p and Mga2p differentially activate and regulate OLE1 transcription. YBR200W BEM1 0.84 3.4 Z S C "SH3-domain protein that binds Cdc24p, Ste5p and Ste20p, and the Rsr1p/Bud2p/Bup5p GTPase" YOR096W RPS7A 0.84 1.9 Homology to human S7 and Xenopus S8 YKR071C DRE2 0.84 1.1 Protein required for cell viability YFR021W AUT10 0.84 1.3 Required for cytoplasm to vacuole targeting of proaminopeptidase I and starvation induced autophagy (AUT10). Needed for pre-Meiotic Replication (NMR1). YBL090W MRP21 0.84 1.6 Mitochondrial Ribosomal Protein YJL028W 0.84 2.8 YNL192W CHS1 0.84 2.8 K S disrupts mating and sporulation efficiently YJL084C 0.84 2.4 YLR436C ECM30 0.84 1.2 ExtraCellular Mutant YEL062W NPR2 0.84 1.5 Putative post-transcriptional regulator of nitrogen permeases YHR159W 0.84 3.0 S YMR068W AVO2 0.84 1.1 Adheres VOraciously (to TOR2) YDR345C HXT3 0.84 1.8 Low-affinity glucose transporter YIL092W 0.84 1.2 YNL012W SPO1 0.84 1.0 "dispensable for mitosis, premeiotic DNA synthesis, synaptonemal complexes, and recombination, but required for meiotic spindle pole body duplication/separation, meiosis I, meiosis II, and spore formation" YMR148W 0.84 1.9 C YDR219C 0.84 2.7 C YDR306C 0.83 0.8 YOR223W 0.83 0.9 YBR193C MED8 0.83 1.1 Member of RNA Polymerase II transcriptional regulation mediator YLR225C 0.83 2.3 S YDL133W 0.83 1.1 YOL113W SKM1 0.83 2.5 Serine/threonine protein kinase with similarity to Ste20p and Cla4p YPL115C BEM3 0.83 1.0 Gtpase-activating protein activity toward the essential bud-site assembly GTPase Cdc42 YPL253C VIK1 0.83 3.1 Z S vegetative interaction with Kar3p YFL026W STE2 0.83 3.4 K S alpha-factor pheromone receptor; seven-transmembrane domain protein YAL040C CLN3 0.83 3.8 K S C role in cell cycle START; involved in G(sub)1 size control YLR072W 0.83 1.6 YOL130W ALR1 0.83 0.8 aluminium resistance YLR082C SRL2 0.83 1.4 Suppressor of Rad53 null Lethality YKL050C 0.83 1.9 YFR034C PHO4 0.83 2.3 Z Transcription factor that activates expression of phosphate pathway YBL101C ECM21 0.83 1.8 ExtraCellular Mutant YLR045C STU2 0.83 4.3 Z S C "May play a role in attachment, organization, and/or dynamics of microtubule ends at the spindle pole body" YLR096W KIN2 0.83 1.4 Serine/threonine protein kinase YJL063C MRPL8 0.83 1.6 Mitochondrial ribosomal protein MRPL8 (YmL8) (E. coli L17) YDR255C RMD5 0.83 1.7 Required for Meiotic nuclear Division YKL179C COY1 0.83 1.4 CASP Of Yeast YOR273C TPO4 0.83 4.3 S C Polyamine transport protein YLR312C 0.83 2.0 YDR393W SHE9 0.83 0.8 Mrna (identified by a library screen) that causes growth arrest when overexpressed.
Mitochondrial Distribution and Morphology YBR158W CST13 0.83 6.0 S C Chromosome STability YBR141C 0.83 0.8 YNL248C RPA49 0.83 1.1 49-kDa alpha subunit of RNA polymerase A YGL200C EMP24 0.83 2.7 S C "type I transmembrane protein, component of COPII-coated, ER-derived transport vesicles" YLL059C 0.83 2.5 YJL110C GZF3 0.83 1.2 Dal80 homolog YDR351W SBE2 0.83 1.0 Required for bud growth YHL007C STE20 0.83 0.9 Involved in pheromone response and pseudohyphal growth pathways YGL007W 0.83 1.6 YCR061W 0.83 1.1 YBL102W SFT2 0.83 1.4 similar to mammalian syntaxin 5 YDR072C IPT1 0.83 1.8 necessary for synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C) YHR139C SPS100 0.83 2.9 involved in spore development YER006W NUG1 0.83 1.4 NUclear GTPase YBL085W BOI1 0.83 1.4 Involved in bud growth YOR071C 0.82 1.4 YBR014C 0.82 1.0 YJL116C NCA3 0.82 3.3 "With NCA2, regulates proper expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase" YPL124W SPC29 0.82 3.7 Z S C spindle pole body component YHR052W CIC1 0.82 0.8 Core interacting component 1 YHL023C RMD11 0.82 0.8 Required for Meiotic nuclear Division YJL156C SSY5 0.82 1.1 Product of gene unknown YOR154W 0.82 1.3 YOR322C 0.82 1.1 YJL122W 0.82 1.5 YGR070W ROM1 0.82 2.0 Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-binding Protein YHR131C 0.82 0.9 YJR092W BUD4 0.82 5.3 S C co-assembles with Bud3p at bud sites YGL179C 0.82 2.2 YJL057C IKS1 0.82 1.2 ira1* kinase suppressor YER047C SAP1 0.82 1.8 interacts with Sin1p YLL010C PSR1 0.82 1.7 Plasma membrane Sodium Response 1 YPL141C 0.82 5.0 S YKR067W GPT2 0.82 1.4 Encodes a Glycerol-3-phosphate acyltransferase YEL067C 0.82 1.3 YKR089C 0.82 1.1 YOR044W 0.82 1.0 YNL046W 0.82 1.8 S C YHR066W SSF1 0.82 1.4 putative involvement in mating YHL048W COS8 0.82 1.4 "Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YDR274C 0.82 3.5 YJR098C 0.82 1.2 YDR247W 0.82 4.1 S YOL061W PRS5 0.82 1.3 Phosphoribosylpyrophosphate synthetase (ribose-phosphate pyrophosphokinase) YJL092W HPR5 0.82 3.8 K Z S C Required for proper timing of committment to meiotic recombination and the transition from Meiosis I to Meiosis II YJL079C PRY1 0.82 7.0 S C "Pathogen Related in Sc, contains homology to the plant PR-1 class of pathogen related proteins. The protein sequence is over 60% identical with the Pry2p & Pry3p over 145 resid. PRY1 is >35% identical (50% similar) to tobacco PR-1c protein." YDL089W 0.82 2.2 S YGL090W LIF1 0.82 2.9 S Ligase Interacting Factor 1; physically interacts with DNA ligase 4 protein (Lig4p) YJR054W 0.82 2.7 S YDR217C RAD9 0.81 1.3 "Required for DNA damage-induced G2 arrest in mitosis, required for ionizing radation-induced G1 arrest, and other cdc13-induced G2 arrest in meiosis" YOR192C 0.81 2.0 YEL061C CIN8 0.81 3.7 Z S C Kinesin-related protein involved in establishment and maintenance of mitotic spindle YMR005W TAF4 0.81 1.7 Protein required for protein synthesis YIL095W PRK1 0.81 1.0 p53 regulatory kinase YPL128C TBF1 0.81 3.6 S TTAGGG repeat binding factor YGL197W MDS3 0.81 2.1 Mck1 Dosage Suppressor 3; negative regulator of early meiotic gene expression YER059W PCL6 0.81 1.7 PHO85 cyclin YNL301C RPL18B 0.81 1.4 Homology to rat ribosomal protein L18 YOL120C RPL18A 0.81 1.3 Homology to rat ribosomal protein L18 YPL219W PCL8 0.81 1.0 PHO85 cyclin YMR106C YKU80 0.81 1.7 "Exhibits DNA binding activity on its own, associates with Hdf1p to form major DNA end-binding complex" YNL020C ARK1 0.81 1.0 actin regulating kinase YLR139C SLS1 0.81 1.4 "Protein involved in mitochondrial gene expression, may facilitate translation by delivering mRNAs to membrane-bound translational activation complexes" YAL024C LTE1 0.81 1.8 Gdp/GTP exchange factor required for growth at low temperatures YML071C COG8 0.81 0.9 Conserved Oligomeric Golgi complex 8
dependent on RIC1 YLR177W 0.81 0.8 YDR425W 0.81 1.0 YHR081W LRP1 0.81 1.2 Like an rRNA Processing protein YNL019C 0.81 2.0 YPL188W POS5 0.81 1.1 involved in oxidative stress YER075C PTP3 0.81 1.0 Protein tyrosine phosphatase YIL144W TID3 0.81 3.0 S Product of gene unknown YNL005C MRP7 0.81 0.8 Mitochondrial ribosomal protein MRP7 (YmL2) (E. coli L27) YCR069W CPR4 0.81 2.2 S cyclophilin homolog YMR140W SIP5 0.81 1.1 Sip5 facilitates the interaction between the Reg1Glc7 phosphatase and the Snf1 kinase. YLR464W 0.81 4.5 Z S YPL241C CIN2 0.81 4.0 S C involvement in microtubule function YBR033W EDS1 0.81 1.6 Expression dependent on Slt2 YOR178C GAC1 0.81 1.5 "Regulatory subunit for phosphoprotein phosphatase type 1 (PP-1), also known as Glc7p, which regulates glycogen synthase-2" YLR263W RED1 0.81 1.2 "Required for full chr. pairing & chr. condensation seen by in situ hybridization, axial elements, stable localization of Hop1p & synaptonemal complexes; at HIS2 required for normal levels of double strand breaks" YMR086W 0.81 1.6 YDR160W SSY1 0.81 1.1 "Ssy1p controls expression of several transporter genes, including BAP2, TAT1, PTR2 and YDR046c" YOR206W NOC2 0.81 1.8 NucleOlar Complex 2; involved in nuclear export of pre-ribosomes YDR186C 0.81 1.3 YJR059W PTK2 0.81 1.6 Putative serine/threonine protein kinase that enhances spermine uptake YDR239C 0.81 1.6 YMR042W ARG80 0.81 2.0 Regulator of arginine-responsive genes with ARG81 and ARG82 YIL010W DOT5 0.81 1.5 Derepression Of Telomeric silencing
homologous to 4 other S.c. thioredoxin peroxidases YGR249W MGA1 0.81 1.4 Mga1p shows similarity to heat shock transcription factor YNL033W 0.81 2.0 YLR073C 0.81 1.6 YBR073W RDH54 0.81 3.9 S C genetic interaction with DMC1 YBR225W 0.80 1.5 YHL015W RPS20 0.80 1.1 "Homology to rat S20, human S20, Xenopus S22, and E. coli S10" YMR232W FUS2 0.80 2.2 "Involved in cell fusion during mating, also required for the alignment of parental nuclei before nuclear fusion" YMR059W SEN15 0.80 1.4 Trna splicing endonuclease 15kDa subunit YOR315W 0.80 4.8 S C YML064C TEM1 0.80 3.4 S Gtp-binding protein of the ras superfamily involved in termination of M-phase YDR463W STP1 0.80 1.1 Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YPR079W MRL1 0.80 1.4 Mannose 6-phosphate Receptor Like YER019C-A SBH2 0.80 1.9 "Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum" YKR098C UBP11 0.80 2.3 Ubiquitin-specific protease YPL072W UBP16 0.80 2.0 putative deubiquitinating enzyme YNL253W 0.80 0.9 YOR078W BUD21 0.80 1.4 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); YCR033W SNT1 0.80 1.9 Z YKL048C ELM1 0.80 3.6 Z S C cell morphology YEL050C RML2 0.80 1.2 mitochondrial ribosomal protein L2 of the large subunit YAR050W FLO1 0.80 1.5 FLO5- and FLO8-determined flocculation are considerably less sensitive to mannose than FLO1-determined flocculation. YPL228W CET1 0.80 1.5 "Interacts with Ceg1p, the mRNA capping enzyme alpha subunit; removes gamma-phosphate from triphosphate-terminated RNA" YLR238W 0.80 1.4 YOR060C 0.80 1.9 YBR138C HDR1 0.80 4.7 S C High-Dosage Reductional segregation defective. Converts reductional segregation to equational when borne on a 2um plasmid YKR055W RHO4 0.80 1.6 ras homolog--GTP binding protein YAL031C FUN21 0.80 1.3 Function unknown now YLR441C RPS1A 0.80 1.9 Homologous to rat S3A YKR099W BAS1 0.80 2.1 Transcription factor regulating basal and induced activity of histidine and adenine biosynthesis genes YLR237W THI7 0.80 2.2 Thiamine Metabolism YML076C WAR1 0.80 1.1 ORF YEL002C WBP1 0.80 0.8 wheat germ agglutinin-binding protein YBR007C 0.80 2.2 S C YDR115W 0.80 1.3 YDR069C DOA4 0.80 1.0 deubiquitinating enzyme; vacuole biogenesis gene YER169W RPH1 0.80 1.6 Regulator of PHR1 YMR280C CAT8 0.80 1.4 CAT8 controls the key enzymes of gluconeogenesis in S. cerevisiae. YPR008W HAA1 0.80 2.6 Homolog of Ace1 Activator YER032W FIR1 0.80 5.0 Z S C "Factor Interacting with REF2, interacts strongly with REF2 protein in 2-hybrid screen" YAL046C 0.80 1.0 YOR161C 0.80 1.8 YJL185C 0.80 1.1 YLR290C 0.80 0.8 YMR155W 0.80 1.5 YPL101W ELP4 0.80 1.3 "ELongator Protein 4; 50kD subunit. Homolog of ATPases, yet with substitutions of amino acids critical for ATP hydrolysis." YML063W RPS1B 0.80 1.7 Homologous to rat ribosomal protein S3A YML068W ITT1 0.80 1.5 Inhibitor of Translation Termination YIL171W 0.80 1.7 YOL027C MDM38 0.80 0.9 Mitochondrial Distribution and Morphology YAL023C PMT2 0.80 2.4 Transfers mannosyl residues from dolichyl phosphate-D-mannose to seryl and threonyl residues in proteins; acts in complex with Pmt1p YPR032W SRO7 0.80 1.5 Suppressor of rho3 YGR138C TPO2 0.80 4.7 S Polyamine transport protein YOR127W RGA1 0.80 2.5 S putative GTPase-activating protein for the polarity-establishment protein Cdc42p or Rho1p; activates the pheromone-response pathway YBL011W SCT1 0.80 1.0 High copy suppresor of choline-transport mutants YKR046C 0.80 2.6 S YMR224C MRE11 0.80 0.8 "Disp. for premeiotic DNA synthesis, but required for both double strand break formation & resection, synaptonemal complexes, meiotic recombination & viable spores. Localizes to discrete sites in rad50 mutants" YHR080C 0.80 1.2 YNL298W CLA4 0.80 1.5 Involved in localizing cell growth with respect to the septin ring YDL149W APG9 0.80 1.6 Integral membrane protein YDR006C SOK1 0.80 1.2 gene dosage suppressors of the conditional growth defect of several temperature-sensitive A kinase mutants YEL042W GDA1 0.80 3.1 S converts nucleoside diphosphates to nucleoside monophosphates to recycle nucleosides and promote transport of additional nucleotide sugars into golgi YAL010C MDM10 0.79 1.5 Mitochondrial outer membrane protein involved in mitochondrial morphology and inheritance YKL208W CBT1 0.79 1.0 Subunit of complex involved in processing of the 3' end of cytochrome b pre-mRNA YKL101W HSL1 0.79 5.0 K Z S C Histone Synthetic Lethal
Negative regulator of Swe1 kinase YJL095W BCK1 0.79 1.1 bypass requirement for protein kinase C homolog YKL219W COS9 0.79 1.7 "Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YML083C 0.79 1.2 YNL080C 0.79 1.3 YDR042C 0.79 1.7 YOL015W 0.79 1.8 YLL003W SFI1 0.79 0.9 Product of gene unknown YER041W YEN1 0.79 1.1 YER158C 0.79 2.2 YKL122C SRP21 0.79 2.1 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YLR296W 0.79 1.7 YEL009C GCN4 0.79 1.5 transcriptional activator of amino acid biosynthetic genes YJR043C POL32 0.79 3.4 S C Polymerase-associated gene YHR202W 0.79 1.4 YPL168W 0.79 1.3 YIL152W 0.79 1.3 YHR035W 0.79 1.4 YGL075C MPS2 0.79 2.1 "Monopolar spindle two, encodes a membrane protein localized at the nuclear envelope and the spindle pole body throughout the cell cycle. The protein is approximately 45 kDa, and contains a coiled-coil motif and a hydrophobic domain." YPR030W CSR2 0.79 1.8 chs5 spa2 rescue; overexpression rescues the lethality of chs5 spa2 at 37 degrees YLR451W LEU3 0.79 1.3 "Regulates genes involved in branched chain amino acid biosynthesis and in ammonia assimilation. Positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis." YML016C PPZ1 0.79 1.4 may play a role in regulating osmotic stability YIL044C AGE2 0.79 0.8 ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector YNL066W SUN4 0.79 2.2 Protein involved in the aging process. Related to glucanases. YOR037W CYC2 0.79 0.8 Involved in import of cytochrome c into mitochondria YGR013W SNU71 0.79 0.9 "associated with U1 snRNP (no counterpart in mammalian U1 snRNP; contains few SR-, RE- and RD-dipeptides" YFR023W PES4 0.79 1.9 Suppressor of DNA polymerase epsilon mutation YGR130C 0.79 1.0 YGL061C DUO1 0.79 2.7 S Death Upon Overexpression YEL032W MCM3 0.79 5.4 Z S C Member of complex that acts at ARS's to initiate replication YPL140C MKK2 0.79 0.9 "Member of MAP kinase pathway involving PKC1, BCK1, and SLT2. Shows functional redundancy with MKK1" YDR356W SPC110 0.79 3.9 K S C may be involved in connecting nuclear microtubules to the spindle pole body YAR002W NUP60 0.79 1.1 nuclear pore protein YFL050C ALR2 0.79 2.3 aluminium resistance YNR047W 0.79 1.1 YMR163C 0.79 2.7 S YDR409W SIZ1 0.79 1.1 Sap and mIZ. Contains two known protein motifs: SAP (DNA binding) and MIZ-finger; ubiquitin-like protein ligase 1 YLR214W FRE1 0.79 2.3 S Ferric (and cupric) reductase YJL201W ECM25 0.79 3.0 Z S ExtraCellular Mutant YOR338W 0.79 1.8 YBR021W FUR4 0.79 2.1 uracil permease YIL115C NUP159 0.79 0.8 Located on cytoplasmic side of nuclear pore complex; may be involved in nuclear import or mRNA export; binds to karyopherin beta and a nuclear transport substrate in vitro YDR369C XRS2 0.79 2.2 "classified as an early recombination function, required for DNA repair but dispensable for mitotic recombination (xrs2 is hyper-Rec during vegatative growth), required for double strand breaks, meiotic recombination and spore viability" YJL090C DPB11 0.79 1.8 "Part of the DNA polymerase II complex, acts in a checkpoiint pathway during S-phase" YBL017C PEP1 0.79 1.4 vacuolar protein sorting receptor for carboxypeptidase Y and proteinase A; related to Sortilin YLR135W SLX4 0.79 1.6 S YOL034W SMC5 0.79 1.9 S Structural maintenance of chromosomes (SMC) protein YER026C CHO1 0.79 1.5 phosphatidylserine synthase YBL113C 0.78 3.9 S YMR144W 0.78 2.3 S YOR134W BAG7 0.78 2.3 Structural homolog of SAC7 YHR178W STB5 0.78 2.4 S C binds Sin3p in two-hybrid assay YOL038W PRE6 0.78 1.1 alpha-type of subunit of 20S proteasome YOR073W 0.78 4.4 Z S C YDR312W SSF2 0.78 1.3 high copy suppressor of G beta subunit temperature sensitive mutation YER096W SHC1 0.78 1.9 Required for proper maturation of the ascospore through its participation in the synthesis of the chitosan layer. YPR070W MED1 0.78 1.1 Subunit 1 of the Mediator complex essential for transcriptional regulation YDR207C UME6 0.78 1.2 Regulator of both repression and induction of early meiotic genes. Ume6p requires Ume4 for mitotic repression and interacts with and requires Ime1p and Rim11p for induction of meiosis-specific transcription YPL093W NOG1 0.78 1.9 Nucleolar G-protein 1; LPG15w (working nomenclature) YKR024C DBP7 0.78 1.5 Dead-box protein YJR089W BIR1 0.78 1.0 baculoviral IAP repeat-containing protein YIL130W GIN1 0.78 1.2 Gcn5 INdependent YKR064W 0.78 1.1 YGL005C COG7 0.78 1.0 Conserved Oligomeric Golgi complex 7
Complexed with Cog8p YOR107W RGS2 0.78 1.2 Regulator of G-protein Signalling for gpa2; belongs to the RGS protein family and acts on Gpa2 YGR065C VHT1 0.78 2.0 S vitamin H transporter YNR066C 0.78 3.9 S YDR423C CAD1 0.78 1.3 "Transcriptional activator involved in resistance to 1,10-phenanthroline; member of yeast Jun-family of transcription factors related to mammalian c-jun" YNR068C 0.78 0.8 YJL013C MAD3 0.78 2.0 checkpoint protein required for cell cycle arrest in response to loss of microtubule function YER111C SWI4 0.78 5.3 K S C Involved in cell cycle dependent gene expression YOR070C GYP1 0.78 1.3 Gtpase activating protein for Ypt1p YGR238C KEL2 0.78 2.8 S C "protein containing kelch repeats, similar to YHR158c and YPL263c" YKR021W 0.78 3.1 S C YMR261C TPS3 0.78 1.8 115 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex YGL243W TAD1 0.78 0.9 Deaminates adenosine-37 to inosine in eukaryotic tRNA-Ala. YOR310C NOP58 0.78 1.2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 57 kDa nucleolar protein involved in the pre-rRNA processing steps that lead to formation of 18 S rRNA; interacts with Nop1p YDL101C DUN1 0.78 3.9 S C "Dun1 kinase has complex checkpoint functions including DNA damage-dependent cell cycle arrest in G(2)M, transcriptional induction of repair genes, and regulation of postreplicative DNA repair pathways." YMR078C CTF18 0.78 4.3 Z S C Chromosome transmission YJL002C OST1 0.78 1.8 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YNL069C RPL16B 0.78 1.7 Homology to rat ribosomal protein L13a YER144C UBP5 0.78 1.2 Putative Ubiquitin-specific protease YDL220C CDC13 0.78 1.7 "Regulator of telomere replication. Recruits telomerase to the telomere. Required for G2/M transition in mitosis, synaptonemal complexes, recombination, meiosis I, meiosis II, and spores. Dispensable for premeiotic DNA synthesis." YKR034W DAL80 0.78 1.6 Negative regulator of multiple nitrogen catabolic genes YNL225C CNM67 0.78 2.6 S C chaotic nuclear migration; predicted mass is 67kDa YMR180C CTL1 0.78 1.1 CET1-Like Gene #1 (CET1 = capping enzyme triphosphatase 1) YMR036C MIH1 0.78 1.1 Mitotic Inducer Homolog
S. pombe cdc25+ homolog YGL251C HFM1 0.78 1.3 DNA helicase that functions in meiotic crossing over YNL076W MKS1 0.78 0.9 Pleiotropic regulatory factor involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation YJL179W PFD1 0.78 1.1 "Prefoldin subunit 1; putative homolog of subunit 1 of bovine prefoldin, a chaperone comprised of six subunits" YDR251W PAM1 0.78 2.4 multicopy suppressor of protein phosphatase 2A YHR065C RRP3 0.77 1.0 Required for maturation of the 35S primary transcript of pre-rRNA and is required for cleavages leading to mature 18S RNA YJL025W RRN7 0.77 0.9 involved in the transcription of 35S rRNA genes by RNA polymerase I YJL214W HXT8 0.77 1.6 High-affinity hexose transporter YDR522C SPS2 0.77 2.2 Middle/late gene of meiosis YPL030W 0.77 1.5 YMR067C 0.77 1.4 YDR406W PDR15 0.77 1.3 similar to Pdr5p and Pdr10p YFL032W 0.77 1.1 YBR172C SMY2 0.77 2.0 partial suppressor of myo2-66 YGL167C PMR1 0.77 0.8 "Ca++-Pump, ATPase" YCR039C MATALPHA2 0.77 2.0 "Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific genes. In diploid cells alpha2 acts together with a1 to repress transcription of haploid-specific genes." YCL067C HMLALPHA2 0.77 1.6 "Homeobox-domain containing protein which, in haploid cells, acts with MCM1 to repress a-specific genes. In diploid cells alpha2 acts together with a1 to repress transcription of haploid-specific genes." YAL001C TFC3 0.77 1.4 C transcription factor tau (TFIIIC) subunit 138 YHR095W 0.77 1.8 YKL162C 0.77 1.9 YDR261C EXG2 0.77 2.2 S "Exo-1,3-b-glucanase" YLR110C CCW12 0.77 2.2 YKL043W PHD1 0.77 3.7 S protein similar to StuA of Aspergillus nidulans YDL035C GPR1 0.77 1.4 G-protein-coupled receptor at plasma membrane; interactions in two-hybrid system with Gpa2p YKL093W MBR1 0.77 1.6 Involved in mitochondrial biogenesis YKR042W UTH1 0.77 4.5 S "Youth, involved in determining yeast longevity" YIL087C 0.77 1.4 YGL161C 0.77 1.2 YJL192C 0.77 1.1 YLR260W LCB5 0.77 1.0 involved in sphingolipid biosynthesis YPL146C 0.77 1.3 YIL149C MLP2 0.77 1.3 involved in translocation of macromolecules between the nucleoplasm and the NPC YDL083C RPS16B 0.77 2.5 Homology to rat S16 YNL144C 0.77 1.4 YBR295W PCA1 0.77 1.2 thought to play a role in resistance to copper ion toxicity YNR038W DBP6 0.77 1.2 Dead Box Protein 6 YDR067C 0.77 1.2 YLR005W SSL1 0.77 0.8 Component of RNA polymerase transcription factor TFIIH YMR133W REC114 0.77 1.1 "meiosis-specific recombination gene; dispensable for mitotic recombination and axial elements in meiosis but required for synaptonemal complexes, meiotic recombination, and spore viability; classified as an early recombination gene" YCR091W KIN82 0.77 2.4 Putative serine/threonine protein kinase most similar to cyclic nucleotide-dependent protein kinase subfamily and the protein kinase C subfamily YPL038W MET31 0.77 1.1 Involved in methionine metabolism YPR005C HAL1 0.77 2.2 "Protein induced by NaCl, KCl, or sorbitol; involved in halotolerance (tolerance to salt)" YDR323C PEP7 0.77 1.0 vacuolar segregation protein required for vacuole inheritance and vacuole protein sorting YAR071W PHO11 0.77 5.7 S "Acid phosphatase, secreted" YDL204W RTN2 0.77 1.2 reticulon gene member of the RTNLA (reticulon-like A) subfamily YOR371C GPB1 0.77 1.1 "Gpa2 interacting partner; Homolog of GPB2
Functions, with Gpb2, in the cAMP-PKA pathway via interactions with Gpa2 and another unknown target." YGL023C PIB2 0.77 0.9 Phosphatidylinositol 3-phosphate binding YOL078W AVO1 0.77 0.8 Adheres VOraciously (to TOR2) YDR191W HST4 0.77 5.6 Z S Homolog of SIR2 YLL027W ISA1 0.77 1.7 Iron Sulfur Assembly -- IscA/NifA homolog YJR046W TAH11 0.77 1.0 Essential protein. YJL073W JEM1 0.76 2.8 S C DnaJ-like protein of the endoplasmic reticulum membrane YOR378W 0.76 2.3 YMR141C 0.76 1.3 YOR004W 0.76 1.1 YBR114W RAD16 0.76 2.4 Nucleotide excision repair protein with DNA helicase domain of Snf2p family YDR501W PLM2 0.76 3.9 S Plasmid Maintenance YMR184W 0.76 1.3 YPR025C CCL1 0.76 1.5 essential for cell proliferation YDL224C WHI4 0.76 1.1 whi (Wee) mutants give small cell size YOR052C 0.76 2.8 S YFR051C RET2 0.76 1.4 coatomer (COPI) complex delta subunit YFR016C 0.76 1.1 YHR006W STP2 0.76 2.6 S Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YOL011W PLB3 0.76 3.1 S Phospholipase B YDR089W 0.76 3.8 Z S YKR095W MLP1 0.76 1.0 involved in translocation of macromolecules between the nucleoplasm and the NPC YLR175W CBF5 0.76 0.9 major low affinity 55 kDa Centromere/microtubule binding protein YOR216C RUD3 0.76 0.8 Relieves uso1-1 transport defect; golgin-160 related protein YIL150C DNA43 0.76 1.6 Protein required for S-phase (DNA synthesis) initiation or completion YLR371W ROM2 0.76 0.8 Gdp-GTP Exchange Protein (GEP) for the Rho1p Small GTP-binding Protein; high copy suppressor of cik1 and kar3 deletion mutants. YCL061C MRC1 0.76 4.2 S C Mediator of the Replication Checkpoint; required for full activation of Rad53p in response to replication stress. YHR175W CTR2 0.76 1.6 Putative low-affinity copper transport protein YMR008C PLB1 0.76 2.3 Responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol YKR093W PTR2 0.76 2.6 Functions in transport of small peptides into the cell YMR290C HAS1 0.76 1.6 Helicase Associated with SET1 YBR045C GIP1 0.76 1.1 Developmentally-regulated protein phosphatase 1 (Glc7) interacting protein which is required for spore formation. YPR157W 0.76 5.3 Z S C YOR195W SLK19 0.76 3.6 Z S synthetic lethal KAR3 YNL218W MGS1 0.76 1.3 Maintenance of Genome Stability 1 YDR124W 0.76 2.1 YLR119W SRN2 0.76 1.5 Suppressor of rna1-1 mutation YOR047C STD1 0.76 1.2 interacts with the SNF1 protein kinase and TBP in two-hybrid and in in vitro binding studies YER132C PMD1 0.76 0.9 Paralog of MDS3 YHR126C 0.76 2.9 S YLL002W RTT109 0.76 4.5 Z S C "Regulator of Ty1 Transposition; Regulation of mitochondrial network; Killed in Mutagen, sensitive to diepoxybutane and/or mitomycin C" YHL027W RIM101 0.76 0.9 Regulator of IME2 (RIM)
Rim101p is similar to the Aspergillus Phenotype-response regulator PacC and the Yarrowia proteinase YlRim1010p; transcriptional activator required for entry into meiosis YPR013C 0.76 2.1 S YLR091W 0.76 1.0 YJL222W VTH2 0.76 0.8 vps ten homolog YHR215W PHO12 0.76 3.5 S "acid phosphotase, nearly identical to Pho11p" YOR272W YTM1 0.76 1.3 microtubule-associated protein YPL032C SVL3 0.76 2.9 Z S Styryl dye vacuolar localization YLR228C ECM22 0.76 1.2 C involved in cell wall biogenesis (putative) YNL240C NAR1 0.76 1.1 Nuclear architecture related protein with homology to human Narf (Nuclear prelamin A Recognition Factor) YKL025C PAN3 0.76 1.5 Dun1 and Pan2-Pan3 cooperate to regulate the stoichiometry and activity of postreplication repair complexes. YLR343W 0.76 2.7 S YNL206C RTT106 0.76 1.9 "Regulator of Ty1 Transposition - same phenotype as RTT101 - RTT105, disruption causes increase in Ty1 transposition. Isolated from the same screen as the other named RTT genes." YDR326C 0.76 1.6 YDR331W GPI8 0.76 1.4 Protein involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins YBR059C AKL1 0.76 1.1 Ark-family kinase-like protein. This protein is the third member (After Ark1p and Prk1p) of the Ark-family kinases in S. cerevisiae. YBL019W APN2 0.76 1.5 "AP endonuclease 2, homolog of human HAP1 and E. coli exoIII" YMR075W RCO1 0.76 1.9 Hypothetical ORF YPR019W CDC54 0.76 4.8 S C essential for initiation of DNA replication; homolog of S. pombe CDC21 YGL148W ARO2 0.76 1.2 Chorismate synthase YOR346W REV1 0.76 1.4 Protein required for mutagenesis by physical and chemical agents YGL093W SPC105 0.76 3.1 Z S Spindle Pole Component of molecular weight 105kDa YNR019W ARE2 0.76 1.4 Acyl-CoA cholesterol acyltransferase (sterol-ester synthetase) YAL017W PSK1 0.76 1.3 contains serine/threonine protein kinase domain and shows homology with the SNF1 serine/threonine protein kinase YDR458C 0.76 1.1 YBR150C TBS1 0.76 1.6 Probable Zn-finger protein YML112W CTK3 0.76 1.4 CTD kinase-I gamma subunit YBR098W MMS4 0.76 2.2 endonuclease YHR182W 0.76 1.0 YDR452W PPN1 0.76 1.0 Phosphate metabolism; transcription is regulated by PHO system YHR158C KEL1 0.75 1.6 "protein containing kelch repeats, similar to YGR238c" YPL094C SEC62 0.75 1.5 membrane component of ER protein translocation apparatus YPL221W BOP1 0.75 3.4 S bypass of PAM1 YMR004W MVP1 0.75 1.3 Protein required for sorting proteins to the vacuole YNR011C PRP2 0.75 0.8 Dead-box protein required for the first catalytic event of pre-mRNA splicing. YGR282C BGL2 0.75 2.3 "Cell wall endo-beta-1,3-glucanase" YLR081W GAL2 0.75 1.3 "Galactose transport, also able to transport hexoses" YJL069C UTP18 0.75 1.3 U3 protein YBR263W SHM1 0.75 1.4 "Serine hydroxymethyltransferase, mitochondrial" YLR417W VPS36 0.75 1.4 Defective in vacuolar protein sorting YPL026C SKS1 0.75 1.7 multicopy suppressor of snf3 and grr1 mutants YCR084C TUP1 0.75 2.2 C general repressor of transcription (with Cyc8p); mediates glucose repression YDL159W STE7 0.75 0.9 "Serine/threonine/tyrosine protein kinase of the pheromone pathway, homologous to MAP kinase kinase family" YOR016C ERP4 0.75 1.4 Emp24p/Erv25p related protein 4 YOR219C STE13 0.75 1.2 dipeptidyl aminopeptidase YDR446W ECM11 0.75 2.5 ExtraCellular Mutant YMR265C 0.75 1.7 YLR018C POM34 0.75 1.3 nuclear pore integral membrane protein YAR035W YAT1 0.75 1.2 "Outer carnitine acetyltransferase, mitochondrial" YOR175C 0.75 1.9 YPL016W SWI1 0.75 2.1 C "Global transcription activator that acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators; involved in the regulation of expression of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2" YDR033W MRH1 0.75 8.1 K S C "Membrane protein related to Hsp30p; Localized by immunofluorescence to membranes, mainly the plasma membr. punctuate immunofluorescence pattern observed in buds. The nuclear envelope, but not vacuole or mitochondrial membranes also stained" YLL035W GRC3 0.75 0.9 Product of gene unknown YJL157C FAR1 0.75 6.3 K S C Factor arrest protein YDR523C SPS1 0.75 3.7 "dispensable for mitosis, involved in middle/late stage of meiosis, required for spore wall formation" YIL173W VTH1 0.75 1.2 vps ten homolog YFL033C RIM15 0.75 1.8 RIM15 is glucose-repressed; RIM15 is required for IME2 expression YCR028C FEN2 0.75 0.9 Fenpropimorph resistance gene. Protein shows similarity to Dal5p and members of the allantoate permease family of the major facilitator superfamily (MFS). YGR042W 0.75 2.8 S YFL024C EPL1 0.75 1.6 "Enhancer of Polycomb-Like (from D. melanogaster). Subunit of the Nucleosomal Acetyltransferase of H4 complex (NuH4). May be required for silencing in S. cerevisiae, based on analogous functions within other eukaryotes." YBR270C 0.75 1.0 YNR065C YSN1 0.75 1.0 Yeast SortiliN 1 YPL248C GAL4 0.75 1.2 Positive regulator of GAL genes YER089C PTC2 0.75 1.2 Protein phosphatase type 2C YNL054W VAC7 0.75 1.5 Integral 128-kDa vacuolar membrane protein; may function to regulate Fab1 kinase activity. YIL004C BET1 0.75 1.2 Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins YPR133C IWS1 0.75 1.0 Interacts with Spt6 YJL112W MDV1 0.75 1.6 WD repeat protein that regulates steps in the Dnm1p-dependent process of mitochondrial fission. YMR212C EFR3 0.75 1.1 PHO _E_ighty _F_ive _R_equiring YKR056W TRM2 0.75 1.5 tRNA methyltransferase YJL174W KRE9 0.75 1.2 cell wall beta-glucan assembly YBR298C MAL31 0.75 1.9 "Part of the complex locus MAL3; functional in S288C; highly homologous to MAL61 from S. cerevisiae, MAL61 from S. carlsbergenesis strains JM1901 and CB11, and MAL1T from strain 4059" YLR131C ACE2 0.75 5.6 K Z S C involved in transcriptional regulation of CUP1 YNR006W VPS27 0.75 1.3 hydrophilic protein; has cysteine rich putative zinc finger esential for function YOR148C SPP2 0.75 1.0 Required for final stages of splicesome maturation; promotes step 1 of splicing YPR081C GRS2 0.74 1.4 "Possible pseudogene; has similarity to Grs1p glycyl-tRNA synthetase, but expression is very low and GRS2 cannot substitute for GRS1" YPL169C MEX67 0.74 1.2 "Involved in nuclear mRNA export, binds both poly(A)" YIL127C 0.74 1.5 YPR106W ISR1 0.74 5.5 S Inhibition of staurosporine resistance YOR205C 0.74 1.3 YDR419W RAD30 0.74 0.9 Radiation sensitive. Replication fork is protected from inaccurate synthesis by Pol eta in the absence of DNA damage. YEL057C 0.74 1.0 YER167W BCK2 0.74 1.2 Serine/threonine protein kinase of the protein kinase C pathway YDR034C LYS14 0.74 1.7 Transcriptional activator of lysine pathway genes with 2-aminoadipate semialdehyde as co-inducer; saccharopine reductase synthesis YPR185W APG13 0.74 1.7 autophagy YBR093C PHO5 0.74 2.0 S "Acid phosphatase, repressible" YHL050C 0.74 4.0 Z S YDR317W 0.74 1.0 YKL105C 0.74 1.3 YNL339C YRF1-6 0.74 4.5 Z S Y'-helicase protein 1 YIR039C YPS6 0.74 1.1 Gpi-anchored aspartic protease (Yapsin 6) YPL020C ULP1 0.74 1.3 Ubl (ubiquitin-like protein)-specific protease 1; initially processes Smt3; also acts as a deconjugating enzyme for Smt3 YPR181C SEC23 0.74 0.8 cytoplasmic GTPase-activating protein YGL083W SCY1 0.74 1.8 Suppressor of GTPase mutant YLR013W GAT3 0.74 2.7 S The amino acid sequence of this ORF is very homologous to that of GAT4/YIR013C. YPL283C YRF1-7 0.74 3.6 S Y'-helicase protein 1 YGR296W YRF1-3 0.74 4.4 Z S Y'-helicase protein 1 YHR031C RRM3 0.74 2.1 C involved in rDNA replication and Ty1 transposition YKL222C 0.74 1.1 YHR195W NVJ1 0.74 1.3 Vac8p binding protein; nucleus-vacuole junction YER005W YND1 0.74 0.8 Yeast Nucleoside Diphosphatase YDL027C 0.74 2.7 YJL105W SET4 0.74 2.6 YOR033C EXO1 0.74 3.2 Z S Protein that complements a drug-hypersensitive mutation. EXO1 plays a structural role in MMR and stabilizes multiprotein complexes containing a number of MMR proteins. YDR095C 0.74 1.6 YPR090W 0.74 1.2 YGR089W 0.74 1.9 YLR086W SMC4 0.74 0.9 Stable Maintenance of Chromosomes YPL133C RDS2 0.74 2.1 S C Regulator of drug sensitivity YOR217W RFC1 0.74 1.3 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YBR229C ROT2 0.74 1.3 "Reversal of tor2 lethality. Involved in Beta-1,6-glucan synthesis." YKL055C OAR1 0.74 1.3 3-oxoacyl-[acyl-carrier-protein] reductase YCL039W 0.74 1.0 YIL091C 0.74 0.9 YKL189W HYM1 0.74 1.5 "The homolog in Aspergillus nidulans, hymA, is involved in development, see Karos, M. and Fischer, R. (1996). hymA (hypha-like metulae), a new developmental mutant of Aspergillus nidulans. Microbiol. 142:3211-3218." YGL201C MCM6 0.74 3.1 S C Member of the MCM/P1 family of proteins involved in DNA replication YNR053C NOG2 0.74 1.4 Nuclear/Nucleolar GTP-binding protein 2 YEL060C PRB1 0.74 2.8 S "dispensable for haploidization and sporulation, but needed for full protein degradation during sporulation, and proper spore morphology" YMR007W 0.74 2.4 C YHR039C MSC7 0.74 1.8 C Meiotic Sister-Chromatid recombination YDR359C VID21 0.74 1.2 Vacuolar import degradation YOR088W 0.74 1.5 YDR109C 0.74 1.1 YAR033W 0.74 1.3 YKL168C KKQ8 0.73 1.6 Serine/threonine protein kinase of unknown function YML035C AMD1 0.73 1.7 putative alpha-mannosidase YOR328W PDR10 0.73 1.2 Putative ABC transporter highly similar to Pdr5p YFL051C 0.73 4.0 YKR094C RPL40B 0.73 1.2 Homology to rat L40 YIL148W RPL40A 0.73 1.3 Homology to rat L40 YHR097C 0.73 2.9 YJL096W MRPL49 0.73 1.6 mitochondrial ribosomal protein of the large subunit YMR231W PEP5 0.73 2.0 peripheral vaculor membrane protein; putative Zn-finger protein YLL019C KNS1 0.73 1.2 protein kinase homolog YOL019W 0.73 5.0 S C YDL095W PMT1 0.73 2.6 Z S C Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway; acts in complex with Pmt2p YJL168C SET2 0.73 1.9 Contains a 'SET' or 'TROMO' domain at the N-terminus of the protein
Methyltransferase activity is important for transcriptional repression activity YKR097W PCK1 0.73 1.4 phosphoenolpyruvate carboxylkinase YJL219W HXT9 0.73 3.1 High-affinity hexose transporter YGL178W MPT5 0.73 1.7 Product of gene unknown YPR022C 0.73 1.1 YBR028C 0.73 1.6 YBR292C 0.73 1.2 YLR257W 0.73 1.3 YDL058W USO1 0.73 0.9 "involved intracellular protein transport, coiled-coil protein necessary for protein transport from ER to Golgi" YOR208W PTP2 0.73 1.6 protein tyrosine phosphatase YDR266C 0.73 1.7 YBR182C SMP1 0.73 1.7 "Second MEF2-like Protein 1
Transcription factor of the MADS (Mcm1p, Agamous, Deficiens, SRF) box family; closely related to RLM1" YDR011W SNQ2 0.73 2.4 S ABC transporter YMR242C RPL20A 0.73 1.2 Homology to rat L18a YNR023W SNF12 0.73 1.5 "73 kDa subunit of the SWI/SNF transcription activation complex, homolog of Rsc6p subunit of the RSC chromatin remodeling complex" YMR011W HXT2 0.73 5.7 S hexose transporter YLR187W 0.73 1.8 YLR413W 0.73 4.2 S YLR410W VIP1 0.73 1.1 Homologous to S. pombe asp1+ YOR028C CIN5 0.73 1.7 Protein involved in silencing YBR233W PBP2 0.73 2.0 Overexpression confers resistance to the antimalarial drug mefloquine YJL005W CYR1 0.73 1.3 "Required for START A of cell cycle, and glucose and nitrogen repression of sporulation" YLR002C NOC3 0.73 1.2 NucleOlar Complex 2; involved in the nuclear export of pre-ribosomes YGR170W PSD2 0.73 1.0 converts phosphatidylserine to phosphatidylethanolamine YNL289W PCL1 0.73 4.4 K S C G(sub)1 cyclin that associates with PHO85 YOR171C LCB4 0.73 1.4 involved in sphingolipid biosynthesis YJL194W CDC6 0.73 4.1 K S C Protein involved in initiation of DNA replication YJL191W RPS14B 0.73 1.5 "Homology to human S14 and rat S14, E. coli S11" YDR273W DON1 0.73 1.3 prospore membrane localizing protein YMR272C SCS7 0.73 1.3 "Required for the hydroxylation of the very long chain fatty acid (VLCFA), located in the endoplasmic reticulum" YAL055W PEX22 0.73 1.0 Product of gene unknown YGR223C 0.73 1.3 YPR121W THI22 0.73 1.5 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YNL106C INP52 0.73 1.4 Synaptojanin-like protein YGR260W TNA1 0.73 2.0 S Transporter of Nicotinic Acid YGR159C NSR1 0.73 1.4 nuclear localization sequence binding protein YDR389W SAC7 0.73 1.7 C Suppressor of actin mutation YDR206W EBS1 0.72 0.9 EST1-like bcy1 Suppressor YNL326C 0.72 1.8 S YPL194W DDC1 0.72 1.7 DNA damage checkpoint gene YCR095C 0.72 0.8 YER137C 0.72 1.0 YDR484W SAC2 0.72 0.8 May interact with actin as a component or controller of the assembly or stability of the actin cytoskeleton YBR161W 0.72 3.2 Z S YDR137W RGP1 0.72 1.0 "Ric1p-Rgp1p is an exchange factor, and peripheral membrane protein complex restricted to the Golgi." YLR069C MEF1 0.72 1.4 mitochondrial elongation factor G-like protein YDL214C PRR2 0.72 2.1 YFL054C 0.72 2.0 YOR214C 0.72 1.3 YIL047C SYG1 0.72 2.5 Protein for which truncation and overexpression can suppress lethality of G-alpha protein deficiency YLR080W EMP46 0.72 1.2 Evidence suggests that Emp46p and Emp47p are required for the export of specific glycoprotein cargo from the endoplasmic reticulum. YGR126W 0.72 0.8 YER152C 0.72 2.9 S YOL053W 0.72 1.1 YML061C PIF1 0.72 3.1 S C involved in repair and recombination of mitochondrial DNA; also plays a role in (nuclear) chromosomal telomere formation and elongation YJL127C SPT10 0.72 0.9 chromatin maintenance and transcriptional regulation YGR056W RSC1 0.72 1.0 "RSC1 is a member of RSC complex, which remodels the structure of chromatin" YDR060W MAK21 0.72 2.2 essential for 60s ribosome biogenesis; involved in nuclear export of pre-ribosomes YFR027W ECO1 0.72 3.8 Z S C Establishment of COhesion YDR120C TRM1 0.72 1.4 "N2,N2-dimethylguanosine-specific tRNA methyltransferase" YLR443W ECM7 0.72 1.0 Involved in cell wall maintenance YHR092C HXT4 0.72 2.2 S hexose transporter YMR129W POM152 0.72 1.6 May be involved in duplication of nuclear pores and nuclear pore complexes during S-phase YMR118C 0.72 1.4 YDR348C 0.72 1.9 YNL245C CWC25 0.72 1.0 Complexed with Cef1p YCR031C RPS14A 0.72 2.8 "Homology to mammalian S14, E. coli S11" YDL025C 0.72 0.9 YPL260W 0.72 0.8 YGL249W ZIP2 0.72 1.2 Required for 'ZIPpering' up meiotic chromosomes during chromosome synapsis YDR311W TFB1 0.72 1.1 "Component of transcription initiation factor IIb, 75 kDa subunit" YDL160C DHH1 0.72 1.9 Putative RNA helicase of DEAD box family YDR520C 0.72 1.0 YKL086W 0.72 1.5 YEL076C 0.72 4.5 S YOR255W 0.72 2.4 YBR181C RPS6B 0.72 1.2 "Homology to rat, human, and mouse S6" YPL090C RPS6A 0.72 1.3 "Homology to rat, mouse, and human S6" YOR308C SNU66 0.72 4.9 S 66kD U4/U6.U5 snRNP associated protein YDR009W GAL3 0.72 1.4 Involved in galactose induction of GAL genes YKR029C SET3 0.72 1.7 YDR264C AKR1 0.72 1.2 Negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control YIR003W 0.72 1.5 YLR138W NHA1 0.72 1.2 Putative Na+/H+ antiporter YHL026C 0.72 5.0 S C YDR213W UPC2 0.72 1.5 involved in sterol uptake YFR033C QCR6 0.72 1.3 ubiquinol-cytochrome c oxidoreductase subunit 6 (17 kDa) YNL159C ASI2 0.72 1.2 "Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p." YOL111C 0.72 1.4 YCR023C 0.72 1.7 YJL080C SCP160 0.72 1.3 "May be required during cell division for faithful partitioning of the ER-nuclear envelope membranes, involved in control of mitotic chromsome transmission" YJL033W HCA4 0.72 1.7 putative RNA helicase YOR260W GCD1 0.72 1.0 general control of amino acid biosynthesis and cell cycle initiation YHR213W 0.72 1.0 YHR015W MIP6 0.72 1.7 "RNA-binding protein, interacts with MEX67" YOR344C TYE7 0.72 1.4 may be involved in glycolytic gene expression YEL017W 0.71 4.6 Z S C YFR029W PTR3 0.71 0.9 "Regulator of expression of the PTR2, GAP1, and BAP2 genes; involved in the the control of peptide transport" YDR336W 0.71 0.8 YIL072W HOP1 0.71 1.1 S Meiosis-specific protein involved in homologous chromosome synapsis and chiasmata formation YOR373W NUD1 0.71 3.3 Z C Spindle pole body protein YDR472W TRS31 0.71 1.3 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic YOR172W 0.71 1.0 YOR106W VAM3 0.71 0.9 Syntaxin-related protein; required for vacuolar assembly; PEP12 homolog YOL103W ITR2 0.71 1.3 member of sugar transporter superfamily YKL160W 0.71 1.1 YER155C BEM2 0.71 1.4 Protein with role in bud emergence YJL144W 0.71 1.7 YOR153W PDR5 0.71 5.6 S multidrug resistance transporter YAL042W ERV46 0.71 1.0 ER vesicle protein of 46 kDa YBR184W 0.71 2.0 C YJR080C 0.71 1.0 YIL135C 0.71 1.7 S YIR031C DAL7 0.71 1.9 allantoin pathway YIL158W 0.71 5.7 S C YHL029C 0.71 1.1 YHR085W IPI1 0.71 1.0 Involved in Processing ITS2 YLR336C SGD1 0.71 1.3 Suppressor of Glycerol Defect YPR138C MEP3 0.71 2.7 S ammonia permease of high capacity and low affinity; shows sequence similarity to Mep1p and Mep2p YDR076W RAD55 0.71 1.2 "Required for X-ray damage repair, full sporulation and viable spores" YER022W SRB4 0.71 0.9 subunit of RNA polymerase II holoenzyme/mediator complex YOL029C 0.71 1.5 YDL231C BRE4 0.71 1.4 contains several putative trans-membrane domains YMR171C 0.71 0.9 YMR157C 0.71 1.6 YLR344W RPL26A 0.71 2.0 Homology to rat L26 YMR190C SGS1 0.71 3.1 C "Involved in maintaining genome stability. Homologous to E. coli RecQ and human BLM and WRN proteins that are defective in the cancer-prone disorder Bloom's syndrome and the premature aging disorder Werner's syndrome, respectively" YNR070W PDR18 0.71 1.6 pleiotropic drug resistance YCL055W KAR4 0.71 3.9 K S May assist Ste12p in pheromone-dependent expression of KAR3 and CIK1 YBL059W 0.71 1.3 YNL236W SIN4 0.71 1.0 "involved in positive and negative regualtion of transcription, possibly via changes in chromatin structure; regulation of YGP1 expression" YOL156W HXT11 0.71 2.1 High-affinity hexose transporter YLR023C 0.71 1.1 YHR079C IRE1 0.71 1.1 Involved in myo-inositol biosynthesis; implicated as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus YJL077C ICS3 0.71 1.0 Increased Copper Sensitivity YJL187C SWE1 0.71 5.3 K Z S C Protein kinase that inhibits G2/M transition.
S. pombe wee1+ homolog YGR080W TWF1 0.71 1.0 "Twinfilin A is a member of a conserved family of actin monomer sequestering proteins. TWF1 is comprised almost entirely of two tandem repeats, each having sequence homology with cofilin (COF1)." YMR109W MYO5 0.71 1.2 contains proline-rich tail homology 2 (TH2) and SH3 domains YNL188W KAR1 0.71 1.1 "involved in spindle pole body duplication and karyogamy, interacts with Cdc31p, localizes to the spindle pole body" YJL042W MHP1 0.71 1.1 Similar to a 250 kD Drosophila microtubule-associated protein (MAP) (which can rescue MHP1 null mutant) and to mammalian MAP4 proteins YJR110W 0.71 2.2 S C YPL259C APM1 0.71 0.9 medium subunit of the clathrin-associated protein complex YNL295W 0.71 1.1 YDR358W GGA1 0.70 1.9 "Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-dependent manner. Effector of Arf that facilitates traffic through the late Golgi." YOR230W WTM1 0.70 2.8 S WD repeat containing transcriptional modulator 1 YPL164C MLH3 0.70 1.1 Mutl Homolog YDL155W CLB3 0.70 1.9 K C Involved in mitotic induction and perhaps in DNA replication and spindle assembly YCL034W LSB5 0.70 1.7 LAs17 Binding protein YGL156W AMS1 0.70 1.7 vacuolar alpha mannosidase YIR033W MGA2 0.70 2.0 Product of gene unknown YNL257C SIP3 0.70 0.8 Interacts with SNF1 protein kinase YOR030W DFG16 0.70 1.3 "Involved in cell wall maintenance, filamentous growth" YHR118C ORC6 0.70 1.5 origin recognition complex (ORC) component that binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YHR219W 0.70 3.5 S YDR117C 0.70 1.3 YHR069C RRP4 0.70 0.8 Ribosomal RNA Processing YML114C TAF8 0.70 0.9 TBP Associated Factor 65 KDa YOL003C 0.70 1.5 YPL100W MAI1 0.70 0.8 Maturation of pro-AmInopeptidase I (proAPI) defective; protein similar to Aut10p and YGR223Cp with three putative WD repeats YBR217W APG12 0.70 1.2 autophagy YOR090C PTC5 0.70 1.0 Phosphatase type Two C YNL238W KEX2 0.70 1.8 Z "prohormone processing; golgi localization marker, dispensable for meiotic recombination but partially required for meiosis I and/or meiosis II" YMR054W STV1 0.70 1.8 Stv1p and Vph1p may be equivalent subunits for vacuolar-type H(+)-ATPases located on different organelles YOL163W 0.70 1.3 YJL118W 0.70 4.9 Z S C YOR081C 0.70 1.7 YAL037W 0.70 1.4 YIL019W 0.70 1.8 YLR352W 0.70 1.7 YNL177C 0.70 0.8 YOL154W ZPS1 0.70 2.3 "Zinc and pH regulated Surface protein. Similar to Candida albicans protein Pra1, a pH-regulated cell surface glycoprotein with weak similarity to zinc metalloproteinases." YCL052C PBN1 0.70 1.3 Protease B Non-derepressible YMR165C SMP2 0.70 1.8 involved in plasmid maintenance YLR452C SST2 0.70 4.0 K S Protein involved in desensitization to alpha-factor pheromone YDR108W GSG1 0.70 1.3 Probably has role late in meiosis following DNA replication YCR014C POL4 0.70 0.8 Probable homolog of mammalian DNA polymerase beta; may function in double-stranded DNA break repair YIL162W SUC2 0.70 2.6 S C invertase (sucrose hydrolyzing enzyme) YBR086C IST2 0.70 3.7 S Similar to calcium and sodium channel proteins YNL071W LAT1 0.70 0.8 Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex YBL092W RPL32 0.70 1.0 Homology to rat L32 and mammalian L32 YDL117W CYK3 0.70 4.7 S C involved in CYtoKinesis YDL092W SRP14 0.70 0.8 Signal recognition particle subunit YER038C KRE29 0.70 1.1 Killer toxin REsistant YNL254C 0.70 1.4 YJL083W 0.70 1.2 YER087C-A 0.70 1.6 YPR145W ASN1 0.70 0.8 Asn1p and Asn2p are isozymes YCL049C 0.70 1.2 YNL116W 0.70 1.8 Z YPL075W GCR1 0.70 2.9 S trans-acting positive regulator of the enolase and glyceraldehyde-3-phosphate dehydrogenase gene families YLR026C SED5 0.70 0.9 Sed5p is a t-SNARE (soluble NSF attachment protein receptor) required in ER to Golgi transport. YDR240C SNU56 0.70 0.8 Snurp = Small nuclear ribonucleoprotein particle of MW 56 kDa. Associated with the U1 snRNP; no counterpart in mammalian U1 snRNP. Serine-rich. YFR057W 0.70 2.1 YGR112W SHY1 0.70 1.1 involved in respiration YMR137C PSO2 0.70 1.4 DNA cross-link repair protein YGL050W 0.70 1.1 YJL107C 0.70 1.7 YOR231W MKK1 0.70 1.3 Mitogen-activated kinase-kinase involved in protein kinase C pathway YJR049C UTR1 0.70 1.1 associated with ferric reductase YJL010C 0.70 1.2 YGR038W ORM1 0.70 1.4 Product of gene unknown YKL116C PRR1 0.70 4.8 S C YPL230W 0.70 1.3 YLR310C CDC25 0.70 1.0 cell division cycle blocked at 36 degree C YGR241C YAP1802 0.70 1.0 "Yeast Assembly Polypeptide, member of AP180 protein family, binds Pan1p and clathrin" YMR037C MSN2 0.70 1.5 Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene expression. YLR407W 0.69 1.2 YBR291C CTP1 0.69 1.3 citrate transport protein YDR049W 0.69 1.8 YPR169W JIP5 0.69 0.8 Jumonji Interacting Protein YDR506C 0.69 0.8 YPR091C 0.69 1.5 YBR290W BSD2 0.69 1.3 metal homeostasis protein; putative membrane protein YLL008W DRS1 0.69 1.3 nucleolar DEAD-box protein required for synthesis of 60S ribosomal subunits YDL225W SHS1 0.69 1.0 Interacts with Spa2p and plays a role in cytokinesis YOR241W MET7 0.69 1.2 Z METhionine requiring YBR023C CHS3 0.69 1.6 K Required for chitin synthesis. Enzyme responsible for the hyperaccumulation of chitin in response to cell wall stress. YDL024C DIA3 0.69 3.6 involved in invasive and pseudohyphal growth YCL032W STE50 0.69 0.8 involved in pheromone signal transduction pathway; interacts with G protein and Ste11p YDR421W ARO80 0.69 0.9 YDL031W DBP10 0.69 1.4 C Dead box protein 10 YOL062C APM4 0.69 0.8 "Clathrin associated protein, medium subunit" YNL299W TRF5 0.69 1.0 TRF4 homolog; TRF4/5 function is required for proper mitosis YML123C PHO84 0.69 2.3 S "inorganic phosphate transporter, transmembrane protein" YDR310C SUM1 0.69 1.2 Suppresor of mar1-1 (sir2) mutation YJR160C MPH3 0.69 1.9 "Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of transporting maltose, maltotriose, alpha-methylglucoside and turanose." YGL228W SHE10 0.69 1.0 Mrna (identified by a library screen) that causes growth arrest when overexpressed YLR427W 0.69 0.8 YBR081C SPT7 0.69 1.0 Transcription factor YLR219W MSC3 0.69 1.8 Meiotic Sister-Chromatid recombination YLL045C RPL8B 0.69 1.1 "Homology to human L7a, mouse L7a, rat L7a" YNL065W AQR1 0.69 1.9 "A(acids, azoles) Q(quinidine, quinine) Resistance" YAL009W SPO7 0.69 1.2 "dispensable for mitosis, but required for a normal mutation rate, required for premeiotic DNA synthesis, recombination, meiosis I, meiosis II, glycogen degradation and spores" YAL056W GPB2 0.69 1.5 Gpa2 interacting partner; Homolog of GPB1
Gpb2 binds in the two hybrid system with Gpa2 and plays an inhibitory signaling role attributable to interactions with Gpa2 and an unknown target in the PKA pathway. YJR036C HUL4 0.69 1.3 ubiquitin-protein ligase (E3) YOL136C PFK27 0.69 1.9 6-phosphofructo-2-kinase YPL192C PRM3 0.69 2.9 pheromone-regulated membrane protein YNL230C ELA1 0.69 1.7 "similar to mammalian elongin A, interacts with elongin C" YGR211W ZPR1 0.69 0.9 Involved in nucleolar function; similar to murine ZPR1 protein YNL142W MEP2 0.69 2.0 belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)(+) + NH(3)). YDL042C SIR2 0.69 1.4 "regulator of silencing at HML, HMR, telomeres, and rDNA" YIL133C RPL16A 0.69 0.8 Homology to rat L13a YIL108W 0.69 1.4 YNL209W SSB2 0.69 1.5 stress-seventy subfamily B YIL170W 0.69 1.3 YBR167C POP7 0.69 1.2 Processing of Precursors YCR052W RSC6 0.69 1.5 "a subunit of RSC, a fifteen-protein chromatin remodeling complex and related to the swi/snf complex." YOR017W PET127 0.69 1.4 May be component of mitochondrial translation system with role in promoting accuracy of translational initiation or may play a role in RNA surveillance or RNA processing in mitochondria YDL070W BDF2 0.69 1.7 "bromodomain protein, homolog of BDF1" YOL159C 0.69 1.2 YPL105C 0.68 1.3 YDR148C KGD2 0.68 1.1 dihydrolipoyl transsuccinylase component of alpha-ketoglutarate dehydrogenase complex in mitochondria YOR072W 0.68 1.5 YDR046C BAP3 0.68 2.1 branched-chain amino acid permease YER126C NSA2 0.68 1.2 Killer toxin Resistant; Nop seven associated protein 2 YKR050W TRK2 0.68 1.3 membrane protein; low affinity potassium transport YOL138C 0.68 2.2 YIL031W ULP2 0.68 0.9 Peptidase that removes SUMO-conjugates from proteins YBR207W FTH1 0.68 0.9 FTS3 Homolog 1 YIL050W PCL7 0.68 3.6 Z S C PHO85 cyclin YDR027C LUV1 0.68 2.1 Loss Upsets Vacuole. Isolated in a microtubule complex containing Rbl2p. YMR172W HOT1 0.68 1.7 high osmolarity induced transcription YJR030C 0.68 3.9 S YBR074W 0.68 1.7 YNR051C BRE5 0.68 1.1 protein of unknown function YPL019C VTC3 0.68 1.1 Phosphate metabolism; transcription is regulated by PHO system YGL172W NUP49 0.68 1.3 localizes to discrete spots in the nuclear envelope YPL118W MRP51 0.68 1.1 Mitochondrial Ribosomal Protein YMR206W 0.68 1.7 YPR204W 0.68 4.4 S YDR125C ECM18 0.68 1.9 ExtraCellular Mutant YLR006C SSK1 0.68 1.3 Two-component signal transducer that with Sln1p regulates osmosensing MAP kinase cascade(suppressor of sensor kinase) YOR306C MCH5 0.68 1.5 monocarboxylate permease homologue YDR081C PDC2 0.68 0.8 "Regulates transcription of PDC1 and PDC5, which encode pyruvate decarboxylase" YIL082W-A 0.68 0.9 YER076C 0.68 1.0 YGR071C 0.68 1.7 YHL034C SBP1 0.68 1.6 single stranded nucleic acid binding protein YMR104C YPK2 0.68 1.3 protein kinase YBL023C MCM2 0.68 4.3 S C Member of complex that acts at ARS's to initiate replication YGL192W IME4 0.68 2.3 IME4 appears to activate IME1 in response to cell-type and nutritional signals and thereby regulate meiosis YKR104W 0.68 1.5 YNL117W MLS1 0.68 1.1 carbon-catabolite sensitive malate synthase YGL129C RSM23 0.68 1.9 mitochondrial ribosome small subunit component YOR162C YRR1 0.68 1.9 Yeast Reveromycin-A Resistant YEL036C ANP1 0.68 1.9 "Mannan 8; Protein of the endoplasmic reticulum with a role in retention of glycosyltransferases in the Golgi, also involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol" YNL151C RPC31 0.68 0.9 31-kDa subunit of RNA polymerase III (C); HMG1 like protein YMR192W 0.68 1.1 YNL003C PET8 0.68 2.0 S Member of family of mitochondrial carrier proteins YKR060W 0.68 0.9 YFL048C EMP47 0.68 0.8 47 kDa type I transmembrane protein localized to the Golgi YHR154W RTT107 0.68 2.7 S C Regulator of Ty1 Transposition; Establishes Silent Chromatin YDR475C JIP4 0.68 1.8 Jumonji Interacting Protein YGR131W 0.68 1.4 YNR026C SEC12 0.68 1.3 Required for recruitment of Sar1p and vesicle formation at the endoplasmic reticulum. YCR005C CIT2 0.68 4.1 C non-mitochondrial citrate synthase YER050C RSM18 0.68 1.1 protein similar to bacterial ribosomal subunit S18 YJL177W RPL17B 0.68 1.0 "Homology to rat L17, human L17, and E. coli L22" YDL056W MBP1 0.68 2.7 transcription factor YPL279C 0.68 1.4 YKL022C CDC16 0.68 1.6 "a component of anaphase-promoting complex required for the G2/M transition in mitosis and degradation of mitotic cyclins, required for sporulation" YAL019W FUN30 0.68 1.4 Shows homology to SNF2 transcriptional regulator YGR263C 0.68 1.1 YEL043W 0.68 1.0 YMR309C NIP1 0.68 1.4 "Protein required for nuclear import with some similarity to Nsr1p, another protein involved in nuclear transport" YFR041C 0.67 1.6 YDR378C LSM6 0.67 0.9 Like Sm-F protein YOR158W PET123 0.67 1.7 May be component of mitochondrial translation appartus and may interact with small subunit of mitochondrial ribosomes or with Pet122p to promote translational initiation of cytochrome c oxidase subunit III mRNA YLR312W-A MRPL15 0.67 1.7 Mitochondrial ribosomal protein MRPL15 (YmL15) YKL171W 0.67 1.4 YOR390W 0.67 1.2 YBR001C NTH2 0.67 1.8 hydrolyzes trehalose; may be inolved in growth transition from glucose to glycerol; shows significant sequence similarity to Nth1p YDR138W HPR1 0.67 1.2 Hyperrecombination protein that suppresses intrachromosomal excision recombination YNL309W STB1 0.67 5.1 Z S C binds Sin3p in two-hybrid assay and is present in a large protein complex with Sin3p and Stb2p YDR122W KIN1 0.67 1.6 Serine/threonine protein kinase YJL151C SNA3 0.67 0.9 Homology to PMP3/SNA1 (Sensitivity to Na+) YGR034W RPL26B 0.67 1.0 Homology to rat L26 YPR042C PUF2 0.67 1.8 mRNA binding protein YGL255W ZRT1 0.67 4.1 S C High-affinity zinc transport protein YPL078C ATP4 0.67 0.9 ATP synthase F0 sector subunit 4; analogous to the bovine b subunit YGL012W ERG4 0.67 1.7 Sterol C-24 reductase YCR021C HSP30 0.67 1.8 "Protein induced by heat shock, ethanol treatment, and entry into stationary phase; located in plasma membrane" YKL004W AUR1 0.67 3.1 S involved in phospolipid metabolism YNL118C DCP2 0.67 1.7 Z Mrna Decapping. essential suppressor of the respiratory deficiency of a pet mutant YFL049W 0.67 1.5 YIL101C XBP1 0.67 1.3 DNA-binding transcriptional repressor YPL237W SUI3 0.67 1.0 eIF2 is a heterotrimeric GTP-binding protein
SUI2 encodes the alpha subunit
GCD11 encodes the gamma subunit YFL021W GAT1 0.67 1.4 activator of transcription of nitrogen-regulated genes; inactivated by increases in intracellular glutamate levels YPL250C ICY2 0.67 2.4 S Interacting with the cytoskeleton
Involved in chromatin organization and nuclear transport
Genetically interacts with TCP1 and ICY1 YGL135W RPL1B 0.67 1.5 "Homology to rat L10a, eubacterial L1, and archaebacterial L1; identical to S. cerevisiae L1A (Ssm1p)" YPL220W RPL1A 0.67 1.4 "Homology to rat L10a, eubacterial L1, and archaebacterial L1; identical to S. cerevisiae L1B (Ssm2p)" YKR061W KTR2 0.67 1.9 May be involved in extracellular matrix assembly; involved in N-linked glycosylation of cell wall mannoproteins YGL013C PDR1 0.67 2.3 general positive regulator of permeability genes YBR146W MRPS9 0.67 1.2 Probable mitochondrial ribosomal protein S9 YLR411W CTR3 0.67 1.0 integral membrane protein that functions in high affinity copper transport YDR249C 0.67 2.0 YNL215W IES2 0.67 1.3 Hypothetical ORF YBR060C ORC2 0.67 1.3 origin recognition complex subunit 2 YJR153W PGU1 0.67 2.2 Endo-polygalacturonase YDR462W MRPL28 0.67 0.9 Mitochondrial ribosomal protein MRPL28 (YmL28) YER116C SLX8 0.67 0.9 YOR221C MCT1 0.67 1.5 malonyl-CoA:ACP transferase YLR030W 0.67 2.3 YGL146C 0.67 2.4 YOR244W ESA1 0.67 1.0 contains amino-terminal chromodomains; Essential SAS family Acetyltransferase sharing homology with acetyltransferases from many different organisms YGL263W COS12 0.67 1.5 "Protein with strong similarity to subtelomerically-encoded proteins including Cos2p, Cos4p, Cos8p, YIR040c, Cos5p, Cos9p, and Cos6p" YDR104C SPO71 0.67 0.9 Product of gene unknown YPL084W BRO1 0.67 1.0 BCK1-like resistance to osmotic shock YGL212W VAM7 0.67 2.4 S Regulator of vacuolar morphogenesis YER019W ISC1 0.67 2.7 S C YHR151C 0.67 3.3 S C YGR196C FYV8 0.67 0.8 Function required for Yeast Viability on toxin exposure YKR001C VPS1 0.67 1.8 C involved in vacuolar protein sorting and normal organization of intracellular membranes; probably required for membrane-protein retention in a late Golgi compartment YIL154C IMP2' 0.67 0.8 "Protein involved in nucleo-mitochondrial control of maltose, galactose and raffinose utilization" YDR128W 0.67 1.0 YGR140W CBF2 0.67 2.9 Z S C "110 kd component (Cbf3a) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the CDE III element of centromeres" YJL212C OPT1 0.67 2.0 "Oligopeptide transporter; Opt1p transports tetra- and pentapeptides, including the endogenous opioid pentapeptide leucine enkephalin." YPL162C 0.67 2.5 YPL008W CHL1 0.67 1.6 "Required for mitotic chromosome segregation, needed for wild-type levels of meiotic recombination and spore viability" YGL238W CSE1 0.67 1.4 Protein required for accurate mitotic chromosome segregation YMR073C 0.67 0.8 YPR078C 0.67 2.4 YDL248W COS7 0.67 1.3 "Protein with strong similarity to other subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YDL195W SEC31 0.67 1.4 involved in protein transport from endoplasmic reticulum to Golgi YGR097W ASK10 0.67 0.8 transcriptional activator of the SKN7 mediated 'two-component' regulatory system YML008C ERG6 0.67 1.8 ergosterol synthesis YOR243C PUS7 0.67 1.4 Pseudouridine Synthase YAL022C FUN26 0.67 3.8 S C predicted membrane protein YKL088W 0.67 1.0 YDR282C 0.67 1.7 YFL013C IES1 0.66 0.9 Hypothetical ORF YNL294C RIM21 0.66 1.2 Regulator of IME2 YPR097W 0.66 1.1 YMR006C PLB2 0.66 2.9 Phospholipase B 2 YER148W SPT15 0.66 0.9 TATA-binding protein (TBP) YGL184C STR3 0.66 4.9 S Sulfur TRansfer YGR128C UTP8 0.66 1.0 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YOL004W SIN3 0.66 1.1 DNA binding protein involved in transcriptional regulation YER013W PRP22 0.66 1.1 helicase-like protein YLL034C 0.66 1.7 YNL212W VID27 0.66 1.8 Vacuole import and degradation YDL176W 0.66 1.6 YOR270C VPH1 0.66 1.8 S vacuolar ATPase V0 domain subunit a (100 kDa) YBL052C SAS3 0.66 3.4 Z S C "SAS3 for Something about silencing, gene 3. Influences silencing at HMR." YLR047C 0.66 2.4 YHL004W MRP4 0.66 1.3 Involved in mitochondrial protein synthesis YLR356W 0.66 1.0 YOR291W 0.66 0.9 YOL041C NOP12 0.66 1.5 Nucleolar Protein; isolated as a mutant exhibiting synthetic lethality with a nop2 ts allele. YBL047C EDE1 0.66 0.8 EH domain protein involved in endocytosis YGL180W APG1 0.66 1.5 Required for autophagy YOL082W CVT19 0.66 1.8 Cytoplasm to Vacuole Targeting; Mutant is defective in import of aminopeptidase I through the cytoplasm to vacuole targeting pathway YAL051W OAF1 0.66 1.0 transcription factor YLR189C UGT51 0.66 1.3 Udp-glycosyltransferase YBR180W DTR1 0.66 1.6 dityrosine transporter MFS-MDR YOR138C 0.66 1.5 YHR152W SPO12 0.66 3.0 K S C Thought to be a positive regulator of exit from M-phase in mitosis and meiosis; interacts with Dbf2p and Dbf20p protein kinases YDL247W MPH2 0.66 1.8 "Maltose Permease Homologue. Maltose transporter family member, able to transport hexoses. Capable of transporting maltose, maltotriose, alpha-methylglucoside and turanose." YGL064C MRH4 0.66 1.1 mitochondrial RNA helicase YJR126C VPS70 0.66 1.3 YIL156W UBP7 0.66 1.1 Ubiquitin-specific protease YLR430W SEN1 0.66 1.3 component of a nuclear-localized tRNA splicing complex YLR256W HAP1 0.66 1.8 Activator of CYC1 and CYP3 transcription; positive regulator of cytochrome C genes CYC1 and CYC7 YLR130C ZRT2 0.66 1.2 Low-affinity zinc transport protein YJL216C 0.66 2.7 YGR106C 0.66 1.4 YDR065W 0.66 1.1 YDR466W 0.66 1.1 YOL125W 0.66 1.4 YML100W TSL1 0.66 3.2 S 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product YGL166W CUP2 0.66 1.4 Upregulates metallothionein (CUP1) expression in response to Cu2+ YPL207W 0.66 1.7 YGR090W UTP22 0.66 1.4 U3 protein YNL127W 0.66 1.2 YDR492W 0.66 2.1 YMR136W GAT2 0.66 2.0 Similar to GATA-family of DNA binding proteins YMR308C PSE1 0.66 1.1 Functions in nuclear transport of proteins YGL163C RAD54 0.66 3.6 K S "Required for X-ray damage repair, mitotic recombination, and full meiotic recombination. mRNA increases in meiosis." YML111W BUL2 0.66 0.9 a homologue of BUL1 YBR075W 0.66 1.5 YGL098W USE1 0.66 1.4 Protein required for cell viability YJL165C HAL5 0.66 1.3 "Protein kinase homolog, mutant is salt and pH sensitive" YIR004W DJP1 0.66 1.1 DnaJ-like protein required for Peroxisome biogenesis; Djp1p is located in the cytosol YGR273C 0.66 2.5 YER060W FCY21 0.66 1.2 identical to FCY2 YOR337W TEA1 0.66 2.4 S Mutants are defective in Ty1 Enhancer-mediated Activation YBR157C ICS2 0.66 4.6 S C Increased Copper Sensitivity YGR258C RAD2 0.66 2.4 "Incision step of nucleotide excision repair of DNA damaged by UV light; co-purifies with transcription factor, TFIIH mRNA is cell cycle regulated & induced by DNA damage & by meiosis" YGR295C COS6 0.66 1.9 "Protein with strong similarity to other subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YGL124C MON1 0.66 1.1 Product of gene unknown YDR233C RTN1 0.65 1.3 reticulon gene member of the RTNLA (reticulon-like A) subfamily YGR147C NAT2 0.65 0.9 Transfers acetyl group from acetyl coenzyme A to the N-termini of proteins beginning with methionine YOR152C 0.65 3.1 S YGL140C 0.65 1.6 YHL020C OPI1 0.65 1.3 Negative regulator of phospholipid biosynthesis YDR299W BFR2 0.65 1.3 involved in protein transport step at the Brefeldin A blocks YHR055C CUP1-2 0.65 2.4 required for cell growth at high copper concentrations. YHR053C CUP1-1 0.65 2.5 required for cell growth at high copper concentrations. YNL125C ESBP6 0.65 2.2 Protein with similarity to mammalian monocarboxylate transporters MCT1 and MCT2 YNL072W RNH35 0.65 3.5 S C "RNase H(35), a 35 kDa ribonuclease H" YDR518W EUG1 0.65 2.4 ER protein functionally likely involved in interacting with nascent polypeptides in the ER YOL077C BRX1 0.65 1.2 Essential nucleolar protein required for biogenesis of the 60S ribosomal subunit YPR031W NTO1 0.65 2.6 NuA3 ORF 1 YLR298C YHC1 0.65 0.8 U1 snRNP protein required for pre-mRNA splicing YJL181W 0.65 4.2 Z S C YBR132C AGP2 0.65 1.3 "The acronym may be misleading. AGP2 has been shown to be a carnitine permease, not a general amino acid permease with broad substrate specificity." YFL023W BUD27 0.65 1.1 Function required for yeast viability on toxin exposure YJR120W 0.65 1.0 YKL012W PRP40 0.65 1.4 Splicing component that associates with the yeast U1 small nuclear ribonucleoprotein particle YDL156W 0.65 3.5 Z S C YGL207W SPT16 0.65 3.2 Z S global regulator of transcription YER017C AFG3 0.65 0.9 C ATPase family gene YNL221C POP1 0.65 1.1 Required for processing of pre-tRNAs and the 5.8S rRNA precursor YGR222W PET54 0.65 2.0 translational activator of cytochrome c oxidase subunit III; required for splicing of cytochrome c oxidase subunit I mRNA YHR127W 0.65 2.6 S YMR223W UBP8 0.65 1.3 putative deubiquitinating enzyme YBL111C 0.65 4.0 S YFL012W 0.65 2.3 YNL064C YDJ1 0.65 1.3 yeast dnaJ homolog (nuclear envelope protein); heat shock protein YFL062W COS4 0.65 1.3 "Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YHR090C YNG2 0.65 0.9 Yeast homolog of mammalian Ing1 YMR098C 0.65 1.4 YGL176C 0.65 1.2 YJL023C PET130 0.65 1.3 Nuclear gene encoding mitochondrial protein YNL271C BNI1 0.65 0.9 Protein involved in cytoskeletal control and required for proper bipolar budding pattern; interacts with Rho1p YKR096W 0.65 1.0 YPL254W HFI1 0.65 1.3 Transcription factor involved in global regulation of gene expression YML117W 0.65 1.7 S YIL105C 0.65 2.2 YFR032C 0.65 1.3 YFR014C CMK1 0.65 2.7 Calmodulin-dependent protein kinase YFR001W LOC1 0.65 0.8 Localization of mRNA YHR020W 0.65 1.3 YNL263C YIF1 0.65 3.2 S "Yip1-Interacting Factor, shows similarity to NADH dehydrogenases" YDL113C CVT20 0.65 2.5 Cytoplasm to vacuole targeting YKR009C FOX2 0.65 1.6 peroxisomal multifunctional beta-oxidation protein YDR090C 0.65 0.9 YDL140C RPO21 0.65 0.8 RNA polymerase II large subunit YBR222C FAT2 0.65 1.9 "Fatty acid transporter, very similar to FAT1" YLR383W RHC18 0.65 4.6 Z S C "Protein involved in recombination repair, homologous to S. pombe rad18. Structural maintenance of chromosomes (SMC) protein." YLR197W SIK1 0.65 1.3 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); similar to microtubule binding proteins and to X90565_5.cds YIL112W 0.65 1.4 YPR104C FHL1 0.65 2.7 Putative transcriptional regulator of rRNA-processing genes YER020W GPA2 0.65 2.2 homologous to mammalian G proteins; potential role in regulation of cAMP levels YGR053C 0.65 2.2 YHR072W ERG7 0.65 1.4 carries out complex cyclization step of squalene to lanosterol in sterol biosynthesis pathway YNL277W MET2 0.65 1.9 "catalyzes the conversion of homoserine to O-acetyl homoserine which in turn combines with hydrogen sulfide to form homocysteine, the immediate precursor of methionine" YOR165W SEY1 0.65 1.8 Z Synthetic Enhancement with YOP1 YMR010W 0.65 1.1 YMR021C MAC1 0.65 0.9 metal-binding transcriptional activator YDL005C MED2 0.65 1.1 RNA Polymerase II transcriptional regulation mediator YLR466W YRF1-4 0.65 4.3 Z S Y'-helicase protein 1 YNR075W COS10 0.65 1.4 "Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YIR011C STS1 0.65 1.1 restores protein transport when overexpressed and rRNA stability to a sec23 mutation YOR166C 0.65 0.8 YDL073W 0.65 1.4 YKR078W 0.65 1.4 YJL036W SNX4 0.65 1.2 Sorting NeXin YGL226C-A OST5 0.65 1.5 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from a dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YBR299W MAL32 0.65 1.8 Part of the complex locus MAL3; functional in S288C; highly homologous to MAL62 from S. carlsbergenesis strain CB11 YOL137W 0.65 1.6 C YPL058C PDR12 0.64 3.0 S C similar to Pdr5p YGL077C HNM1 0.64 1.5 choline transport protein; may also control uptake of nitrogen mustard YCR094W CDC50 0.64 1.3 cell division cycle mutant YOR160W MTR10 0.64 1.5 Protein involved in mRNA transport from nucleus to cytoplasm YLR147C SMD3 0.64 0.9 involved in snRNP biogenesis and pre-mRNA splicing YDL198C YHM1 0.64 2.3 C high copy suppressor of abf2 lacking the HMG1-like mitochondrial HM protein; putative mitochondrial carrier protein YPR175W DPB2 0.64 5.9 K Z S C "DNA polymerase epsilon, subunit B" YNR018W 0.64 1.5 YNL201C PSY2 0.64 1.1 Platinum Sensitivity YDL150W RPC53 0.64 1.1 "RNA polymerase III (C) subunit, homologus to human BN51 protein" YFL014W HSP12 0.64 2.5 "induced by heat shock, entry into stationary phase, depletion of glucose, and addition of lipids (fatty acids)" YOL083W 0.64 2.5 YNL251C NRD1 0.64 1.8 RNA recognition motif-containing protein that participates in sequence-specific regulation of nuclear pre-mRNA abundance YHR218W 0.64 5.2 Z S YDR016C DAD1 0.64 2.1 Duo1 And Dam1 interacting; localized to intranuclear spindles and spindle pole bodies YMR252C 0.64 1.3 YDR001C NTH1 0.64 2.1 S hydrolyzes trehalose; may be inolved in growth transition from glucose to glycerol; shows significant sequence similarity to Nth2p YDR005C MAF1 0.64 1.8 Mod5 protein sorting. Negative effector of Pol III synthesis. YLR350W ORM2 0.64 1.0 Homologous to ORM1. YOL047C 0.64 1.3 YPR112C MRD1 0.64 1.8 Multiple RNA Binding Domain; essential for synthesis of the small ribosomal subunit YLR173W 0.64 1.6 YPR192W AQY1 0.64 1.5 Aquaporin YBL098W BNA4 0.64 2.4 S Biosynthesis of Nicotinic Acid YLR212C TUB4 0.64 3.7 S C spindle pole body component that organizes both cytoplasmic and nuclear microtubule arrays YDL079C MRK1 0.64 1.4 putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy YJR052W RAD7 0.64 0.8 Nucleotide excision repair protein involved in G(sub)2 repair of inactive genes YGR292W MAL12 0.64 2.5 Part of the complex locus MAL1; functional in S288C YJR035W RAD26 0.64 1.6 May be involved in transcription-coupled DNA repair YBL074C AAR2 0.64 1.5 splices pre mRNA of the MATa1 cistron YJL093C TOK1 0.64 1.6 Target Of K1 Killer Toxin YHL008C 0.64 2.2 YLR098C CHA4 0.64 1.4 S Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain YMR260C TIF11 0.64 1.2 Translation initiation factor eIF1A YPL062W 0.64 2.7 YGL092W NUP145 0.64 0.8 Nuclear pore complex protein with GLFG motif YDR105C 0.64 1.2 YGR287C 0.64 0.8 YIL099W SGA1 0.64 1.6 "intracellular sporulation-specific glucoamylase involved in glycogen degradation. Induced during starvation of a/a late in sporulation, but dispensable for sporulation" YOR145C 0.64 1.3 YDL181W INH1 0.64 1.7 C ATPase inhibitor YJR147W HMS2 0.64 1.8 High-copy mep2 suppressor YDL207W GLE1 0.64 1.6 Polyadenylated-RNA-export factor; the HIV Rev protein may mimic function of Gle1 YIL005W EPS1 0.64 1.0 YOR118W 0.64 0.8 YPL179W PPQ1 0.64 1.4 May play role in regulation of translation YMR018W 0.64 1.4 YPL132W COX11 0.64 2.3 Mitochondrial membrane protein required for insertion of Cu(B) and magnesium during assembly of cytochrome c oxidase YBL104C 0.64 1.2 YPR179C PLO1 0.64 1.2 Ploidy-related. Nuclear protein YPL187W MF(ALPHA)1 0.64 3.2 S C mating factor alpha YMR024W MRPL3 0.64 1.1 Mitochondrial ribosomal protein MRPL3 (YmL3) YLR078C BOS1 0.64 0.8 necessary for vesicular transport from the ER to the Golgi complex YKL187C 0.64 1.6 YKL033W 0.64 1.2 YIL132C CSM2 0.64 3.3 Z S Chromosome segregation in meiosis YKL180W RPL17A 0.64 1.0 "Homology to rat L17, human L17, and E. coli L22" YLR278C 0.63 1.7 YGR142W BTN2 0.63 1.3 Gene/protein whose expression is elevated in a btn1 minus/Btn1p lacking yeast strain. YPR202W 0.63 4.1 Z S YIL088C 0.63 1.4 YOR232W MGE1 0.63 1.0 involved in protein import into mitochondria YER082C UTP7 0.63 1.6 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR508C GNP1 0.63 1.7 high-affinity glutamine permease YOL066C RIB2 0.63 0.9 Riboflavin biosynthesis YBL032W HEK2 0.63 3.9 Z C Heterogeneous nuclear RNP K-like gene YGL078C DBP3 0.63 1.2 ATP-dependent RNA helicase CA3 of the DEAD/DEAH box family YDR314C 0.63 2.6 YOL157C 0.63 0.9 YKL051W 0.63 1.5 YDR334W SWR1 0.63 1.6 Sick With RSC YHR120W MSH1 0.63 1.3 mutS homolog involved in mitochondrial DNA repair YOL022C 0.63 1.0 YNL169C PSD1 0.63 1.7 S Converts phosphatidylserine to phosphatidylethanolamine. Mitochondrial Psd1p provides ~90% of total cellular phosphatidylserine decarboxylase activity. YKL145W RPT1 0.63 1.2 Required for degradation of ubiquitinated substrates and for anaphase chromosome separation YKL015W PUT3 0.63 1.2 Positive regulator of PUT (proline utilization) genes YOR092W ECM3 0.63 1.4 ExtraCellular Mutant YIL120W QDR1 0.63 1.7 Quinidine Resistance YGR059W SPR3 0.63 2.3 a sporulation-specific homologue of the yeast CDC3/10/11/12 family of bud neck microfilament genes; regulated by ABFI YAL033W POP5 0.63 1.2 Processing Of Precursors - refer to a group of proteins that appear to be components of both RNase P and RNase MRP YNL061W NOP2 0.63 1.5 May participate in nucleolar function during the transition from stationary phase to rapid growth YHR056C RSC30 0.63 1.3 RSC complex component YHR108W GGA2 0.63 2.0 S "Golgi-localized, gamma-adaptin homology, Arf-binding. Interacts with Arf1p and Arf2p in a GTP-dependent manner. Effector of Arf that facilitates traffic through the late Golgi." YML081W 0.63 1.3 YNR028W CPR8 0.63 2.5 Z Shows similarity to the secretory pathway cyclophilin Cpr4 YGR188C BUB1 0.63 4.5 Z S checkpoint gene involved in permitting entry into mitosis depending upon the assembly state of microtubules YLR144C ACF2 0.63 0.8 Identified as an activity necessary for actin polymerization in permeabilized cells YFR031C SMC2 0.63 0.9 Chromosome segregation and condensation YOR112W 0.63 1.9 Z YGL006W PMC1 0.63 0.8 May be involved in depleting cytosol of Ca2+ ions YFL031W HAC1 0.63 1.5 Transcription factor that is required for the unfolded protein-response pathway; binds to CRE motif; homologous to ATF/CREB 1 YIR002C MPH1 0.63 1.7 Mutator PHenotype; Similar to ATP-dependent RNA helicases YHR168W 0.63 1.3 YGR149W 0.63 1.7 YMR135C DCR1 0.63 1.7 Dose-dependent Cell cycle Regulator YPL135W ISU1 0.63 2.3 Iron-sulfur cluster nifU-like protein YLR220W CCC1 0.63 1.0 Functions in the homeostasis of both calcium and manganese ions YER060W-A FCY22 0.63 2.2 identical to FCY2 YHR192W 0.63 0.8 YJR002W MPP10 0.63 1.4 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YHR204W MNL1 0.63 1.6 mannosidase like YLR392C 0.63 1.3 YDR497C ITR1 0.63 1.6 member of sugar transporter superfamily YKL126W YPK1 0.63 1.2 "76.5 kDa Serine/threonine protein kinase with similarity to protein kinase C, is 90% identical to Ypk2p" YDR182W CDC1 0.63 1.2 "Protein that affects bud emergence, intrachromosomal recombination, and nuclear division" YJL131C 0.63 1.0 YJL041W NSP1 0.63 0.8 Nucleoskeletal protein found in nuclear pores and spindle pole body YDR292C SRP101 0.63 1.0 signal recognition particle receptor - alpha subunit YOL087C 0.63 1.1 YMR319C FET4 0.63 1.6 Putative transmembrane low-affinity Fe(II) transporter YKL109W HAP4 0.63 2.6 Regulates respiratory functions; encodes divergent overlapping transcripts YGL099W LSG1 0.63 1.3 Killer toxin REsistant YCR011C ADP1 0.63 1.4 Shows homology to ATP-dependent permeases YOR057W SGT1 0.63 0.8 G2 allele of skp1 suppressor; subunit of SCF ubiquitin ligase complex; essential regulator of cell cycle; essential component of kinetochore assembly pathway. YLR397C AFG2 0.63 1.2 ATPase family gene YGL038C OCH1 0.63 3.7 S initiates the polymannose outer chain elongation of N-linked glycans YLR418C CDC73 0.63 1.6 accessory factor associated with RNA polymerase II by affinity chromatography YMR156C TPP1 0.63 1.5 Three Prime Phosphatase 1 YNL336W COS1 0.63 1.0 "Protein with similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p" YOR108W 0.63 1.3 YDR118W APC4 0.63 0.8 subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope-tagged Apc4p YPL011C TAF3 0.63 0.9 TAF(II) complex (TBP-associated protein complex) component YPR045C 0.63 2.2 S YJL034W KAR2 0.63 2.0 Involved in translocation of nascent polypeptides across the ER membrane YJL094C KHA1 0.63 1.4 putative K+/H+ antiporter YOR249C APC5 0.63 1.1 subunit of the Anaphase Promoting Complex; all known APC subunits co-immunoprecipitate with epitope-tagged Apc5 YHR142W CHS7 0.63 1.1 The seventh gene identified that is involved in chitin synthesis; involved in Chs3p export from the ER YNR050C LYS9 0.63 2.3 S Seventh step in lysine biosynthesis pathway YJL098W SAP185 0.63 1.1 "SIT4 associated protein, MW of 185 kDa" YIL109C SEC24 0.63 1.0 The Sec23p-Sec24p complex is one of three cytoplamic COPII factors involved in ER to Golgi transport YKR028W SAP190 0.63 1.1 190 kDa protein that associates with the SIT4 phosphatase in a cell cycle dependent manner YPL156C PRM4 0.62 1.9 pheromone-regulated membrane protein YBL066C SEF1 0.62 1.9 Suppressor of Essential Function YCR065W HCM1 0.62 4.8 Z S C Dosage-dependent suppressor of cmd1-1 mutation; shows homology to fork head family of DNA-binding proteins YBR031W RPL4A 0.62 3.4 "Homology to rat L4, Xenopus L1, Drosophila L1" YBL056W PTC3 0.62 1.1 protein phosphatase type 2C YHR038W FIL1 0.62 1.9 C Putative mitochondrial ribosome recycling factor YHR061C GIC1 0.62 5.1 Z S C Gtpase-interacting component 1 YGL160W 0.62 1.2 YGR146C 0.62 2.7 S YDL240W LRG1 0.62 2.2 Expressed most highly in sporulating cells; may also play a role during mating YMR269W 0.62 1.9 YBL075C SSA3 0.62 0.8 heat-inducible cytosolic member of the 70 kDa heat shock protein family YNL250W RAD50 0.62 1.3 "coiled-coil protein, contains a purine-binding domain, two heptad repeats and a hydrophobic tail" YER056C FCY2 0.62 0.9 purine-cytosine permease YOR368W RAD17 0.62 1.6 K DNA Damage checkpoint control YLR154C 0.62 3.2 S YGL027C CWH41 0.62 3.4 S C "Glucosidase I, involved in assembly of cell wall beta 1,6 glucan; an ER type II integral membrane N-glycoprotein" YER079W 0.62 2.1 YDR530C APA2 0.62 1.9 "5',5'''-P-1,P-4-tetraphosphate phosphorylase II" YDR012W RPL4B 0.62 2.6 Highly similar to ribosomal protein L4A YLR056W ERG3 0.62 3.4 Z S C-5 sterol desaturase YIL172C 0.62 2.1 YJR095W SFC1 0.62 1.2 succinate-fumarate carrier YDL049C KNH1 0.62 1.5 46% identical at amino acid level to Kre9p; located extracellularly YJL221C FSP2 0.62 1.0 homology to maltase(alpha-D-glucosidase) YDR482C CWC21 0.62 1.4 Complexed With Cef1p YDR119W 0.62 1.0 YHL019C APM2 0.62 1.2 homologous to the medium chain of mammalian clathrin-associated protein complex YDL087C LUC7 0.62 1.0 Living Under Cap-binding complex expression YOR083W WHI5 0.62 2.6 S whiskey (whi) mutant YML059C 0.62 1.0 YDR173C ARG82 0.62 0.9 Regulator of arginine-responsive genes with ARG80 and ARG81 YFR019W FAB1 0.62 1.0 May regulate vacuole homeostasis; mutation causes pleiotropic effects on nuclear migration and orientation and separation of mitotic chromosomes YCR045C 0.62 1.2 YLR022C 0.62 1.3 YMR091C NPL6 0.62 0.9 involved in nuclear protein targeting YLR239C LIP2 0.62 1.6 LIPoyl ligase 2 YDR477W SNF1 0.62 1.1 "Required for release from glucose repression, invertase expression, and sporulation. Required for expression of catabolite-repressed genes when glucose is limiting." YLL001W DNM1 0.62 1.4 Involved in receptor-mediated endocytosis and mitochondrial organization. Required for the cortical distribution of the mitochondrial network. YLR160C ASP3-4 0.62 1.0 nitrogen catabolite-regulated cell-wall L-asparaginase II YLR157C ASP3-2 0.62 1.2 nitrogen catabolite-regulated cell-wall L-asparaginase II YLR155C ASP3-1 0.62 1.2 nitrogen catabolite-regulated cell-wall L-asparaginase II YLR158C ASP3-3 0.62 0.9 nitrogen catabolite-regulated cell-wall L-asparaginase II YPR003C 0.62 1.1 YKL155C RSM22 0.62 0.9 mitochondrial ribosome small subunit component YLR032W RAD5 0.62 2.8 S C putative ATPase/DNA helicase YHR109W CTM1 0.62 2.1 cytochrome c trimethylase YOR209C NPT1 0.62 0.9 homology to bacterial nicotinate phosphoribosyl transferase; NAD(+) salvage pathway YLL006W MMM1 0.62 2.0 Involved in mechanism by which mitochondrial shape is established or maintained YMR219W ESC1 0.62 1.4 Establishes Silent Chromatin YKL135C APL2 0.62 1.0 "Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex" YBR095C RXT2 0.62 1.2 Hypothetical ORF YBR020W GAL1 0.62 1.0 Haploid specific protein localized in the Golgi and plasma membrane YLR362W STE11 0.62 1.0 involved in the mating signalling pathway YGR093W 0.62 0.8 YER124C DSE1 0.62 6.7 S Daughter Specific Expression 1 YJL184W 0.62 0.8 YJR064W CCT5 0.62 0.8 Required for assembly of microtubules and actin in vivo YIL142W CCT2 0.62 0.8 cytoplasmic chaperonin of the Cct ring complex related to Tcp1p; subunit beta YJR015W 0.62 1.6 YJL140W RPB4 0.62 1.2 fourth-largest subunit of RNA polymerase II YMR160W 0.62 1.1 YGL079W 0.62 1.3 YGL241W KAP114 0.62 1.4 KAryoPherin (collective name for homologous family of nuclear transport receptors) of approximately 114kD YDR440W DOT1 0.62 2.8 S involved in meiosis and transcriptional silencing YAL007C ERP2 0.62 2.3 Emp24p/Erv25p related protein 2 YER190W YRF1-2 0.62 4.8 S C Y'-helicase protein 1 YKR022C 0.62 0.9 YGR127W 0.62 1.2 YGL014W PUF4 0.62 1.6 member of the PUF protein family YDL227C HO 0.62 4.1 K S C Homothallic switching YPR007C SPO69 0.62 1.6 Required for sporulation; highly induced during sporulation. YPL109C 0.62 1.3 YHR050W SMF2 0.62 1.9 SMF2 was isolated as a high copy suppressor of a temperature sensitive mutation in the PEP ( mitochondrial matrix protease) gene and may influence PEP-dependent protein import YHR027C RPN1 0.62 1.0 Subunit of 26S Proteasome (PA700 subunit) YCL054W SPB1 0.62 1.4 Suppressor of PaB1 mutant; involved in 60S ribosomal subunit biogenesis YLR001C 0.62 1.4 YML072C 0.62 2.8 Z S YHR197W IPI2 0.62 1.1 Involved in Processing ITS2 YNL049C SFB2 0.62 1.5 binds to Sed5p and Sec23p by distinct domains YBR068C BAP2 0.62 2.3 contains 12 predicted transmembrane domains YKL062W MSN4 0.62 2.0 Transcription factor. Multicopy suppressor of snf1 mutation. Key regulator of stress-responsive gene expression. YNR055C HOL1 0.62 1.8 Z Putative ion transporter similar to the major facilitator superfamily of transporters YBL063W KIP1 0.62 3.8 S C Mitotic spindle assembly YDR093W DNF2 0.62 1.5 Drs2 Neo1 Family YLR152C 0.62 1.9 YDL202W MRPL11 0.62 1.2 Mitochondrial ribosomal protein MRPL11 (YmL11) YLR027C AAT2 0.62 1.5 "aspartate aminotransferase, cytosolic" YNL130C CPT1 0.62 1.7 Phospholipid biosynthesis YDR168W CDC37 0.62 1.0 cell cycle protein necessary for passage through START YDR342C HXT7 0.62 2.5 S Hexose transporter YER177W BMH1 0.62 0.8 Brain Modulosignalin Homolog YMR043W MCM1 0.62 0.9 Involved in cell-type-specific transcription and pheromone response YNL321W 0.62 1.5 YDR338C 0.62 1.1 YJR119C 0.62 1.2 YHL017W 0.62 1.1 YPL005W 0.61 2.0 YBR257W POP4 0.61 1.6 Required for normal 5.8S rRNA processing and for tRNA processing; associated with RNase MRP and RNase P YOR035C SHE4 0.61 1.8 Required for mother cell-specific HO expression YGR270W YTA7 0.61 1.2 Member of CDC48/PAS1/SEC18 family of ATPases YLR234W TOP3 0.61 3.2 S C DNA Topoisomerase III YNL083W 0.61 1.0 YBL029W 0.61 1.7 YKL201C MNN4 0.61 1.4 Required for the transfer of mannosylphosphate to cell wall mannans. YDR253C MET32 0.61 1.6 Involved in methionine metabolism YKL100C 0.61 1.4 YNR059W MNT4 0.61 1.5 MaNnosylTransferase YNR056C BIO5 0.61 1.6 transmembrane regulator of KAPA/DAPA transport YPR029C APL4 0.61 2.0 "Gamma-adaptin, large subunit of the clathrin-associated protein (AP) complex" YGR179C OKP1 0.61 2.0 Outer Kinetochore Protein YOR007C SGT2 0.61 1.7 small glutamine-rich tetratricopeptide repeat containing protein YHR189W 0.61 2.1 YPL249C GYP5 0.61 1.1 GAP for Ypt protein YJR143C PMT4 0.61 2.1 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YGR245C SDA1 0.61 1.4 Severe Depolymerization of Actin YCL036W GFD2 0.61 1.3 Great for FULL DEAD box protein activity YOR062C 0.61 1.3 YDR052C DBF4 0.61 1.4 K Required for Cdc7 kinase activity YKL046C DCW1 0.61 1.5 Defective Cell Wall YGL128C CWC23 0.61 0.9 Complexed with Cef1p YKL090W CUE2 0.61 2.2 Hypothetical ORF YDL091C 0.61 1.1 YOR140W SFL1 0.61 1.1 Transcription factor with domains homologous to myc oncoprotein and yeast Hsf1p required for normal cell surface assembly and flocculence YLR328W NMA1 0.61 0.8 NAD(+) salvage pathway YEL054C RPL12A 0.61 1.3 Homology to rat L12(a) and E. coli L11 YDR418W RPL12B 0.61 2.4 Homology to rat L12(a) and E. coli L11 YCR066W RAD18 0.61 0.9 "Zn finger protein, putative ATPase" YDL138W RGT2 0.61 3.0 S C glucose permease YOR191W RIS1 0.61 1.3 Role in silencing YAL035W FUN12 0.61 1.0 Functions in general translation initiation by promoting Met-tRNAiMet binding to ribosomes. YGR032W GSC2 0.61 1.5 "Highly similar to FKS1 (GSC1). GSC2 and FKS1 encode redundant catalytic components of 1,3-beta-glucan synthase. Deletion of both is lethal" YLR107W REX3 0.61 1.0 RNA EXonuclease; member of 3'->5' exonuclease family. See Moser et al. 1997 Nucleic acids Res. 25:5110-5118 YLL022C HIF1 0.61 4.9 Z S C Hat1 Interacting Factor 1 YHL038C CBP2 0.61 0.8 Protein required for splicing of COB aI5 intron YJR093C FIP1 0.61 1.2 component of a pre-mRNA polyadenylation factor that interacts with poly(A) polymerase YOL122C SMF1 0.61 1.5 Isolated as high copy suppressor of a cdc1 mutation & involved in high affinity Mn2+ uptake. SMF1 was isolated as a high copy suppressor of a ts mutation in the PEP (mito. matrix protease) gene & may influence PEP-dependent protein import YFR046C 0.61 1.6 YOR099W KTR1 0.61 2.2 Z mannosyltransferase involved in O- and N-linked glycosylation YJL134W LCB3 0.61 2.9 Z S Protein involved in incorporation of exogenous long chain bases in sphingolipids YCL051W LRE1 0.61 1.0 involved in laminarase resistance YNL178W RPS3 0.61 1.1 "Homology to mammalian S3. The AP endonuclease activity of Rps3p is affected by pH, KCl, and beta-mercaptoethanol, but not Triton X-100 or EDTA." YGR195W SKI6 0.61 1.0 superkiller; ExtraCellular Mutant; Ribosomal RNA Processing YGL158W RCK1 0.61 1.8 Serine/threonine protein kinase YNL137C NAM9 0.61 1.4 putative mitochondrial S4 ribosomal protein YIL177C 0.61 4.4 Z S YNL287W SEC21 0.61 1.1 non-clathrin coat protein involved in transport between ER and Golgi YMR158W 0.61 1.0 YDR343C HXT6 0.61 2.3 Repression of HXT6 expression by glucose requires SNF3 YKL129C MYO3 0.61 1.7 C myosin I YOR312C RPL20B 0.61 1.8 Homology to rat L18a YMR222C FSH2 0.61 1.6 YNL286W CUS2 0.61 0.8 cold sensitive U2 snRNA Supressor YHR063C PAN5 0.61 1.6 ketopantoate reductase YMR245W 0.61 1.0 YIL122W POG1 0.61 3.8 S Promoter of Growth; weak similarity to human transcription adaptor protein p300 YNL081C 0.61 1.1 YKL174C 0.61 1.3 YGL151W NUT1 0.61 1.5 Negative regulator of URS2 of the HO promoter YAL013W DEP1 0.61 1.1 Regulator of phospholipid metabolism YGL065C ALG2 0.61 2.5 glycosyltransferase YDR038C ENA5 0.61 1.6 Na(+) ATPase YMR058W FET3 0.61 6.4 S FET3 encodes a ferro-O2-oxidoreductase that is part of the high-affinity iron transport system YER154W OXA1 0.61 1.7 Mediates the export of proteins from the mitchondrial matrix to the intermembrane space. YLR406C RPL31B 0.61 2.0 Homology to rat L31 YNR037C RSM19 0.61 1.3 mitochondrial ribosome small subunit component YGR197C SNG1 0.61 1.2 Involved in nitrosoguanidine resistance YER130C 0.61 2.0 YDR147W EKI1 0.61 1.8 Ethanolamine Kinase 1 YBR123C TFC1 0.61 2.1 transcription factor tau (TFIIIC) subunit 95 YMR296C LCB1 0.61 2.2 "Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine." YNL095C 0.61 1.8 YPL112C PEX25 0.61 1.1 required for regulation of peroxisome size and maintenance YPL184C 0.61 1.4 YDR395W SXM1 0.61 0.9 Suppressor of mRNA export mutant; Importin-beta like gene YGL227W VID30 0.61 1.3 vacuole import and degradation (VID); TOR inhibitor (TIN) YGR284C ERV29 0.61 2.6 S ER Vesicle protein of 29 kDa (apparent MW) YDR165W TRM82 0.61 1.0 Transfer RNA methyltransferase YER166W DNF1 0.60 1.1 Drs2 Neo1 Family YML006C GIS4 0.60 1.5 GIG3 suppressor YML065W ORC1 0.60 2.6 S binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YMR204C 0.60 2.0 YGL234W "ADE5,7" 0.60 1.6 glycinamide ribotide synthetase and aminoimidazole ribotide synthetase YIL153W RRD1 0.60 2.1 Resistant to Rapamycin Deletion YDR189W SLY1 0.60 1.3 Hydrophilic suppressor of ypt1 involved in vesicle trafficking between ER and Golgi
Sm like protein YPL036W PMA2 0.60 4.6 S plasma membrane ATPase YMR074C 0.60 1.0 YMR216C SKY1 0.60 1.9 SRPK1-like Kinase in Yeast (SRPK1 is a human serine kinase that specifically phosphoryates arginine-serine rich domains found in the SR family of splicing factors.) YBR195C MSI1 0.60 1.0 "chromatin assembly complex, subunit 3: Encodes the smallest (p50) subunit of the yeast Chromatin Assembly Factor-I (CAF-I) involved in DNA-replication-linked nucleosome assembly. Homologous to the small subunit of the Human CAF-I." YBR273C 0.60 2.6 S YDR031W 0.60 1.4 YJL085W EXO70 0.60 1.7 70 kDa exocyst component protein; the exocyst proteins are required for exocytosis late in the secretory pathway YML009C MRPL39 0.60 1.5 Mitochondrial ribosomal protein MRPL39 (YmL39) YLR038C COX12 0.60 1.5 essential during assembly for full cytochrome c oxidase activity YIL089W 0.60 1.1 YML099C ARG81 0.60 1.1 Regulator of arginine-responsive genes with ARG80 and ARG82 YKR069W MET1 0.60 2.4 S Methionine metabolism YER188W 0.60 1.8 YNL108C 0.60 1.2 YBR147W 0.60 1.9 YKL133C 0.60 0.9 YKL077W 0.60 0.9 YNL190W 0.60 1.4 YIL036W CST6 0.60 0.9 Chromosome STability; contains an ATF/CREB-like bZIP domain; transcriptional activator; interacts with the STB locus on 2-micron plasmid YIR023W DAL81 0.60 1.6 Positive regulator of multiple nitrogen catabolic genes YDR456W NHX1 0.60 1.5 Required for intracellular sequestration of Na+ YER149C PEA2 0.60 2.6 S Pea2p is localized with Spa2p to sites of polarized growth and is required for efficient mating and bipolar budding; it is required for pheromone-induced shmoo formation YGL063W PUS2 0.60 1.3 pseudouridine synthase 2 YCL008C STP22 0.60 0.8 Ste pseudorevertant; required for vacuolar targeting of temperature-sensitive plasma membrane proteins; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype. YDR538W PAD1 0.60 0.8 Phenylacrylic acid decarboxylase YGR054W 0.60 1.1 YEL077C 0.60 4.7 S YKR017C 0.60 1.6 YOL115W TRF4 0.60 1.5 TRF5 homolog; Involved in mitotic chromsome condensation; associates with Smc1p and Smc2p YLR435W 0.60 1.1 YHR071W PCL5 0.60 2.1 PHO85 cyclin YAL058W CNE1 0.60 1.2 Functions in endoplasmic reticulum protein quality control YLR055C SPT8 0.60 1.8 "transcription factor, probable member of histone acetyltransferase SAGA complex" YKL038W RGT1 0.60 1.0 transcriptional repressor and activator YGR095C RRP46 0.60 0.8 Ribosomal RNA Processing YHR036W 0.60 1.2 YOR174W MED4 0.60 1.2 Member of RNA Polymerase II transcriptional regulation mediator YJL129C TRK1 0.60 1.4 180 kDa high affinity potassium transporter YDR039C ENA2 0.60 0.9 plasma membrane protein; putative Na+ pump; P-type ATPase YNL202W SPS19 0.60 1.7 late sporulation specific gene which may function during spore wall formation YJL225C 0.60 4.3 S YPL151C PRP46 0.60 1.8 "protein required for pre-mRNA splicing in vivo, WD-protein homologous to Arabidopsis thaliana pleiotropic regulators PRL1 and PRL2" YKL225W 0.60 1.3 YGL068W 0.60 1.5 YML086C ALO1 0.60 1.0 "D-arabinono-1,4-lactone oxidase" YDR172W SUP35 0.60 0.9 altered form creates [PSI] prion YLR342W FKS1 0.60 3.4 K S Required for viability of calcineurin mutants YFL001W DEG1 0.60 1.2 Similar to rRNA methyltransferase (Caenorhabditis elegans) and hypothetical 28K protein (alkaline endoglucanase gene 5' region) from Bacillus sp. YPR086W SUA7 0.60 1.0 transcription factor TFIIB homolog YAL016W TPD3 0.60 1.1 protein phosphatase 2A regulatory subunit A YKL092C BUD2 0.60 2.0 C GTPase-activating protein (GAP) for Rsr1p/Bud1p YGL105W ARC1 0.60 1.2 associated with tRNA and amino acyl-tRNA synthetases; has affinity for quadruplex nucleic acids YLR181C VTA1 0.60 1.1 Hypothetical ORF YBL014C RRN6 0.60 1.3 involved in the transcription of 35S rRNA genes by RNA polymerase I YPL225W 0.60 1.0 YOR381W FRE3 0.60 1.9 similar to FRE2 YBR271W 0.60 1.1 YDR056C 0.60 1.9 YBR239C 0.60 1.0 YER110C KAP123 0.60 2.2 "Karyopherin of predicted MW 122.524 Da. Similar to Kap95p (YLR347C) and Kap104p *YBR017C). Ran binding protein, Homolog of importin-beta" YJR031C GEA1 0.60 3.1 Z component of a complex guanine nucleotide exchange activity for the ADP-ribosylation factor ARF YIR010W DSN1 0.60 3.6 Z S Dosage Suppressor of NNF1 YDL148C NOP14 0.60 1.5 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); NucleOlar Protein 14 YKL205W LOS1 0.60 0.8 Nuclear pore protein involved in pre-tRNA splicing YOL084W PHM7 0.60 1.4 YBL005W PDR3 0.60 1.0 Zinc-finger transcription factor related to Pdr1p YGR150C 0.60 1.4 YER106W MAM1 0.60 1.6 Monopolar microtubule Attachment during Meiosis I YOR330C MIP1 0.60 1.9 catalytic subunit of mitochondrial DNA polymerase YDL098C SNU23 0.60 1.2 23 kD U4/U6.U5 snRNP associated protein YDR215C 0.60 2.5 YBR039W ATP3 0.59 1.4 participates in catalysis of ATP hydrolysis/synthesis and in the assembly/stability of F1 YBR083W TEC1 0.59 4.4 K S C "transcription factor of the TEA/ATTS DNA-binding domain family, regulator of Ty1 expression" YNL275W 0.59 0.9 YBR058C UBP14 0.59 1.2 Functional homolog of mammalian isopeptidase T; may facilitate proteolysis by preventing unanchored ubiquitin chains from competitively inhibiting polyubiquitin-substrate binding to the 26S proteasome YKL039W PTM1 0.59 1.3 Putative membrane protein YAL043C PTA1 0.59 1.1 pre-tRNA processing YDR536W STL1 0.59 1.0 sugar transporter-like protein YCL046W 0.59 1.2 YKL034W TUL1 0.59 1.2 Transmembrane Ubiquitin Ligase YEL028W 0.59 1.9 YLR254C 0.59 3.3 S C YDL060W TSR1 0.59 0.9 YDL199C 0.59 0.9 YHR124W NDT80 0.59 1.6 Meiosis-specific gene; mRNA is sporulation specific; required for exit from pachytene and for full meiotic recombination YDR510W SMT3 0.59 1.5 may be involved in function and/or structure of the eukaryotic kinetochore
homologous to SUMO-1 YMR101C SRT1 0.59 2.4 cis-prenyltransferase involved in dolichol synthesis YGL082W 0.59 1.5 YLR226W BUR2 0.59 1.6 bypass UAS Requirement YJL101C GSH1 0.59 1.2 encodes the first enzyme involved in glutathione biosynthesis YEL001C 0.59 1.1 YDL078C MDH3 0.59 1.4 malate dehydrogenase YOL063C MOR1 0.59 1.2 MMS1 Related YGR081C 0.59 0.8 YDR150W NUM1 0.59 3.1 K S C "May function in nuclear migration during mitosis and meiosis by affecting astral microtubule functions, perhaps by being involved in polymerization and stabilization of microtubules" YNL194C 0.59 1.0 YCR015C 0.59 1.6 YBR279W PAF1 0.59 2.6 "RNA polymerase II-associated, nuclear protein that may serve as both a positive and negative regulator of a subset of genes, perhaps operating in parallel with Gal11p" YMR293C 0.59 1.7 YHR190W ERG9 0.59 1.0 squalene synthetase YHL016C DUR3 0.59 0.8 Urea active transport protein YCR099C 0.59 2.8 YLR182W SWI6 0.59 2.0 Involved in cell cycle dependent gene expression YCL050C APA1 0.59 1.2 "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase I" YJL106W IME2 0.59 1.3 "Positive regulator of meiosis, dispensable for mitosis, stimulates early, middle and late gene expression and negatively regulates IME1" YGR110W 0.59 1.5 YDR028C REG1 0.59 1.2 The reg1 locus encodes a gene which is involved in RNA processing and is a negative regulator of glucose-repressible genes. YJL019W MPS3 0.59 3.7 Z S MonoPolar Spindle YMR196W 0.59 1.9 YBR237W PRP5 0.59 2.2 RNA helicase homolog YAL021C CCR4 0.59 0.9 carbon catabolite repression; transcriptional regulator for some glucose-repressed genes including ADH2 YAL011W SWC1 0.59 1.3 Hypothetical ORF YDR325W YCG1 0.59 1.8 C Yeast Condensin G YPL167C REV3 0.59 1.1 "DNA polymerase zeta, which is unique in its ability to bypass thymine dimers during replication, is composed of Rev3p and Rev7p." YLR335W NUP2 0.59 1.6 Localizes to discrete spots in the nuclear envelope; probably functions in transport through nuclear pore YLR396C VPS33 0.59 1.0 vacuolar sorting protein essential for vacuolar morphogenesis and function YMR197C VTI1 0.59 1.2 Involved in cis-Golgi membrane traffic YMR198W CIK1 0.59 4.8 K Z S C chromosome instability and karyogamy; CIK1 is important for proper organiziation of microtubule arrays and establishment of a spindle; is essential for karyogamy; and expression is regulated by KAR4 and mating YAR018C KIN3 0.59 5.9 K S C protein kinase YAL048C 0.59 1.4 YLR448W RPL6B 0.59 1.1 Homology to rat and human L6; involved initiation of protein synthesis YDR152W 0.59 1.1 YDR316W 0.59 1.8 YJR073C OPI3 0.59 1.7 Second and third steps of methylation pathway for phosphatidylcholine biosynthesis YNL166C BNI5 0.59 2.5 S bud neck involved; localizes to mother-bud neck in a septin-dependent manner; bni5 shows synthetic enhancement of septin Ts- mutant phenotypes. YLL036C PRP19 0.59 1.3 "Required for error prone repair, induced mitotic recombination, and sporulation" YMR273C ZDS1 0.59 1.4 Negative regulator of cell polarity YDR091C RLI1 0.59 1.6 Strong protein homology (68% identical) to human RNase L Inhibitor (RLI). Required for vegetative growth and early sporulation. YJR162C 0.59 1.9 YBR008C FLR1 0.59 2.6 S Fluconazole Resistance 1 YLR419W 0.59 0.9 YJL045W 0.59 2.4 YDR208W MSS4 0.59 1.6 Involved in actin cytoskeleton organization; multicopy suppressor of stt4 mutation YOR084W 0.59 3.7 Z S YMR276W DSK2 0.59 1.4 Required with RAD23 for duplication of the spindle pole body YHL042W 0.59 1.3 YDR469W SDC1 0.59 1.1 likely involved in chromatin remodeling
member of Set1p complex YNL101W 0.59 1.7 YLR099C ICT1 0.59 2.4 S Increased Copper Tolerance; Similar to Ecm18p YPR010C RPA135 0.59 1.1 135 kDa subunit of RNA polymerase I YNL011C 0.59 0.8 YBR272C HSM3 0.59 1.0 Involved in DNA mismatch repair pathways YER140W 0.59 2.4 YPL154C PEP4 0.59 1.5 vacuolar proteinase A YHR169W DBP8 0.59 1.4 "Dead-Box Protein 8, ATP-dependent helicase involved in rRNA processing" YFL004W VTC2 0.59 0.8 Phosphate metabolism; transcription is regulated by PHO system YLR132C 0.59 1.1 YHR107C CDC12 0.59 1.7 involved in proper bud growth YOR238W 0.59 1.1 YDR362C TFC6 0.59 0.8 91 kDa tau91 subunit of transcription factor IIIC (TFIIIC) YLR077W 0.59 1.2 YGL208W SIP2 0.59 1.3 "Member of a family of proteins, including Sip1p and Gal83p, that interact with Snf1p and Snf4p and are involved in the response to glucose starvation" YDR270W CCC2 0.58 1.0 copper-transporting P-type ATPase with similarity to human Menkes and Wilsons genes YMR286W MRPL33 0.58 2.2 essential for mitochondrial function YDR123C INO2 0.58 1.4 Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis YKL110C KTI12 0.58 1.2 Protein involved in resistance to K. lactis killer toxin; RNA polymerase II Elongator associated protein YGR100W MDR1 0.58 1.4 Mac1-dependent regulator YIL067C 0.58 1.3 YDL218W 0.58 2.1 YJR132W NMD5 0.58 3.0 Involved in nuclear import YER164W CHD1 0.58 1.3 "Sole S. cerevesiae member of CHD gene family containing Chromodomain, Helicase domain, and DNA-binding domain" YIR017C MET28 0.58 3.5 S C Transcriptional activator of sulfur amino acid metabolism YOR212W STE4 0.58 1.1 beta subunit of G protein coupled to mating factor receptor YLL028W TPO1 0.58 5.7 S Polyamine transport protein YDL121C 0.58 1.0 YGL002W ERP6 0.58 1.4 Emp24p/Erv25p related protein 6 YFL042C 0.58 1.7 YDR017C KCS1 0.58 1.2 Converts inositol hexakisphosphate to diphosphoinositol polyphosphates. Contains two leucine heptad repeats. Essential for biogenesis of the yeast vacuole and the cell's responses to certain environmental stresses. YNL145W MFA2 0.58 4.7 K S lipopeptide mating pheromone YJR106W ECM27 0.58 1.4 ExtraCellular Mutant YCL030C HIS4 0.58 3.0 histidinol dehydrogenase YHR206W SKN7 0.58 1.2 Protein with similarity to DNA-binding region of heat shock transcription factors YDL238C 0.58 1.5 YPR105C COG4 0.58 1.0 Conserved Oligomeric Golgi complex 4
Complexed with Cog8p YDL015C TSC13 0.58 1.4 ER protein involved in very long chain fatty acid synthesis YJL037W 0.58 1.6 YBL109W 0.58 2.3 YOR352W 0.58 1.4 YPR117W 0.58 1.0 YOL112W MSB4 0.58 2.3 S Multicopy Suppressor of Bud Emergence YJL146W IDS2 0.58 0.9 IME2-Dependent Signalling YKL023W 0.58 1.4 YGL008C PMA1 0.58 4.5 S Major regulator of cytoplasmic pH. Part of the P2 subgroup of cation-transporting ATPases; functions physiologically to pump protons out of the cell. YKL124W SSH4 0.58 0.8 Suppressor of SHR3; confers leflunomide resistance when overexpressed YER125W RSP5 0.58 1.0 involved in ubiquitin-mediated protein degradation YNR061C 0.58 1.3 YOL117W RRI2 0.58 2.0 subunit of COP9 Signalosome-like protein complex that cleaves the ubiquitin-like protein Rub1 from Cdc53 YGL123W RPS2 0.58 1.1 Homology to rat S2 and E. coli S5 YDR330W 0.58 1.9 YJR045C SSC1 0.58 0.9 Nuclear-encoded mitochondrial protein; member of the heat shock protein 70 (HSP70) family; most similar to E. coli DnaK protein; acts as a chaperone for protein import across the inner membrane YDR438W 0.58 0.9 YLR246W ERF2 0.58 1.1 Mutation has an Effect on Ras Function. Implicated in signaling pathway. YOR114W 0.58 4.1 Z S YMR284W YKU70 0.58 1.5 "Shows homology to 70-kDa subunit of mammalian Ku protein, the regulatory subunit of the DNA-dependent protein kinase" YNR035C ARC35 0.58 1.0 Arp complex subunit YDR085C AFR1 0.58 3.5 S coordinates regulation of alpha-factor receptor signalling and induction of morphogenesis during conjugation YDL237W 0.58 1.3 YKR007W 0.58 0.9 YPL017C 0.58 2.1 YNL045W 0.58 1.5 YGR101W PCP1 0.58 1.5 putative mitochondrial rhomboid protease YLR092W SUL2 0.58 1.8 Sulfate uptake YML125C 0.58 3.1 S YDR245W MNN10 0.58 1.4 Required for mannan synthesis and for polarized growth and bud emergence YIL001W 0.58 1.4 YCR008W SAT4 0.58 1.2 Protein with similarity to Npr1p protein kinase YDR279W 0.58 2.9 S YFR037C RSC8 0.58 1.7 C "8th largest subunit of RSC. Rsc8p mediates multiple RSC complex interactions, undergoes dimerization via the C-term coiled-coil segment, associates with SWI2/SNF2 ATPase Sth1p, forms a complex with RSC6p." YLR461W PAU4 0.58 1.5 member of the seripauperin protein/gene family (see Gene_class PAU) YOR093C 0.58 1.4 YLL046C RNP1 0.58 1.4 C ribonucleoprotein 1 YGL045W 0.58 1.0 YKR051W 0.58 1.0 YBR018C GAL7 0.58 1.1 galactose-1-phosphate uridyl transferase YLR090W XDJ1 0.58 1.6 "Homolog of E. coli DnaJ, closely related to Ydj1p" YHR032W 0.58 1.4 YPR196W 0.58 1.1 YEL055C POL5 0.58 1.0 DNA polymerase V that has motifs typical of DNA polymerase family. Aphidicolin-sensitive; stimulated by yeast proliferating cell nuclear antigen (PCNA). YPR048W TAH18 0.58 1.3 Product of gene unknown YLR033W RSC58 0.58 1.2 Remodels the structure of chromatin complex 58KDa subunit YPL217C BMS1 0.58 1.3 BMH1 sensitive YGL150C INO80 0.58 1.9 Shows similarity to the Snf2p family of DNA-dependent ATPases YHR102W KIC1 0.58 0.9 Kinase that interacts with Cdc31p; N-rich kinase 1 YBR120C CBP6 0.58 1.0 Translational activator of COB mRNA YDR371W CTS2 0.58 1.0 chitinase YMR016C SOK2 0.58 1.6 Protein that can when overexpressed suppress mutants of cAMP-dependent protein kinase YDL222C 0.58 1.8 YFR036W CDC26 0.58 1.2 "component of anaphase-promoting complex; required for ubiquitination of Clb2p and Clb3p, is a nuclear protein, and is induced by heat shock" YBR026C MRF1' 0.58 1.8 Involved in mitochondrial fatty acid biosynthesis YPL053C KTR6 0.58 1.7 "Similar to KRE2, mannosylphosphate transferase which may recognize any oligosaccharides with at least one alpha-1,2-linked mannobiose unit. Required for the transfer of mannosylphosphate to cell wall mannans." YNL291C MID1 0.58 0.8 N-glycosylated integral plasma membrane protein YPL172C COX10 0.58 1.7 Required for an essential posttranslational stage in assembly of cytochrome oxidase YKR106W 0.58 1.4 YIR008C PRI1 0.58 1.9 K p48 polypeptide of DNA primase YGR217W CCH1 0.58 1.5 calcium channel YLL065W 0.58 3.8 YCR071C IMG2 0.58 1.2 required for integrity of mitochondrial genome YJL047C RTT101 0.58 0.9 Regulator of Ty1 Transposition YDL116W NUP84 0.58 1.0 "component of nuclear pores; Part of complex with Nup120p, Nup85p, Sec13p, and a Sec13p homolog" YBR122C MRPL36 0.58 0.8 Mitochondrial ribosomal protein MRPL36 (YmL36) YGL183C MND1 0.57 1.9 needed for Meiotic Nuclear Divisions YOR348C PUT4 0.57 1.4 proline-specific permease (also capable of transporting alanine and glycine) YEL037C RAD23 0.57 1.1 ubiquitin-like protein YDR481C PHO8 0.57 3.3 S repressible alkaline phosphatase YLR014C PPR1 0.57 1.1 C Positive regulator of URA1 and URA3 YBR284W 0.57 1.2 YIL068C SEC6 0.57 1.2 cytoplasmic protein involved in fusion of post-Golgi vesicles with the plasma membrane. The Exocyst complex is required for exocytosis. YER077C 0.57 1.7 YOR323C PRO2 0.57 2.7 S second enzyme in proline biosynthesis YMR244W 0.57 2.7 YMR103C 0.57 1.5 YGL233W SEC15 0.57 0.9 Protein involved in vesicle traffic between Golgi and plasma membrane. The Exocyst complex is required for exocytosis. YOR022C 0.57 1.1 YDR074W TPS2 0.57 2.2 Trehalose-6-phosphate phosphatase YKR086W PRP16 0.57 2.5 putative ATP-binding protein YDL007W RPT2 0.57 1.0 Probable 26S protease subunit and member of CDC48/PAS1/SEC18 family of ATPases YKL220C FRE2 0.57 1.5 "Ferric reductase, similar to Fre1p" YER184C 0.57 0.8 YPL021W ECM23 0.57 4.5 S ExtraCellular Mutant; similar to SRD1. Negative regulator of pseudohyphal growth. YKL134C 1-Oct 0.57 1.7 mitochondrial protein import machinery component involved in the biogenesis of the oxidative phosphorylation system YNL232W CSL4 0.57 1.2 "Represses the replication of double-stranded RNA viruses, protecting the host from the otherwise lethal effects of the virus" YOR358W HAP5 0.57 1.4 Regulates respiratory functions; subunit of a heterotrimeric complex required for CCAAT binding YCL048W 0.57 1.5 YPR093C 0.57 1.5 YNL216W RAP1 0.57 2.6 Z S "DNA-binding protein involved in either activation or repression of transcription, depending on binding site context. Also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure." YOL102C TPT1 0.57 1.2 Gene encodes a protein implicated in the last step of tRNA splicing in yeast: transfer of the splice junction 2'-phosphate from ligated tRNA to NAD YGR103W NOP7 0.57 1.3 Nucleolar protein present in purified ribosome assembly intermediates. Required for rRNA processing; required for essential steps leading to synthesis of 60S ribosomal subunits. YDL019C OSH2 0.57 1.1 Oxysterol Binding Protein YOL032W 0.57 1.4 YNR008W LRO1 0.57 1.0 Lecithin cholesterol acyl transferase (LCAT) Related Orf YGL009C LEU1 0.57 1.6 LEU1 encodes the second enzyme in leucine biosynthesis. YNL051W COG5 0.57 1.4 Conserved Oligomeric Golgi complex 5
Complexed with Cog8p YGL186C 0.57 1.4 YLL026W HSP104 0.57 2.5 "involved in thermal and ethanol tolerance, inheritance of [PSI+], and reactivation of mRNA splicing after heat shock" YOL006C TOP1 0.57 1.7 topoisomerase I YNL041C COG6 0.57 1.0 Conserved Oligomeric Golgi complex 6
Complexed with Cog8p; interacts with Cog2p YER103W SSA4 0.57 1.8 member of 70 kDa heat shock protein family YPL049C DIG1 0.57 1.7 "Down-regulator of Invasive Growth, Regulator of Sterile Twelve, binds Fus3 and Ste12" YPL165C SET6 0.57 1.3 YPL242C IQG1 0.57 4.1 S C "Homolog of the mammalian IQGAP1 and 2 genes; probable regulator of cellular morphogenesis, inducing actin-ring formation in association with cytokinesis" YMR210W 0.57 1.1 YML133C 0.57 3.7 S YEL023C 0.57 1.5 YPR199C ARR1 0.57 1.5 Similar to transcriptional regulatory elements YAP1 and cad1 YKL072W STB6 0.57 1.2 binds Sin3p in two-hybrid assay YKL217W JEN1 0.57 1.0 "Repressed by glucose, induced by lactic acid; in high copy, weakly suppresses cpr3 null mutan phenotype on lactate medium at 37 degrees" YHL003C LAG1 0.57 1.4 YKL008C YGR199W PMT6 0.57 1.3 Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YBL067C UBP13 0.57 1.3 similar to Ubp9p YOL148C SPT20 0.57 0.9 Transcription factor YLL033W 0.57 2.4 Z YJL113W 0.57 1.7 YGR239C PEX21 0.57 1.3 Peroxin; Pex18p and Pex21p are partially functionally redundant. YMR213W CEF1 0.57 1.9 homolog of S. pombe cdc5+ YDR259C YAP6 0.57 1.8 bZIP protein YOR387C 0.57 1.0 YIR036C 0.57 2.1 S YDR390C UBA2 0.57 1.2 Protein with homology to mammalian ubiquitin activating (E1) enzyme YCL025C AGP1 0.57 3.4 S broad substrate range permease which transports asparagine and glutamine with intermediate specificity YJR154W 0.57 3.1 S YOR307C SLY41 0.57 4.8 S multicopy suppressor of ypt1 deletion YMR079W SEC14 0.57 1.1 Required for vesicle budding from the Golgi YNL330C RPD3 0.57 0.8 Transcription modifier; required for vegetative repression of early meiosis-specific as well as non-meiotic genes; required for mitotic intragenic and intergenic recombination and for sporulation YBR287W 0.57 2.6 S YKR003W OSH6 0.57 2.0 Oxysterol Binding Protein YLR357W RSC2 0.57 1.1 "RSC2 is a member of RSC complex, which Remodels the Structure of Chromatin. Also essential for the 2-micron plasmid to overcome maternal inheritance bias." YPR027C 0.57 1.5 YKL021C MAK11 0.57 0.9 essential for cell growth and replication of M dsRNA virus; contains four beta-transducin repeats YOR290C SNF2 0.57 1.7 involved in the coordinate regulation of phospholipid synthesis YOL092W 0.57 1.4 YLR395C COX8 0.57 1.6 C Cytochrome-c oxidase chain VIII YJL200C 0.57 2.0 YML113W DAT1 0.57 1.5 "datin, an oligo(dA).oligo(dT)-binding protein" YIR014W 0.57 1.1 YOR100C CRC1 0.56 1.2 carnitine carrier YMR089C YTA12 0.56 1.1 Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane YNL185C MRPL19 0.56 1.1 mitochondrial ribosomal protein of the large subunit YCR105W 0.56 1.3 YPR120C CLB5 0.56 5.3 K Z S C role in DNA replication during S phase; additional functional role in formation of mitotic spindles along with Clb3 and Clb4 YER058W PET117 0.56 0.9 Required for assembly of active cytochrome c oxidase YOL013C HRD1 0.56 0.9 Ubiquitin-protein ligase for endoplasmic reticulum-associated degradation. YBL008W HIR1 0.56 1.0 Involved in cell-cycle regulation of histone transcription YDR499W LCD1 0.56 1.4 required for the DNA integrity checkpoint pathways; S. pombe Rad26 functional homolog (putative) YLR083C EMP70 0.56 2.9 identified as a 24 kDa cleavage product in endosome-enriched membrane fractions YGR274C TAF1 0.56 0.9 TAFII complex component required for activated transcription YJR127C ZMS1 0.56 1.5 Product of gene unknown YPL160W CDC60 0.56 1.0 cytosolic leucyl tRNA synthetase YLR192C HCR1 0.56 0.9 High Copy suppressor of RPG1 YER031C YPT31 0.56 1.1 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment YHR140W 0.56 2.5 YFL046W 0.56 0.8 YER055C HIS1 0.56 1.2 involved in the first step of histidine biosynthesis YOR079C ATX2 0.56 1.7 Multi-copy suppressor of SOD-linked defects YHL010C 0.56 1.4 YDR384C ATO3 0.56 1.4 Ammonium Transport Outwards; member of the TC 9.B.33 YaaH family of putative transporters YPR137W RRP9 0.56 1.2 "part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Rrp9p is an ortholog of the human U3-55k protein; the human cDNA partially complements a yeast rrp9 null mutant. (Pluk et al. (1998) Mol. Cell. Biol. 18, 488-498.)" YHR157W REC104 0.56 1.3 "meiosis-specific recombination gene, dispensable for mitotic recombination and axial elements in meiosis, required for tripartite synaptonemal complexes, meiotic recombination and spore viability; classified as an early recombination gene" YNR072W HXT17 0.56 1.5 Hexose transporter YDR256C CTA1 0.56 1.7 catalase A YGL094C PAN2 0.56 2.4 Required for Pab1p-stimulated poly(A) ribonuclease activity YNL187W 0.56 1.1 YDR188W CCT6 0.56 0.8 "cytoplasmic chaperonin of the Cct ring complex (previously called TCP1 or TRiC), distantly related to Tcp1p and to Hsp60" YLR467W YRF1-5 0.56 4.8 S Y'-helicase protein 1 YDR545W YRF1-1 0.56 2.9 S Y'-helicase protein 1 YBR069C TAT1 0.56 2.4 S "Amino acid transport protein for valine, leucine, isoleucine, and tyrosine" YLL012W 0.56 2.7 Z S YMR093W UTP15 0.56 1.2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR434W GPI17 0.56 1.3 Glycosyl Phosphatidyl Inositol 17 YDR444W 0.56 1.6 YMR316W DIA1 0.56 2.5 "may be involved in invasive growth, pseudohyphal growth" YJL164C TPK1 0.56 1.9 putative catalytic subunit of cAMP-dependent protein kinase YGR085C RPL11B 0.56 1.5 Homology to rat L11 and E. coli L5; involved in protein synthesis YOR101W RAS1 0.56 2.1 ras proto-oncogene homolog YPR174C 0.56 5.1 Z S C YPR009W SUT2 0.56 0.9 Involved in sterol uptake; homologous to SUT1 YDL206W 0.56 0.9 YPR102C RPL11A 0.56 1.7 Homology to rat L11 and E. coli L5 YHR105W 0.56 1.1 YPL195W APL5 0.56 1.0 "Delta-like subunit of the yeast AP-3 complex which functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function" YHR149C 0.56 3.2 Z S YNL237W YTP1 0.56 1.2 Yeast putative Transmembrane Protein YAL026C DRS2 0.56 1.2 "P-type ATPase, potential aminophospholipid translocase" YOR321W PMT3 0.56 2.8 S Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YBL105C PKC1 0.56 1.5 Protein Kinase C YEL059C-A SOM1 0.56 1.8 "high copy suppressor of imp1 mutation, may be required for the function of the Imp1 peptidase and/or the protein sorting machinery" YER170W ADK2 0.56 3.7 S Adenylate kinase (mitochondrial GTP:AMP phosphotransferase) YJL070C 0.56 1.8 YDR505C PSP1 0.56 1.4 high-copy suppressor of cdc17 DNA polymerase alpha mutations YBR015C MNN2 0.56 2.5 "Probable type II membrane protein involved in mannan synthesis. Catalyzes addition of first mannose to branches on poly l,6-mannose backbone of outer chain of cell wall N-linked mannans." YLR222C UTP13 0.56 1.1 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YLR166C SEC10 0.56 1.3 "100 kD component of the Exocyst complex; required for exocytosis. The Exocyst complex contains the gene products encoded by SEC3, SEC5, SEC6, SEC8, SEC10, SEC15 and EXO70." YPR187W RPO26 0.56 0.9 "subunit common to RNA polymerases I, II, and III" YOR229W WTM2 0.56 5.1 Z S C WD repeat containing transcriptional modulator 2 YKL008C LAC1 0.56 5.1 S Longevity-assurance gene 1 cognate (LAG1 cognate) YNL143C 0.56 1.3 YLR300W EXG1 0.56 4.3 S "Has a broad specificity for beta-1,3-linkages as well as beta-1,6-linkages, and also for other beta-glucosidic linked substrates, such as cellobiose." YMR128W ECM16 0.56 1.2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); ExtraCellular Mutant
DEAH-box protein involved in ribosome synthesis YBR043C AQR2 0.56 2.0 Z C "A(acid, azole) Q(quinidine) Resistance" YJL124C LSM1 0.56 1.3 "Like Sm protein; the finding that Lsm1 contains the Sm consensus motifs and most closely resembles Sm-B has been controversial (Fromont-Racine et al, 1997 Nature Genetics 16:277-282, and Bertrand Seraphin, personal communication)." YDL177C 0.56 2.1 YOR011W AUS1 0.56 1.0 ABC(ATP-binding cassette) protein involved in Uptake of Sterols YIL065C FIS1 0.56 1.8 Involved in mitochondrial division YML018C 0.56 1.2 YPR067W ISA2 0.56 1.7 Iron Sulfur Assembly -- IscA/NifA homolog YGL164C 0.56 1.7 YJL171C 0.56 1.4 YMR049C ERB1 0.56 1.6 Eukaryotic Ribosome Biogenesis YDL017W CDC7 0.56 1.4 "Required for mitotic DNA synthesis but dispensable for premeiotic DNA synthesis and spindle pole body duplication; required for synaptonemal complexes, meiotic recombination, spindle pole body separation and spindles" YFR013W IOC3 0.56 1.0 Iswi One Complex YLR382C NAM2 0.56 2.7 C mitochondrial leucyl tRNA synthetase YHR098C SFB3 0.56 2.3 S binds to Sed5p and Sec23p by distinct domains
Lethal with sec-thirteen YCL018W LEU2 0.56 1.7 leucine biosynthesis YBR294W SUL1 0.56 1.5 Putative sulfate permease YDR476C 0.56 1.1 YJR042W NUP85 0.56 1.3 Protein in nuclear pore complex; may function in nuclear envelope integrity; may also be involved in tRNA biogenesis YCR044C PER1 0.56 0.9 Protein Processing in the ER YML095C RAD10 0.56 1.0 endonuclease (with Rad1p) that degrades single-stranded DNA for repair YNL279W PRM1 0.56 2.6 pheromone-regulated membrane protein YBR223C TDP1 0.56 1.9 Tyrosine-DNA Phosphodiesterase YOL018C TLG2 0.56 0.9 member of the syntaxin family of t-SNAREs YOR316C COT1 0.56 1.2 C Protein involved in cobalt accumulation; dosage dependent suppressor of cobalt toxicity YHR014W SPO13 0.56 1.4 Spo13 acts as a transcriptional activator in a one-hybrid assay (see Henninger et al (1996) SPO13 and control of meiotic chromosome segregation in Saccharomyces cerevisiae) YDR062W LCB2 0.56 1.4 "Serine palmitoyltransferase catalyses the committed step in sphingolipid synthesis, the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine." YHR007C ERG11 0.56 1.7 cytochrome P450 lanosterol 14a-demethylase YMR238W DFG5 0.56 2.7 S "Protein required for filamentous growth, cell polarity, and cellular elongation" YPL235W RVB2 0.56 0.8 "RUVB-like protein, TIP49b Homologue" YML030W 0.56 1.7 YHR138C 0.56 1.9 YGR030C POP6 0.56 1.0 Processing Of Precursors - a group of proteins that appear to be components of both RNase P and RNase MRP YNR052C POP2 0.56 0.9 Putative transcription factor YJR086W STE18 0.56 1.5 gamma subunit of G protein coupled to mating factor receptors YJL008C CCT8 0.55 0.8 Required for assembly of microtubules and actin in vivo YJL153C INO1 0.55 3.8 involved in the rate limiting step of inositol biosynthesis YDL241W 0.55 1.8 YKL121W 0.55 1.2 YLR330W CHS5 0.55 1.1 "Involved in chitin synthase III activity, also required for homozygosis in the first stages of mating" YJR051W OSM1 0.55 1.2 osmotic growth protein YDR221W 0.55 1.6 YLR053C 0.55 1.2 YMR026C PEX12 0.55 0.8 C3HC4 zinc-binding integral peroxisomal membrane protein YAL027W 0.55 0.9 YML132W COS3 0.55 1.7 "Protein with strong similarity to subtelomerically-encoded proteins such as Cos5p, Ybr302p, Cos3p, Cos1p, Cos4p, Cos8p, Cos6p, Cos9p (COS3 and YBR302C code for identical proteins)" YOR103C OST2 0.55 1.7 Oligosaccharyltransferase catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synthesized proteins in ER lumen YBR302C COS2 0.55 1.2 "Protein with similarity to members of the Cos3/Cos5/Cos1/Cos4/Cos8/Cos6/Cos9 family, coded from subtelomeric region" YMR122C 0.55 1.8 YML043C RRN11 0.55 1.8 "rDNA transcription factor CF component, which also contains Rrn6p and Rrn7p, which is required for rDNA transcription by RNA polymerase I" YCR024C 0.55 1.2 YGR288W MAL13 0.55 1.8 "Part of complex locus MAL1; nonfunctional in S288C, shows homology to both functional & nonfunctional MAL-activator proteins in other Sc strains & to other nonfunctional MAL-activator sequences from S288C (i.e. MAL33, YPR196W, & YFL052W)" YHR144C DCD1 0.55 0.9 dCMP deaminase YHL002W HSE1 0.55 0.8 Has Symptoms of class E vps mutant YBR084C-A RPL19A 0.55 1.4 Homology to rat L19 YBL027W RPL19B 0.55 1.5 Homology to rat L19 YDL040C NAT1 0.55 0.8 "Required for entry into stationary phase, heat shock-resistance, a mating-type functions, and sporulation; forms a complex with Ard1p" YHR176W FMO 0.55 0.9 "catalyzes the O2- and NADPH-dependent oxidations of biological thiols, including oxidation of glutathione to glutathione disulfide" YHR137W ARO9 0.55 2.7 S aromatic amino acid aminotransferase II YML116W ATR1 0.55 2.5 S aminotriazole resistance YLR221C RSA3 0.55 1.3 RiboSome Assembly YDR443C SSN2 0.55 1.1 Required for stable association of Srb10p-Srb11p kinase with RNA polymerase holoenzyme; regulates YGP1 epxression; component of RNA polymerase II holoenzyme and Kornberg's mediator (SRB) subcomplex YLR164W 0.55 2.5 YDR478W SNM1 0.55 1.1 Has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. YKR018C 0.55 1.1 YHR119W SET1 0.55 1.2 Gene has a 'SET' or 'TROMO' domain at its carboxyterminus like the trithorax gene family from human and Drosophila with postulated function in chromatin-mediated gene regulation. YKR072C SIS2 0.55 0.9 Involved in cell cycle control and ion homeostasis YOL033W MSE1 0.55 1.6 Mitochondrial glutamyl-tRNA synthetase YOR168W GLN4 0.55 1.5 glutaminyl-tRNA synthetase YMR277W FCP1 0.55 2.1 TFIIF interacting Component of CTD Phosphatase YBR278W DPB3 0.55 1.2 K C C and C' subunits of DNA polymerase II YMR208W ERG12 0.55 1.5 mevalonate catabolism YML088W UFO1 0.55 1.1 F-box protein YER033C ZRG8 0.55 1.3 Zinc regulated gene YOR256C 0.55 4.1 S YDR244W PEX5 0.55 0.8 Essential for import of proteins with SKL-like import signal into peroxisomal matrix YOR043W WHI2 0.55 1.2 "Protein involved in growth regulation. Whi2 and its binding partner, Psr1-phosphatase, are required for a full activation of the general stress response, possibly through the dephosphorylation of Msn2." YGL095C VPS45 0.55 1.3 Protein of the Sec1p family essential for vacuolar protein sorting YBL033C RIB1 0.55 1.3 First step in the riboflavin biosynthesis pathway YNL152W 0.55 1.8 YOR301W RAX1 0.55 1.8 A rax1 mutation converts the budding pattern of an axl1 null mutant from bipolar to axial. YIL107C PFK26 0.55 0.8 6-Phosphofructose-2-kinase YJR061W 0.55 1.0 YHR155W 0.55 0.9 YLL067C 0.55 3.6 Z S YNL059C ARP5 0.55 1.0 Actin-related protein. Part of the carboxypeptidase Y pathway. YBR187W 0.55 2.1 YGL139W 0.55 2.9 Z YPR148C 0.55 1.9 YNL121C TOM70 0.55 1.0 Translocase of Outer Mitochondrial membrane YFL041W FET5 0.55 1.9 ferrous iron transport YBR198C TAF5 0.55 1.0 TAF(II) complex (TBP-associated protein complex) component required for activated transcription by RNA polymerase II YBR030W 0.55 1.1 YER160C 0.55 1.5 YML057W CMP2 0.55 1.4 calmodulin binding protein homologous to mammalian calcineurin YBL103C RTG3 0.55 1.7 bHLH/Zip transcription factor which regulates CIT2 gene expression YER162C RAD4 0.55 0.9 Nucleotide excision repair protein YML029W USA1 0.55 1.8 "Identified by its interaction with the U1 snRNP-specific protein, Snp1p." YDR375C BCS1 0.55 1.5 "Mitochondrial protein of the CDC48/PAS1/SEC18 ATPase family, required for expression of functional Rieske iron-sulfur protein" YDR294C DPL1 0.55 1.4 dihydrosphingosine phosphate lyase (also known as sphingosine phosphate lyase) YML023C 0.55 1.5 YMR028W TAP42 0.55 1.1 "Two A phosphatase Associated Protein, apparant MW of 42 kDA" YDR030C RAD28 0.55 2.1 "Protein involved in the same pathway as Rad26p, has beta-transducin (WD-40) repeats" YHL012W 0.55 1.0 YOR342C 0.55 2.7 S YOR254C SEC63 0.55 1.5 Protein involved in protein import into ER YIR034C LYS1 0.55 2.4 saccharopine dehydrogenase YDR307W 0.55 2.3 S YIL014W MNT3 0.55 1.3 MaNnosylTransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans YDR063W 0.55 0.9 YER151C UBP3 0.55 1.7 Possible role for UBP3 in controlling the activity or assembly of the SIR protein complex. YGL153W PEX14 0.55 0.9 Peroxisomal peripheral membrane protein (peroxin) involved in import of peroxisomal matrix proteins YML118W NGL3 0.55 1.7 DNase/RNase (putative); CCR4 C-terminal homolog; displays homology to drosophila Angel gene; homolog to ngl1 and ngl2 YFR010W UBP6 0.55 1.1 deubiquitinating enzyme (putative) YBR216C 0.55 0.9 YLR386W VAC14 0.55 2.1 VACuole morphology and inheritance mutant YJL111W CCT7 0.55 0.8 Required for assembly of microtubules and actin in vivo YOL048C 0.55 1.2 YLR057W 0.55 3.0 S YDL180W 0.55 2.1 S YOR303W CPA1 0.55 1.3 "Carbamoyl phosphate synthetase, arginine specific" YOR292C 0.55 1.5 YML062C MFT1 0.55 0.8 Protein involved in mitochondrial import of fusion proteins YBL101W-B 0.55 1.1 YMR071C 0.55 2.7 YDL128W VCX1 0.55 1.7 S "Similar to sodium/calcium exchangers, including bovine Na+/Ca2+,K+ antiporter; putative vacuolar transmembrane protein" YMR061W RNA14 0.55 0.9 Protein with a role in mRNA stability and/or poly(A) tail length YNL293W MSB3 0.55 2.2 Multicopy Suppressor of Bud Emergence YJL012C VTC4 0.55 1.1 Phosphate metabolism; transcription is regulated by PHO system YBL006C 0.55 1.1 YFR011C 0.55 1.2 YGL210W YPT32 0.55 1.2 probably involved in intra-Golgi transport or in the formation of transport vesicles at the most distal Golgi compartment YOR302W 0.55 0.9 YLR210W CLB4 0.55 3.8 K Z S C Involved in mitotic induction YBL043W ECM13 0.55 1.9 ExtraCellular Mutant YML012W ERV25 0.55 2.6 S COPII coat component of certain ER-derived vesicles YDR057W YOS9 0.55 1.1 Appears to play a direct role in the transport of GPI-anchored proteins to the Golgi apparatus. YLR025W SNF7 0.55 1.3 Involved in derepression of SUC2 in response to glucose limitation YML101C CUE4 0.55 1.7 Hypothetical ORF YNR013C PHO91 0.55 1.7 Low-affinity phosphate transporter YBR118W TEF2 0.55 2.4 translational elongation factor EF-1 alpha YPR080W TEF1 0.55 1.8 translational elongation factor EF-1 alpha YGL112C TAF6 0.55 1.1 TATA-binding protein-associated-factor YDR397C NCB2 0.55 1.1 Negative Cofactor B2 is the beta subunit of a negative regulator of RNA polymerase II holoenzyme. It is homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) YGL155W CDC43 0.55 1.1 may participate in a ras-like C-terminus modification of proteins involved in nuclear division and bud growth YDR449C UTP6 0.55 1.2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YGR092W DBF2 0.55 5.3 K S C Kinase required for late nuclear division. Cdc15 promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. YDL164C CDC9 0.54 4.7 K Z S C "essential for mitosis and meiosis, dispensable for intragenic recombination, but required for haploidization and spores" YNL138W SRV2 0.54 1.1 N-terminal domain appears to be involved in cellular responsiveness to RAS. YDL099W 0.54 1.7 YAR031W PRM9 0.54 1.9 pheromone-regulated membrane protein YAL005C SSA1 0.54 3.1 Stress-seventy subfamily A YML121W GTR1 0.54 1.1 Involved in the function of the Pho84 phosphate transporter YNL302C RPS19B 0.54 1.4 Homology to rat S19 YOR274W MOD5 0.54 2.1 C transfer RNA isopentenyl transferase YDR171W HSP42 0.54 1.8 Similar to HSP26; expression is regulated by stress conditions YLR369W SSQ1 0.54 1.2 Stress seventy Q. involved in the synthesis and assembly of iron/sulfur clusters into proteins. YLR102C APC9 0.54 1.3 subunit of the Anaphase Promoting Complex YER052C HOM3 0.54 1.3 First step in common pathway for methionine and threonine biosynthesis YPR194C OPT2 0.54 1.3 oligopeptide transporter YJR065C ARP3 0.54 1.2 actin-related gene YLR288C MEC3 0.54 2.3 Z S Involved in checkpoint control and DNA repair YER186C 0.54 1.1 YIL033C BCY1 0.54 1.8 "Involved in heat shock resistance, glycogen accumulation, and sporulation" YKL042W SPC42 0.54 3.3 K Z S C "involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane" YLR259C HSP60 0.54 1.2 60 kDa heat shock protein YBL061C SKT5 0.54 2.2 S "protoplast regeneration and killer toxin resistance gene, may be a post-translational regulator of chitin synthase III activity, interacts with Chs3p" YIR007W 0.54 1.2 YDR218C SPR28 0.54 2.1 Septin-related protein expressed during sporulation YHR200W RPN10 0.54 1.4 "homolog of the mammalian S5a protein, component of 26S proteasome" YNL026W 0.54 0.9 YGR048W UFD1 0.54 1.6 Ubiquitin fusion degradation protein YJL186W MNN5 0.54 1.4 mannan synthesis YGR257C 0.54 0.8 YKL002W DID4 0.54 1.4 YNL008C ASI3 0.54 1.1 "Amino acid Sensor-Independent (ASI) genes encode membrane proteins Asi1p, Asi2p and Asi3p. Asi1p and Asi3p have conserved ubiquitin ligase-like RING domains at their C-termini" YNL062C GCD10 0.54 1.2 First identified as negative regulator of GCN4 expression YHR207C SET5 0.54 1.3 YGL119W ABC1 0.54 1.7 Z "multicopy suppressor of a cytochrome b mRNA translation defect, essential for the electron transfer in the bc1 complex" YLL009C COX17 0.54 1.5 Involved in copper metabolism and assembly of cytochrome oxidase YGL185C 0.54 2.2 Z S YKL096W-A CWP2 0.54 4.6 S "major constituent of the cell wall containing GPI-anchor, plays a role in stabilizing the cell wall, low pH resistance protein" YHR214C-B 0.54 1.1 YKR087C 0.54 0.9 YHR048W 0.54 0.8 YML042W CAT2 0.54 2.2 "Carnitine O-acetyltransferase, peroxisomal and mitochondrial" YER085C 0.54 1.8 YMR294W JNM1 0.54 1.5 coiled-coil domain protein required for proper nuclear migration during mitosis (but not during conjugation) YOL131W 0.54 1.1 YEL031W SPF1 0.54 1.4 Sensitivity to a killer toxin (SMK toxin) produced by Pichia Farinosa YPL145C KES1 0.54 2.1 Homologous to human oxysterol-binding protein; implicated in ergosterol biosynthesis and regulation of Golgi-derived transport vesicle biogenesis YPL274W SAM3 0.54 2.7 S S-adenosylMethionine Permease YMR100W MUB1 0.54 1.5 Homolog of samB gene of Aspergillus nidulans (deletion of samB results in mislocalization of septa YDL210W UGA4 0.54 1.4 GABA-specific transport protein YNR060W FRE4 0.54 1.7 similar to FRE2 YJR082C EAF6 0.54 3.3 Esa1p-Associated Factor-6 YER165W PAB1 0.54 0.9 "Poly(A) binding protein, cytoplasmic and nuclear" YBR186W PCH2 0.54 1.4 Pachytene CHeckpoint YBL024W NCL1 0.54 0.9 "Nuclear protein 1, similar to NOP2 and human proliferation associated nucleolar protein p120" YIR006C PAN1 0.54 1.0 Involved in actin organization and endocytosis YGR066C 0.54 1.5 YIL052C RPL34B 0.54 0.8 Homology to rat L34 YDR322W MRPL35 0.54 1.1 Mitochondrial ribosomal protein MRPL35 (YmL35) YDR064W RPS13 0.54 1.7 Homology to rat S13 YBL097W BRN1 0.54 2.9 C "BaRreN, a gene with sequence similarity to Drosophila barren and Xenopus XCAP-H, and a functional homolog of human BRRN1" YCR096C HMRA2 0.54 1.7 "Silenced copy of A2, which encodes a protein of unknown function." YDR381W YRA1 0.54 1.3 Yeast RNA Annealing Protein YOR194C TOA1 0.54 1.8 "Transcription factor IIA, large chain" YNL087W 0.54 2.0 YGL055W OLE1 0.54 6.7 S C converts saturated fatty acyl-CoAs into cis-Delta-9 unsaturated fatty acids. YJL068C 0.54 1.4 YLR097C 0.54 1.8 YJR029W 0.54 1.0 YNL034W 0.54 1.8 YEL041W 0.53 1.7 YDR026C 0.53 1.1 YIL048W NEO1 0.53 1.0 ATPase that leads to neomycin-resistant protein when overexpressed YML020W 0.53 2.2 S YIL021W RPB3 0.53 1.2 45 kDa subunit of RNA polymerase II YNL311C 0.53 1.4 YGR177C ATF2 0.53 3.7 Z S Alcohol acetyltransferase YJR083C 0.53 2.0 YDR222W 0.53 1.8 YPL210C SRP72 0.53 1.2 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YKL112W ABF1 0.53 2.6 transcriptional activator and ARS1 binding protein YPL123C RNY1 0.53 2.1 RiboNuclease from Yeast YER109C FLO8 0.53 1.3 "Nuclear protein required for diploid filamentous growth, haploid invasive growth and flocculation; note that S288C strains have a mutation in this gene" YGR230W BNS1 0.53 3.9 S C bypasses need for SPO12 YLR085C ARP6 0.53 1.2 Actin-related protein. Part of the carboxypeptidase Y pathway. YPL178W CBC2 0.53 1.1 cap binding complex YLR115W CFT2 0.53 1.4 "cleaves pre-mRNAs prior to polyadenylation; homologous to both the 73- and 100-kDa subunits of mammalian cleavage and polyadenylation specificity factor (CPSF), as well as to YSH1/BRR5" YLR324W 0.53 1.3 YGR033C 0.53 1.0 YDL122W UBP1 0.53 2.1 Ubiquitin-specific protease YDR461W MFA1 0.53 3.4 S a-factor mating pheromone precursor YNL305C 0.53 1.1 YHR022C 0.53 2.7 S C YCR019W MAK32 0.53 1.5 Protein necessary for structural stability of L-A double-stranded RNA-containing particles YDR361C BCP1 0.53 1.0 Hypothetical ORF YNL018C 0.53 2.9 YNR069C 0.53 2.3 YER053C 0.53 2.5 YDR337W MRPS28 0.53 2.3 S Mitochondrial ribosomal protein MRPS28 (E. coli S15) YPL245W 0.53 1.2 YBL005W-B 0.53 1.0 YJL062W LAS21 0.53 1.2 Local Anesthetics Sensitive: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins. YNL022C 0.53 0.9 YFR024C-A LSB3 0.53 2.5 LAs17 Binding protein YGR067C 0.53 2.3 YJR041C 0.53 1.7 YPL087W YDC1 0.53 1.5 Yeast dihydro-ceramidase YDR430C CYM1 0.53 1.0 CYtosolic Metalloprotease YNL147W LSM7 0.53 1.9 Like Sm-G protein YBR062C 0.53 1.1 YDR211W GCD6 0.53 1.0 "Guanine nucleotide exchange factor, 81 kDa subunit" YGR167W CLC1 0.53 1.5 Clathrin light chain YHR117W TOM71 0.53 0.9 "Translocase of the Outer Mitochondrial membrane, 71.9 kDa" YPL096W PNG1 0.53 1.3 de-N-glycosylation enzyme YLR188W MDL1 0.53 1.8 ATP-binding cassette (ABC) transporter family member YMR105C PGM2 0.53 2.6 Phosphoglucomutase YOL057W 0.53 1.4 YPL223C GRE1 0.53 2.2 Induced by osmotic stress YDL075W RPL31A 0.53 1.3 Homology to rat L31 YBR285W 0.53 2.3 YIL023C 0.53 1.9 YML013W SEL1 0.53 1.0 SEcretion Lowering YGR264C MES1 0.53 1.2 methionyl tRNA synthetase YER065C ICL1 0.53 1.0 component of glyoxylate cycle YJR076C CDC11 0.53 2.4 Z C involved in proper bud growth YPL037C EGD1 0.53 1.1 beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; GAL4 enhancer protein YKL063C 0.53 1.5 YAR014C BUD14 0.53 1.5 YAL034C FUN19 0.53 1.4 Function unknown now YEL030W ECM10 0.53 1.6 ExtraCellular Mutant YER027C GAL83 0.53 1.5 Glucose repression protein YGL216W KIP3 0.53 3.6 Z S Kinesin-related protein YFR035C 0.53 1.4 YDL030W PRP9 0.53 1.0 "involved in pre-spliceosome assembly, important for U2 snRNP addition" YLL024C SSA2 0.53 1.9 member of 70 kDa heat shock protein family YGL175C SAE2 0.53 2.7 Involved in meiotic recombination and chromosome metabolism YOL051W GAL11 0.53 0.9 Regulates transcription of a diverse array of genes. Required for mating and sporulation. YPR006C ICL2 0.53 1.4 2-methylisocitrate lyase YER138C 0.53 1.7 YGR289C MAL11 0.53 2.2 "Part of MAL1 complex locus; encodes funct. maltose permease in all strains, exhibits sign. seq. variability; shows homol. to functional maltose permease from S. carlsbergenesis; member of the 12 tm domain superfamily of sugar transporters" YEL053C MAK10 0.53 1.4 Glucose-repressible protein YDR126W SWF1 0.53 1.4 Spore Wall Formation YBR240C THI2 0.53 1.0 Transcriptional activator of thiamine biosynthetic genes YLL004W ORC3 0.53 1.3 Third subunit of the origin recognition complex YOR197W MCA1 0.53 1.4 metacaspase YAR002C-A ERP1 0.53 0.8 Emp24p/Erv25p related protein YBR139W 0.53 3.2 S YLR291C GCD7 0.53 0.8 "translation initiation factor eIF2b, 43 kDa subunit; negative regulator of GCN4 expression" YDR403W DIT1 0.53 0.8 "Disp. for spores & spore viability - required for dityrosine accumul. in the outer spore wall (s.w.), s.w. maturation & resist. to ether & lytic enzymes. Spore-autonomous function in heterozygotes. mRNA is trans. mid/late in s.w. formation" YBL028C 0.53 1.3 YBR154C RPB5 0.53 1.1 "25-kDa RNA polymerase subunit (common to polymerases I, II and III)" YLL007C 0.53 1.7 YJL155C FBP26 0.53 2.0 "fructose-2,6-bisphosphatase" YLR088W GAA1 0.53 1.4 ER protein essential for attaching GPI (glycosylphosphatidylinositol) to protein YHL043W ECM34 0.53 1.0 ExtraCellular Mutant YLL066C 0.53 4.4 S YKL188C PXA2 0.53 1.4 Homolog of the human adrenoleukodystrophy transporter; forms a heterodimer with Pxa1p of two half ATP-binding cassette transporters in the peroxisome membrane YJL141C YAK1 0.53 1.0 Serine-threonine protein kinase YCR054C CTR86 0.53 1.1 CTR86 shares a terminator region with THR4. CTR86 contains aGCN4 responsive site suggesting it may also be involved in amino acid biosynthesis. YDL123W SNA4 0.53 1.0 Homology to PMP3/SNA1 (Sensitivity to Na+) YML128C MSC1 0.53 2.6 Meiotic Sister-Chromatid recombination YER179W DMC1 0.53 1.4 "Dispensable for double strand breaks, synaptonemal complexes, gene conversion in return to growth assay. Required for full pairing by in situ hybrid. assay, wt time of appearance of synaptonemal complexes and reciprocal Rec in growth assay" YDR121W DPB4 0.53 1.0 "DNA Polymerase B (II), 4th subunit" YJL044C GYP6 0.53 3.3 Z S GTPase-activating protein for Ypt6 YNL193W 0.53 0.8 YMR185W 0.53 1.0 YIL076W SEC28 0.52 1.8 S Part of a heptameric protein complex that regulates retrograde Golgi-to-ER protein traffic in eukaryotic cells; coatomer forms the COP I vesicle coat whose functions are essential YBR296C PHO89 0.52 4.3 Z S Probable Na+/Pi symporter YNL088W TOP2 0.52 1.5 "dispensable for premeiotic DNA synthesis and recombination, but required for meiosis I" YLR308W CDA2 0.52 3.4 Required for proper formation of the ascospore wall YPR111W DBF20 0.52 2.9 S C kinase required for late nuclear division YLL039C UBI4 0.52 1.8 involved in stress response system YIR026C YVH1 0.52 1.5 nitrogen starvation-induced protein phosphatase YLR439W MRPL4 0.52 1.2 essential for mitochondrial function and for proper cell growth under non-respiratory conditions YGR107W 0.52 1.3 YAL020C ATS1 0.52 1.6 Protein with similarity to human RCC1 protein YPR063C 0.52 1.3 YBR036C CSG2 0.52 0.8 "Required for growth in high (>25mM) calcium, contains 9 or 10 putative membrane spanning regions" YHL018W 0.52 2.1 YLR087C CSF1 0.52 0.9 "Cold Sensitive for Fermentation
in cs mutants, fermentation capacity is almost none at 5 deg C, but restored to wild type at 25 deg C" YNR030W ECM39 0.52 1.8 mannosyltransferase YDR170C SEC7 0.52 1.0 Involved in protein transport at multiple stages of the secretory pathway YBR169C SSE2 0.52 1.4 "HSP70 family member, highly homologous to Sse1p" YHL046C 0.52 1.3 YLR267W BOP2 0.52 1.4 bypass of PAM1 YMR126C 0.52 1.6 YNR045W PET494 0.52 1.1 translational activator of cytochrome c oxidase YHL037C 0.52 2.0 YNL229C URE2 0.52 0.9 Nitrogen catabolite repression regulator that acts by inhibition of GLN3 in good nitrogen source. Altered form of Ure2p creates [URE3] prion. YKL156W RPS27A 0.52 1.0 Homology to mammalian S27 YLR199C 0.52 1.3 YNL312W RFA2 0.52 4.2 K Z S C "Involved in nucleotide excision repair
RFA1, RFA2, and RFA3 make up RPA" YJR027W 0.52 1.1 YBR017C KAP104 0.52 1.2 "Karyopherin of 103,613 Da. Similar to yeast karyopherin beta (Kap95p; YLR347c)" YKL128C PMU1 0.52 1.8 "Phospho MUtase homolog. Small region homologous to active site of phospho-mutases, these move phosphates via a phospho-histidine intermediate. Homologs include: Sc GPM1, bact. Pgm, Hs Bpgm & rat fructose-2,6-bisphosphatase" YJR155W AAD10 0.52 2.7 Z S C high degree of similarity with the AAD of P. chrysosporium YLR262C YPT6 0.52 1.5 Ras-like GTP binding protein involved in the secretory pathway. Ypt6p is required for fusion of endosome-derived vesicles with the late Golgi. YNL165W 0.52 2.7 S YGR121C MEP1 0.52 1.8 belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH(4)(+) + NH(3)). YDL072C 0.52 1.4 YBR131W CCZ1 0.52 0.9 Calcium Caffeine Zinc sensitivity YML082W 0.52 1.1 YPL003W ULA1 0.52 1.7 Required for activation of RUB1 (ubiquitin-like protein) together with UBA3. Related to AOS1 and to N-terminus of UBA1. Collaborates with UBC12 in conjugation of RUB1 to other proteins. Required for modification of CDC53/cullin with RUB1 YIR025W MND2 0.52 0.9 needed for Meiotic Nuclear Division YBR048W RPS11B 0.52 2.0 "Homology to rat S11, human S11, and E. coli S17" YDR025W RPS11A 0.52 2.6 "Homology to rat S11, human S11, and E. coli S17" YGR235C 0.52 1.1 YOR015W 0.52 1.2 YLR268W SEC22 0.52 1.4 Synaptobrevin (v-SNARE) homolog present on ER to Golgi vesicles YNL100W 0.52 0.9 YLR440C 0.52 1.4 YGR191W HIP1 0.52 1.5 histidine permease YML102W CAC2 0.52 4.3 Z S C Involved in DNA-replication-linked nucleosome assembly; homologous to the p60 subunit of the Human CAF-I YHR076W PTC7 0.52 1.6 YMR123W PKR1 0.52 1.1 Pichia farinosa Killer toxin Resistance YEL069C HXT13 0.52 1.5 high-affinity hexose transporter YJL163C 0.52 1.3 YDR040C ENA1 0.52 2.0 Plasma membrane Na+ pump; P-type ATPase YPL023C MET12 0.52 1.6 Gene encodes mthfr which catalyzes step before methionine synthesis. YML045W 0.52 1.7 YCL007C CWH36 0.52 1.3 calcofluor white hypersensitivity YOL121C RPS19A 0.52 0.9 Homology to rat S19 YKL182W FAS1 0.52 1.6 S "pentafunctional enzyme consisting of the following domains : acetyl transferase, enoyl reductase, dehydratase and malonyl/palmityl transferase" YGR171C MSM1 0.52 1.3 mitochondrial methionyl-tRNA synthetase YBR297W MAL33 0.52 1.7 "Part of complex locus MAL3; nonfunctional in S288C, shows homology to both functional & nonfunctional MAL-activator proteins in other Sc strains & to other nonfunctional MAL-activator sequences from S288C (i.e. MAL33, YPR196W, & YFL052W)" YDR054C CDC34 0.52 1.5 "ubiquitin-conjugating enzyme, E2" YGR183C QCR9 0.52 1.8 C 7.3 kDa subunit 9 of the ubiquinol cytochrome c oxidoreductase complex YGL203C KEX1 0.52 1.2 Killer toxin and alpha factor precursor processing. Kex1p can cleave lys and arg residues from the C-terminus of peptides and proteins. YIL085C KTR7 0.52 1.3 Putative mannosyltransferase of the KRE2 family YLR167W RPS31 0.52 1.4 Homology to rat S27a YPR062W FCY1 0.52 1.3 cytosine deaminase highly homologous to Candida albicans cytosine deaminase YBL072C RPS8A 0.52 3.1 Homology to mammalian S8 YER102W RPS8B 0.52 1.5 Homology to mammalian S8 YPL214C THI6 0.52 1.2 thiamin biosynthetic bifunctional enzyme YOR357C GRD19 0.52 0.8 Functions in Golgi retention. YPL166W 0.52 1.3 YDR416W SYF1 0.52 1.0 SYnthetic lethal with cdcForty YNL164C IBD2 0.52 0.8 Inhibition of Bud Division YNL119W 0.52 1.3 YGL194C HOS2 0.52 1.5 "Protein with similarity to Hda1p, Rpd3p, Hos1p, and Hos3p" YNL027W CRZ1 0.52 1.2 calcineurin responsive zinc-finger YFR009W GCN20 0.52 0.8 Positive effector of the EIF-2-alpha kinase activity of GCN2; component of a heteromeric complex that includes GCN1 and GCN20 YCR090C 0.52 1.2 YLR423C APG17 0.52 1.2 required for activation of Apg1 protein kinase YGR278W CWC22 0.52 1.3 Complexed with Cef1p YOR046C DBP5 0.52 1.1 Dead-Box protein 5 YDR527W 0.52 1.6 YLR347C KAP95 0.52 1.4 S protein involved in nuclear import; required for the docking of import substrate to the nuclear membrane/pore; identified as an rna1-1 synthetic lethal YBL016W FUS3 0.52 2.1 Required for the arrest of cells in G(sub)1 in response to pheromone and cell fusion during conjugation YER016W BIM1 0.52 3.2 S C binding to microtubules YOL128C YGK3 0.52 1.4 Yeast homologue of mammalian Glycogen Synthase 3 YOR276W CAF20 0.52 0.8 "binds to eIF-4E, the mRNA cap-binding protein, and represses cap-dependent translation initiation by interfering with the interaction of eIF4E and eIF4G" YPR084W 0.52 1.0 YIL055C 0.52 2.3 YDR382W RPP2B 0.52 2.8 "Homology to rat P2, human P2, and E.coli L12eIA" YKR082W NUP133 0.52 1.7 "Nuclear pore complex protein involved in poly(A)+ RNA transport, nuclear pore distribution, and possibly in the biogenesis of functional tRNA" YOR124C UBP2 0.52 1.0 Ubiquitin-specific protease YPL272C 0.52 0.8 YPR135W CTF4 0.52 4.5 Z S May function in DNA synthesis YBR168W 0.52 1.1 YOR029W 0.51 2.5 YNL278W CAF120 0.51 1.4 CCR4 Associated Factor 120 kDa YHR028C DAP2 0.51 1.1 Dipeptidyl aminopeptidase B (DPAP B) YDR129C SAC6 0.51 0.8 fibrim homolog (actin-filament bundling protein) YMR112C MED11 0.51 1.2 14 Kd mediator subunit of RNA polymerase II holoenzyme YOR237W HES1 0.51 3.2 Protein implicated in ergosterol biosynthesis YDL063C 0.51 1.8 YPL270W MDL2 0.51 1.4 ATP-binding cassette (ABC) transporter family member YPR049C CVT9 0.51 1.4 "Oligomeric, coiled-coil, peripheral membrane protein" YMR092C AIP1 0.51 2.0 Protein localizes to actin cortical patches. Probable binding site on actin lies on front surface of subdomain 3 and 4. YDR014W RAD61 0.51 1.5 Affects radiation sensitivity YGR201C 0.51 0.8 YDR043C NRG1 0.51 1.3 involved in regulation of glucose repression YKR031C SPO14 0.51 1.2 "Catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid. Dispensable for mitosis, premeiotic DNA synthesis, recombination, meiosis I. Required for commitment to meiosis, meiosis II and sporulation." YER025W GCD11 0.51 0.8 eIF2 is a heterotrimeric GTP-binding protein
SUI2 encodes the alpha subunit
SUI3 encodes the beta subunit YPL181W RXT1 0.51 1.2 Hypothetical ORF YBL010C 0.51 1.7 YJL020C BBC1 0.51 1.3 shows synthetic fitness defect with bni1 mutants and associates with the Bee1p-Vrp1p-Myo3/5p complex YDR176W NGG1 0.51 1.5 Involved in glucose repression of GAL4p-regulated transcription YDR542W 0.51 1.4 YML097C VPS9 0.51 0.8 "Required for Golgi to vacuole trafficking, shares similarity to mammalian ras inhibitors" YKL052C ASK1 0.51 3.5 S C Associated with Spindles and Kinetochores YDR068W DOS2 0.51 1.4 Product of gene unknown YOR001W RRP6 0.51 1.9 Ribosomal RNA Processing YMR077C VPS20 0.51 0.9 vaculolar protein sorting (putative) YDL217C TIM22 0.51 1.2 Mitochondrial inner membrane protein involved in import of proteins of the ADP/ATP carrier (AAC) family YIL097W FYV10 0.51 2.0 Function required for Yeast Viability on toxin exposure YNR031C SSK2 0.51 1.4 Suppressor of Sensor Kinase (SLN1) YNL180C RHO5 0.51 1.5 Rho family of small GTPases YHR067W RMD12 0.51 1.8 S Required for Meiotic nuclear Division YDR488C PAC11 0.51 3.0 S C Protein required in the absence of Cin8p YEL047C 0.51 3.6 S YHR132C ECM14 0.51 1.0 ExtraCellular Mutant YDR166C SEC5 0.51 1.2 107 kDa component of the Exocyst complex; required for exocytosis. YER030W 0.51 1.4 YPL240C HSP82 0.51 2.5 82 kDa heat shock protein; homolog of mammalian Hsp90 YOL025W LAG2 0.51 1.1 affects longevity YNL329C PEX6 0.51 1.4 Required for peroxisome assembly YGL060W 0.51 2.5 S YBL034C STU1 0.51 1.6 Suppressor of cold-sensitive tub2 mutation; shown to be a component of the mitotic spindle YHR146W CRP1 0.51 2.9 S Cruciform DNA Binding Protein 1 YDR036C 0.51 0.9 YER067W 0.51 1.5 YDR100W 0.51 0.8 YDR242W AMD2 0.51 1.4 putative amidase YML019W OST6 0.51 1.7 Putative new 37kDa subunit of N-oligosaccharyltransferase complex YNL036W NCE103 0.51 2.7 endogenous substrate for nonclassical export (Cleves et al. J Cell Biol 1996 133:1017-26). YJL048C 0.51 1.2 YOL141W PPM2 0.51 1.4 carboxy methyl transferase; homolog of PPM1 YMR200W ROT1 0.51 1.4 Reversal of tor2 lethality YLL043W FPS1 0.51 1.3 Suppressor of tps1/fdp1 and member of the MIP family of transmembrane channels; may be involved in glycerol efflux YML032C RAD52 0.51 0.8 "Required for X-ray damage repair & various types of intra- and interchr. mitotic recombination, including HO switching & plasmid exchange. Disp. for premeiotic DNA synthesis, double strand breaks & heteroduplex formation." YER056C-A RPL34A 0.51 2.3 Homology to rat L34 YIL176C 0.51 1.6 YJL223C PAU1 0.51 1.3 member of the seripauperin protein/gene family (see Gene_class PAU) YMR173W DDR48 0.51 1.5 DNA damage inducible; implicated in the production or recovery of mutations YIL063C YRB2 0.51 1.5 Ran-GTPase-binding protein involved in nuclear export YLL052C AQY2 0.51 1.0 aquaporin water channel in yeast YOR080W DIA2 0.51 1.2 Digs Into Agar YKR015C 0.51 1.1 YNL099C OCA1 0.51 1.9 Oxidant-induced Cell-cycle Arrest 1 YOR119C RIO1 0.51 1.9 Essential in yeast; plays a role in cell cycle progression. YKL104C GFA1 0.51 3.1 Z S catalyzes first step in hexosamine pathway required for biosynthesis of cell wall precursors YPL190C NAB3 0.51 0.9 May be required for packaging pre-mRNAs into ribonucleoprotein structures amenable to efficient nuclear RNA processing YBR177C EHT1 0.51 1.8 alcohol acyl transferase YOL109W 0.51 2.1 YIR012W SQT1 0.51 1.1 Involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p YKL212W SAC1 0.51 0.8 "Inactivation of Sac1p leads to specific increase in cellular levels of phosphatidylinositol 4-phosphate, accompanied by changes in vacuole morphology and accumulation of lipid droplets." YBR247C ENP1 0.51 0.9 Essential nuclear protein YGL229C SAP4 0.51 1.3 "SAP4 is related to SAP155, SAP185, and SAP190, all of which associate with the SIT4 protein phosphatase" YGL223C COG1 0.51 0.8 Conserved Oligomeric Golgi complex 1
Complexed with Cog8p; interacts with Cog2p YJL109C UTP10 0.51 1.8 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YDR167W TAF10 0.51 1.4 TFIID subunit (TBP-associated factor) with predicted molecular weight of 23 kD. YOR377W ATF1 0.51 2.3 Alcohol acetyltransferase YMR311C GLC8 0.51 1.7 Homolog of mammalian protein phosphatase inhibitor 2. YDL020C RPN4 0.51 1.1 Involved in ubiquitin degradation pathway. May act as common transcription factor on proteasomal and proteasome-related genes. YPL018W CTF19 0.51 1.1 Chromosome Transmission Fidelity YJL198W PHO90 0.51 1.7 Low-affinity phosphate transporter YLR105C SEN2 0.51 1.0 tRNA splicing endonuclease subunit YNL265C IST1 0.51 1.3 Similar to Nuf1p (spindle pole body component) YHR075C PPE1 0.51 2.3 carboxyl methyl esterase YOR186W 0.50 1.4 YJR130C STR2 0.50 1.5 Sulfur TRansfer YPL106C SSE1 0.50 1.2 "HSP70 family member, highly homologous to Ssa1p and Sse2p" YEL049W PAU2 0.50 1.5 member of the seripauperin protein/gene family (see Gene_class PAU) YCR035C RRP43 0.50 1.5 C Ribosomal RNA Processing YHR078W 0.50 0.8 YBR137W 0.50 1.5 YMR110C 0.50 1.8 YGL120C PRP43 0.50 1.6 Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA YOR384W FRE5 0.50 1.7 similar to FRE2 YGR087C PDC6 0.50 2.7 "Third, minor isozyme of pyruvate decarboxylase" YKL107W 0.50 1.6 YHR123W EPT1 0.50 2.5 S "sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase" YCR106W RDS1 0.50 1.7 Regulator of drug sensitivity YOL144W NOP8 0.50 1.3 Nucleolar protein required for 60S ribosome biogenesis YKL018W SWD2 0.50 1.0 member of Set1p complex YGR294W 0.50 1.0 YOL073C 0.50 1.6 YPL024W NCE4 0.50 1.3 Negative regulator of Cts1 Expression YGR286C BIO2 0.50 3.0 Biotin synthase YPR125W 0.50 1.3 YNL009W IDP3 0.50 1.2 peroxisomal NADP-dependent isocitrate dehydrogenase YPL152W RRD2 0.50 1.8 Resistant to Rapamycin Deletion 2 YDR533C 0.50 1.5 YDR044W HEM13 0.50 2.6 "Oxygen-repressed, sixth step in heme biosynthetic pathway" YIL110W 0.50 1.2 YMR239C RNT1 0.50 1.3 Ribonuclease III YML130C ERO1 0.50 1.5 "essential, FAD-dependent oxidase of protein disulfide isomerase" YBR125C PTC4 0.50 1.8 Phosphatase type Two C YJR032W CPR7 0.50 1.3 a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product YBR301W DAN3 0.50 1.6 delayed anaerobic gene YBR155W CNS1 0.50 1.9 cyclophilin seven suppressor YKL195W 0.50 1.3 YOR259C RPT4 0.50 1.0 Proteasome Cap Subunit YKR083C DAD2 0.50 1.1 C Duo1 And Dam1 interacting; Helper of AsK1 YEL048C 0.50 0.9 YNL115C 0.50 1.8 YGL258W VEL1 0.50 2.1 Increased in velum formation in flor strain YLL031C GPI13 0.50 2.2 Glycosylphosphatidylinositol (GPI) biosynthesis YMR046C 0.50 0.9 YGR062C COX18 0.50 1.9 "Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space" YKL159C RCN1 0.50 1.1 Regulator of calcineurin YFR028C CDC14 0.50 2.1 K Required for mitosis and sporulation YEL058W PCM1 0.50 1.8 Z Phosphoacetylglucosamine Mutase YBR268W MRPL37 0.50 1.2 C Probable mitochondrial protein L37 YIL151C 0.50 0.9 YGR141W VPS62 0.50 0.9 YER063W THO1 0.50 1.7 Suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O) YGR215W RSM27 0.50 0.9 mitochondrial ribosome small subunit component YDR339C 0.50 0.9 YPL231W FAS2 0.50 1.2 Trifunctional enzyme YEL034W HYP2 0.50 1.7 Translation initiation factor eIF-5A YIL138C TPM2 0.50 2.1 S Tropomyosin isoform 2 YDR190C RVB1 0.50 1.5 S "RUVB-like protein, TIP49a Homologue" YOL124C 0.50 1.5 YFL010C WWM1 0.50 1.2 WW domain containing protein interacting with Metacaspase (MCA1) YLR141W RRN5 0.50 1.6 involved in transcription of rDNA by RNA polymerase I. UAF interacts directly with an upstream element of the promoter and mediates its stimulatory function. YPL077C 0.50 0.8 YJR141W 0.50 1.1 YDR101C ARX1 0.50 1.4 YJR158W HXT16 0.50 1.2 hexose transporter YKL181W PRS1 0.50 0.9 ribose-phosphate pyrophosphokinase YML004C GLO1 0.50 1.0 Regulated by HOG (high osmolarity glycerol)-MAP (mitogen-activated protein) kinase pathway in osmotic stress response YMR195W ICY1 0.50 1.7 Interacting with the cytoskeleton
Involved in chromatin organization and nuclear transport
Genetically interacts with TCP1 and ICY2 YLR445W 0.50 1.8 YPL224C MMT2 0.50 1.2 Protein involved in mitochondrial iron accumulation YFR006W 0.50 1.2 YDR276C PMP3 0.50 2.3 S plasma membrane protein involved in salt tolerance YPR116W 0.50 1.5 YLR273C PIG1 0.50 5.1 Z S C Putative type 1 phosphatase regulatory subunit; interacts with Gsy2p YHR171W APG7 0.50 1.4 autophagy YOR362C PRE10 0.49 1.6 proteasome component YC1 (protease yscE subunit 1) YGL173C KEM1 0.49 0.8 Kar1-1 nuclear-fusion-defect Enhancing Mutation. Plays a role in cytoplasmic mRNA degradation. YHL013C 0.49 1.5 YKL183W LOT5 0.49 2.4 S LOw Temperature responsive YOR327C SNC2 0.49 1.3 mediate the targeting and transport of secretory proteins YOR076C SKI7 0.49 1.2 Antiviral protein. Ski7p G protein appears to function as a signal-coupling factor between the two multi-complexes operating in the 3'-to-5' mRNA-decay pathway. YPR162C ORC4 0.49 1.6 Part of complex that binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YOR027W STI1 0.49 1.9 Heat shock protein also induced by canavanine and entry into stationary phase YGR143W SKN1 0.49 5.6 S C Involved in (1->6)-beta-glucan biosynthesis YPL064C CWC27 0.49 1.3 Complexed with Cef1p YEL044W IES6 0.49 1.3 Ino Eighty Subunit 6 YJL204C RCY1 0.49 1.0 ReCYcling 1 YAR028W 0.49 1.7 YGR001C 0.49 1.5 YOL152W FRE7 0.49 0.9 similar to FRE2 YLR106C MDN1 0.49 0.8 "midasin, a large protein with an N-terminal domain, a central AAA domain (with similarity to dynein) composed of 6 tandem AAA protomers, and a C-terminal M-domain containing MIDAS (Metal Ion Dependent Adhesion Site) sequence motifs" YBR231C AOR1 0.49 1.8 C Actin Overexpression Resistant YIL118W RHO3 0.49 2.1 ras homolog--GTP binding protein YPL130W SPO19 0.49 2.1 sporulation-defective; SPO19 was found as a weak high-copy suppressor of the spo1-1 ts mutation. The gene is specifically induced late in meiosis (Primig et al. (2000) Nat Genet 26:415-423) YER171W RAD3 0.49 0.9 DNA helicase component of transcription factor b (yeast homolog of human TFIIH) YGL257C MNT2 0.49 2.1 MaNnosylTransferase; involved in adding the 4th and 5th mannose residues of O-linked glycans YPR088C SRP54 0.49 0.8 Signal recognition particle subunit (homolog of mammalian SRP54) YOL133W HRT1 0.49 1.3 High level expression Reduces Ty3 Transposition YJL132W 0.49 1.4 YGR266W 0.49 1.3 YIL071C PCI8 0.49 2.2 Proteasome-COP9 signalosome-eukarytotic Initiation factor 3 (PCI) domain-containing protein YJR097W 0.49 1.1 YGR233C PHO81 0.49 1.0 Positive regulatory protein of phosphate pathway YJL172W CPS1 0.49 2.1 carboxypeptidase yscS YMR251W 0.49 1.9 YOR155C 0.49 1.8 YIL073C SPO22 0.49 1.6 "sporulation-defective; SPO22 contains phospholipase A2 signature sequence (positions 135-143, found by Emotif search). The gene is specifically induced early in meiosis (Primig et al. (2000) Nat Genet 26:415-423)" YGL131C SNT2 0.49 1.6 Hypothetical ORF YAR044W OSH1 0.49 1.2 May be involved in ergosterol synthesis YMR237W 0.49 1.0 YMR306W FKS3 0.49 1.2 Protein with similarity to Gls1p and Gls2p (GB:Z49212) YBR179C FZO1 0.49 1.0 may be involved in mitochondrial fusion YCL040W GLK1 0.49 3.7 S C Glucose phosphorylation YER003C PMI40 0.49 4.7 Z S C catalyzes the interconversion of fructose-6-P and mannose-6-P YOR386W PHR1 0.49 1.9 photolyase YKR088C 0.49 1.4 YER049W 0.49 0.8 YJR109C CPA2 0.49 2.0 carbamyl phosphate synthetase YMR250W GAD1 0.49 3.9 glutamate decarboxylase YEL013W VAC8 0.49 0.9 An armadillo repeat-containing protein localized on the vacuolar membrane YHR186C KOG1 0.49 0.8 Kontroller Of Growth YIL045W PIG2 0.49 1.5 Interacts with Gsy2p YKL085W MDH1 0.49 1.0 mitochondrial malate dehydrogenase YDL139C SCM3 0.49 1.0 Suppressor of chromosome missegregation YGR200C ELP2 0.49 1.2 ELongator Protein 2; 90kD subunit; has WD40 repeats YLR432W IMD3 0.49 1.3 IMP dehydrogenase homolog YFL011W HXT10 0.49 3.1 S high-affinity hexose transporter YDR257C RMS1 0.49 1.7 Transcription regulator YLR390W ECM19 0.49 1.2 ExtraCellular Mutant YOL127W RPL25 0.49 1.7 Homology to E. coli L23 and rat L23a YJL087C TRL1 0.49 1.2 tRNA ligase YPL006W NCR1 0.49 0.9 Niemann-Pick Type C homologous gene YDR197W CBS2 0.49 2.3 Translational activator of COB mRNA; soluble protein YBR049C REB1 0.49 3.3 Z DNA binding protein which binds sites found in genes transcribed by both RNA polymerase I and RNA polymerase II. Reb1p is required for termination of RNA polymerase I transcription. YDL115C IWR1 0.49 0.9 Interacts with RNA Polymearse II YPL095C 0.49 2.5 Z S YOR179C 0.49 1.3 YKL091C 0.49 2.4 YKL191W DPH2 0.49 1.6 "Diptheria toxin resistance protein, required for diphthamide biosynthesis" YPL086C ELP3 0.49 1.2 elongator protein; histone and other protein acetyltransferase; has sequence homology to known HATs and NATs YMR191W 0.49 1.7 YIL030C SSM4 0.49 1.8 Protein involved in mRNA turnover YKL154W SRP102 0.49 1.1 Signal recognition particle receptor beta subunit YNL316C PHA2 0.49 0.9 prephenate dehydratase YML103C NUP188 0.49 1.6 Localized at both the cytoplasmic and nucleoplasmic faces of the nuclear pore complex (NPC); may form the octagonal core structure of NPC YCL031C RRP7 0.49 1.5 involved in rRNA processing YPL229W 0.49 0.9 YJR121W ATP2 0.49 1.3 "F(1)F(0)-ATPase complex beta subunit, mitochondrial" YBR234C ARC40 0.49 1.6 "Arp2/3 complex subunit, 40 kilodalton" YPL004C 0.49 2.5 C YOR280C FSH3 0.49 1.2 YBL049W 0.49 1.8 YDR402C DIT2 0.49 1.5 Disp. for spores & spore viab. - required for dityrosine biosynth. & dityrosine accumul. in outer spore wall (s.w.); s.w. matur. & resist. to ether & lytic enz. mRNA trans. mid/late during s.w. formation YGR134W CAF130 0.49 0.9 CCR4 Associated Factor 130 kDa YHR160C PEX18 0.49 2.0 Peroxin; Pex18p and Pex21p are partially functionally redundant. YLR125W 0.49 1.3 YKL001C MET14 0.49 4.0 S adenylylsulfate kinase YNL258C DSL1 0.49 1.5 "dsl1 mutations are suppressed by a dominant allele of SLY1, called sly1-20" YPR186C PZF1 0.49 1.0 Transcription factor IIIA (TFIIIA) with putative Zn-fingers YCR037C PHO87 0.49 2.7 May collaborate with Pho86p and Pho84p in inorganic phosphate uptake; protein contains 12 predicted transmembrane domains YDR496C PUF6 0.49 1.0 member of the PUF protein family YBL042C FUI1 0.49 1.1 uridine permease YDL093W PMT5 0.49 3.1 Z S C Transfers mannose residues from dolichyl phosphate-D-mannose to specific serine/threonine residues of proteins in the secretory pathway YKL009W MRT4 0.49 1.5 mRna turnover 4 YGR052W 0.49 1.9 YLR108C 0.49 1.7 YLR401C 0.49 1.1 YKR090W PXL1 0.49 2.6 S Paxillin-like protein 1 YBR235W 0.49 1.1 YJR149W 0.49 2.2 YGL016W KAP122 0.49 1.1 Member of the karyopherin-beta family with possible role in nuclear transport and regulation of pleiotropic drug resistance. YGR099W TEL2 0.49 3.5 Z S Involved in controlling telomere length YGR204W ADE3 0.49 0.9 "Required for the biosynthesis of purines, thymidylate, methionine, histidine, pantothenic acid and formylmethionyl-tRNA" YCR098C GIT1 0.49 2.4 permease involved in the uptake of glycerophosphoinositol (GroPIns) YHL025W SNF6 0.49 1.4 Involved in global regulation of transcription YOR144C ELG1 0.48 3.0 Z S C "Enhanced Level of Genomic instability, Repressor of Ty1 Transposition" YER157W COG3 0.48 1.6 Conserved Oligomeric Golgi complex 3
secretion (golgi retention) deficient YJR040W GEF1 0.48 1.0 "Integral membrane protein highly homologous to voltage-gated chloride channels from humans, mice and fish" YGL242C 0.48 1.7 YOR123C LEO1 0.48 1.1 member of the RNA polymerase II-associated Paf1 complex YFR020W 0.48 1.5 YPL239W YAR1 0.48 1.2 YAR1 encodes a 200-amino-acid protein with two ANK repeat motifs and an acidic C terminus rich in PEST-like sequences YDR376W ARH1 0.48 1.3 adrenodoxin oxidoreductase homolog YMR062C ECM40 0.48 1.3 ExtraCellular Mutant YDL230W PTP1 0.48 1.7 phosphotyrosine-specific protein phosphatase YDR329C PEX3 0.48 1.1 48-kDa peroxisomal integral membrane protein YDR045C RPC11 0.48 0.9 TFIIS-like small Pol III subunit C11 YBR002C RER2 0.48 1.4 cis-prenyltransferase involved in dolichol synthesis YCR068W CVT17 0.48 1.4 Cytoplasm to vacuole targeting mutant YNL259C ATX1 0.48 1.8 "antioxidant protein and metal homeostasis factor, protects against oxygen toxicity" YBR241C 0.48 2.0 YLL064C 0.48 1.5 YNR076W PAU6 0.48 1.6 member of the seripauperin protein/gene family YDR289C RTT103 0.48 1.9 Regulator of Ty1 Transposition YLR233C EST1 0.48 2.1 S C Telomere elongation protein (ever shorter telomeres) YML126C ERG13 0.48 1.5 involved in mevalonate synthesis YPR035W GLN1 0.48 2.2 glutamine synthetase YOR356W 0.48 1.1 YPL170W 0.48 1.7 YOR299W BUD7 0.48 0.8 bud site selection YGR088W CTT1 0.48 0.8 cytoplasmic catalase T YDR205W MSC2 0.48 1.4 Meiotic Sister-Chromatid recombination; transmembrane protein (putative) showing some protein similarity to Zrc1p and Cot1p YJR047C ANB1 0.48 2.4 hypusine containg protein; ANB1 is expressed under anaerobic conditions and repressed under aerobic conditions whereas its homolog HYP2 is inversely regulated YLL055W 0.48 1.4 YOL101C 0.48 4.9 S YGL031C RPL24A 0.48 1.7 Homology to rat L24 YFR030W MET10 0.48 2.3 S subunit of assimilatory sulfite reductase YIR009W MSL1 0.48 1.3 involved in splicing YAL054C ACS1 0.48 1.4 one of 2 acetyl-coA synthetases in yeast YDL106C PHO2 0.48 0.8 Regulation of phosphate metabolism YLR437C 0.48 3.4 Z S YJR161C COS5 0.48 1.2 "Protein with similarity to members of the Ybr302p/Ycr007p/Cos8p/Cos9p family, coded from subtelomeric region" YKR100C 0.48 0.9 YFL003C MSH4 0.48 1.6 "dispensable for DNA repair, required for full levels of reciprocal exchange and spore viability" YMR017W SPO20 0.48 1.8 DBF2 Interacting Protein; SNAP 25 homolog YAL014C SYN8 0.48 1.4 "SNARE protein releated to mammalian SYNtaxin 8, ULP1 Interacting Protein 2" YMR162C DNF3 0.48 1.3 Drs2 Neo1 Family YOR075W UFE1 0.48 2.0 S t-SNARE that resides on the endoplasmic reticulum and mediates retrograde traffic from the Golgi complex YDL132W CDC53 0.48 1.4 "acts together with Cdc4p and Cdc34p to control the G1-S phase transition, assists in mediating the proteolysis of the Cdk inhibitor Sic1p in late G1" YNL273W TOF1 0.48 3.6 Z S C topoisomerase I interacting factor 1 YOL024W 0.48 1.5 YHR001W OSH7 0.48 0.9 Oxysterol Binding Protein YHL022C SPO11 0.48 1.7 "Dispensable for mitosis, premeiotic DNA synthesis, spindle pole body duplication, meiosis I, meiosis II & spores. Required for chromosome pairing seen by in situ hybridization, double strand breaks, synaptonemal complexes." YDR303C RSC3 0.48 1.7 Zinc cluster protein YMR033W ARP9 0.48 1.5 involved in transcriptional regulation YHR045W 0.48 0.9 YLR283W 0.48 0.9 YDL223C HBT1 0.48 0.9 Hub1 target YJR003C 0.48 2.5 S YDL109C 0.48 0.8 YOR189W IES4 0.48 1.1 Ino Eighty Subunit 4 YNL297C MON2 0.48 1.0 protein with similarity to N-terminal region of the human protein BIG1 YGR229C SMI1 0.48 0.9 "Protein involved in (1,3)-beta-glucan synthesis, possibly through regulation of cell wall glucan and chitin synthesis; chromatin binding protein" YOL088C MPD2 0.48 1.8 S protein disulfide isomerase related protein YPL247C 0.48 2.7 YCR072C 0.48 1.1 YPR168W NUT2 0.48 1.9 Negative regulator of URS2 of the HO promoter YOL114C 0.48 2.4 S YDR380W ARO10 0.48 1.7 S YPL013C 0.48 1.0 YLR341W SPO77 0.48 1.4 Sporulation YOL129W VPS68 0.48 1.4 YPR195C 0.48 0.8 YNR063W 0.48 1.1 YDR058C TGL2 0.48 1.5 Triglyceride Lipase YPL015C HST2 0.48 2.0 Homolog of SIR2 YDR041W RSM10 0.48 1.2 mitochondrial ribosome small subunit component YLR024C UBR2 0.48 1.4 ubiquitin-protein ligase (E3) YBR005W 0.48 1.8 YLR433C CNA1 0.48 1.0 calmodulin binding protein homologous to mammalian calcineurin YGL202W ARO8 0.48 0.8 aromatic amino acid aminotransferase YAR027W UIP3 0.48 1.2 Ulp1 Interacting Protein 3 YLR015W BRE2 0.48 1.0 C "putative transcription factor, contains a PHD finger motif; homology to D. melanogaster Ash2p trithorax transcription factor
member of Set1p complex" YAR042W SWH1 0.48 1.9 Similar to mammalian oxysterol-binding protein YLR359W ADE13 0.48 1.3 Adenylosuccinate Lyase YJL082W IML2 0.48 1.3 Similar to Ykr018p YOR360C PDE2 0.48 1.9 low-Km (high-affinity) cAMP phosphodiesterase YPR140W 0.48 2.0 YOR304W ISW2 0.48 1.2 has strong homology to Drosophila ISWI YDL243C AAD4 0.48 1.2 high degree of similarity with the AAD of P. chrysosporium YGR173W 0.48 1.4 YBL037W APL3 0.48 3.8 clathrin Associated Protein complex Large subunit YDR111C 0.48 1.4 YFR017C 0.48 2.8 C YER122C GLO3 0.48 2.0 Zinc-finger-containing protein with similarity to Gcs1p and Sps18p YAL068C 0.48 1.4 YFR055W 0.48 2.0 YMR029C 0.48 1.7 YDR394W RPT3 0.48 1.3 probable 26S protease subunit and member of the CDC48/PAS1/SEC18 family of ATPases YKL173W SNU114 0.48 1.1 involved in splicing YLR373C VID22 0.47 3.1 Z S Vacuole import and degradation YAR075W 0.47 1.2 YLR321C SFH1 0.47 1.2 "Involved in chromatin modeling, cell cycle progression" YLR429W CRN1 0.47 0.8 "coronin, an actin-binding protein originally identified in Dictyostelium" YGR120C COG2 0.47 1.9 Conserved Oligomeric Golgi complex 2
Secretion deficient YIR021W MRS1 0.47 1.9 RNA splicing protein of the mitochondrial carrier (MCF) family YJL029C VPS53 0.47 1.4 Required for Vacuolar Protein Sorting YPR016C TIF6 0.47 1.4 "similar to human translation initiation factor 6 (eIF6); however, TIF6 does not act as a true translation initiation factor.The protein may be involved in the biogenesis and or stability of the 60S ribosomal subunits" YMR243C ZRC1 0.47 1.7 Zinc- and cadmium-resistance protein YDR516C EMI2 0.47 2.3 Early Meiotic Induction YDR532C KRE28 0.47 1.3 Killer toxin REsistant YDL245C HXT15 0.47 1.2 High-affinity hexose transporter YDR162C NBP2 0.47 0.9 "interacts with Nap1, which is involved in histone assembly" YJL125C GCD14 0.47 1.9 General Control Derepression YHR163W SOL3 0.47 1.4 weak multicopy suppressor of los1-1 YML080W DUS1 0.47 0.8 tRNA dihydrouridine synthase YLR116W MSL5 0.47 1.4 branchpoint bridging protein -- component of the splicing commitment complex YHL009C YAP3 0.47 1.1 bZIP protein; transcription factor YOR128C ADE2 0.47 1.5 phosphoribosylamino-imidazole-carboxylase YLR137W 0.47 1.5 YBL051C PIN4 0.47 3.4 [PSI+] induction YGL025C PGD1 0.47 0.8 "Probable transcription factor, polyglutamine domain protein" YML074C FPR3 0.47 1.2 "binds the immunosuppressant drugs, FK506 and rapamycin, and is localized to the nucleolus; binds to nuclear localization signal-containing peptides in vitro" YKR079C 0.47 1.6 S YJL133W MRS3 0.47 1.0 mitochondrial carrier protein YBL091C MAP2 0.47 0.8 methionine aminopeptidase 2 YOR032C HMS1 0.47 1.3 High-copy mep2 suppressor YBR192W RIM2 0.47 1.4 Protein of the mitochondrial carrier (MCF) family that is required for respiration YNL021W HDA1 0.47 1.7 component of histone deacetylase A YKR002W PAP1 0.47 1.0 poly(A) polymerase YGL253W HXK2 0.47 1.5 Glucose phosphorylation YIL034C CAP2 0.47 0.8 capping - addition of actin subunits YER139C 0.47 2.6 YDR158W HOM2 0.47 1.6 threonine and methionine pathway YOR063W RPL3 0.47 1.6 Homology to rat L3 YKL089W MIF2 0.47 2.7 S centromere protein required for normal chromosome segregation and spindle integrity YGL114W 0.47 1.9 YNL207W RIO2 0.47 1.0 Protein required for cell viability YML070W DAK1 0.47 1.6 putative dihydroxyacetone kinase YKL148C SDH1 0.47 1.7 "Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone." YDR198C 0.47 1.3 YDL146W 0.47 1.4 YKL210W UBA1 0.47 1.0 similar to Uba2p YDR300C PRO1 0.47 1.2 catalyzes first step in proline biosynthesis YLR004C 0.47 1.7 YKR065C 0.47 0.9 YCL058C FYV5 0.47 1.2 Function required for Yeast Viability on toxin exposure YLR399C BDF1 0.47 1.5 "Required for sporulation, possible component of chromatin; affects synthesis of snRNA" YPR014C 0.47 2.6 S YBR289W SNF5 0.47 1.2 Involved in global regulation of transcription YEL011W GLC3 0.47 2.2 Glycogen branching enzyme YPL116W HOS3 0.47 4.5 Z S C "Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos1p" YBR050C REG2 0.47 1.3 Possible regulatory subunit for the PP1 family protein phosphatase Glc7p YBR238C 0.47 2.4 YLR129W DIP2 0.47 1.5 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); DOM34 Interacting Protein YPL176C 0.47 1.1 YJL196C ELO1 0.47 3.0 S C "elongation enzyme 1, required for the elongation of the saturated fatty acid tetradecanoic acid (14:0) to that of hexadecanoic acid (16:0)" YGL110C CUE3 0.47 0.8 Hypothetical ORF YNL104C LEU4 0.47 0.9 leucine biosynthesis YGL190C CDC55 0.47 1.1 Involved in cellular morphogenesis YER120W SCS2 0.47 2.0 "Suppressor of Choline Synthesis
Likely to be involved in regulating INO1 expression, suppressor of a dominant nuclear mutation that is inositol-dependent in the presence of choline" YGL036W 0.47 1.6 YOL095C HMI1 0.47 1.3 Helicase in MItochondria YGR236C SPG1 0.47 2.1 Hypothetical ORF YDL134C PPH21 0.47 1.1 serine-threonine protein phosphatase 2A YPL265W DIP5 0.47 2.9 S dicarboxylic amino acid permease YNL325C FIG4 0.47 0.9 FIG4 expression is induced by mating factor. YMR304W UBP15 0.47 0.8 putative deubiquitinating enzyme YDL186W 0.47 1.3 YFL053W DAK2 0.47 2.3 dihydroxyacetone kinase YMR167W MLH1 0.47 1.0 "Required for mismatch repair in mitosis and meiosis, low levels of postmeiotic segregation, and high spore viability" YDR151C CTH1 0.47 1.2 RNA triphosphatase/NTPase YEL019C MMS21 0.47 1.2 Protein involved in DNA repair YJL100W LSB6 0.47 0.9 LAs17 Binding protein YPR161C SGV1 0.47 0.9 CDC28/cdc2 related protein kinase YKL178C STE3 0.47 3.7 S The a factor receptor encoded by the STE3 gene allows yeast cells of the Alpha mating type to recognize cells of the a mating type YLR351C NIT3 0.47 1.7 "Nit protein, nitrilase superfamily member" YGR116W SPT6 0.47 1.1 may be involved in transcription elongation by mediating interactions between RNA polymerase II and chromatin YLR314C CDC3 0.47 1.7 involved in proper bud growth YGR061C ADE6 0.47 1.1 5'-phosphoribosylformyl glycinamidine synthetase YBL046W 0.47 1.0 YIL032C 0.47 1.9 YBR188C NTC20 0.47 0.8 Prp19p (NineTeen)-associated Complex protein YMR094W CTF13 0.47 2.0 "58 kd component (Cbf3c) of the multisubunit 'Cbf3' kinetochore protein complex, which binds to the CDE III element of centromeres" YPL209C IPL1 0.47 3.0 S C Regulation of yeast chromosome segregation YBR066C NRG2 0.47 2.1 homologue of NRG1 YCR016W 0.47 1.1 YDR080W VPS41 0.47 1.7 vacuolar protein sorting YGL087C MMS2 0.47 0.8 Member of error-free postreplication DNA repair pathway YNL006W LST8 0.47 0.8 Required for amino acid permease transport from the Golgi to the cell surface YOR085W OST3 0.47 1.8 Catalyzes the transfer of oligosaccharide from dolichol-oligosaccharide donor to consensus glycosylation acceptor sites (asparagines) in newly synth. proteins - ER lumen; may enhance oligosacch. transfer to subset of acceptor substrates YOR313C SPS4 0.46 3.9 S sporulation-specific protein YNL222W SSU72 0.46 0.9 "functionally related to TFIIB, affects start site selection in vivo" YGR174C CBP4 0.46 1.2 Essential for the expression and activity of ubiquinol-cytochrome c reductase YDR459C 0.46 1.9 YBR152W SPP381 0.46 2.7 Suppressor of Pre-mRNA Processing mutant YKR048C NAP1 0.46 0.8 nucleosome assembly protein I YGR096W TPC1 0.46 1.1 thiamine pyrophosphate carrier YLR266C PDR8 0.46 1.8 Pleiotropic Drug Resistance YDR018C 0.46 2.2 YJR016C ILV3 0.46 1.1 catalyzes third step in common pathway leading to biosynthesis of branched-chain amino acids YGR063C SPT4 0.46 0.8 "Zn-finger protein, transcriptional regulator" YAL064W 0.46 1.4 YBL039C URA7 0.46 1.9 Last step in pyrimidine biosynthesis pathway; URA7 is very similar to URA8 CTP synthase YCR051W 0.46 0.8 YFL063W 0.46 1.2 YGR281W YOR1 0.46 1.0 C multispecific organic anion transporter important for tolerance against toxic environmental organic anions YOR177C MPC54 0.46 2.5 Meiotic Plaque Component YKL140W TGL1 0.46 1.0 triglyceride lipase-cholesterol esterase YNL123W 0.46 1.6 YMR044W IOC4 0.46 1.0 Iswi One Complex YLL058W 0.46 2.1 YOL067C RTG1 0.46 1.8 "Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus" YIL029C 0.46 1.2 YMR065W KAR5 0.46 2.2 appears to be required for the completion of nuclear membrane fusion and may play a role in the organization of the membrane fusion complex YKR054C DYN1 0.46 2.1 Dynein YER045C ACA1 0.46 1.8 contains an ATF/CREB-like bZIP domain; transcriptional activator YJL089W SIP4 0.46 2.0 Possibly involved in Snf1p regulated transcriptional activation YLR114C 0.46 1.5 YMR113W FOL3 0.46 1.0 FOLinic acid requiring YGL130W CEG1 0.46 0.8 "mRNA guanylyltransferase (mRNA capping enzyme), alpha subunit" YDR107C 0.46 1.0 YKL010C UFD4 0.46 1.0 Ubiquitin Fusion Degradation YLL057C 0.46 1.2 YGR049W SCM4 0.46 1.2 Protein that suppresses ts allele of CDC4 when overexpressed YHR021W-A ECM12 0.46 2.7 ExtraCellular Mutant YJR090C GRR1 0.46 1.0 F box protein with several leucine rich repeats YOL104C NDJ1 0.46 1.8 Involved in meiotic chromosome segregation; may stabilize homologus DNA interactions at telomeres and is required for a telomere activity in distributive segregation; is associated with telomeres YPR073C LTP1 0.46 1.1 Homologous to mammalian phosphotyrosine phosphatase YMR205C PFK2 0.46 0.8 phosphofructokinase beta subunit YCL009C ILV6 0.46 1.2 acetolactate synthase regulatory subunit YDL126C CDC48 0.46 1.4 "Microsomal protein of CDC48/PAS1/SEC18 family of ATPases; full length homology to mammalian protein VCP; involved in secretion, peroxisome formation and gene expression" YPL278C 0.46 1.1 YDR024W FYV1 0.46 1.7 Function required for Yeast Viability on toxin exposure YMR186W HSC82 0.46 1.3 constitutively expressed heat shock protein YIL051C MMF1 0.46 1.7 Maintenance of Mitochondrial Function YHL032C GUT1 0.46 1.2 Glycerol utilization YIL155C GUT2 0.46 2.0 "glycerol-3-phosphate dehydrogenase, mitochondrial" YOR250C CLP1 0.46 2.0 S cleavage/polyadenylation factor IA subunit; interacts with Pcf11p in the 2-hybrid system YPR144C UTP19 0.46 0.9 "U3 protein, localized to the nucleolus" YBR163W DEM1 0.46 0.8 weak similarity to Pta1p (pre-tRNA processing protein) YER175C TMT1 0.46 1.4 Trans-aconitate Methyltransferase 1 YGL147C RPL9A 0.46 1.1 Homology to rat L9 YBL022C PIM1 0.46 1.0 mitochondrial ATP-dependent protease YNL091W NST1 0.46 0.9 Negative affector of Salt Tolerance YIL093C RSM25 0.46 1.0 mitochondrial ribosome small subunit component YLR213C CRR1 0.46 1.0 CRH-Related YFR039C 0.46 2.5 Z S YKL139W CTK1 0.46 1.0 putative kinase subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal domain); also called CTDK-I alpha subunit YDR411C 0.46 1.0 YOR051C 0.46 1.4 YLR134W PDC5 0.46 1.5 pyruvate decarboxylase YOR196C LIP5 0.46 0.9 Involved in lipoic acid metabolism YOR132W VPS17 0.46 2.8 Peripheral membrane protein required for vacuolar protein sorting YOR036W PEP12 0.46 2.2 integral membrane protein; c-terminal TMD; located in endosome YGL118C 0.46 1.4 YLR281C 0.46 1.3 C YGL019W CKB1 0.46 1.0 beta (38kDa) subunit of protein kinase CK2 YDR061W 0.46 1.3 YCR017C CWH43 0.46 1.2 YBR269C 0.46 1.3 YOR215C 0.46 1.9 YNL097C PHO23 0.46 1.4 Involved in expression of PHO5 YFL057C 0.46 1.3 YOR002W ALG6 0.46 1.0 Required for glucosylation in the N-linked glycosylation pathway YMR221C 0.46 0.9 YLR449W FPR4 0.46 1.5 "Homolog of homolog of the nucleolar FKBP, Fpr3" YOL014W 0.46 3.0 S C YPR021C 0.46 1.6 YHR042W NCP1 0.46 1.6 NADP-cytochrome P450 reductase YPL174C NIP100 0.46 1.6 Nuclear import protein YFR045W 0.46 1.1 YHR164C DNA2 0.45 0.8 DNA replication helicase YNL307C MCK1 0.45 1.7 "Disp. for mitosis, required for chr. segregation, benomyl resist., basal IME1 transcript. in mitosis, IME1 induction in meiosis & ascus mat. independ. of IME1; maybe in mitotic chr. segregation specific to CDEIII" YLR422W 0.45 1.3 YMR266W RSN1 0.45 1.5 overexpression Rescues sro7/sop1 in NaCl YER098W UBP9 0.45 1.6 similar to Ubp13p YLR446W 0.45 1.2 YDR448W ADA2 0.45 1.8 S "transcription factor, member of ADA and SAGA, two transcriptional adaptor/HAT (histone acetyltransferase)complexes" YKR053C YSR3 0.45 1.8 Yeast Sphingolipid Resistance Gene YNL133C FYV6 0.45 1.4 Function required for Yeast Viability on toxin exposure YHR033W 0.45 0.9 YIR018W YAP5 0.45 1.2 bZIP protein; transcription factor YKL125W RRN3 0.45 0.8 Required for transcription of rDNA by RNA Polymerase I YDR272W GLO2 0.45 2.0 Cytoplasmic glyoxylase-II YDR098C GRX3 0.45 1.6 "Member of a glutaredoxin subfamily in Sc together with GRX4 & GRX5. Sign. sequence diff. with the other glutaredoxin subfamily, formed by the previously described GRX1 & GRX2 glutaredoxins (Luikenhuis MBC 9:1081, 1998)" YOR110W TFC7 0.45 1.2 Transcription factor for RNA polymerase III YPR103W PRE2 0.45 1.9 responsible for the chymotryptic activity of the yeast 20S proteasome YPR152C 0.45 1.3 YJR148W BAT2 0.45 3.7 S C Branched-Chain Amino Acid Transaminase YPL236C 0.45 1.0 YJL108C PRM10 0.45 1.3 pheromone-regulated membrane protein YAL059W ECM1 0.45 1.4 putative transmembrane domain protein involved in cell wall biogenesis YCL043C PDI1 0.45 1.8 S Catalyzes the formation and isomerization of disulfide bonds during the folding of secretory proteins. YPL189W GUP2 0.45 1.1 Involved in active glycerol uptake YPL057C SUR1 0.45 4.3 S C Involved in maintenance of phospholipid levels YPR193C HPA2 0.45 1.8 Histone and other Protein Acetyltransferase; Has sequence homology to known HATs and NATs YDR353W TRR1 0.45 2.1 S Thioredoxin reductase YJL017W 0.45 2.5 YNL040W 0.45 0.8 YDR139C RUB1 0.45 1.0 Related to ubiquitin (53% identical). Homolog of mammalian ubiquitin-like protein NEDD8. Matures by proteolytic removal of C-terminal asparagine (ASN) residue. Requires the proteins ULA1 & UBA3 for activation YBR199W KTR4 0.45 1.0 "Putative alpha-1,2-mannosyltransferase" YNL308C KRI1 0.45 1.1 KRRI-Interacting protein 1 YDL036C 0.45 1.3 YGR060W ERG25 0.45 1.3 membrane-bound non-heme di-iron oxygenase involved in lipid metabolism. YMR152W YIM1 0.45 1.9 "Mitochondrial inner membrane protease, similar to E. coli leader peptidase" YPL104W MSD1 0.45 1.3 "Aspartyl-tRNA synthetase, mitochondrial" YKL098W 0.45 1.0 YDR035W ARO3 0.45 1.3 "DAHP synthase; a.k.a. phospho-2-dehydro-3-deoxyheptonate aldolase, phenylalanine-inhibited; phospho-2-keto-3-deoxyheptonate aldolase; 2-dehydro-3-deoxyphosphoheptonate aldolase; 3-deoxy-D-arabine-heptulosonate-7-phosphate synthase" YOR284W 0.45 2.8 C YLR299W ECM38 0.45 1.7 ExtraCellular Mutant; cik1 suppressor YLR020C 0.45 0.8 YJR005W APL1 0.45 1.7 "beta-adaptin, large subunit of the clathrin-associated protein complex" YHL030W ECM29 0.45 1.6 ExtraCellular Mutant YDR383C NKP1 0.45 1.8 C Non-essential kinetochore protein YER061C CEM1 0.45 1.3 homology with beta-keto-acyl synthases YNL304W YPT11 0.45 2.4 S C similar to Ypt1 and other Ras-like GTP-binding proteins YMR039C SUB1 0.45 1.5 Suppressor of TFIIB mutations YOR049C RSB1 0.45 2.6 S Resistance to Sphingoid long-chain Base. Putative transporter or flippase that translocates LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane. YOR305W 0.45 1.6 YDR202C RAV2 0.45 1.5 Regulator of (H+)-ATPase in Vacuolar membrane YLL011W SOF1 0.45 0.9 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); 56 kDa nucleolar snRNP protein that shows homology to beta subunits of G-proteins and the splicing factor Prp4 YPL091W GLR1 0.45 1.7 converts oxidized glutathine and NADPH into two glutathiones and NADP+ YPL173W MRPL40 0.45 1.4 Mitochondrial ribosomal protein MRPL40 (YmL40) YDR174W HMO1 0.45 0.9 High mobility group (HMG)-like protein YKL041W VPS24 0.45 1.0 involved in secretion YKL213C DOA1 0.45 1.3 Required for normal intracellular ubiquitin metabolism and for normal rates of proteolysis of ubiquitin-dependent proteolytic substrates in vivo YKL119C VPH2 0.45 1.2 "Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex." YDL215C GDH2 0.45 1.3 NAD-dependent glutamate dehydrogenase YNL102W POL1 0.45 5.1 K S C "Required for mitotic DNA synthesis, premeiotic DNA synthesis, recombination, and full sporulation" YGR047C TFC4 0.45 1.3 transcription factor tau (TFIIIC) subunit 131 YFL055W AGP3 0.45 1.2 The acronym may be misleading. AGP3 has not been shown to be a general amino acid permease with broad substrate specificity YAL003W EFB1 0.45 2.2 "Translation elongation factor EF-1beta, GDP/GTP exchange factor for Tef1p/Tef2p" YDR391C 0.45 1.9 YGL137W SEC27 0.45 1.2 Involved in endoplasmic-to-Golgi protein trafficking YLR060W FRS1 0.45 1.0 "Phenylalanyl-tRNA synthetase, alpha subunit, cytoplasmic" YLR216C CPR6 0.45 1.9 a cyclophilin related to the mammalian CyP-40; physically interacts with RPD3 gene product YNL079C TPM1 0.45 1.2 tropomyosin I YOR183W FYV12 0.45 2.1 Function required for Yeast Viability on toxin exposure YFR018C 0.45 1.1 YCL005W 0.45 1.8 YHR041C SRB2 0.45 1.1 RNA polymerase II holoenzyme/mediator subunit YLR200W YKE2 0.45 1.0 Yeast nuclear gene encoding a protein showing homology to mouse KE2 and containing a putative leucine-zipper motif YJR001W 0.45 3.3 S YML069W POB3 0.45 1.5 binds to catalytic subunit of DNA polymerase alpha (Pol1p) YHR023W MYO1 0.45 5.5 S C myosin class II YDL166C FAP7 0.45 0.8 Nuclear protein involved in oxidative stress response YGR017W 0.45 2.1 YDR485C VPS72 0.45 1.0 YDR214W AHA1 0.45 1.8 Activator of Heat Shock Protein 90 ATPase YPL216W 0.45 0.8 YOR038C HIR2 0.45 1.7 Involved in cell-cycle regulation of histone transcription YNL317W PFS2 0.45 1.3 Polyadenylation Factor I subunit 2 YJR063W RPA12 0.45 1.4 A12.2 subunit of RNA polymerase I YOR188W MSB1 0.45 3.4 S C Protein that may play a role in polarity establishment and bud formation YOL132W GAS4 0.45 4.0 S Hypothetical ORF YJR094C IME1 0.45 1.4 Transcriptional activator of meiotic gene expression. YKL058W TOA2 0.45 1.0 "Transcription factor IIA, small chain" YCR004C YCP4 0.45 1.4 Protein with similarity to S. pombe brefeldin A resistance protein obr1 and E. coli WrbA protein which stimulates binding of Trp repressor to DNA YPL222W 0.45 3.0 YIL126W STH1 0.45 1.9 C "helicase related protein, snf2 homolog" YPL126W NAN1 0.45 1.0 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Net1-Associated Nucleolar protein 1 YPL208W 0.45 4.1 Z S C YDR410C STE14 0.45 1.4 farnesyl cysteine-carboxyl methyltransferase YPR159W KRE6 0.45 2.3 K S cell wall beta-glucan assembly YPL098C 0.45 1.4 YBR196C PGI1 0.45 2.0 Phosphoglucoisomerase YML031W NDC1 0.45 1.2 "dispensable for mitotic spindle pole body duplication, but required for insertion of nascent spindle pole bodies into the nuclear envelope. ndc1 parental spindle pole bodies form monopolar spindles in mitosis. Required for meiosis II." YDL051W LHP1 0.45 1.0 Protein homologous to human La (SS-B) autoantigen YDR525W API2 0.45 1.9 APIcal 2 YNL173C MDG1 0.45 2.8 S C "multicopy suppressor of bem1 mutation, may be involved in G-protein mediated signal transduction; binds cruciform DNA" YDR246W TRS23 0.45 1.2 Trapp subunit of 23 kDa YLL032C 0.45 5.3 Z S YPR134W MSS18 0.45 1.4 Protein involved in splicing intron a15beta of COX1 YNR049C MSO1 0.45 0.8 "multicopy suppressor of sec1; small hydrophilic protein, enriched in microsomal membrane fraction, interacts with Sec1p" YOL064C MET22 0.45 2.0 Putative phosphatase gene involved in salt tolerance and methionine biogenesis; halotolerance YDR096W GIS1 0.45 1.3 putative zinc finger protein; repressor of PHR1 transcription YEL075C 0.45 4.8 Z S YDL169C UGX2 0.45 3.1 S Product of gene unknown YKL165C MCD4 0.45 3.7 Z S C Required for GPI anchor synthesis YLR368W MDM30 0.44 1.2 "F-box protein, loss of mitochondrial function.
Mitochondrial Distribution and Morphology" YLR084C RAX2 0.44 2.6 S Involved in the maintenance of bipolar pattern YER118C SHO1 0.44 3.5 Z S C Transmembrane osmosensor (structurally unrelated to SLN1) with four transmembrane segments & a cytoplasmic SH3-domain. The SH3-domain interacts with a proline-rich motif in the N-terminal region of Pbs2p (a MAP kinase kinase homolog) YMR297W PRC1 0.44 2.2 "dispensable for haploidization and sporulation, but required for full protein degradation during sporulation" YAL064C-A 0.44 1.1 YJL114W 0.44 2.5 YNL246W VPS75 0.44 0.9 YDR519W FPR2 0.44 0.9 binds the immunosuppressant drug FK506 YBR127C VMA2 0.44 0.9 "vacuolar H-ATPase regulatory subunit (subunit b), 60 kDa subunit of V1 sector" YMR124W 0.44 1.1 YML075C HMG1 0.44 1.5 Induces cell to assemble stacks of paired nuclear-associated membranes called karmellae. YAL067C SEO1 0.44 3.2 S Suppressor of Sulfoxyde Ethionine resistance YDL100C ARR4 0.44 1.3 provides low levels of resistance to arsenicals YFL037W TUB2 0.44 3.6 Z S beta subunit of tubulin monomer; involved in chromosome segregation and nuclear migration YDL111C RRP42 0.44 1.0 Ribosomal RNA Processing YDR143C SAN1 0.44 0.9 (putative) transcriptional regulator YLR272C YCS4 0.44 1.7 loss of cohesion YOL098C 0.44 1.2 YDL165W CDC36 0.44 1.1 Required for Start B in mitosis and for meiosis I spindle pole body separation YDR535C 0.44 2.3 YBR106W PHO88 0.44 1.2 May be a membrane protein involved in inorganic phosphate transport and regulation of Pho81p function YMR063W RIM9 0.44 1.2 Regulator of IME2 (RIM)
required for IME1 expression YIL075C RPN2 0.44 0.8 involved in tRNA processing and degradation of ubiquitinated proteins YER004W 0.44 2.1 YOR394W 0.44 2.1 YPL282C 0.44 0.9 YOR199W 0.44 1.4 YPR047W MSF1 0.44 2.2 alpha subunit of yeast mitochondrial phenylalanyl-tRNA synthetase YMR127C SAS2 0.44 1.5 "Protein involved in silencing HMR, homologous to acetyltransferases" YGL144C 0.44 1.9 YHR205W SCH9 0.44 2.1 S "protein kinase involved in growth control, may be redundant with cAMP pathway" YJR138W IML1 0.44 1.3 Product of gene unknown YKL047W 0.44 2.3 YOR003W YSP3 0.44 1.2 subtilisin-like protease III YNL318C HXT14 0.44 1.6 High-affinity hexose transporter YDR328C SKP1 0.44 1.6 Involved in kinetochore function and ubiquitin-mediated proteolysis YER178W PDA1 0.44 1.1 alpha subunit of pyruvate dehydrogenase (E1 alpha) YFL047W RGD2 0.44 1.0 specific GTPase activating protein (RhoGAP) YLR215C CDC123 0.44 0.8 Product of gene unknown YGR187C HGH1 0.44 1.3 HMG1/2 homolog YPR190C RPC82 0.44 1.1 82-kDa subunit of RNA polymerase III (C) YPL050C MNN9 0.44 1.2 Protein required for complex glycosylation YHR088W RPF1 0.44 1.1 protein that localizes to the nucleolus YKL199C YKT9 0.44 1.1 Protein of unknown function YMR220W ERG8 0.44 1.0 Involved in isoprene and ergosterol biosynthesis pathways YOL054W PSH1 0.44 1.4 Pob3/Spt16 Histone associated YNL113W RPC19 0.44 1.4 subunit common to RNA polymerases I (A) and III (C) YML104C MDM1 0.44 1.2 Required for nuclear and mitochondrial transmission to daughter buds. YKL196C YKT6 0.44 1.0 "Synaptobrevin (v-SNARE) homolog with similarity to Sec22p, Snc1p, and Snc2p, essential for endoplasmic reticulum-Golgi transport" YPR071W 0.44 1.9 YER115C SPR6 0.44 1.1 sporulation-specific protein YPL027W SMA1 0.44 2.3 Spore Membrane Assembly YLR455W 0.44 5.1 Z S C YHR134W WSS1 0.44 1.1 weak suppressor of smt3 YGL054C ERV14 0.44 1.1 ER-derived vesicles YNL249C MPA43 0.44 1.2 Overexpression leads to increased levels of the lyase PDC1 YBR006W UGA2 0.44 1.8 involved in utilization of GABA as a nitrogen source YGL115W SNF4 0.44 0.8 "involved in release from glucose repression, invertase expression, and sporulation" YJR060W CBF1 0.44 1.4 "centromere binding factor; binds in vivo to CDE I sites in centromeres (and some promoters), and induces DNA bending, required for mitotic segregation and normal growth rate" YPL186C UIP4 0.44 3.3 C Ulp1 Interacting Protein 4 YDL114W 0.44 2.6 YDL097C RPN6 0.44 1.5 "Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit S9/p44.5." YEL052W AFG1 0.44 1.1 ATPase family gene YMR146C TIF34 0.44 1.1 p39 subunit of translation initiation factor eIF3 YCL020W 0.44 0.9 YGL033W HOP2 0.44 2.8 HOmologous Pairing YER034W 0.44 1.6 YHR079C-A SAE3 0.44 1.1 Involved in meiotic recombination and chromosome metabolism YNL098C RAS2 0.44 0.8 "Ras proto-oncogene homolog. Ras2 is involved in growth on non-fermentable carbon sources, the starvation response, sporulation, pseudohyphal growth and aging." YPR026W ATH1 0.44 1.7 "Null mutant is viable; increased tolerance to dehydration, freezing, and toxic levels of ethanol
hydrolyzes trehalose" YDR450W RPS18A 0.44 2.0 Homology to rat S18 and E. coli S13 YDL212W SHR3 0.44 1.2 Protein required for appearance of amino acid permeases on the cell surface YOR275C RIM20 0.43 1.0 Regulator of IME2 YJR010W MET3 0.43 5.7 Z S one of three genes essential for the assimilatory reduction of sulfate to sulfide (with sulfite as an intermediate product) YOR380W RDR1 0.43 1.1 Repressor of drug resistance YEL056W HAT2 0.43 0.8 "subunit of histone acetyltransferase; may regulate activity of Hat1p, the catalytic subunit of histone acetyltransferase" YLR061W RPL22A 0.43 2.7 Homology to rat L22 YIL114C POR2 0.43 1.9 S Mitochondrial porin YPL089C RLM1 0.43 1.2 serum response factor-like protein that may function downstream of MPK1 (SLT2) MAP-kinase pathway YKL099C UTP11 0.43 1.7 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YGR276C RNH70 0.43 1.9 S "RNase H(70), a 70 kDa ribonuclease H" YEL051W VMA8 0.43 1.2 vacuolar ATPase V1 domain subunit D YPR184W GDB1 0.43 3.3 Glycogen debranching enzyme; the enzyme that debranches the glycogen having a glucanotranferase + 1-6amyloglucosidase activity YKL068W NUP100 0.43 1.1 C Participates in nucleocytoplasmic transport; member of GLFG-containing family of nucleoporins YNL163C RIA1 0.43 1.2 RIbosome Assembly; Elongation Factor Like YLR456W 0.43 1.3 YPL258C THI21 0.43 3.2 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YER104W RTT105 0.43 1.4 "same phenotype as RTT101, 102, 103, 104" YPL144W 0.43 1.9 YGR105W VMA21 0.43 1.1 "Protein involved in vacuolar H-ATPase assembly or function. Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex." YPL271W ATP15 0.43 1.7 nuclear gene for ATP synthase epsilon subunit YHR201C PPX1 0.43 1.0 Cytosolic exopolyphosphatase YOR059C 0.43 1.4 YDL144C 0.43 1.8 YPL246C 0.43 1.3 YMR211W DML1 0.43 1.0 Drosophila melanogaster Misato-like YEL018W EAF5 0.43 1.2 C Esa1p-Associated Factor-5 YIL026C IRR1 0.43 4.1 S C Irregular; involved in sister chromatid cohesion YOL016C CMK2 0.43 2.8 S Calmodulin-dependent protein kinase YGR267C FOL2 0.43 1.2 First enzyme in biosynthetic pathway for folic acid and tetrahydrobioptern YBL107C 0.43 1.8 YKL084W 0.43 1.6 YDL141W BPL1 0.43 1.7 Biotin:apoprotein ligase YGR040W KSS1 0.43 0.8 Recovery from alpha factor arrest YOR142W LSC1 0.43 1.3 "alpha subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cycle" YFL039C ACT1 0.43 1.8 "Involved in cell polarization, endocytosis and other cytoskeletal functions" YPL138C SPP1 0.43 1.2 likely involved in chromatin remodeling
member of Set1p complex YFR053C HXK1 0.43 3.0 Glucose phosphorylation YNL055C POR1 0.43 1.5 "Outer mitochondrial membrane porin (voltage-dependent anion channel, or VDAC)" YHR110W ERP5 0.43 5.7 Z S C Emp24p/Erv25p related protein 5 YBR254C TRS20 0.43 1.9 Trapp subunit of 20 kDa YMR246W FAA4 0.43 2.8 S "acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates imported fatty acids and provides substrates for N-myristoylation" YPL007C TFC8 0.43 2.2 Transcription factor for RNA polymerase III YML037C 0.43 0.9 YMR038C LYS7 0.43 1.1 "Involved in lysine biosynthesis, oxidative stress protection" YJL031C BET4 0.43 1.8 catalyzes prenylation of Ypt1p (as a subunit of PGGTase-II) YGR145W ENP2 0.43 1.6 Essential Nucleolar Protein 2 YJR131W MNS1 0.43 1.5 specific alpha-mannosidase YDR539W 0.43 1.4 YDL084W SUB2 0.43 1.6 Suppressor of the cold-sensitive snRNP biogenesis mutant brr1-1 YAR015W ADE1 0.43 1.9 phosphoribosyl amino imidazolesuccinocarbozamide synthetase YDR164C SEC1 0.43 1.4 Hydrophilic protein involved at the late stage of secretion YNL029C KTR5 0.43 1.0 Putative mannosyltransferase of the KRE2 family YDR374C 0.43 1.7 YMR177W MMT1 0.43 1.7 Protein involved in mitochondrial iron accumulation YHR113W 0.43 3.0 S C YKL060C FBA1 0.43 1.6 aldolase YJL059W YHC3 0.43 1.6 Homolog of human CLN3 YBR176W ECM31 0.43 1.4 ExtraCellular Mutant YDL057W 0.43 1.4 YOL165C AAD15 0.43 1.3 high degree of similarity with the AAD of P. chrysosporium YBR280C 0.43 1.6 YJL138C TIF2 0.43 0.8 translation initiation factor eIF4A YKR059W TIF1 0.43 1.7 translation initiation factor eIF4A YNL155W 0.43 1.6 YJL061W NUP82 0.43 1.4 Interacts with nuclear pore complex and participates in nucleocytoplasmic transport; required for poly(A)+ RNA export YOL068C HST1 0.43 1.1 Homolog of SIR2 YPL199C 0.43 1.2 YDR298C ATP5 0.43 1.8 Subunit 5 of the mitochondrial ATP synthase complex; homologous to bovine OSCP and E. coli delta. YDR288W 0.43 1.2 YMR168C CEP3 0.43 1.1 "Cbf3 kinetochore complex binds CDE III centromere element; Cep3p contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain and a putative coiled coil dimerization domain" YMR218C TRS130 0.43 1.5 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic; 130 kD subunit YNR001C CIT1 0.43 1.6 C citrate synthase. Nuclear encoded mitochondrial protein. YGR057C LST7 0.43 0.8 Required for amino acid permease transport from the Golgi to the cell surface YBL068W PRS4 0.43 1.1 ribose-phosphate pyrophosphokinase 4 YPL113C 0.43 0.8 YMR023C MSS1 0.43 1.3 May play a part in mitochondrial translation YAR019C CDC15 0.43 1.3 "Promotes the exit from mitosis by directly switching on the kinase activity of Dbf2. Required for mitosis and sporulation, cell division cycle blocked at 36 C." YOR133W EFT1 0.43 1.1 translation elongation factor 2 (EF-2) YDR385W EFT2 0.43 1.0 translation elongation factor 2 (EF-2) YLR348C DIC1 0.43 1.8 mitochondrial dicarboxylate transport protein YER159C BUR6 0.43 1.6 Homolog of DRAP1 (NC2alpha) YGR153W 0.43 2.1 S YOR350C MNE1 0.43 1.0 similar to Lucilia illustris mitochondria cytochrome oxidase YGL030W RPL30 0.43 1.5 Homology to rat and mouse L30 YPL204W HRR25 0.43 1.1 "Similar to YCK1 and YCK2, two other casein kinase I isoforms; found primarily in nucleus; may be involved in DNA-damage repair" YNL252C MRPL17 0.43 1.2 mitochondrial ribosomal protein of the large subunit YIL113W SDP1 0.43 1.3 Hypothetical ORF YBR072W HSP26 0.43 3.1 heat shock protein 26 YHR003C 0.43 1.6 YMR085W 0.43 1.4 YHR026W PPA1 0.43 1.1 vacuolar ATPase V0 domain subunit c'' YHR216W IMD2 0.43 0.9 IMP Dehydrogenase YKL170W MRPL38 0.43 2.5 mitochondrial ribosomal protein L14 YGR163W GTR2 0.43 0.9 "(putative) small GTPase, similar to Gtr1" YJR025C BNA1 0.43 2.4 biosynthesis of nicotinic acid YBL058W SHP1 0.43 1.3 isolated as a suppressor of the lethality caused by overexpression of the phosphoprotein phosphatase 1 catalytic subuniut encoded by GLC7 YKR075C 0.43 2.3 YPR037C ERV2 0.43 1.4 "Essential for Respiration and Vegetative growth 2. Protein forms dimers in vivo/vitro, contains a conserved YPCXXC motif at carboxyl-terminal, binds FAD as cofactor, and catalyzes formation of disulfide bonds in protein substrates." YJL038C 0.42 2.5 YMR178W 0.42 1.0 YFL036W RPO41 0.42 1.7 mitohcondrial RNA polymerase YOR045W TOM6 0.42 1.5 involved in supporting the cooperativity between receptors and the general insertion pore and facilitating the release of preproteins from import components YMR120C ADE17 0.42 1.3 AICAR transformylase/IMP cyclohydrolase YFR049W YMR31 0.42 1.7 mitochondrial ribosomal protein (precursor) YNL067W RPL9B 0.42 1.5 Homology to rat L9 YLR058C SHM2 0.42 2.6 S serine hydroxymethyltransferase YOR226C ISU2 0.42 0.9 Iron-sulfur cluster nifU-like protein YMR264W CUE1 0.42 0.9 Cue1p assembles with Ubc7p. Cue1p recruits Ubc7p to the cytosolic surface of the endoplasmic reticulum. Assembly with Cue1p is a prerequisite for the function of Ubc7p YLR017W MEU1 0.42 0.9 Protein that regulates ADH2 gene expression YER035W EDC2 0.42 1.0 Enhancer of mRNA Decapping YKL151C 0.42 2.5 S YGL108C 0.42 1.2 YKR014C YPT52 0.42 1.0 rab5-like GTPase involved in vacuolar protein sorting and endocytosis YBR143C SUP45 0.42 1.2 Recessive omnipotent suppressor. The wild-type gene functions in termination of translation. YLR345W 0.42 2.0 YLR044C PDC1 0.42 1.8 pyruvate decarboxylase YMR299C 0.42 2.2 YGR026W 0.42 1.4 YML060W OGG1 0.42 4.4 Z S C "Excises 7,8-dihydro-8-oxoguanine (8-OxoG) when 8-OxoG is oppposite cytosine or thymine (but not adenine)" YLR223C IFH1 0.42 2.0 Interacts with fork head protein. Protein controlling pre-rRNA processing machinery in conjunction with Fhl1p YOR097C 0.42 1.9 YDR392W SPT3 0.42 1.4 Transcription factor YGR252W GCN5 0.42 2.0 functions in the Ada and SAGA (Spt/Ada) complexes to acetylate nucleosomal histones YGR240C PFK1 0.42 2.4 S phosphofructokinase alpha subunit YBR056W 0.42 2.4 YEL012W UBC8 0.42 1.2 Ubiquitin-conjugating enzyme that is able to ubiquitinate histones in vitro YDR183W PLP1 0.42 1.6 Phosducin-Like Protein YCR020C PET18 0.42 1.3 Transcription regulator YLR408C 0.42 0.9 YPL131W RPL5 0.42 1.4 Homology to rat ribosomal protein L5; required for assembly of stable 60S ribosomal subunits YNL261W ORC5 0.42 1.4 May be subunit of origin recognition complex (ORC) that mediates the ATP-dependent binding to origins; the ORC binds to origins of replication and thereby directs DNA replication and is also involved in transcriptional silencing YCR047C BUD23 0.42 1.5 YPR163C TIF3 0.42 1.1 Suppressor of translation mutants YFL025C BST1 0.42 1.1 Negatively regulates COPII vesicle formation YER113C 0.42 1.0 YGL017W ATE1 0.42 1.0 arginyl-tRNA-protein transferase YOR283W 0.42 1.7 S YOR269W PAC1 0.42 1.4 Required for viability in the absence of the kinesin-related Cin8p mitotic motor. YBR205W KTR3 0.42 0.9 "Putative alpha-1,2-mannosyltransferase" YMR015C ERG5 0.42 2.8 S cytochrome P450 involved in C-22 denaturation of the ergosterol side-chain YBR101C 0.42 1.1 YMR241W YHM2 0.42 1.4 Yeast suppressor gene of HM mutant (abf2) YMR298W 0.42 1.9 YLR153C ACS2 0.42 1.4 one of 2 acetyl-coA synthetases in yeast YER072W VTC1 0.42 1.2 Null mutant identified in different genetic screens both by its ability to reverse the Cdc42p suppression of a cdc24-4ts mutant and its ability to suppress the vacuolar ATPase null phenotype YKL097C 0.42 1.6 YGR247W CPD1 0.42 1.2 "2',3'-cyclic nucleotide 3'-phosphodiesterase, similar to cyclic phosphodiesterases from Arapidopsis and wheat" YGR046W 0.42 1.0 YPL211W NIP7 0.42 1.1 Nip7p is required for 60S ribosome subunit biogenesis YCR026C 0.42 1.3 YLR285W 0.42 1.4 YKL103C LAP4 0.42 3.3 S vacuolar aminopeptidase ysc1 YBR003W COQ1 0.42 0.9 hexaprenyl diphosphate synthesis YCR018C SRD1 0.42 2.7 S involved in the processing of pre-rRNA to mature rRNA YLR393W ATP10 0.42 0.8 essential for assembly of a functional mitochondrial ATPase complex YCR046C IMG1 0.42 1.9 Required for respiration and maintenance of mitochondrial genome YOR117W RPT5 0.42 1.2 Probable 26S protease subunit and member of the CDC48/PAS1/SEC18 family of ATPases YMR255W GFD1 0.42 1.0 Great for FULL DEAD box protein activity YGL256W ADH4 0.42 1.0 Alcohol dehydrogenase type IV YKL037W 0.42 1.6 YAL038W CDC19 0.42 2.1 Required for START A in the cell cycle and sporulation YOL069W NUF2 0.42 4.5 Z S C Protein associated with spindle pole body and critical for nuclear division YLL013C PUF3 0.42 0.9 "member of the PUF protein family, which is named for the founding members, PUmilio and Fbf" YNR036C 0.42 1.2 YOL052C SPE2 0.42 1.3 S-adenosylmethionine decarboxylase YML038C YMD8 0.42 1.8 similar to vanadate resistance protein Gog5 YLR424W 0.42 2.4 YDR003W 0.42 1.2 YLR133W CKI1 0.42 1.8 choline kinase YOL055C THI20 0.42 0.9 THI for thiamine metabolism. Transcribed in the presence of low level of thiamine (10-8M) and turned off in the presence of high level (10-6M) of thiamine. Under the positive control of THI2 and THI3. YOR361C PRT1 0.42 0.8 translation initiation factor eIF3 subunit YGL211W 0.42 1.0 YGL206C CHC1 0.42 1.4 vesicle coat protein YOL045W PSK2 0.42 1.2 PAS domain-containing Serine/threonine Kinase YJL049W 0.42 1.4 YIL121W 0.42 2.3 S YDL161W ENT1 0.42 1.0 epsin N-terminal homology-containing protein YHR112C 0.41 1.1 YBR245C ISW1 0.41 1.2 has strong homology to Drosophila ISWI YDR346C SGI1 0.41 2.3 S mutant Suppressor of Growth Inhibition by phosphorylated sphingoid bases YLR028C ADE16 0.41 1.7 AICAR transformylase/IMP cyclohydrolase YPL043W NOP4 0.41 1.5 RNA recognition motif-containing protein YPL148C PPT2 0.41 2.2 Phosphopantetheine:protein transferase (PPTase) that activates the low molecular weight acyl carrier protein (ACP) of mitochondrial type II fatty acid synthase (FAS). YBR041W FAT1 0.41 1.4 Putative membrane-bound long-chain fatty acid transport protein homologous to mouse fatty acid transport protein YDR110W FOB1 0.41 0.9 The gene product is essential for both DNA replication fork blocking and recombinational hotspot activities. YDR291W 0.41 0.8 YJL035C TAD2 0.41 2.2 tRNA-specific adenosine-34 deaminase subunit Tad2p YIL129C TAO3 0.41 6.0 Z S Identified in a hunt for mutants that activate OCH1 transcription YGR193C PDX1 0.41 1.2 Plays a structural role in pyruvate dehydrogenase complex YJR104C SOD1 0.41 1.2 "Cu, Zn superoxide dismutase" YDR280W RRP45 0.41 1.3 Ribosomal RNA Processing YAL002W VPS8 0.41 0.8 involved in vacuolar protein sorting; required for localization and trafficking of the CPY sorting receptor YMR262W 0.41 2.1 YDR083W RRP8 0.41 1.4 YBR121C GRS1 0.41 0.9 Glycyl-tRNA synthase YNL139C RLR1 0.41 0.9 Required for LacZ RNA expression from certain plasmids; suppressor of the Transcriptional (T) defect of Hpr1 (H) by Overexpression (O); plays a role in transcription elongation by RNA polymerase II YBR261C 0.41 1.7 YBR055C PRP6 0.41 0.9 RNA splicing factor YGR055W MUP1 0.41 3.8 S high affinity methionine permease YGL196W 0.41 1.2 YJR129C 0.41 1.4 YGL097W SRM1 0.41 1.9 Z Gdp/GTP exchange factor for Gsp1p/Gsp2p YDR260C SWM1 0.41 1.6 Spore Wall Maturation 1 YOR136W IDH2 0.41 2.1 NAD+-dependent isocitrate dehydrogenase YKR023W 0.41 1.2 YLR206W ENT2 0.41 1.7 epsin N-terminal homology-containing protein YMR182C RGM1 0.41 0.9 Putative transcriptional repressor with proline-rich zinc fingers YMR002W 0.41 2.0 S YKL193C SDS22 0.41 1.0 Interacts with and may be a positive regulator of GLC7 which encodes type1 protein phosphatase YPL233W NSL1 0.41 1.4 Nnf1 Synthetic Lethal 1 YLR304C ACO1 0.41 1.7 "Aconitase, mitochondrial" YOL145C CTR9 0.41 2.0 CTR9 is required for normal CLN1 and CLN2 G1 cyclin expression YBR112C CYC8 0.41 1.4 General repressor of transcription (with Tup1p); mediates glucose repression YDR051C 0.41 1.4 YPL022W RAD1 0.41 0.8 UV endonuclease YPR034W ARP7 0.41 2.3 S involved in transcriptional regulation YIL159W BNR1 0.41 2.0 C "Bni1p-related protein, helps regulate reorganization of the actin cytoskeleton, potential target of Rho4p" YNL001W DOM34 0.41 1.5 an ORF of unknown function located in a centromeric region duplicated between chromosomes III and XIV (DOM34 homologue on chromosome III is a pseudogene) YGR165W 0.41 1.3 YNL073W MSK1 0.41 2.2 C mitochondrial lysine-tRNA synthetase YGR198W 0.41 1.1 YDR268W MSW1 0.41 0.9 mitochondrial tryptophanyl-tRNA synthetase YFL058W THI5 0.41 1.6 proposed biosynthetic enzyme involved in pyrimidine biosynthesis pathway above the hydroxymethyl-pyrimidine precursor leading to the thiaminemoiety YOR245C DGA1 0.41 1.0 DiacylGlycerol Acyltransferase YGR082W TOM20 0.41 0.8 Translocase of Outer Mitochondrial membrane YPR036W VMA13 0.41 1.1 vacuolar ATPase V1 domain subunit H (54 kDa) YAR020C PAU7 0.41 1.1 "similar to Pau3, member of Pau1 family" YGL062W PYC1 0.41 3.3 converts pyruvate to oxaloacetate YML002W 0.41 1.1 YBR258C SHG1 0.41 0.8 YMR226C 0.41 1.3 YLR297W 0.41 4.3 S C YJL102W MEF2 0.41 1.4 mitochondrial elongation factor G-like protein YJR139C HOM6 0.41 1.1 catalyzes third step in common pathway for methionine and threonine biosynthesis YFL007W BLM3 0.41 1.2 bleomycin resistance YOL028C YAP7 0.41 1.4 basic leucine zipper (bZIP) transcription factor YEL027W CUP5 0.41 2.0 vacuolar ATPase V0 domain subunit c (17 kDa) YCR042C TAF2 0.41 4.9 S C TATA binding protein-associated factor (TAF) YMR217W GUA1 0.41 0.9 GMP synthase YGL067W NPY1 0.41 1.5 hydrolyzes the pyrophosphate linkage in NADH and related nucleotides YMR174C PAI3 0.41 2.2 Cytoplasmic inhibitor of proteinase Pep4p YFL008W SMC1 0.41 3.3 S C coiled-coil protein involved in chromosome structure or segregation YDR429C TIF35 0.41 1.5 Translation initiation factor 3 p33 subunit YOL031C 0.41 1.1 YPR101W SNT309 0.41 2.4 Synergistic to prp19 (NineTeen) mutation. Essential for mRNA splicing. YLR093C NYV1 0.41 1.2 Synaptobrevin (v-SNARE) homolog involved in vacuolar vesicle fusion YBR115C LYS2 0.41 1.3 "A key step in fungal biosynthesis of lysine, enzymatic reduction of alpha-aminoadipate at C6 to the semialdehyde, requires two gene products in Saccharomyces cerevisiae, Lys2 and Lys5." YLR377C FBP1 0.41 1.3 "fructose-1,6-bisphosphatase" YOL162W 0.41 1.7 YDR373W FRQ1 0.41 1.5 Product of gene unknown YKL057C NUP120 0.41 1.0 Nucleoporin YBR165W UBS1 0.41 1.6 General positive regulator of CDC34; Suppress some cdc34 mutations when over-expressed YMR193W MRPL24 0.41 2.8 Mitochondrial ribosomal protein MRPL24 (YmL24) YNL077W 0.41 1.7 YLL063C AYT1 0.41 0.9 Transacetylase YOL081W IRA2 0.41 1.8 Negatively regulates cAPK by antagonizing CDC25 YBR091C MRS5 0.41 0.8 "Involved in mitochondrial biogenesis, may share a common function with Mrs11p" YDR281C PHM6 0.41 2.9 Phosphate metabolism; transcription is regulated by PHO system YMR302C PRP12 0.41 1.0 Integral membrane mitochondrial protein YHR136C SPL2 0.41 1.1 Suppressor of plc1-delta. Isolated as a dosage suppressor of the temperature-sensitive phenotype of a plc1 null mutant. Also suppresses the hyperosmotic-sensitive phenotype of the plc1 null mutant. YBR170C NPL4 0.41 1.2 Nuclear pore or nuclear pore-associated protein required for nuclear membrane integrity and nuclear transport YJL088W ARG3 0.41 1.6 Sixth step in arginine biosynthesis YJR078W BNA2 0.41 2.3 Biosynthesis of Nicotinic Acid YJL137C GLG2 0.40 3.4 S C self-glucosylating initiator of glycogen synthesis; similar to mammalian glycogenin YML106W URA5 0.40 2.3 Fifth step in pyrimidine biosynthesis pathway YLR148W PEP3 0.40 1.3 vacuolar membrane protein YJL162C 0.40 1.1 YNR034W SOL1 0.40 0.8 Multicopy Suppressor Of los1 YBR133C HSL7 0.40 2.9 S Histone Synthetic Lethal
Negative regulator of Swe1 kinase YMR300C ADE4 0.40 1.8 phosphoribosylpyrophosphate amidotransferase YER086W ILV1 0.40 1.1 threonine deaminase YDL167C NRP1 0.40 1.4 asparagine-rich protein YJL217W 0.40 3.2 S YOR008C-A 0.40 0.1 YKL075C 0.40 1.4 YDR275W 0.40 1.2 YKL127W PGM1 0.40 3.3 S C "phosphoglucomutase, minor isoform" YBR230C 0.40 2.9 YIL116W HIS5 0.40 1.7 responsive to control of general amino acid biosynthesis YMR131C RRB1 0.40 1.2 RiboSome Assembly 2 YOL071W EMI5 0.40 1.6 Early Meiotic Induction YGL059W 0.40 2.0 C YLR303W MET17 0.40 4.3 S O-Acetylhomoserine-O-Acetylserine Sulfhydralase YDR301W CFT1 0.40 1.0 "Functions in cleavage of 3'-ends of pre-mRNAs, prior to polyadenylation; 23.5% identical to the 160-kDa subunit of mammalian cleavage and polyadenylation specificity factor (CPSF-160)" YJR084W CSN12 0.40 1.7 COP9 signalosome (CSN) YBR057C MUM2 0.40 1.2 Muddled Meiosis YLR245C CDD1 0.40 1.4 Involved in cytidine and deoxycytidine metabolism YGL174W BUD13 0.40 1.4 YBR283C SSH1 0.40 1.5 SEC61 homolog involved in co-translational pathway of protein transport YGR184C UBR1 0.40 1.0 Ubiquitin-protein ligase YGR169C PUS6 0.40 1.3 RNA:Psi-synthase YPL196W OXR1 0.40 1.7 OXidation Resistance YFL020C PAU5 0.40 1.3 member of the seripauperin protein/gene family (see Gene_class PAU) YDL168W SFA1 0.40 1.2 Long-chain alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) YPR155C NCA2 0.40 1.7 S Regulates proper expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase YOR005C DNL4 0.40 1.2 DNA ligase IV homolog YGR250C 0.40 0.8 YGR172C YIP1 0.40 1.3 Golgi integral membrane protein; binds to the transport GTPases Ypt1p and Ypt31p YPR074C TKL1 0.40 1.4 Transketolase 1 YDR232W HEM1 0.40 1.2 First enzyme in heme biosynthetic pathway YOR376W 0.40 2.5 YHR047C AAP1' 0.40 1.1 arginine/alanine aminopeptidase YPR058W YMC1 0.40 1.2 putative mitochondrial carrier protein YBL055C 0.40 1.3 YOL119C MCH4 0.40 2.9 S monocarboxylate permease homologue YIR030C DCG1 0.40 1.0 Product of gene unknown YDL043C PRP11 0.40 1.4 snRNA-associated protein YJL039C NUP192 0.40 1.1 large yeast nucleoporin YPL122C TFB2 0.40 1.3 Transcription/repair factor TFIIH subunit YJR039W 0.40 0.9 YPL183C 0.40 1.4 YML077W BET5 0.40 1.0 Bet5p/18kD component of TRAPP YJL123C 0.40 1.2 YGR136W LSB1 0.40 1.4 LAs17 Binding protein YNL084C END3 0.40 1.1 Required for endocytosis and organization of the cytoskeleton YOL058W ARG1 0.40 3.1 S arginosuccinate synthetase YHR025W THR1 0.40 0.9 homoserine kinase YGL107C RMD9 0.40 1.0 Required for Meiotic nuclear Division YLR063W 0.40 1.9 YDR388W RVS167 0.40 1.2 "The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress." YDL110C 0.40 1.1 YBL086C 0.40 1.5 YPL175W SPT14 0.40 1.5 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein YJR124C 0.40 1.5 YOL153C 0.40 1.9 YPL157W TGS1 0.40 1.5 TrimethylGuanosine Synthase YHR187W IKI1 0.40 0.9 RNA polymerase II Elongator associated protein YHL036W MUP3 0.40 1.6 methionine uptake YPR200C ARR2 0.40 1.6 Required for arsenate but not for arsenite resistance YOR385W 0.40 2.5 YHR177W 0.40 1.5 YCR107W AAD3 0.40 1.9 high degree of similarity with the AAD of P. chrysosporium YHR074W QNS1 0.40 1.6 Glutamine-dependent NAD Synthetase YLR375W STP3 0.40 1.5 Involved in pre-tRNA splicing and in uptake of branched-chain amino acids YLL061W MMP1 0.40 2.6 S C S-MethylMethionine Permease YGR234W YHB1 0.40 1.6 S may play a role in the oxidative stress response YMR048W CSM3 0.40 3.7 S C Chromosome segregation in meiosis YNL328C MDJ2 0.40 2.8 S "Protein of the mitochondrial inner membrane with similarity to E. coli DnaJ and other DnaJ-like proteins, function partially overlaps that of Mdj1p" YNL134C 0.40 3.9 S YNL181W 0.40 2.5 S YIL037C PRM2 0.40 3.1 pheromone-regulated membrane protein YHR133C 0.40 1.4 YIR043C 0.40 1.5 YBR276C PPS1 0.40 1.6 C Protein Phosphatase S phase YJR053W BFA1 0.40 2.3 Byr four alike YEL065W SIT1 0.40 4.7 S Siderophore Iron Transport YBR117C TKL2 0.40 1.4 "transketolase, homologous to tkl1" YGL250W 0.40 1.3 YMR214W SCJ1 0.40 2.0 dnaJ homolog YMR138W CIN4 0.40 0.9 Protein involved in chromosome segregation and microtubule function; homologue of human Arl2 YFL045C SEC53 0.40 3.0 involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for protein assembly in endoplasmic reticulum YLR388W RPS29A 0.39 1.3 Homology to rat S29 YAL053W 0.39 2.1 S YMR270C RRN9 0.39 1.8 Upstream activation factor subunit YHR060W VMA22 0.39 0.8 "Required for V-ATPase activity. Required for the biogenesis of a functional vacuolar ATPase (V-ATPase), but not part of the final enzyme complex." YLR039C RIC1 0.39 1.3 involved in transcription of ribosomal protein genes and ribosomal RNA YGL142C GPI10 0.39 1.3 "Involved in glycosyl phosphatidyl inositol synthesis; could be the target of the GPI synthesis inhibitor, YW3548; Most likely an alpha 1,2 mannosyltransferase utilized for the addition of the third mannose onto the GPI core structure." YDR180W SCC2 0.39 1.6 Sister chromatid cohesion protein YNL213C 0.39 1.2 YBR135W CKS1 0.39 1.5 subunit of the Cdc28 protein kinase YMR082C 0.39 1.4 YDR517W GRH1 0.39 1.8 Yeast (GR)ASP65 (H)omologue YLR174W IDP2 0.39 1.5 "concerts isocitrate and NADP+ to 2-oxoglutarate, CO2, and NADPH" YBL076C ILS1 0.39 1.6 cytoplasmic isoleucyl-tRNA synthetase YOR369C RPS12 0.39 1.7 Homology to rat S12 YLR384C IKI3 0.39 0.9 RNA polymerase II Elongator subunit YGL252C RTG2 0.39 0.9 "Protein involved in interorganelle communication between mitochondria, peroxisomes, and nucleus" YPR170C 0.39 1.3 YPL047W 0.39 1.6 YHR001W-A QCR10 0.39 1.9 8.5 kDa subunit of the ubiqunol-cytochrome c oxidoreductase complex YOR104W PIN2 0.39 2.6 S [PSI+] induction YNL217W 0.39 1.8 YHR018C ARG4 0.39 2.8 argininosuccinate lyase YLR196W PWP1 0.39 1.0 periodic tryptophan protein
Protein with periodic trytophan residues that resembles members of beta-transducin superfamily because of presence of WD-40 repeats YPL243W SRP68 0.39 1.0 part of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in protein targeting to the endoplasmic reticulum (ER) membrane YJR006W HYS2 0.39 3.3 Z S C Putative role in DNA replication YCR101C 0.39 2.4 YMR258C 0.39 1.7 YDL054C MCH1 0.39 0.8 Monocarboxylate Permease Homologue YMR108W ILV2 0.39 0.8 acetolactate synthase YDR175C RSM24 0.39 1.1 mitochondrial ribosome small subunit component YKR016W 0.39 1.5 YPL092W SSU1 0.39 3.5 putative sulfite pump YOL161C 0.39 1.3 YBL013W FMT1 0.39 1.4 Formyl-Methionyl-tRNA Transformylase (consistent with name of bacterial homologs) YLR178C TFS1 0.39 3.4 (putative) lipid binding protein; supressor of a cdc25 mutation YNL242W APG2 0.39 2.0 Defective in autophagy; required for sporulation YMR025W CSI1 0.39 0.8 COP9 signalosome interactor YPL031C PHO85 0.39 1.2 involved in phosphate and glycogen metabolism and cell cycle progression YAL018C 0.39 1.8 YGR024C 0.39 1.2 YGL089C MF(ALPHA)2 0.39 4.6 S C alpha mating factor YGL244W RTF1 0.39 1.0 "Directly or indirectly regulates DNA-binding properties of Spt15p, TATA box-binding protein, and relative activities of different TATA elements. Member of RNA polymerase II-associated Paf1 complex." YLR421C RPN13 0.39 0.8 Proteasome subunit YPR180W AOS1 0.39 1.4 along with Uba2p forms a heterodimeric activating enzyme for Smt3p YBL044W 0.39 2.6 YHL021C 0.39 2.3 YDR457W TOM1 0.39 1.3 Temperature dependent Organization in Mitotic nucleus YIL003W DRE3 0.39 1.2 Protein required for cell viability YDR460W TFB3 0.39 1.9 Transcription/repair factor TFIIH subunit YGR148C RPL24B 0.39 2.0 Homology to rat L24 YOR056C NOB1 0.39 1.6 Nin1 (One) Binding protein YIR027C DAL1 0.39 1.5 allantoinase YBL078C AUT7 0.39 1.3 "Forms a protein complex with Aut2p to mediate attachment of autophagosomes to microtubules. Defective in maturation of the vacuolar protein, aminopeptidase I" YGR021W 0.39 0.9 YKL204W EAP1 0.39 1.0 Translation initiation factor eIF-4E associated protein YLR104W 0.39 1.1 YOR222W ODC2 0.39 1.4 YFL030W 0.39 2.0 YIL098C FMC1 0.39 1.7 Formation of Mitochondrial Complexes YIL057C 0.39 1.9 YCL038C AUT4 0.39 2.5 S C Autophagy gene essential for breakdown of autophagic vesicles in the vacuole YPL252C YAH1 0.39 1.4 Yeast Adrenodoxin Homologue 1; This protein is targeted to the mitochondrial matrix as shown by using a specific polyclonal antibody YOL139C CDC33 0.39 1.2 Required for START A of cell cycle and sporulation YER015W FAA2 0.39 1.4 "acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 2), activates endogenous but not imported fatty acids and provides substrates for N-myristoylation" YBR080C SEC18 0.39 1.2 cytoplasmic protein involved in protein transport between ER and Golgi; ATPase YMR134W 0.39 2.3 YDL143W CCT4 0.39 0.9 cytoplasmic chaperonin subunit required for actin cytoskeleton assembly or function YBR265W TSC10 0.39 1.5 catalyzes the second step in the synthesis of phytosphingosine YDR352W 0.39 1.2 YPR017C DSS4 0.39 1.6 dominant suppressor of sec4 YMR056C AAC1 0.39 2.1 "minor species of mitochondrial ADP/ATP translocator, highly homologous to PET9 (AAC2) and AAC3" YKL149C DBR1 0.39 1.2 RNA lariat debranching enzyme YNL068C FKH2 0.39 2.4 Z Fork Head homolog two YOR006C 0.39 1.4 YNR054C 0.39 1.1 YJR125C ENT3 0.39 1.6 epsin N-terminal homology-containing protein YJR007W SUI2 0.39 1.6 eIF2 is a heterotrimeric GTP-binding protein
SUI3 encodes the beta subunit
GCD11 encodes the gamma subunit YJL130C URA2 0.39 1.0 First and second steps of pyrimidine biosynthesis YGR036C CAX4 0.39 1.9 "CAX4p contains 3 short stretches of amino acids that are characteristic for a wide variety of phosphatases, including lipid phosphatases and a protein phosphatase." YDR318W MCM21 0.39 1.5 Involved in minichromosome maintenance YGR044C RME1 0.39 6.1 K S C mediates cell type control of sporulation; negatively regulates IME1 and sporulation YOR129C 0.39 2.6 S YBL030C PET9 0.39 2.4 S the major mitochondrial ADP/ATP translocator; highly homologous to AAC1 and AAC3 YDR543C 0.39 1.5 YBL106C SRO77 0.39 1.1 Suppressor of defect in the small GTPase Rho3p YLR249W YEF3 0.39 1.5 "contains two ABC cassettes, and binds and hydrolyses ATP" YHR170W NMD3 0.39 1.0 putative Upf1p-interacting protein YJL099W CHS6 0.39 2.7 S C Involved in chitin biosynthesis and/or its regulation YJR123W RPS5 0.39 1.4 "ribosomal small subunit protein homologous to mammalian S5 (has approx. 70% identity with human, rat and hydrozoan S5). It is the least basic of the non-acidic ribosomal proteins. It is phosphorylated in yeast." YNL244C SUI1 0.39 1.2 translation initiation factor 3 (eIF3) YPL255W BBP1 0.39 2.7 S Involved in mitotic cell cycle and meiosis YMR149W SWP1 0.39 1.5 "oligosaccharyl transferase glycoprotein complex, delta subunit" YLR320W MMS22 0.39 1.0 YKR020W VPS67 0.39 1.0 whiskey (whi) mutant YHR165C PRP8 0.38 0.8 protein involved in mRNA splicing; lies at the catalytic center of the spliceosome; makes extensive contacts with the U5 snRNA and with the pre-mRNA YGL043W DST1 0.38 1.2 Transcription elongation factor S-II
Meiotic DNA recombination factor YDR142C PEX7 0.38 1.0 May serve as intraperoxisomal receptor for type 2 peroxisomal proteins (such as thiolase) YBR267W 0.38 1.5 YLR227C ADY4 0.38 0.8 Accumulation of dyads YPL212C PUS1 0.38 1.1 Involved in tRNA biogenesis YOR065W CYT1 0.38 2.2 C Cytochrome c1 YOR239W ABP140 0.38 1.0 actin filament binding protein YGR019W UGA1 0.38 2.1 gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) YGR231C PHB2 0.38 2.0 Possible role in aging YGR144W THI4 0.38 1.9 Protein highly expressed in early stationary phase during growth on molasses YAL012W CYS3 0.38 1.8 catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine YBL079W NUP170 0.38 1.5 Component of yeast nuclear pore complex; may play a role in localizing specific nucleoporins to nuclear pore complex; High identity with Sc nucleoporin NUP157 & to mammalian nucleoporin Nup155p. Complemented with Nup155p YPL226W NEW1 0.38 1.3 "This gene encodes a protein with an Q/N-rich amino terminal domain that acts as a prion, termed [NU]+." YDR002W YRB1 0.38 1.5 Yeast Ran Binder #1; suppressor of FUS1; homolog of mouse HTF9a and human RanBP1 YMR229C RRP5 0.38 0.9 Part of small ribosomal subunit (SSU) processosome (contains U3 snoRNA). Rrp5p is the only ribosomal RNA processing trans-acting factor that is required for the synthesis of both 18S and 5.8S rRNAs. YPR108W RPN7 0.38 1.1 "Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit S10/p44" YNL014W HEF3 0.38 1.2 Translational elongation factor EF-3B YNL075W IMP4 0.38 1.4 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Interacts With Mpp10. Imp4p is a specific component of the U3 snoRNP and is required for pre-18S rRNA processing. YJL207C 0.38 1.7 YMR253C 0.38 2.8 S YNL025C SSN8 0.38 0.8 "Component of RNA polymerase II holoenzyme, involved in RNA pol II carboxy-terminal domain phosphorylation. Activity of the kinase (SSN3)/cyclin (SSN8) pair required, along with SSN6 & TUP1, for transcriptional repression of a-specific genes" YMR166C 0.38 2.4 YJR116W 0.38 1.8 YJL176C SWI3 0.38 2.1 transcription factor YHL049C 0.38 5.4 Z S YOR026W BUB3 0.38 1.8 C Protein required for cell cycle arrest in response to loss of microtubule function YCR003W MRPL32 0.38 1.7 Mitochondrial ribosomal protein MRPL32 (YmL32) YNL039W BDP1 0.38 1.4 RNA polymerase III Transcription factor TFIIIB (90 kDa subunit; also called TFIIIB90 or B'' or B''90 component) YOR228C 0.38 1.9 YIL175W 0.38 1.9 YMR278W 0.38 1.9 S YLR438W CAR2 0.38 3.2 S ornithine aminotransferase YHR129C ARP1 0.38 1.4 actin-related protein of the dynactin complex YBR100W 0.38 1.2 YHR172W SPC97 0.38 2.4 S C Spindle Pole Body component with an molecular weight of 97 kDa YOR176W HEM15 0.38 3.5 S "Performs last step in heme biosynthesis pathway, inserting ferrous iron into protoporphyrin IX" YKR103W 0.38 2.0 S YLR241W 0.38 1.4 YPR173C VPS4 0.38 1.9 Defective in vacuolar protein sorting; homologous to mouse SKD1 and to human hVPS4 YBR085W AAC3 0.38 1.5 highly homologous to PET9 (AAC2) and AAC1; expression occurs only under anaerobic conditions YBR246W 0.38 1.0 YGL157W 0.38 1.9 YER078C 0.38 1.5 YDR237W MRPL7 0.38 1.1 Mitochondrial ribosomal protein MRPL7 (YmL7) YGR003W 0.38 1.2 YNL024C 0.38 1.3 YCR079W 0.38 0.9 YGL121C GPG1 0.38 2.7 "G protein gamma. Gpg1 interacts with Gpa2, Gpb1 (YOR371c), and Gpb2 (YAL056w) in yeast two hybrid assays. The interaction between Gpa2 and Gpg1 is indirect and requires Gpb1 OR Gpb2." YGR208W SER2 0.38 1.0 phosphoserine phosphatase YDL076C RXT3 0.38 1.2 Hypothetical ORF YPL266W DIM1 0.38 1.9 "Dimethyladenosine transferase, (rRNA(adenine-N6,N6-)-dimethyltransferase),reponsible for m6[2]Am6[2]A dimethylation in 3'-terminal loop of 18S rRNA" YGL125W MET13 0.38 2.2 S putative methylenetetrahydrofolate reductase (mthfr) YLR253W 0.38 1.2 YER014W HEM14 0.38 2.0 converts protoporphyrinogen IX to protoporphyrin IX (in synthesis of heme) YLR370C ARC18 0.38 1.4 Arp2/3 complex subunit YCL028W RNQ1 0.38 1.1 Rich in asparagine (N) and glutamine (Q) YPR189W SKI3 0.38 0.9 "dsRNA virus protection family member, contains 8 copies of the tetratricopeptide (TPR) domain" YML094W GIM5 0.38 1.3 "Prefoldin subunit 5; putative homolog of subunit 5 of bovine prefoldin, a chaperone comprised of six subunits" YPR055W SEC8 0.38 1.6 "121 kDa component of the Exocyst complex, which is required for exocytosis, and which also contains the gene products encoded by SEC3, SEC5, SEC6, SEC10, SEC15, and EXO70" YMR323W 0.38 1.6 YLR387C 0.38 1.0 YOR347C PYK2 0.38 2.8 "Pyruvate kinase, glucose-repressed isoform" YLR380W CSR1 0.38 2.7 Z S "chs5 spa2 rescue; isolated as a multicopy suppressor of the lethality of chs5 spa2 double mutant at 37 degrees. Also Sec14p homolog, putative phosphatidylinositol transfer protein." YER091C MET6 0.38 3.6 S cobalamin-independent methionine synthase YDL244W THI13 0.38 1.0 Product of gene unknown YEL071W DLD3 0.38 2.5 D-lactate dehydrogenase YAL044C GCV3 0.38 1.7 H-protein subunit of the glycine cleavage system YDL066W IDP1 0.38 0.8 Mitochondrial form of NADP-specific isocitrate dehydrogenase YNL050C 0.38 1.1 YFR026C 0.38 3.6 C YDR078C SHU2 0.38 1.1 Suppressor of hydroxy-urea sensitivity YGR086C 0.38 4.1 S YER044C ERG28 0.38 1.6 Transmembrane domain containing protein which may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or to tether these enzymes to the ER YFL044C 0.38 2.9 S YLL041C SDH2 0.38 2.2 "Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone." YPL193W RSA1 0.38 1.0 RiboSome Assembly YPR046W MCM16 0.38 1.1 Involved in a nonessential role that governs the kinetochore-microtubule mediated process of chromosome segregation YDR082W STN1 0.38 1.1 "involved in telomere length regulation, function in telomere metabolism during late S phase" YCR036W RBK1 0.38 1.7 ribokinase YHR039C-A VMA10 0.38 0.8 vacuolar H-ATPase 13 kDa subunit of VO membrane sector YPL121C MEI5 0.38 1.9 Meiotic protein required for synapsis and meiotic recombination YPL107W 0.38 1.3 YIL006W 0.38 1.0 YBR166C TYR1 0.38 2.0 Step of tyrosine biosynthesis pathway YOR296W 0.38 0.8 YDL183C 0.38 0.9 YDL080C THI3 0.38 1.3 Positive regulatory factor with thiamin pyrophosphate-binding motif for thiamin metabolism YDR297W SUR2 0.38 4.0 Z S C Suppressor of rvs161 and rvs167 mutations YJR156C THI11 0.37 1.5 "thiamine regulated gene, homologous to S. pombe NMT1A. Proposed biosynthetic enzyme involved in pyrimidine biosynth. pathway above the hydroxymethyl-pyrimidine precursor leading to the thiamine moiety. Three copies THI5, THI11 & THI12" YLR071C RGR1 0.37 1.0 "affects chromatin structure, transcriptional regulation of diverse genes and sporulation, required for glucose repression, HO repression, RME1 repression and sporulation" YBR044C TCM62 0.37 2.3 mitochondrial protein; (putative) chaperone YHR058C MED6 0.37 1.0 RNA polymerase II transcriptional regulation mediator YMR107W 0.37 2.1 YBR140C IRA1 0.37 1.3 "Inhibitory regulator of the RAS-cAMP pathway, negatively regulates cAPK by antagonizing CDC25" YDL153C SAS10 0.37 1.2 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); Something About Silencing 10 YDR470C UGO1 0.37 0.8 outer membrane protein required for for mitochondrial fusion YGL126W SCS3 0.37 3.0 Required for inositol prototrophy YPR018W RLF2 0.37 5.7 Z S C "Chromatin Assembly Complex, subunit 1: largest (p90) subunit of three-subunit protein complex (yeast CAF-I) involved in DNA-replication-linked nucleosome assembly. Homol. to p150 subunit human Chromatin Assembly Factor-I (CAF-I)" YAL039C CYC3 0.37 2.3 cytochrome c heme lyase (CCHL) YOR187W TUF1 0.37 1.3 "Translation elongation factor Tu, mitochondrial" YLR149C 0.37 1.9 YHR030C SLT2 0.37 2.7 S Suppressor of lyt2 YPL139C UME1 0.37 1.6 Negative regulator of meiosis. Unscheduled Meiotic gene Expression. YLL056C 0.37 1.0 YDR004W RAD57 0.37 1.4 "Required for X-ray damage repair, meiotic recombination, wild-type levels of sporulation and viable spores" YGR084C MRP13 0.37 2.4 35 kDa mitochondrial ribosomal small subunit protein YLR315W NKP2 0.37 1.3 Non-essential Kinetochore Protein YDL103C QRI1 0.37 3.6 Z S C UDP-N-acetylglucosamine pyrophosphorylase YLR275W SMD2 0.37 0.9 U1 snRNP protein of the Sm class YLR034C SMF3 0.37 2.5 S "Putative metal transporter, Nramp homolog, homolog of SMF1 and SMF2" YJL143W TIM17 0.37 1.1 Mitochondrial inner membrane protein involved in protein import YGR028W MSP1 0.37 1.3 40 kDa putative membrane-spanning ATPase YPR040W TIP41 0.37 1.0 SDF1 the first obserwed null phenotype was Sporulation DeFiciency YJL046W 0.37 1.0 YBR275C RIF1 0.37 2.4 C "RAP1-interacting factor, involved in establishment of repressed chromatin" YGL225W VRG4 0.37 3.2 K S May regulate Golgi function and glycosylation in Golgi YMR069W 0.37 1.7 YCL011C GBP2 0.37 0.8 "G-strand Binding Protein
binds single-stranded telomeric repeat sequences in vitro; similar to Gbp1p, a single-stranded telomeric DNA-binding protein from Chlamydomonas reinhardtii" YIL106W MOB1 0.37 4.6 K S C Mps One Binder YPL281C ERR2 0.37 1.4 enolase-related subtelomeric sequence (ERR1 and ERR2 code for identical proteins) YOR393W ERR1 0.37 2.2 enolase-related subtelomeric sequence (ERR1 and ERR2 code for identical proteins) YLR361C DCR2 0.37 0.9 Dose-Dependent Cell cycle Regulator YCR100C 0.37 2.9 YJL043W 0.37 2.3 YJL210W PEX2 0.37 1.6 Required for peroxisome biogenesis YKL143W LTV1 0.37 1.9 Protein required for viability at low temperature YFR015C GSY1 0.37 2.2 S Highly similar to GSY2. GSY2 is the predominantly expressed glycogen synthase YDR022C CIS1 0.37 1.7 Involved in microtubule assembly YLR292C SEC72 0.37 1.3 protein involved in membrane protein insertion into the ER YLR051C 0.37 1.5 YJL050W MTR4 0.37 1.2 Dead-box family helicase required for mRNA export from nucleus YML040W 0.37 0.9 YMR169C ALD3 0.37 2.3 "Expression induced in response to heat shock, oxidative and osmotic stress. NAD+ is preferred coenzyme." YNL092W 0.37 0.8 YFR002W NIC96 0.37 2.3 S "Part of complex at nuclear pore containing in addition NSP1p, NUP49p, and p54" YIL024C 0.37 1.2 YOR317W FAA1 0.37 2.0 S C cellular lipid metabolism and protein N-myristolation YML073C RPL6A 0.37 0.9 Homology to rat L6 and human L6 YCL059C KRR1 0.37 1.3 Involved in cell division and spore germination YDL145C COP1 0.37 1.2 alpha subunit of the coatamer complex; gamma-alpha-COP YPL213W LEA1 0.37 1.2 Looks Exceptionally like U2A YHR199C 0.37 0.9 YBR281C 0.37 1.3 YLR454W 0.37 1.7 YOR374W ALD4 0.37 2.8 "Glucose repressed. Utilizes NADP+ or NAD+ as a coenzyme equally well. (sold by SIGMA under the catalogue number A5550, according to A. Blomberg)." YDR313C PIB1 0.37 1.3 Phosphatidylinositol(3)-phosphate binding YGL247W BRR6 0.37 1.1 Bad Response to Refrigeration YCR012W PGK1 0.37 1.7 3-phosphoglycerate kinase YDL170W UGA3 0.37 0.9 "Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4)" YGR203W 0.37 0.8 YGL020C MDM39 0.37 1.8 Spore Wall Formation.
Mitochondrial Distribution and Morphology YIR040C 0.37 1.6 YDR234W LYS4 0.37 1.4 homoaconitase YJR102C VPS25 0.37 1.5 vacuolar protein sorting (putative) YGR077C PEX8 0.37 1.4 Required for peroxisome assembly YKR066C CCP1 0.37 1.5 Cytochrome-c peroxidase YDL046W 0.37 1.1 YKL082C 0.37 1.8 YHR017W YSC83 0.37 1.0 similar to S. douglasii YSD83 YOR234C RPL33B 0.37 1.3 Homology to rat L35a YDR201W SPC19 0.37 1.8 Spindle Pole Component of molecular weight 23kDa YDR365C 0.37 1.4 YOL059W GPD2 0.37 2.1 Involved in glycerol production via conversion of glyerol-3-phosphate and NAD+ to glycerol phosphate and NADH YHR011W DIA4 0.37 1.9 protein similar to bacterial seryl-tRNA synthases YBR204C 0.37 2.4 S YER156C 0.37 1.0 YOR265W RBL2 0.37 1.4 binds to beta-tubulin and may participate in microtubule morphogenesis YPL143W RPL33A 0.37 1.1 Homology to rat L35a YKR006C MRPL13 0.37 1.1 mitochondrial ribosomal protein YmL13 YDL147W RPN5 0.37 1.2 "Regulatory Particle Non-ATPase, homolog of mammalian proteasomal subunit p55" YBR218C PYC2 0.37 1.9 converts pyruvate to oxaloacetate YMR014W BUD22 0.37 1.2 YOR335C ALA1 0.37 0.8 Cytoplasmic alanyl-tRNA synthetase gene YGR125W 0.37 1.3 YDR021W FAL1 0.37 2.2 "Similar to eukaryotic initiation factor eIF4a; required for pre-rRNA processing at sites A0, A1, and A2; may be involved in 18S rRNA maturation" YGR213C RTA1 0.37 1.3 involved in 7-aminocholesterol resistance YDR145W TAF12 0.37 0.9 TFIID subunit (TBP-associated factor) with predicted molecular weight of 61 kD. YBL041W PRE7 0.37 1.0 proteasome subunit YHR147C MRPL6 0.37 1.3 Mitochondrial ribosomal protein MRPL6 (YmL6) YNL128W TEP1 0.37 1.4 "Similar to human tumor suppressor gene known as TEP1, MMAC1 and PTEN1" YKL007W CAP1 0.37 1.7 capping - addition of actin subunits YMR203W TOM40 0.36 1.1 Translocase of Outer Mitochondrial membrane YAR003W SWD1 0.36 2.6 S C likely involved in chromatin remodeling
member of Set1p complex YIL096C 0.36 1.1 YMR040W 0.36 1.8 YGL191W COX13 0.36 1.2 Modulates cytochrome c oxidase activity YJR008W 0.36 1.5 YPR109W 0.36 1.3 YML017W PSP2 0.36 1.3 Polymerase suppressor 2; Suppressors of group II intron-splicing defect. YPL264C 0.36 2.4 S C YGL070C RPB9 0.36 1.4 RNA polymerase II subunit YLR059C REX2 0.36 1.4 RNA exonuclease YPR061C 0.36 1.2 YKL130C SHE2 0.36 3.0 S C Required for mother cell-specific HO expression YDL052C SLC1 0.36 1.4 fatty acyltransferase homologous to E. coli plsC gene; functionally complements plsC mutants YPR060C ARO7 0.36 1.0 chorismate mutase YAL025C MAK16 0.36 1.5 putative nuclear protein YOL040C RPS15 0.36 1.9 Homology to rat S15 and E. coli S19 YIL124W AYR1 0.36 1.5 Subcellular location of Ayr1p: lipid particles and endoplasmic reticulum of the yeast YDR347W MRP1 0.36 1.0 shows allele-specific genetic interactions with pet122 and pet123 YNL111C CYB5 0.36 1.9 S cytochrome b5 YLR074C BUD20 0.36 1.4 YLR151C PCD1 0.36 2.6 S C peroxisomal nudix hydrolase active towards coenzyme A and its derivatives YNL313C 0.36 2.2 YKL078W DHR2 0.36 1.5 DEAH-box protein involved in ribosome synthesis YMR312W ELP6 0.36 1.4 "ELongator Protein 6; 30kD subunit. Homolog of ATPases, yet with substitutions of amino acids critical for ATP hydrolysis." YPR178W PRP4 0.36 1.1 Specific component of the U4/U6 and U4/U6-U5 snRNPs which associates transiently with the spliceosome before the first step of splicing. YGL145W TIP20 0.36 0.9 transport protein that interacts with Sec20p; required for protein transport from the endoplasmic reticulum to the golgi apparatus YER043C SAH1 0.36 1.1 putative S-adenosyl-L-homocysteine hydrolase YBR129C OPY1 0.36 0.9 imparts Far- phenotype YKR039W GAP1 0.36 5.1 S general amino acid permease YDL010W 0.36 4.2 S C YGL141W HUL5 0.36 2.1 ubiquitin-protein ligase (E3) YOR173W DCS2 0.36 1.4 "Similar to mRNA decapping enzyme, HIT superfamily." YOL056W GPM3 0.36 1.9 converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YLR354C TAL1 0.36 2.0 "Transaldolase, enzyme in the pentose phosphate pathway" YGR162W TIF4631 0.36 1.1 also called eIF4 (eIF-4) gamma YOR251C 0.36 1.1 YOR389W 0.36 1.3 YOL021C DIS3 0.36 0.8 Possible component of RCC1-Ran pathway YGL215W CLG1 0.36 0.8 cyclin-like protein that interacts with Pho85p in affinity chromatography YPR122W AXL1 0.36 0.9 "determinant in axial budding pattern of haploid cells, involved in processing of a-factor" YHR037W PUT2 0.36 1.6 delta-1-pyrroline-5-carboxylate dehydrogenase YCR086W CSM1 0.36 1.7 C Chromosome segregation in meiosis YKL172W EBP2 0.36 2.8 S EBNA1-binding protein homolog YER081W SER3 0.36 1.6 catalyzes the first step in serine biosynthesis; isozyme of SER33 YKR076W ECM4 0.36 1.2 ExtraCellular Mutant YMR279C 0.36 1.2 YGL044C RNA15 0.36 1.6 Protein with a role in mRNA stability and/or poly(A) tail length YER046W SPO73 0.36 1.1 Sporulation YER161C SPT2 0.36 1.0 non-specific DNA binding protein (sin1) YKL211C TRP3 0.36 0.9 anthranilate synthase Component II and indole-3-phosphate (multifunctional enzyme) YLL040C VPS13 0.36 1.1 C vacuolar Protein Sorting YML129C COX14 0.36 1.4 "Mitochondrial membrane protein, required for assembly of cytochrome c oxidase" YML093W UTP14 0.36 1.3 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YLR113W HOG1 0.36 1.2 Osmoregulation. Hog1p is activated under stress conditions when the cAMP cellular content is low. YPL117C IDI1 0.36 1.4 catalyzes activation step in isoprenoid biosynthetic pathway YLR205C HMX1 0.36 2.0 Homology to heme oxygenases YHL040C ARN1 0.36 2.3 S Transporter that specifically recognizes siderophore-iron chelates and is expressed under conditions of iron deprivation. YBR286W APE3 0.36 0.9 Aminopeptidase yscIII YHR167W THP2 0.36 1.1 affects transcription elongation YLR242C ARV1 0.36 2.2 similar to Nup120p and C.elegans R05H5.5 protein and Nup120p YJL193W 0.35 2.5 YGL037C PNC1 0.35 4.2 S NAD(+) salvage pathway gene YIL102C 0.35 1.1 YCR060W 0.35 1.2 YGL018C JAC1 0.35 0.9 may be involved in assembly/maturation of mitochondrial iron-sulfur proteins YMR111C 0.35 0.9 YEL005C VAB2 0.35 1.5 Vac8p binding protein of 31 kDa YDL045C FAD1 0.35 0.9 "Flavin adenine dinucleotide (FAD) synthetase, which performs second step in synthesis of FAD from riboflavin" YKR008W RSC4 0.35 2.3 "RSC4 is a member of RSC complex, which remodels the structure of chromatin." YGR212W 0.35 0.9 YNL175C NOP13 0.35 2.1 Nucleolar Protein 13 YJR044C VPS55 0.35 1.4 Vacuolar Protein Sorting YPR198W SGE1 0.35 1.1 multi-copy suppressor of gal11 null; member of drug-resistance protein family YCR027C RHB1 0.35 1.0 rheb homologue YJR010C-A SPC1 0.35 1.3 Homolog of the SPC12 subunit of mammalian signal peptidase complex. Protein is important for efficient signal peptidase activity. YLR367W RPS22B 0.35 1.4 Homology to rat S15a YAL060W BDH1 0.35 2.2 "(2R,3R)-2,3-butanediol dehydrogenase" YJL055W 0.35 0.9 YDL234C GYP7 0.35 1.8 GTPase-activating protein YCR002C CDC10 0.35 1.9 S cell division cycle blocked at 36 degree C YER018C SPC25 0.35 3.1 S C Spindle Pole Component of molecular weight 25kDa YEL070W 0.35 0.8 YIL049W DFG10 0.35 2.2 "Protein required for filamentous growth, cell polarity, and cellular elongation" YBR164C ARL1 0.35 1.1 Hydrolyzes GTP; myristylated; in soluble fraction. Part of the carboxypeptidase Y pathway. YEL066W HPA3 0.35 2.2 Histone and other Protein Acetyltransferase; Has sequence homology to known HATs and NATs YDR192C NUP42 0.35 1.4 interacts specifically with the HIV-1 Rev protein effector domain;
Ulp1 Interacting Protein 1 YMR295C 0.35 2.1 S YPL203W TPK2 0.35 1.1 Involved in nutrient control of cell growth and division YGL237C HAP2 0.35 1.3 Global regulator of respiratory genes YGL015C 0.35 1.3 YMR034C 0.35 1.5 YER105C NUP157 0.35 1.0 yeast nuclear pore complex component YGR058W 0.35 0.9 YDR324C UTP4 0.35 1.6 C part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YNL270C ALP1 0.35 2.8 Homologous to permeases Can1p and Lyp1p YDR131C 0.35 1.3 YHR166C CDC23 0.35 1.1 Required for mitosis and RNA synthesis YFL052W 0.35 2.6 YHR070W TRM5 0.35 1.0 tRNA modification enzyme YOR039W CKB2 0.35 1.5 "protein kinase CK2, beta' subunit" YHR087W 0.35 4.6 YDL045W-A MRP10 0.35 0.9 Involved in mitochondrial translation YOR116C RPO31 0.35 2.0 RNA polymerase III large subunit YGL169W SUA5 0.35 1.5 Protein involved in translation initiation YGL066W SGF73 0.35 1.2 SaGa associated Factor 73kDa YIL074C SER33 0.35 2.8 S catalyzes the first step in serine biosynthesis; isozyme of SER3 YNR002C FUN34 0.35 1.7 Highly homologous to Ycr010p and similar to Yarrowia lipolytica glyoxylate pathway regulator GPR1 (see MIPS); member of the TC 9.B.33 YaaH family of putative transporters YNL315C ATP11 0.35 1.9 essential for assembly of a functional F1-ATPase; binds the beta subunit of F1-ATPase. YPL201C 0.35 1.3 YBL007C SLA1 0.35 1.4 "Involved in assembly of cortical actin cytoskeleton, contains 3 SH3 domains, interacts with Bee1p" YML124C TUB3 0.35 1.5 alpha-tubulin YMR055C BUB2 0.35 2.7 S Protein required for cell cycle arrest in response to loss of microtubule function YPL215W CBP3 0.35 1.1 Protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex) YGL039W 0.35 1.6 YLL015W BPT1 0.35 0.9 bile pigment transporter YDR308C SRB7 0.35 2.2 "Suppressor of RNA polymerase II, possible component of the holoenzyme" YBR126C TPS1 0.35 2.4 "Probable regulator of glucose influx into the cell & into glycolytic pathway, indirectly regulating glucose-induced signalling (activation & inactivation) & initial step(s) of glucose metabolism. Homologue of E. coli otsA protein" YPL076W GPI2 0.35 1.2 "Required for synthesis of N-acetylglucoaminylphosphatidylinositol, the first intermediate in synthesis of glycosylphosphatidylinositol (GPI) anchors" YMR315W 0.35 1.9 YPR100W 0.35 1.4 YOR271C 0.35 1.0 YFL066C 0.35 2.9 S YML054C CYB2 0.35 1.3 "Expression is repressed by glucose and anaerobic conditions, is induced by L-lactate and is regulated by GRR1, ROX3, HAP1, HXK2 and CYC8" YIL070C MAM33 0.35 1.4 33-kDa mitochondrial acidic matrix protein YNL191W 0.35 1.8 YPR113W PIS1 0.35 2.0 phosphatidylinositol synthase YBR103W SIF2 0.35 1.8 Sir4p-Interacting Factor YLR460C 0.35 1.4 YCR093W CDC39 0.35 0.9 Required for Start B in mitosis and spindle pole body separation at meiosis I YFR008W 0.34 1.0 YJL148W RPA34 0.34 1.9 "RNA polymerase I subunit, not shared (A34.5)" YBR104W YMC2 0.34 1.2 C Mitochondrial carrier protein YJL190C RPS22A 0.34 2.1 Homology to rat S15a YKL061W 0.34 1.1 YKR004C ECM9 0.34 1.4 ExtraCellular Mutant YNR071C 0.34 1.0 YGR207C 0.34 1.2 YNL224C 0.34 0.9 YLR008C 0.34 1.0 YDL067C COX9 0.34 1.5 Plays role in cytochrome c oxidase holoenzyme assembly or stability YPR160W GPH1 0.34 2.7 S Releases glucose-1-phosphate from glycogen YNL331C AAD14 0.34 1.1 aryl-alcohol dehydrogenase located on chromosome 14 YJR012C 0.34 1.2 YGL034C 0.34 2.2 YGR009C SEC9 0.34 0.9 Putative t-SNARE of the plasma membrane YKR058W GLG1 0.34 1.2 self-glucosylating initiator of glycogen synthesis; similar to mammalian glycogenin YOL164W 0.34 1.2 YIL028W 0.34 0.8 YDL071C 0.34 1.0 YMR274C RCE1 0.34 2.8 Protease involved in ras and a-factor terminal proteolysis YGR253C PUP2 0.34 0.9 Proteasome subunit YDR015C 0.34 2.0 YNL132W KRE33 0.34 1.2 Killer toxin REsistant YPR002W PDH1 0.34 2.3 C "prpD homologue; (62% identical to the prpD genes of Escherichia coli and Salmonella typhimurium, which play an unknown but essential role in propionate catabolism)" YPL046C ELC1 0.34 1.2 "similar to mammalian elongin C, interacts with elongin A" YDR541C 0.34 1.4 YBR110W ALG1 0.34 2.5 "beta-1,4-mannosyltransferase" YOL020W TAT2 0.34 1.1 "Tryptophan permease, high affinity" YLL023C 0.34 1.2 YDL213C FYV14 0.34 2.0 Function required for Yeast Viability on toxin exposure YPR114W 0.34 1.2 YNL048W ALG11 0.34 1.4 "Specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-Glycosylation intermediate" YDR263C DIN7 0.34 1.2 DNA-damage inducible gene YDR252W BTT1 0.34 2.0 C beta subunit of the nascent-polypeptide-associated complex (NAC); homologous to human BTF3b; Negative effect on expression of several genes transcribed by RNA polymerase II YKL003C MRP17 0.34 1.2 Mitochondrial ribosomal protein MRP17 YPL103C 0.34 0.9 YDR178W SDH4 0.34 1.6 "Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone." YML021C UNG1 0.34 3.4 K S C uracil DNA glycosylase YJL170C ASG7 0.34 3.7 an a-specific gene that is induced to a higher expression level by alpha factor YLR258W GSY2 0.34 2.8 C Highly similar to GSY1. GSY2 is the predominantly expressed glycogen synthase. Activity is probably regulated by cAMP-dependent and SNF1 protein kinases and type 1 phosphatase YOL110W SHR5 0.34 0.9 Involved in RAS localization and palmitoylation YMR159C APG16 0.34 2.9 autophagy YLR250W SSP120 0.34 1.8 secretory protein YJL011C RPC17 0.34 0.9 Sspecific subunit of Pol III which participates together with C34 in the recruitment of Pol III by the preinitiation complex. YHL039W 0.34 1.3 YPL054W LEE1 0.34 2.5 S Product of gene unknown YOL044W PEX15 0.34 1.6 44 kDa phosphorylated integral peroxisomal membrane protein YGR205W 0.34 2.3 YDR071C 0.34 1.6 YML127W RSC9 0.34 1.4 Remodels the Structure of Chromatin YPL276W 0.34 1.2 YOL142W RRP40 0.34 1.2 Ribosomal RNA Processing YLR159W 0.34 2.8 YLR156W 0.34 1.8 YMR170C ALD2 0.34 1.0 Expression induced in response to high osmotic stress. NAD+ is preferred coenzyme. YOR204W DED1 0.34 1.3 "ATP-dependent RNA helicase of DEAD box family; suppressor of a pre-mRNA splicing mutation, prp8-1" YML085C TUB1 0.34 3.3 alpha-tubulin YPL191C 0.34 1.7 YDR405W MRP20 0.34 0.9 Involved in mitochondrial translation YBL026W LSM2 0.34 1.7 Like Sm-D1 protein YCR020C-A MAK31 0.34 0.9 "Like Sm protein; member of the Sm protein family, though slightly divergent because Mak31/Lsm9p does not contain a glycine or cysteine at amino acid 107." YMR051C 0.34 0.8 YJL147C 0.34 1.0 YEL064C 0.34 2.7 S YOL093W 0.34 1.4 YDL069C CBS1 0.34 1.1 translational activator of cytochrome b YOR143C THI80 0.34 1.4 Thiamin pyrophosphokinase YIR032C DAL3 0.34 1.7 ureidoglycolate hydrolase YDR321W ASP1 0.34 1.2 "Asparaginase I, intracellular isozyme" YOL116W MSN1 0.34 1.5 multicopy supressor of snf1 and sta10 mutations YMR116C ASC1 0.34 1.9 WD repeat protein (G-beta like protein) that interacts with the translational machinery YDR400W URH1 0.34 3.5 S uridine nucleosidase (uridine ribohydrolase); EC 3.2.2.3 YLL017W 0.34 1.7 YPL149W APG5 0.34 1.2 Involved in autophagy YNL306W MRPS18 0.34 0.9 YER185W 0.34 1.4 YJR137C ECM17 0.34 3.6 S C ExtraCellular Mutant YOR020C HSP10 0.34 1.3 "Homolog of E. coli GroES protein; regulates Hsp60, the yeast mitochondrial chaperonin, and is thereby involved in protein folding and sorting in mitochondria" YGR129W SYF2 0.34 2.1 SYnthetic lethal with cdcForty YGR251W 0.34 0.8 YBR211C AME1 0.34 1.7 associated with microtubules and essential YDL200C MGT1 0.34 1.4 6-O-methylguanine-DNA methylase YJR136C 0.33 1.5 YOL123W HRP1 0.33 2.1 Putative polyadenylated-RNA-binding protein located in nucleus; similar to vertebrate hnRNP A/B protein family YOL151W GRE2 0.33 2.3 induced by osmotic stress; similar to dihydroflavonol 4-reductase from plants YOR182C RPS30B 0.33 1.8 Homology to mammalian S30 YLR287C-A RPS30A 0.33 1.7 Homology to mammalian S30 YBR149W ARA1 0.33 2.2 D-arabinose dehydrogenase YNL141W AAH1 0.33 1.7 adenine aminohydrolase (adenine deaminase) YML011C 0.33 1.6 YOR190W SPR1 0.33 1.8 Sporulation regulated genes YDR514C 0.33 1.0 YDR141C DOP1 0.33 1.4 "homolog of Emericella nidulans developmental regulatory gene, dopey (dopA)." YPR131C NAT3 0.33 1.2 "Non-essential gene, growth of null mutants is retarded on both YPD & YPG media. The mating efficiency of MATalpha cells, but not MATa cells, is reduced by nearly three orders of magnitude." YPR128C ANT1 0.33 2.8 S adenine nucleotide transporter YLR264W RPS28B 0.33 1.0 Homology to mammalian S28 YGR157W CHO2 0.33 1.2 First step in the methylation pathway for phosphatidylcholine biosynthesis YDR102C 0.33 1.3 YKR074W 0.33 1.0 YMR228W MTF1 0.33 1.1 Mitochondrial RNA polymerase specificity factor YNL161W CBK1 0.33 1.3 cell wall biosynthesis kinase YBR094W 0.33 2.4 S YLR271W 0.33 0.9 YNL210W MER1 0.33 1.6 "Disp. for axial elements in meiosis but required for full chr. pairing & chr. condensation seen by in situ hybridization, wt level of synaptonemal complexes, heteroduplex DNA, gene conversion & reciprocal recombination & spore viability" YBL001C ECM15 0.33 2.7 ExtraCellular Mutant YEL004W YEA4 0.33 1.8 "Shows sequence similarity to GOG5, a gene involved in vanadate resistance" YHL047C ARN2 0.33 1.0 Siderophore transporter for triacetylfusarinine C YPL262W FUM1 0.33 1.4 Fumarase converts l-malate to fumarate as part of the TCA cycle YMR076C PDS5 0.33 3.6 S C Precocious Dissociation of Sister chromatids YLR340W RPP0 0.33 2.5 "Homology to rat P0, human P0, and E. coli L10e" YGL096W TOS8 0.33 1.3 Target of SBF YPR167C MET16 0.33 2.7 S C 3'phosphoadenylylsulfate reductase YGR076C MRPL25 0.33 1.1 Mitochondrial ribosomal protein MRPL25 (YmL25) YGR186W TFG1 0.33 1.1 Transcription factor TFIIF large subunit YDR407C TRS120 0.33 1.1 targeting complex (TRAPP) component involved in ER to Golgi membrane traffic YOR326W MYO2 0.33 2.3 class V myosin YOR311C HSD1 0.33 1.8 ER membrane protein YMR285C NGL2 0.33 1.2 correct 3'-end formation of 5.8S rRNA at site E is strictly dependent on Ngl2p. YCR104W PAU3 0.33 1.5 member of the seripauperin protein/gene family (see Gene_class PAU) YNL004W HRB1 0.33 0.8 an ORF of unknown function located in a centromeric region duplicated between chromosomes III and XIV YPR072W NOT5 0.33 0.8 "member of the NOT complex, a global negative regulator of transcription" YFL010W-A AUA1 0.33 1.7 Involved in ammonia regulation of GAP1 activity YBR252W DUT1 0.33 1.5 C dUTP metabolism YHR209W 0.33 2.0 YDR127W ARO1 0.33 0.8 "pentafunctional arom polypeptide (contains: 3-dehydroquinate synthase, 3-dehydroquinate dehydratase (3-dehydroquinase), shikimate 5-dehydrogenase, shikimate kinase, and epsp synthase)" YNL172W APC1 0.33 2.6 S anaphase-promoting complex component YFR007W 0.33 1.1 YGR277C 0.33 1.4 YBR236C ABD1 0.33 1.2 RNA (guanine-7-)methyltransferase (cap methyltransferase) YGR255C COQ6 0.33 1.8 Involved in ubiquinone biosynthesis YPR147C 0.33 1.3 YOR115C TRS33 0.33 1.6 S Trapp subunit of 33 kDa YKL209C STE6 0.33 2.3 S "ABC transporter, glycoprotein, component of a-factor secretory pathway" YGR168C 0.33 1.7 YOR147W MDM32 0.33 1.2 Mitochondrial Distribution and Morphology YLR168C 0.33 2.1 YJL026W RNR2 0.33 1.1 small subunit of ribonucleotide reductase YKL056C 0.33 1.7 YDR350C TCM10 0.33 0.9 Product of gene unknown YBR016W 0.33 1.8 YPL055C LGE1 0.33 1.6 large cell size mutant YKL167C MRP49 0.33 1.3 16 kDa mitochondrial ribosomal large subunit protein YBL015W ACH1 0.33 0.9 Mannose-containing glycoprotein which binds concanavalin A YGL222C EDC1 0.33 1.6 Enhancer of mRNA Decapping YHR084W STE12 0.33 1.6 Involved in pheromone and pseudohyphal growth signal transduction pathways YDR432W NPL3 0.33 1.6 S "involved as a protein carrier in mRNA export, involved in mitochondrial protein targeting" YKL184W SPE1 0.33 1.5 Rate limiting step of polyamine biosynthesis pathway YNL023C FAP1 0.33 1.1 FKBP12-associated protein YKL223W 0.33 2.2 YJR122W CAF17 0.33 1.2 CCR4 associated factor YLR070C XYL2 0.33 1.4 XYLitol Dehydrogenase YDR408C ADE8 0.33 0.9 glycinamide ribotide transformylase YCR024C-A PMP1 0.33 5.2 S May regulate plasma membrane H(+)-ATPase YBL069W AST1 0.33 3.3 Protein involved in targeting of plasma membrane [H+]ATPase YGR155W CYS4 0.33 1.0 encodes the first enzyme in cysteine biosynthesis YKL035W UGP1 0.33 3.1 S EC:2.7.7.9
UDP-glucose pyrophosphorylase or UTP-glucose-1-phosphate uridylyltransferase YER101C AST2 0.33 0.8 Protein involved in targeting of plasma membrane [H+]ATPase YJR069C HAM1 0.33 1.0 Product of gene unknown YNL200C 0.33 3.0 YLR117C CLF1 0.33 0.8 "SYnthetic lethal with cdcForty; Crooked neck Like Factor, an ortholog of the Drosophila crooked neck gene, crn" YML110C COQ5 0.33 3.2 S C co-enzyme Q deficient YMR013C SEC59 0.33 1.5 "catalyzes the CTP-mediated phosphorylation of dolichol, the terminal step in dolichyl monophosphate (Dol-P) biosynthesis. required for viability, normal rates of lipid intermediate synthesis, protein N-glycosylation." YPL171C OYE3 0.33 2.0 Old yellow enzyme YKL120W OAC1 0.33 1.8 oxaloacetate carrier YGL246C RAI1 0.33 1.4 Product of gene unknown YAL032C PRP45 0.33 1.0 "protein required for pre-mRNA splicing in vivo and in vitro, associated with the spliceosome, weakly associated with U2, U5 and U6 snRNPs" YKR063C LAS1 0.33 1.0 May regulate expression of genes involved in bud formation and morphogenesis YJL213W 0.33 0.8 YOR167C RPS28A 0.33 1.9 Homology to mammalian S28 YGL127C SOH1 0.33 1.7 "Soh1p has limited sequence similarity to RNA polymerases and interacts with a DNA repair protein, Rad5p, in a two-hybrid system assay; may provide a link between recombination in direct repeats and transcription" YGL224C SDT1 0.33 1.1 suppressor of deletion of TFIIS YPL263C KEL3 0.33 1.5 "Kelch-repeat protein, similar to Kel1 and Kel2" YNL156C 0.32 0.8 YNL241C ZWF1 0.32 1.3 Glucose-6-phosphate dehydrogenase YOL126C MDH2 0.32 1.8 cytosolic malate dehydrogenase YKL142W MRP8 0.32 2.8 mitochondrial ribosomal protein YLR201C 0.32 1.6 YDL029W ARP2 0.32 1.4 Involved in endocytosis and membrane growth and polarity YLR007W NSE1 0.32 1.1 non-SMC element 1. essential for cell proliferation. YHR194W MDM31 0.32 0.9 Mitochondrial Distribution and Morphology YCR034W FEN1 0.32 2.5 C "Involved in synthesis of 1,3-beta-glucan, a component of the cell wall, and elongation of fatty acids up to 24 carbons" YOR349W CIN1 0.32 0.9 "Protein involved in chromosome segregation, required for microtubule stability" YFR031C-A RPL2A 0.32 1.0 Homology to rat L8 and E. coli L2 YDL193W 0.32 1.6 YIR035C 0.32 1.9 YKL206C 0.32 0.9 YCR081W SRB8 0.32 1.2 activation mediator subcomplex of RNA polymerase I holoenzyme YJR140C HIR3 0.32 0.9 Involved in cell-cycle regulation of histone transcription YNR027W BUD17 0.32 0.8 YOR064C YNG1 0.32 1.8 Yeast homolog of mammalian Ing1 YDL246C 0.32 0.9 YNL112W DBP2 0.32 1.8 ATP-dependent RNA helicase of DEAD box family YOL039W RPP2A 0.32 1.0 "Homology to rat P2, human P2, and E.coli L12eIB" YBL093C ROX3 0.32 1.3 RNA polymerase II holoenzyme/mediator subunit YGL004C 0.32 1.2 YBL064C 0.32 2.9 S YOL008W 0.32 2.2 YLR247C 0.32 1.4 YBR096W 0.32 1.6 YBR019C GAL10 0.32 1.5 UDP-glucose 4-epimerase YDR468C TLG1 0.32 1.0 member of the syntaxin family of t-SNAREs YHR106W TRR2 0.32 2.2 S mitochondrial thioredoxin reductase YOL049W GSH2 0.32 1.0 Glutathione Synthetase YGR037C ACB1 0.32 1.8 Involved in transport of newly synthesized acyl-CoA esters from the fatty acid synthetase to acyl-CoA-consuming processes YML001W YPT7 0.32 1.5 "Gtp-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, and for fusion of endosomes to vacuoles when expressed from high copy plasmid" YBR034C HMT1 0.32 1.0 hnRNP methyltransferase YNL010W 0.32 0.9 YKL221W MCH2 0.32 1.4 monocarboxylate permease homologue YHR210C 0.32 1.4 YJL167W ERG20 0.32 1.2 May be rate-limiting step in sterol biosynthesis pathway YFL034C-B MOB2 0.32 0.8 Mps One Binder YER153C PET122 0.32 1.3 translational activator of cytochrome c oxidase subunit III YDR287W 0.32 1.2 YKL224C 0.32 1.1 YMR240C CUS1 0.32 0.8 cold sensitive U2 snRNA Suppressor YCR075C ERS1 0.32 2.1 Suppressor of ERD1 mutation; seven transmembrane domain protein YBR108W 0.32 4.3 S YHR162W 0.32 1.2 YDR513W TTR1 0.32 1.6 Glutaredoxin (thioltransferase) (glutathione reductase) YAL061W 0.32 1.5 YIL104C SHQ1 0.32 2.3 S required for SnoRNAs of the box H/ACA Quantitative accumulation YBR035C PDX3 0.32 0.9 pyridoxine (pyridoxiamine) phosphate oxidase YGL220W 0.32 1.0 YER141W COX15 0.32 1.2 cytochrome oxidase assembly factor YOR294W RRS1 0.32 1.0 Regulator for ribosome synthesis YNL223W AUT2 0.32 1.5 Involved in autophagy. Interacts with Tub1p and Tub2p and forms a complex with Aut7p. Required for sporulation. YMR183C SSO2 0.32 2.9 S SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion YDR512C EMI1 0.32 1.9 Early Meiotic Induction YOR285W 0.32 1.2 YHR013C ARD1 0.32 0.9 subunit of the major N alpha-acetyltransferase; complexes with Nat1p YJL203W PRP21 0.32 1.1 RNA splicing factor YAR073W IMD1 0.32 1.8 IMP dehydrogenase homolog YPR085C 0.32 1.0 YBR053C 0.32 3.2 S C YGR043C 0.32 1.6 YMR288W HSH155 0.32 0.8 YEL035C UTR5 0.32 2.1 Product of gene unknown YOR329C SCD5 0.32 1.2 Multicopy suppressor of clathrin deficiency and of ts mutants of IPL1 YLR179C 0.32 1.5 YKL194C MST1 0.32 1.5 mitochondrial threonine-tRNA synthetase YGL053W PRM8 0.32 1.8 pheromone-regulated membrane protein YFL065C 0.32 3.8 S YNL262W POL2 0.32 5.2 K Z S C DNA polymerase II YJR011C 0.32 1.6 YDR480W DIG2 0.32 2.5 "Down-regulator of Invasive Growth, Regulator of Sterile Twelve" YFL040W 0.32 1.6 YNL227C 0.31 1.3 YMR247C 0.31 1.1 YPR041W TIF5 0.31 1.4 "eIF5 mediates hydrolysis of eIF2-GTP (SUI2,SUI3,GCD11) at start codons" YOR340C RPA43 0.31 1.5 DNA-dependent RNA polymerase I subunit A43 YGL198W 0.31 1.0 YER131W RPS26B 0.31 1.9 Homology to rat S26 YCR007C 0.31 2.8 YML092C PRE8 0.31 1.1 proteasome component Y7 YOR193W 0.31 1.2 YER117W RPL23B 0.31 1.3 Homology to rat L23 and E. coli L14 YOR242C SSP2 0.31 1.1 S Sporulation SPecific YBL087C RPL23A 0.31 1.9 Homology to E. coli L14 and rat L23 YML047C PRM6 0.31 2.2 pheromone-regulated membrane protein YLR295C ATP14 0.31 0.8 ATP synthase subunit h YPR158W 0.31 1.4 YNR074C 0.31 1.3 YHL001W RPL14B 0.31 1.0 Homology to mammalian L14 YCL064C CHA1 0.31 4.6 catabolism of hydroxy amino acids YDL082W RPL13A 0.31 1.0 Homology to rat L13 YGL022W STT3 0.31 2.3 Required for protein glycosylation YLL048C YBT1 0.31 1.4 "Yeast bile transporter, similar to mammalian bile transporter" YMR318C ADH6 0.31 1.2 NADPH-dependent alcohol dehydrogenase YOR213C SAS5 0.31 0.9 "Involved in silencing at telomeres, HML and HMR" YFR038W 0.31 1.5 C YGL040C HEM2 0.31 1.2 "converts delta-aminolevulinic acid to porphobilinogen, an intermediate in the synthesis of heme" YDR441C APT2 0.31 0.8 similar to adenine phosphoribosyltransferase; appears to be a nonfunctional pseudogene YLR016C 0.31 1.4 YMR022W QRI8 0.31 1.6 part of the HRDDER pathway of ER-associated protein degradation YBR175W SWD3 0.31 1.2 likely involved in chromatin remodeling
member of Set1p complex YDR302W GPI11 0.31 3.3 Z S Glycosylphosphatidylinositol (GPI) assembly YKL197C PEX1 0.31 1.1 member of the AAA-protein family YJR033C RAV1 0.31 1.1 Regulator of (H+)-ATPase in vacuolar membrane YJR014W 0.31 1.0 YDR511W ACN9 0.31 1.9 C YMR027W HRT2 0.31 0.8 "High level expression reduced Ty3 Transposition. Do not confuse with HRT1/HRT2/RBX1/ROC1/YOL133W, which has been referred to as HRT2 in Swaroop et al (2000) Oncogene 19:2855-66." YNL052W COX5A 0.31 1.0 "One of two genes (COX5A and COX5B, both nuclear-encoded) coding for subunit V of cytochrome c oxidase; COX5A gene product is the predominantform of subunit V found in holocytochrome c oxidase under normal growth conditions" YML053C 0.31 1.9 YDR357C 0.31 1.8 YCL047C 0.31 1.3 YBL004W UTP20 0.31 2.4 U3 protein YDR066C 0.31 1.3 YKL186C MTR2 0.31 1.3 mRNA transport regulator YIR029W DAL2 0.31 0.9 allantoicase YDR435C PPM1 0.31 1.4 carboxy methyl transferase for protein phosphatase 2A catalytic subunit YKR049C 0.31 1.8 YPL134C ODC1 0.31 1.8 Oxodicarboxylate carrier YML079W 0.31 1.2 YHR191C CTF8 0.31 1.2 (putative) kinetochore protein YBR076W ECM8 0.31 0.8 ExtraCellular Mutant YJL154C VPS35 0.31 1.3 Protein involved in vacuolar sorting YBL088C TEL1 0.31 1.8 Involved in controlling telomere length; ataxia telangiectasia (ATM) gene homolog YNR058W BIO3 0.31 1.4 biotin biosynthesis YDR023W SES1 0.31 1.0 seryl-tRNA synthetase YDL233W 0.31 1.3 YER042W MXR1 0.31 3.0 S peptide Methionine sulfoXide Reductase 1 YLR326W 0.31 3.9 Z S C YDR341C 0.31 0.9 YMR030W 0.31 2.1 YOR257W CDC31 0.31 1.4 "Required for spindle pole body duplication and mitosis in meiosis II; calcium-binding protein component of spindle pole bodies, localizes to half-bridges and interacts with KAR1" YIR041W 0.31 1.2 YKL132C 0.31 2.2 YBR228W SLX1 0.31 1.2 YGR214W RPS0A 0.31 1.4 Homology to rat Sa YFL061W 0.31 2.5 YNL335W 0.31 1.5 YDL102W CDC2 0.31 3.0 K S "essential for mitotic and meiotic DNA synthesis, dispensable for meiotic spindle pole body duplication, but required for synaptonemal complexes and full intragenic recombination, spindle pole body separation and spindle formation" YIL009W FAA3 0.31 4.8 S C "acyl-CoA synthetase (long-chain fatty acid CoA ligase) (fatty acid activator 3), activates endogenous but not imported fatty acids and provides substrates for N-myristoylation" YMR189W GCV2 0.31 3.5 S Glycine CleaVage system YPL012W RRP12 0.31 1.1 Required for normal pre-rRNA Processing. Member of a group of seven genes whose expression is repressed during growth on glucose before and during the diauxic shift. YDR502C SAM2 0.31 1.9 methionine biosynthesis regulation YBR253W SRB6 0.31 0.9 involved in transcription as part of Srb/Mediator complex YLR404W 0.31 1.0 YJR100C 0.31 0.8 YDR135C YCF1 0.31 1.1 Metal resistance protein with similarity to human cystic fibrosis protein CFTR and multidrug resistance proteins YIL119C RPI1 0.31 4.4 S inhibitor of ras YIR013C GAT4 0.31 1.6 very short and so far mRNA can't be detected YPL063W 0.31 0.8 YPR183W DPM1 0.31 2.5 dolichol phosphate mannose synthase YDR364C CDC40 0.31 1.1 "Required for proper timing of DNA synthesis at all temperatures and completion of DNA synthesis at a restrictive temperature in both mitosis and meiosis, and for completion of meiotic recombination, meiosis I, meiosis II and spores" YNL110C NOP15 0.30 1.5 Nucleolar protein 15 YBL020W RFT1 0.30 1.5 67 kDa integral membrane protein YLR307W CDA1 0.30 1.1 Required for proper formation of the ascospore wall YLR276C DBP9 0.30 1.1 Dead-Box Protein 9 YNL195C 0.30 1.5 YLR243W 0.30 1.1 YGL073W HSF1 0.30 1.2 heat shock transcription factor YLR136C TIS11 0.30 2.9 "Zinc finger containing homolog of mammalian TIS11, glucose repressible gene" YOR087W YVC1 0.30 1.5 vacuolar cation channel YER123W YCK3 0.30 1.2 plasma membrane-bound casein kinase I homolog YLR128W 0.30 1.3 YER174C GRX4 0.30 1.2 "Member of a glutaredoxin subfamily in Sc together with GRX3 & GRX5. Significant sequence diff. with the other glutaredoxin subfamily, formed by the previously described GRX1 & GRX2 glutaredoxins (Luikenhuis MBC 9:1081, 1998)" YJR057W CDC8 0.30 1.3 K "essential for mitotic DNA synthesis. Required for premeiotic DNA synthesis, synaptonemal complexes, recombination, meiosis I, meiosis II, and spores" YGR254W ENO1 0.30 1.6 enolase I YER142C MAG1 0.30 1.3 3-methyladenine DNA glycosylase YHR153C SPO16 0.30 4.7 Z S C Early meiotic protein required for efficient spore formation YHR091C MSR1 0.30 1.3 Nuclear-encoded mitochondrial protein YLR462W 0.30 4.9 Z S YGR178C PBP1 0.30 0.8 Poly(A)-binding protein binding protein YLR043C TRX1 0.30 0.9 thioredoxin YDR489W 0.30 2.0 YGL205W POX1 0.30 0.8 fatty-acyl coenzyme A oxidase YLR372W SUR4 0.30 2.6 Z S Required for conversion of 24-carbon fatty acids to 26-carbon species YBR251W MRPS5 0.30 1.5 Probable mitochondrial ribosomal protein S5 YGR078C PAC10 0.30 1.2 "Polypeptide 3 of a Yeast Non-native Actin Binding Complex, homolog of a component of the bovine NABC complex" YIL161W 0.30 1.4 YBR208C "DUR1,2" 0.30 1.5 Urea amidolyase (contains urea carboxylase and allophanate hydrolase) YPR033C HTS1 0.30 0.9 Nuclear gene that specifies two messages for cytoplasmic and mitochondrial forms YMR271C URA10 0.30 1.5 Fifth step in pyrimidine bio5 YJR108W ABM1 0.30 0.9 aberrant microtubules YDR354W TRP4 0.30 1.3 anthranilate phosphoribosyl transferase YKL006W RPL14A 0.30 0.9 Homology to mammalian L14 YGR072W UPF3 0.30 1.7 factor stimulating decay of mRNAs containing premature stop codons; acts with Nmd2p and Nam7p YOL076W MDM20 0.30 1.7 Mitochondrial distribution and morphology YIR015W RPR2 0.30 1.2 RNase P Ribonucleoprotein - name given to subunits that are unique to RNase P (not subunits of RNase MRP) YER066W 0.30 1.2 YBR029C CDS1 0.30 1.3 "CDP-diacylglycerol synthase, CTP-phosphatidic acid cytidylyltransferase, CDP-diglyceride synthetase" YCR010C ADY2 0.30 1.3 Accumulation of DYads; member of the TC 9.B.33 YaaH family of putative transporters YJR135C MCM22 0.30 1.5 Required for maintenance of chromosomes and minichromosomes YKR081C RPF2 0.30 1.8 YJR070C 0.30 1.4 YDL232W OST4 0.30 1.5 subunit or accessory component of oligosaccharyltransferase YKL059C MPE1 0.30 1.4 Protein required for cell viability YCL057W PRD1 0.30 0.9 Saccharolysin (oligopeptidase yscD) YBR024W SCO2 0.30 1.3 Originally identified as a multicopy suppressor of a respiratory defective mutant; homolog of Sco1p YMR066W SOV1 0.30 0.9 Synthesis Of Var YML046W PRP39 0.30 1.4 May function to facilitate or stabilize the interaction between U1 snRNP and the 5' splice site in pre-mRNAs YBR227C MCX1 0.30 1.5 "Mitochondrial ATP-binding protein, similar to ClpX" YPL048W CAM1 0.30 1.2 Calcium and phospholipid binding protein homologous to translation elongation factor 1-gamma (EF-1gamma) YLL025W 0.30 1.4 YBR243C ALG7 0.30 4.0 Z S ER protein that transfers Glc-Nac-P from UDP-GlcNac to Dol-P YDR177W UBC1 0.30 1.2 ubiquitin-conjugating enzyme YBR293W 0.30 0.8 YDL002C NHP10 0.30 1.1 Non-Histone Protein 10 YDL235C YPD1 0.30 0.9 Ypd1p is an intermediate protein between Sln1p and Ssk1p in the phosphorelay reaction. YBR210W 0.30 0.9 YBR097W VPS15 0.30 1.4 myristoylated protein kinase involved in vacuolar protein sorting YHR179W OYE2 0.30 1.6 "NAPDH dehydrogenase (old yellow enzyme), isoform 2" YOR266W PNT1 0.30 0.9 Involved in targeting of proteins to the mitochondrial inner membrane; Pentamidine resistance protein YIL166C 0.30 1.7 YGL248W PDE1 0.30 0.9 "3',5'-Cyclic-nucleotide phosphodiesterase, low affinity" YNL038W GPI15 0.30 1.5 Glysosyl Phosphatidyl Inositol YFR052W RPN12 0.30 1.2 Part of 26S proteasome complex that may activate Cdc28p YJR145C RPS4A 0.30 2.3 Homology to rat S4 and human S4 YPL111W CAR1 0.30 2.5 S arginase YOR164C 0.30 0.8 YGL189C RPS26A 0.30 2.8 Homology to rat S26 YGR132C PHB1 0.30 0.9 antiproliferative protein involved in determination of replicative life span YLR403W SFP1 0.30 2.0 Inhibits nuclear protein localization when present in multiple copies YPL025C 0.30 2.3 S YJR034W PET191 0.30 1.0 Required for assembly of active cytochrome c oxidase YPR057W BRR1 0.30 1.7 Protein involved in snRNP biogenesis YKR052C MRS4 0.30 1.1 "mitochondrial carrier protein, highly homologous to Mrs3p" YDR185C 0.30 0.9 YPL051W ARL3 0.30 1.2 Similar to ADP-ribosylation factor. Part of the carboxypeptidase Y pathway. YOR314W 0.30 4.0 S YJL003W COX16 0.30 1.1 Cytochrome oxidase assembly YBR144C 0.30 1.7 YPR164W MMS1 0.30 1.7 "sensitive to methyl methanesulfonate (MMS), diepoxybutane, and mitomycin C" YPL232W SSO1 0.30 2.3 S SSO1 and SSO2 encode syntaxin homologs (post-Golgi t-SNAREs); act in late stages of secretion YDR368W YPR1 0.30 2.2 S C homologous to the aldo-keto reductase protein family YLR450W HMG2 0.29 1.8 Induces cells to assemble peripheral ER membrane arrays and short nuclear-associated membrane stacks. Rate-limiting enzyme in sterol biosynthesis. YGL232W 0.29 1.0 YOR181W LAS17 0.29 1.1 "Homolog of human WASP, proline-rich protein" YNL015W PBI2 0.29 3.9 S Proteinase inhibitor that inhibits protease Prb1p (yscB or IB2) YDR161W TCI1 0.29 1.2 protein phosphatase Two C-Interacting protein YOR246C 0.29 2.2 YHR044C DOG1 0.29 1.4 2-deoxyglucose-6-phosphate phosphatase YOL009C MDM12 0.29 1.8 Required for normal mitochondrial morphology and distribution YOR354C MSC6 0.29 1.8 Meiotic Sister-Chromatid recombination YMR314W PRE5 0.29 1.1 alpha-type of subunit of 20S proteasome YBR105C VID24 0.29 1.0 also involved in vacuolar protein targeting YDR254W CHL4 0.29 1.7 Protein necessary for stability of ARS-CEN plasmids; suggested to be required for kinetochore function YOL160W 0.29 1.2 YGR224W AZR1 0.29 1.5 MFS-MDR YNL162W RPL42A 0.29 1.0 Homology to rat L36a and human L36a YHR141C RPL42B 0.29 0.9 Homology to rat L36a and human L36a YPR094W RDS3 0.29 1.3 Protein required for cell viability YBR011C IPP1 0.29 1.0 Inorganic pyrophosphatase YFR004W RPN11 0.29 1.1 Suppressor of mutant (ts on glycerol) tRNA gene deficient in the processing of its 3'-end; homologous to S. pombe PAD1 gene - global positive regulator of nuclear transcription and is involved in maintenance of chromatin structure YDL112W TRM3 0.29 1.5 Trna ribose methylase YKL029C MAE1 0.29 2.7 Mitochondrial malic enzyme YMR187C 0.29 0.8 YLR329W REC102 0.29 1.2 "Dispensable for mitotic recombination, DNA damage repair, axial elements & meiotic chromosome condensation; required for wild-type level of chromosome pairing seen by in situ hybridization, tripartite synaptonemal complexes" YBR194W 0.29 1.4 YEL016C 0.29 2.0 YNL126W SPC98 0.29 4.3 S C Involved in microtubule organization by the SBP YDR032C PST2 0.29 1.9 Protoplasts-SecreTed protein; the gene product was detected among the proteins secreted by regenerating protoplasts YJL208C NUC1 0.29 1.2 mitochondrial nuclease YJL104W MIA1 0.29 1.5 Hypothetical ORF YDR305C HNT2 0.29 0.9 "Fhit homolog, member of the histidine triad superfamily of nucleotide binding-proteins" YOL043C NTG2 0.29 1.3 Endonuclease III-like glycosylase YJR055W HIT1 0.29 1.1 Protein required for growth at high temperature YNL320W 0.29 1.2 YLR203C MSS51 0.29 0.9 Protein required for the maturation and translation of COX1 mRNA YDL201W TRM8 0.29 1.0 Transfer RNA methyltransferase YKL150W MCR1 0.29 1.5 C NADH-cytochrome b5 reductase YNR003C RPC34 0.29 1.2 34-kDa subunit of RNA polymerase III (C) YGR192C TDH3 0.29 2.0 Glyceraldehyde-3-phosphate dehydrogenase 3 YOL158C ENB1 0.29 3.1 S Siderophore transporter for enterobactin; AFT1 regulon YBR025C 0.29 0.8 YGR008C STF2 0.29 2.1 ATPase stabilizing factor YCL001W RER1 0.29 1.4 "Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi, where it may function in returning membrane proteins to the ER" YNL290W RFC3 0.29 2.2 RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YNR016C ACC1 0.29 1.5 C acetyl-CoA carboxylase YPL198W RPL7B 0.29 1.2 Homolog of mammalian ribosomal protein L7 and E. coli L30 YDR179C CSN9 0.29 2.4 C Cop9 Signalosome(CSN) YLR231C BNA5 0.29 1.2 S Biosynthesis of Nicotinic Acid YPL088W 0.29 2.5 YNR062C 0.29 1.5 YHR054C 0.29 1.0 YGL170C SPO74 0.29 1.8 Sporulation YLL005C SPO75 0.29 1.9 Sporulation YLR109W AHP1 0.29 3.2 thioredoxin peroxidase YER054C GIP2 0.29 1.8 "Glc7-interacting protein; shares homology with PIG2; contains conserved 25 residue motif, called the GVNK motif, also found in GAC1, PIG1, PIG2, and RGI, the mammalian type 1 phosphatase targeting subunit." YDL022W GPD1 0.29 2.2 glycerol-3-phosphate dehydrogenase YMR130W 0.29 1.0 YGR016W 0.29 1.0 YJR024C 0.29 0.9 YEL017C-A PMP2 0.29 3.4 May regulate plasma membrane H(+)-ATPase; nearly identical to PMP1 YOR388C FDH1 0.29 1.8 Protein with similarity to formate dehydrogenases YOR332W VMA4 0.29 2.2 S vacuolar ATPase V1 domain subunit E (27 kDa) YGR135W PRE9 0.29 1.0 proteasome component Y13 YDL047W SIT4 0.29 1.6 SIT4 suppress mutations in DBF2 YBR040W FIG1 0.29 3.8 "Factor-Induced Gene 1: expression is induced by the mating pheromones, a and alpha factor; required for efficient mating" YJR152W DAL5 0.29 0.9 allantoate permease YDL130W RPP1B 0.29 1.7 "Homology to rat P1, human P1, and E. coli L12eIIB" YDR437W 0.29 1.6 YER135C 0.29 1.9 YNR012W URK1 0.29 1.9 converts ATP and uridine to ADP and UMP YFL029C CAK1 0.29 0.9 binds and phosphorylates Cdc28p YER073W ALD5 0.29 1.3 Utilizes NADP+ as the preferred coenzyme. Activated by K+. YJL091C 0.29 2.7 S YDL077C VAM6 0.29 1.6 Required for the vacuolar morphogenesis in yeast YFR025C HIS2 0.29 1.0 Histidinolphosphatase YJR009C TDH2 0.29 2.1 glyceraldehyde 3-phosphate dehydrogenase YCR102C 0.29 1.5 YNL107W YAF9 0.29 0.9 Yeast homolog of the human leukemogenic protein AF9; member of a yeast chromatin modifying complex YER062C HOR2 0.28 2.1 RHR2 (GPP1) encodes another DL-glycerol-3-phosphatase YPR203W 0.28 5.3 Z S YHR024C MAS2 0.28 1.0 53 kDa subunit of the mitochondrial processing protease YBR087W RFC5 0.28 2.2 S RFC is a multisubunit DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YMR088C 0.28 1.3 YIL167W 0.28 4.0 S C YJL060W BNA3 0.28 3.2 S Biosynthesis of Nicotinic Acid YNL274C 0.28 2.7 YPL041C 0.28 1.9 YLR270W DCS1 0.28 2.6 trehalase-associated protein; hydrolase in the HIT superfamily. YLR420W URA4 0.28 1.2 Third step in pyrimidine biosynthesis pathway YCR092C MSH3 0.28 0.8 "acts in mismatch repair in mitosis and meiosis but to a lesser extent than MSH2, required for microsatellite stability" YDL104C QRI7 0.28 1.6 similar to H.influenzae sialoglycoprotease YLR224W 0.28 1.1 YCL037C SRO9 0.28 1.7 C Associates with translating ribosomes; may function in the cytoplasm to modulate mRNA translation; may be involved in organization of actin filaments YKL141W SDH3 0.28 1.0 "Yeast succinate dehydrogenase (SDH) is a tetramer of non-equivalent subunits--Sdh1p, Sdh2p, Sdh3p, Sdh4p--that couples the oxidation of succinate to the transfer of electrons to ubiquinone." YBL050W SEC17 0.28 1.2 peripheral membrane protein required for vesicular transport between ER and Golgi
similar to alpha-SNAP
part of cis-SNARE complex
required for 'priming' step in homotypic vacuole fusion YBR052C 0.28 3.5 C YDL059C RAD59 0.28 1.0 Involved in mitotic recombination YOR287C 0.28 1.9 YKL157W APE2 0.28 1.6 "Removal of intron fused YKL158W and YKL157W (Davis et al.(2000) NAR 28:1700-6)." YPL028W ERG10 0.28 0.9 induced under stress conditions YPR166C MRP2 0.28 1.0 14 kDa mitochondrial ribosomal protein; homologous to E. coli S14 protein YMR009W 0.28 1.4 YMR060C TOM37 0.28 1.2 Translocase of the Outer Mitochondrial membrane YMR209C 0.28 0.8 YLR180W SAM1 0.28 3.0 Z S S-adenosylmethionine synthetase YDL178W DLD2 0.28 1.1 "D-lactate dehydrogenase, located in mitochondrial matrix" YBR004C 0.28 1.4 YDR258C HSP78 0.28 3.0 Similar to E. coli ClpB protein; involved in folding of some mitochondrial proteins YIR024C GIF1 0.28 1.0 G1 Factor needed for normal G1 phase YDR367W 0.28 1.6 YPR127W 0.28 1.6 YOR258W HNT3 0.28 2.0 S "histidine triad superfamily, third branch" YGL111W NSA1 0.28 1.6 Nop seven associated YGR256W GND2 0.28 1.9 "6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2" YPL082C MOT1 0.28 1.3 involved in TBP (TATA-binding protein) regulation YGR075C PRP38 0.28 0.9 RNA splicing factor YER145C FTR1 0.28 2.9 S "high-affinity iron transporter, primarily expressed under oxygenated conditions." YER051W 0.28 0.9 YBL108W 0.28 2.1 YKR105C 0.28 1.5 YKL144C RPC25 0.28 0.8 Subunit of RNA polymerase III YDL006W PTC1 0.28 1.3 serine-threonine protein phosphatase YAL062W GDH3 0.28 2.1 Involved in glutamate biosynthesis YER074W RPS24A 0.28 1.0 Homology to rat S24 YIL069C RPS24B 0.28 1.0 Homology to rat S24 YGL076C RPL7A 0.28 0.8 Homology to rat L7 and E. coli L30 YOR375C GDH1 0.28 1.4 NADP-specific glutamate dehydrogenase YKL026C GPX1 0.28 1.6 Glutathione peroxidase paralogue YLR211C 0.28 1.3 YIL157C 0.28 1.5 YPL071C 0.28 1.4 YOR365C 0.28 0.8 YLR186W EMG1 0.28 0.9 Essential for Mitotic Growth YMR175W SIP18 0.28 1.1 Salt-Induced Protein YHL014C YLF2 0.28 0.9 Protein with weak similarity to B. subtilis GTP-binding protein and to human glycogen phosphorylases YLR011W LOT6 0.28 0.9 LOw Temperature responsive YKL114C APN1 0.28 1.2 major apurinic/apyrimidinic endonuclease/3'-repair diesterase YIL015C-A 0.28 2.7 YBR183W YPC1 0.28 1.6 Yeast Phyto-ceramidase YPR068C HOS1 0.28 0.9 "Protein with similarity to Hda1p, Rpd3p, Hos2p, and Hos3p" YIL008W URM1 0.28 1.1 ubiquitin-like protein YOR077W RTS2 0.28 1.7 similar to mouse KIN7 protein YGR210C 0.28 1.2 YHR089C GAR1 0.28 1.1 small nucleolar RNP proteins YNL044W YIP3 0.28 1.8 Interacts with YPT proteins YKL216W URA1 0.28 0.9 The enzyme catalyzes the conversion of dihydroorotic acid to orotic acid YHL041W 0.28 1.8 YOR185C GSP2 0.28 1.8 "maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras superfamily" YIR042C 0.28 2.2 YGR020C VMA7 0.28 1.3 vacuolar H-ATPase 14 kDa subunit (subunit F) of the catalytic (V1) sector YGL106W MLC1 0.28 1.4 may stabilize Myo2p by binding to the neck region YMR282C AEP2 0.28 1.9 Required for the translation of OLI1 mRNA. YMR254C 0.28 3.0 S C YBR077C 0.28 1.3 YCR073C SSK22 0.28 1.4 C "functionally redundant with, and homologous to, SSK2" YHR174W ENO2 0.27 1.6 enolase YLR459W CDC91 0.27 2.1 member of major facilitator superfamily YDL174C DLD1 0.27 1.5 mitochondrial enzyme D-lactate ferricytochrome c oxidoreductase YKL094W YJU3 0.27 1.9 Product of gene unknown YLR012C 0.27 1.1 YOR224C RPB8 0.27 1.7 "16-kDa RNA polymerase subunit (common to polymerases I, II and III)" YKL214C YRA2 0.27 0.9 Yeast RNA Annealing protein YGR098C ESP1 0.27 2.1 Esp1 promotes sister chromatid separation by mediating dissociation from the chromatin of the cohesin Scc1. The anaphase-promoting complex promotes anaphase by mediating destruction of Pds1 which binds to Esp1 and inhibits its activity YLR236C 0.27 3.8 S C YPR139C VPS66 0.27 1.3 YPR129W SCD6 0.27 0.9 multicopy suppressor of clathrin deficiency YAR068W 0.27 1.7 YLL051C FRE6 0.27 2.4 similar to FRE2 YDL086W 0.27 1.7 YNR032W PPG1 0.27 1.0 Serine/threonine protein phosphatase involved in glycogen accumulation YNR064C 0.27 0.8 YDR494W RSM28 0.27 2.1 Ribosomal Small subunit Mitochondria YDR493W 0.27 2.6 S C YKL106W AAT1 0.27 1.0 "aspartate aminotransferase, mitochondrial" YER147C SCC4 0.27 1.5 a major role for the Scc2p/Scc4p complex appears to be to facilitate the loading of cohesin complexes onto chromosomes. YGR102C 0.27 0.8 YMR257C PET111 0.27 1.6 translational activator of cytochrome c oxidase subunit II YDL219W DTD1 0.27 1.7 D-Tyr-tRNA(Tyr) deacylase YDL205C HEM3 0.27 1.3 catalyzes the third step in heme biosynthesis YDR473C PRP3 0.27 0.9 snRNP from U4/U6 and U5 snRNPs YOR236W DFR1 0.27 0.8 dihydrofolate reductase YIR005W IST3 0.27 1.3 U2 snRNP associated protein YDR020C 0.27 2.2 YMR041C 0.27 1.0 YMR047C NUP116 0.27 1.0 Involved in nucleocytoplasmic transport; may be required for biogenesis of tRNA YBR220C 0.27 1.2 YHR128W FUR1 0.27 0.9 Regulation of the pyrimidine salvage pathway YMR096W SNZ1 0.27 2.0 Snooze: stationary phase-induced gene family; involved in cellular response to nutrient limitation and growth arrest YDR465C RMT2 0.27 1.6 Protein Arginine Methyltransferase; R = arginine; MT = methyltransferase YHR029C 0.27 2.0 S YDR500C RPL37B 0.27 0.9 Homology to rat L37 YJR118C ILM1 0.27 1.4 Product of gene unknown YHR116W 0.27 1.1 YGL254W FZF1 0.27 1.1 involved in sulfite resistance YIL090W 0.27 1.7 YMR020W FMS1 0.27 1.7 "Multicopy suppressor of fenpropimorph resistance (fen2 mutant), shows similarity to Candida albicans corticosteroid-binding protein CBP1" YLR126C 0.27 2.5 C YGL154C LYS5 0.27 0.8 Responsible for the posttranslational conversion of the alpha-aminoadipate semialdehyde reductase Lys2 from the inactive apo-form into the catalytically active holo-form. YGR209C TRX2 0.27 1.2 thioredoxin YBL045C COR1 0.27 0.8 44 kDa core protein of yeast coenzyme QH2 cytochrome c reductase YLR381W CTF3 0.27 2.9 C kinetochore-related protein YPR110C RPC40 0.27 1.0 RNA polymerase III (C) subunit YML022W APT1 0.27 1.2 Adenine phosphoribosyltransferase YFL018C LPD1 0.27 0.9 an FAD flavoprotein which contains a pair of redox-active cysteines involved in the transfer of reducing equivalents from the FAD cofactor to the substrate YLR204W QRI5 0.27 0.9 Product of gene unknown YOR267C HRK1 0.27 0.9 Hygromycin Resistance Kinase
YDL014W NOP1 0.27 1.1 part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA) YPL234C TFP3 0.27 1.3 vacuolar ATPase V0 domain subunit c' (17 kDa) YBR162W-A YSY6 0.27 1.3 Protein that participates in secretory pathway YLR389C STE23 0.27 1.3 involved in a-factor processing YML003W 0.27 1.2 YML028W TSA1 0.27 1.0 antioxidant enzyme that provides protection against oxidation systems capable of generating reactive oxygen and sulfur species YKL054C DEF1 0.27 0.9 RNA polymerase II DEgradation Factor 1 YMR259C 0.27 1.2 YDL090C RAM1 0.27 1.2 essential for processing of ras proteins YHL024W RIM4 0.27 0.9 Regulator of IMe2 expression YDR236C FMN1 0.27 1.8 Riboflavin kinase YPR153W 0.27 2.7 YPL067C 0.27 1.1 YGR119C NUP57 0.27 1.6 "Forms complex with Nsp1p, Nup49p, and Nic96p at nuclear pore; this complex participates in nucleocytoplasmic transport; in vitro, Nsp1p, Nup49p and Nup57p form a 1:1:1 stoichiometric complex to which Nic96p can also bind" YAL015C NTG1 0.27 2.1 endonuclase III like glycosylase involved in DNA repair YMR035W IMP2 0.27 1.1 Inner membrane protease (mitochondrial protein) YFL016C MDJ1 0.27 1.9 involved in protection against heat-induced protein aggregation but not necessary for protein import into the mitochondrion YOL002C 0.27 2.3 YDR086C SSS1 0.27 1.6 involved in transfer of secretory precursors through the endoplasmic reticulum membrane YIL094C LYS12 0.26 2.0 S "homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate." YDR007W TRP1 0.26 0.9 "Note that the sequence of TRP1 from strain S228C, which is the sequence stored in SGD, contains an ochre mutation at codon 67." YDR250C 0.26 2.0 YBR221C PDB1 0.26 0.8 beta subunit of pyruvate dehydrogenase (E1 beta) YEL008W 0.26 1.6 YLR163C MAS1 0.26 1.3 mitochondrial processing protease subunit YOR067C ALG8 0.26 1.0 adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein YNL093W YPT53 0.26 1.5 Involved in vacuolar protein sorting and endocytosis YNL090W RHO2 0.26 1.1 Gtp-binding protein of the rho subfamily of ras-like proteins YOR202W HIS3 0.26 1.4 imidazoleglycerol-phosphate dehydratase YGR285C ZUO1 0.26 1.1 Zuotin has region of DnaJ homology YEL072W RMD6 0.26 1.3 Required for Meiotic nuclear Division YDR019C GCV1 0.26 2.2 Required for metabolizing glycine as a nitrogen source YML091C RPM2 0.26 1.7 C involved in processing of mitochondrial precursor tRNAs and protein import YKL066W 0.26 3.9 S C YDR531W 0.26 1.2 YMR147W 0.26 2.4 YOL107W 0.26 1.2 YER080W 0.26 1.2 YLR172C DPH5 0.26 0.9 diphthamide biosynthesis YPR069C SPE3 0.26 0.9 biosynthesis of spermidine YLR251W SYM1 0.26 1.8 stress-induced yeast MPV17 homolog YDL124W 0.26 2.5 C YLR244C MAP1 0.26 1.0 methionine aminopeptidase YHR046C INM1 0.26 1.1 inositol monophosphatase YJR107W 0.26 0.9 YGL104C VPS73 0.26 1.4 YGL010W 0.26 1.5 YNL037C IDH1 0.26 3.2 S alpha-4-beta-4 subunit of mitochondrial isocitrate dehydrogenase 1 YOR207C RET1 0.26 2.2 second-largest subunit of RNA polymerase III YJL001W PRE3 0.26 1.3 "Responsible for the postacidic activity of the yeast 20S proteasome, and necessary for hydrolysis of peptidylglutamyl-peptide." YBL082C RHK1 0.26 2.8 Z "Resistance to Hansenula Killer 1, hypothetical F-458 protein" YCL068C 0.26 1.2 YIL103W 0.26 1.7 YGR015C 0.26 1.8 YBR145W ADH5 0.26 0.9 alcohol dehydrogenase isoenzyme V YPL097W MSY1 0.26 1.8 Tyrosyl-tRNA synthetase YCR009C RVS161 0.26 1.8 "Protein required for viability after N, C, or S starvation. The BAR adaptor proteins encoded by RVS167 and RVS161 form a complex that regulates actin, endocytosis, and viability following starvation or osmotic stress." YBL080C PET112 0.26 2.0 "May serve important general function in mitochondrial gene expression, probably in translation; required for translation of COX2 mRNA" YHR099W TRA1 0.26 1.1 TRA1 is the homolog of the human protein TRRAP which we have isolated as an essential cofactor of c-Myc. YOR252W 0.26 0.9 YIL007C 0.26 1.5 YNL333W SNZ2 0.26 2.7 Snooze: stationary phase-induced gene family YMR064W AEP1 0.26 1.3 Requried for the translation of OLI1 mRNA. YPL033C 0.26 1.2 YJL205C-A NCE101 0.26 2.3 involved in secretion of proteins that lack classical secretory signal sequences YEL007W 0.26 0.8 YLR293C GSP1 0.26 1.0 "maintenance of nuclear organization; homologous to mammalian Ran, a small nuclear GTPase of the ras superfamily" YFR047C BNA6 0.26 1.8 Biosynthesis of Nicotinic Acid YGL236C MTO1 0.26 1.9 Mitochondrial Translation Optimization; Strong similarity to E. coli GidA YBR248C HIS7 0.26 1.1 "glutamine amidotransferase:cyclase, also called imidazole glycerol phosphate synthase" YGR271W SLH1 0.26 1.5 SKI2-like helicase YMR132C 0.26 1.5 YOL096C COQ3 0.26 1.3 "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase" YJR066W TOR1 0.26 1.1 Involved in cell cycle signaling and meiosis YJR094W-A RPL43B 0.26 1.3 Homology to human L37a YGL230C 0.26 1.8 YOR113W AZF1 0.26 1.2 "probable transcription factor, asparagine-rich zinc-finger protein, suppressor of mutation in the nuclear gene for the core subunit of mitochondrial RNA polymerase" YPR043W RPL43A 0.26 1.5 Homology to human L37a YMR117C SPC24 0.26 1.7 Spindle Pole Component of molecular weight 24kDa YLR405W 0.26 1.6 YBL018C POP8 0.26 0.9 Processing Of Precursors - a group of proteins that appear to be components of both RNase P and RNase MRP YOR149C SMP3 0.26 1.1 "Involved in glycosyl phosphatidyl inositol synthesis; most likely an alpha 1,2 mannosyltransferase utilized for addition of the fourth, side-branching mannose onto the GPI core structure." YNL063W 0.26 1.9 YEL026W SNU13 0.26 1.3 "part of small (ribosomal) subunit (SSU) processosome (contains U3 snoRNA); RNA binding protein (putative), similar to Nhp2p" YEL046C GLY1 0.26 1.5 L-threonine aldolase that catalyzes cleavage of L-allo-threonine and L-threonine to glycine YLR170C APS1 0.26 1.9 Involved in a subset of clathrin functions at the Golgi YER128W 0.26 1.0 YAL008W FUN14 0.26 1.9 Product of gene unknown YDR404C RPB7 0.26 1.8 dissociable subunit of RNA polymerase II YJR117W STE24 0.25 1.1 zinc metallo-protease that catalyzes the first step of N-terminal processing of the yeast a-factor precursor YPR001W CIT3 0.25 1.3 Mitochondrial isoform of citrate synthase YDR319C 0.25 1.2 YDR286C 0.25 1.3 YLR414C 0.25 1.2 YFL059W SNZ3 0.25 3.2 Snooze: stationary phase-induced gene family YMR090W 0.25 2.9 C YER107C GLE2 0.25 0.9 "Nuclear pore protein required for poly(A)+ RNA export, has beta-transducin (WD-40) repeats" YER039C HVG1 0.25 1.4 Homologous to VRG4 YLR284C ECI1 0.25 0.8 enoyl-CoA isomerase YHR051W COX6 0.25 2.1 subunit VI of cytochrome c oxidase YML120C NDI1 0.25 2.3 S NADH dehydrogenase (ubiquinone) YHL044W 0.25 1.6 YLR323C CWC24 0.25 0.9 Complexed with Cef1p YHR043C DOG2 0.25 1.6 2-deoxyglucose-6-phosphate phosphatase YOR126C IAH1 0.25 2.8 S isoamyl acetate-hydrolyzing esterase YGL181W GTS1 0.25 1.1 Putative zinc-finger transcription factor YDR248C 0.25 2.1 YJL097W 0.25 1.5 YKL095W YJU2 0.25 1.5 Product of gene unknown YKL014C 0.25 1.7 YMR139W RIM11 0.25 0.9 "Required for Ime1p phosphorylation, association of the Ime1p-Ume6p meiotic activator, early meiotic gene expression, and sporulation" YOR159C SME1 0.25 2.0 "Required for pre-mRNA splicing, cap modification and U1, U2, U4 and U5 snRNA stability" YPR201W ARR3 0.25 2.4 Putative membrane protein involved in arsenite transport YDL044C MTF2 0.25 1.3 Necessary for the stability and/or processing of some large mitochondrial transcripts YML014W 0.25 0.9 YLR066W SPC3 0.25 1.1 signal peptidase subunit YKR070W 0.25 1.1 YLR150W STM1 0.25 0.9 Multicopy suppressor of tom1 and pop2 mutations. Genetically interacts with CDC13 to maintain telomere structure. YBR256C RIB5 0.25 1.0 S Riboflavin biosynthesis YHR135C YCK1 0.25 2.9 S membrane-bound casein kinase I homolog YDL088C ASM4 0.25 1.1 Suppressor of thermosensitive mutations in the DNA polymerase delta gene YKR080W MTD1 0.25 1.8 "NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase" YBL089W 0.25 1.1 YLR208W SEC13 0.25 1.0 cytoplasmic protein involved in release of transport vesicles from the ER YNL007C SIS1 0.25 1.6 HSP40 family chaperone YFL064C 0.25 4.6 Z S YHR083W 0.25 0.8 YJR144W MGM101 0.25 1.9 Involved in mitochondrial genome maintenance YML005W 0.25 0.9 YDR503C LPP1 0.25 4.5 Z S Lipid phosphate phosphatase YOR091W 0.25 1.0 YOR351C MEK1 0.25 1.1 "Disp. for chr. pairing & chr. condensation seen by in situ hybrid. Required for full double strand breaks, normal length synaptonemal complexes, meiotic recomb. & spore viability. mek1 is rescued by spo13 & in early recomb. function" YIL139C REV7 0.25 1.5 Protein required for mutagenesis by physical and chemical agents YBR046C ZTA1 0.25 1.3 "Zeta-crystallin homolog, has similarity to E. coli quinone oxidoreductase and human zeta-crystallin which has quinone oxidoreductase activity" YOR131C 0.25 1.6 YHR086W NAM8 0.25 4.4 S C "May be non-essent. part of mito. splicing. Assoc. with spliceosomal snRNPs. Disp. for mitosis & premeiotic DNA synth. Required in meiosis-specific splicing of MER2 & MER3, double strand breaks, synaptonemal complexes" YIL165C 0.25 1.7 YMR256C COX7 0.25 1.3 C subunit VII of cytochrome c oxidase YFL038C YPT1 0.25 1.0 involved in the secretion pathway at the ER-to-Golgi step; required for sporulation YCL069W 0.25 1.3 YOL146W 0.25 1.8 YOR184W SER1 0.25 1.6 phosphoserine transaminase YJL030W MAD2 0.25 0.8 spindle checkpoint complex subunit YFL006W 0.25 2.2 S YIL035C CKA1 0.25 1.2 alpha subunit of protein kinase CK2 YDR087C RRP1 0.25 1.3 involved in processing rRNA precursor species to mature rRNAs YOR262W 0.24 1.2 YNL032W SIW14 0.24 1.8 Synthetic interaction with Whi2 YMR145C NDE1 0.24 3.7 S Hypothetical ORF YMR072W ABF2 0.24 2.4 "HMG-1 homolog, mitochondrial" YOL140W ARG8 0.24 0.8 Acetylornithine aminotransferase YBR213W MET8 0.24 1.0 Protein involved in the expression of PAPS reductase and sulfite reductase. Also executes last 2 steps in the biosynthesis of sirohaem. YGL049C TIF4632 0.24 0.9 also called eIF4 (eIF-4) gamma YPL244C HUT1 0.24 1.1 similar to UDP-galactose transporter YDL085W NDE2 0.24 1.6 Hypothetical ORF YER037W PHM8 0.24 1.3 involved in phosphate metabolism YIL042C 0.24 0.8 YNL264C PDR17 0.24 0.9 involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; putative phosphatidylinositol transfer protein. YMR313C 0.24 1.5 YCR082W 0.24 1.6 YFL056C AAD6 0.24 1.4 high degree of similarity with the AAD of P. chrysosporium YNL280C ERG24 0.24 1.3 sterol C-14 reductase YLR124W 0.24 3.4 YNR004W 0.24 2.5 YJR101W RSM26 0.24 0.9 mitochondrial ribosome small subunit component YDL021W GPM2 0.24 1.3 Similar to GPM1 (phosphoglycerate mutase); converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YDR050C TPI1 0.24 1.9 induced under stress conditions YAL036C FUN11 0.24 0.8 Function Unknown Now; similar to Xenopus GTP-binding protein DRG YFR042W 0.24 1.7 YGR227W DIE2 0.24 0.9 De-repression of ITR1 Expression YGL047W 0.24 1.0 YLR229C CDC42 0.24 1.5 cell division cycle blocked at 36 degree C YML048W GSF2 0.24 1.1 Glucose Signaling Factor YKL013C ARC19 0.24 1.2 Arp complex subunit YOR089C VPS21 0.24 1.1 Rab5-like GTPase involved in vacuolar protein sorting and endocytosis post vesicle internalization; geranylgeranylated; geranylgeranylation required for membrane association YIL084C SDS3 0.24 1.1 Suppressor of Defective Silencing 3
Functions are similar to those of SIN3 and RPD3 YMR087W 0.24 1.3 YLR301W 0.24 1.0 YJR013W 0.24 1.0 YOR137C SIA1 0.24 2.9 Suppressor of eIF5A YGR275W RTT102 0.24 1.8 Regulator of Ty1 Transposition YJL052W TDH1 0.24 2.2 Glyceraldehyde-3-phosphate dehydrogenase 1 YDR453C TSA2 0.24 2.2 thioredoxin peroxidase YMR322C 0.24 1.5 YGL084C GUP1 0.24 1.6 Involved in active glycerol uptake YOL086C ADH1 0.24 2.1 Alcohol dehydrogenase YLR360W VPS38 0.24 1.1 involved in vacuolar protein targeting YLR447C VMA6 0.24 1.2 vacuolar ATPase V0 domain subunit d (36 kDa) YGR206W 0.24 1.4 YBL081W 0.24 0.9 YLR029C RPL15A 0.24 1.9 Homology to rat L15 YBR191W RPL21A 0.24 2.6 Homology to rat L21 YDR414C ERD1 0.24 1.1 Protein required for retention of luminal ER proteins YDR267C 0.24 1.0 YCL035C GRX1 0.24 1.3 Glutaredoxin YLL042C APG10 0.24 1.2 Involved in autophagy; protein-conjugating enzyme involved in the Apg12p-Apg5p conjugation pathway YOR111W 0.24 1.5 YKL069W 0.24 3.5 Z S C YJR062C NTA1 0.24 1.7 "Removes amide group from N-terminal asparagine and glutamine, to generate aspartate and glutamate, which are destabilizing terminal residues" YMR084W 0.24 2.0 YOR086C 0.24 1.0 YEL025C SRI1 0.23 2.6 S Swi/SNF and RSC interacting protein 1 YPL218W SAR1 0.23 1.6 "Secretion-Associated, Ras-related. Component of COPII coat of vesicles; required for ER to Golgi protein transport" YHR183W GND1 0.23 1.6 "6-phosphogluconate dehydrogenase, decarboxylating; converts 6-phosphogluconate + NADP to ribulose-5-phosphate + NADPH + CO2" YLR318W EST2 0.23 1.5 ever shorter telomeres YIL064W 0.23 0.8 YOL042W NGL1 0.23 1.4 "DNase/RNase (putative); CCR4 C-terminal homolog, homology to drosophila Angel gene" YJL126W NIT2 0.23 0.9 "Nit protein, nitrilase superfamily member" YIR037W HYR1 0.23 1.7 Hydroperoxide resistance conferring gene YML131W 0.23 2.6 YBR201W DER1 0.23 1.5 Degradation in the Endoplasmic Reticulum YIL168W SDL1 0.23 3.1 S L-serine dehydratase YDR136C VPS61 0.23 2.7 Vacuolar Protein Sorting YBR136W MEC1 0.23 2.0 "Required for mitotic growth, DNA repair and mitotic recombination, regulates phosporylation of Rad53p, required for dmc1 arrest and meiotic recombination" YIL082W 0.23 2.3 YLL014W 0.23 1.7 YKR057W RPS21A 0.23 1.4 Homology to rat S21 YEL003W GIM4 0.23 0.9 "Prefoldin subunit 2; putative homolog of subunit 2 of bovine prefoldin, a chaperone comprised of six subunits" YDL081C RPP1A 0.23 2.7 "Homology to rat P1, human P1, and E.coli L12eIIA" YJR105W ADO1 0.23 0.8 adenosine kinase YDR332W 0.23 1.0 YGL117W 0.23 1.7 YNL070W TOM7 0.23 0.9 Involved in mitochondrial protein import YKL207W 0.23 1.0 YJL145W SFH5 0.23 1.4 putative phosphatidylinositol transfer protein YPL147W PXA1 0.23 1.7 Pxa1p and Pxa2p appear to be subunits of a peroxisomal ATP-binding cassette transporter necessary for transport of long-chain fatty acids into peroxisomes YDR344C 0.23 1.2 YML087C 0.23 1.7 YER002W NOP16 0.23 2.0 Nucleolar protein 16 YNL129W 0.23 1.3 YGR244C LSC2 0.23 1.3 "beta subunit of succinyl-CoA ligase (synthetase; ATP-forming), a mitochondrial enzyme of the TCA cycle" YPL275W 0.23 1.4 YDR010C 0.23 1.9 YBR171W SEC66 0.23 1.6 "glycoprotein complexed with Sec62p and Sec63p in the Sec63 complex, an integral endoplasmic reticulum membrane protein complex required for translocation of presecretory proteins" YMR202W ERG2 0.23 2.5 S sterol biosynthesis YCR032W BPH1 0.23 1.5 beige protein homologue 1 YOR040W GLO4 0.23 1.4 Mitochondrial glyoxylase-II YPL273W SAM4 0.23 1.0 AdoMet-homocysteine methyltransferase YCR001W 0.23 1.3 YKR101W SIR1 0.23 1.4 repressor of silent mating loci YJR074W MOG1 0.23 1.3 Required for nuclear-protein import YLR240W VPS34 0.23 1.7 phosphatidylinositol 3-kinase YPR154W PIN3 0.23 0.8 [PSI+] induction YNL220W ADE12 0.23 1.3 adenylosuccinate synthetase YJR133W XPT1 0.23 1.2 Xanthine Phosphoribosyl Transferase YHL006C SHU1 0.23 0.9 suppressor of HU sensitivity involved in recombination YGL226W 0.23 1.8 YCL065W 0.23 2.3 S YJL183W MNN11 0.23 2.9 "member of a cis Golgi complex that is involved in mannan synthesis, other complex members include Mnn10p, Hoc1p, Anp1p, Mnn9p" YLR376C PSY3 0.23 2.1 C Platinum Sensitivity YMR121C RPL15B 0.23 1.2 Homology to rat L15 YDR013W 0.23 1.8 C YDL061C RPS29B 0.23 2.4 Homology to rat S29 YHR008C SOD2 0.23 1.7 Manganese-containing superoxide dismutase YKL138C MRPL31 0.23 1.0 15.5 kDa mitochondrial ribosomal protein YmL31 YHR104W GRE3 0.23 3.7 Induced by osmotic stress; similar to xylose reductase from other fungi. Reduces xylose to xylitol. YMR207C HFA1 0.23 1.0 Similar to acetyl-coenzyme A carboxylase YOR157C PUP1 0.23 1.1 putative proteasome subunit YKL040C NFU1 0.23 1.0 Nifu-like protein YLR048W RPS0B 0.23 1.7 Homology to rat Sa; closely related to mammalian p40/laminin receptor precursors (LRPs); required for translation and contributes to the assembly and/or stability of the 40S ribosomal subunit YDR471W RPL27B 0.23 1.2 Homology to mammalian L27 YLL054C 0.23 1.2 YPL080C 0.23 1.1 YNR077C 0.23 1.2 YML055W SPC2 0.23 1.0 "subunit of signal peptidase complex, homologous to mammalian protein SPC25" YOR298W 0.23 3.8 S YGR268C 0.23 0.9 YDR315C IPK1 0.23 1.1 inositol polyphosphate kinase YOL094C RFC4 0.23 2.2 S RFC is a DNA binding protein and ATPase that acts as a processivity factor for DNA polymerases delta and epsilon and loads proliferating cell nuclear antigen (PCNA) on DNA YNR057C BIO4 0.23 1.3 dethiobiotin synthetase YLR316C TAD3 0.23 1.3 tRNA-specific adenosine-34 deaminase subunit Tad3p YLR306W UBC12 0.23 1.5 "Required for conjugation of RUB1 (ubiquitin-like protein) to other proteins. Collaborates with ULA1/UBA3 RUB1-activating enzyme. Related to ubiquitin-conjugating enzymes (UBC1-8, UBC10-11, UBC13). Related to SMT3-conjugating enzyme UBC9" YGR154C 0.22 1.1 YGR280C PXR1 0.22 1.6 PinX1-Related gene
G-patch NucleOlar protein YPL079W RPL21B 0.22 1.3 Homology to rat L21 YOR021C 0.22 1.3 YNL231C PDR16 0.22 2.7 S involved in pleiotropic drug resistance by controlling lipids in various cellular compartments; positively regulated by PDR1; putative phosphatidylinositol transfer protein. YBL038W MRPL16 0.22 0.9 Mitochondrial ribosomal protein MRPL16 YML107C 0.22 1.8 YGR031W 0.22 1.2 YCL056C 0.22 1.0 YIL111W COX5B 0.22 1.3 Cytochrome-c oxidase chain Vb YNL196C SLZ1 0.22 1.1 "sporulation-specific protein with a leucine zipper motif, regulated by the transcription factor Ume6 and expressed early in meiosis" YCR040W MATALPHA1 0.22 2.7 Z S transcription factor involved in the regulation of alpha-specific genes YCL066W HMLALPHA1 0.22 2.0 S transcription factor involved in the regulation of alpha-specific genes YLR378C SEC61 0.22 1.6 membrane component of ER protein translocation apparatus YPR096C 0.22 1.7 YPL002C SNF8 0.22 0.9 appears to be functionally related to SNF7 YPR028W YOP1 0.22 3.1 Ypt Interacting Protein YJL072C 0.22 2.3 S YMR283C RIT1 0.22 1.4 Modifies initiator methionine tRNA to distinguish it from elongator methionine tRNA YNL260C 0.22 1.1 YJL173C RFA3 0.22 4.4 K Z S C "RFA1, RFA2, and RFA3 make up RPA" YBR037C SCO1 0.22 1.2 inner mitochondrial membrane protein YKL067W YNK1 0.22 5.1 Z S C Nucleoside diphosphate kinase YGL240W DOC1 0.22 1.5 Doc1p and Cdc26p are associated with the anaphase-promoting complex and are involved in the degradation of Clb2p YIL027C KRE27 0.22 0.8 Killer toxin REsistant YBR159W 0.22 1.8 YMR287C MSU1 0.22 2.3 Protein essential for mitochondrial biogenesis YCR038C BUD5 0.22 1.8 GTP/GDP exchange factor for Rsr1 protein YEL038W UTR4 0.22 1.2 Product of gene unknown YHR010W RPL27A 0.22 1.6 Homology to mammalian L27 YPR054W SMK1 0.22 1.5 involved in sporulation YFR043C 0.22 1.2 YMR097C MTG1 0.22 1.7 Hypothetical ORF YIL020C HIS6 0.22 1.0 phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase YGR232W NAS6 0.22 1.4 Interaction with the 19S regulatory particle of the 26S proteasome detected by coimmunoprecipitation. YBR070C 0.22 5.6 Z S C YGR243W 0.22 2.6 YKL152C GPM1 0.22 1.6 converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis YBR153W RIB7 0.22 1.3 "Protein involved in the biosynthesis of riboflavin, second step in the riboflavin biosynthesis pathway" YFR012W 0.22 1.5 YGL221C NIF3 0.22 0.8 similar to Listeria monocytogenes major sigma factor (rpoD gene product) YJR050W ISY1 0.22 0.9 "Interacts with Syf1p, Prp39p and Ypl213wp. May play a role in mRNA splicing." YLL062C MHT1 0.22 3.3 S C S-Methylmethionine Homocysteine methylTransferase YMR225C MRPL44 0.22 1.7 Mitochondrial ribosomal protein MRPL44 (YmL44) YML051W GAL80 0.22 1.2 inhibits transcription activation by Gal4p in hte absence of galactose YAL029C MYO4 0.22 1.5 "Required for mother-specific HO expression, needed for the accumulation in daughter nuclei of Ash1p" YJL006C CTK2 0.22 1.5 cyclin-related subunit of the kinase complex that phosphorylates the RPO21 CTD (carboxy-terminal domain); also called CTDK-I beta subunit YBL095W 0.22 1.7 YPL257W 0.22 0.9 YML066C SMA2 0.22 2.3 S Spore Membrane Assembly YHR016C YSC84 0.22 1.6 SH3 domain in C-terminus YKL203C TOR2 0.22 1.8 "putative protein/phosphatidylinositol kinase involved in signaling activation of translation initiation, distribution of the actin cytoskeleton, and meiosis" YJR058C APS2 0.22 1.5 Related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex YGR216C GPI1 0.22 1.4 "Participates in synthesis of N-acetylglucoaminylphosphatidylinositol, the first intermediate in synthesis of glycosylphosphatidylinositol (GPI) anchors" YNL086W 0.22 1.2 YMR099C 0.22 1.6 YGR118W RPS23A 0.22 1.7 Homology to rat S23 and E. coli S12 YPR132W RPS23B 0.22 1.0 Homology to rat S23 and E. coli S12 YHR093W AHT1 0.22 0.9 the AHT1 DNA sequence is upstream of HXT4 and contains an HXT4 regulatory element which is a multicopy suppressor of glucose transport defects; probable non-functional ORF YDR196C 0.21 1.4 YDL064W UBC9 0.21 1.9 Conjugates Smt3p to proteins YOL149W DCP1 0.21 1.2 Decapping protein involved in mRNA degradation YLR118C 0.21 1.1 YPR191W QCR2 0.21 2.2 40 kDa ubiquinol cytochrome-c reductase core protein 2 YBR160W CDC28 0.21 1.1 C Catalytic subunit of the main cell cycle cyclin-dependent kinase YPR011C 0.21 1.2 YMR150C IMP1 0.21 1.3 Inner membrane protease (mitochondrial protein) YPR004C 0.21 1.8 YNL281W HCH1 0.21 1.3 high copy Hsp90 supressor YIR022W SEC11 0.21 1.1 signal peptidase subunit YOR293W RPS10A 0.21 1.2 Homology to rat S10 YOR319W HSH49 0.21 1.9 Human SAP Homolog 49. A yeast homolog of a human spliceosome associated protein (SAP) called SAP 49. YLR075W RPL10 0.21 1.3 "similar to members of the QM gene family, which is implicated in differentiation in other eukaryotes and tumorigenesis in humans; homology to rat L10; ubiquinol-cytochrome C reductase complex subunit VI requiring protein" YOR278W HEM4 0.21 1.0 catalyzes the fourth step in the heme biosynthesis pathway YOR095C RKI1 0.21 0.9 Ribose-5-phosphate ketol-isomerase YDL135C RDI1 0.21 2.0 Rho GDP dissociation inhibitor with activity toward Rho1p YOR289W 0.21 1.9 YPR182W SMX3 0.21 0.9 Sm or Sm-like snRNP protein YPR082C DIB1 0.21 1.2 Homolog of S. pombe dim1+ YHR181W 0.21 1.1 YKL070W 0.21 2.0 YBL025W RRN10 0.21 1.7 subunit of UAF (upstream activation factor); involved in promoting high level transcription of rDNA YDR515W SLF1 0.21 1.7 Associates with translating ribosomes; may function in cytoplasm to modulate mRNA translation; regulates the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in medium containing copper salts YOR120W GCY1 0.21 1.9 "Galactose-induced transcript, product is homologous to mammalian aldo/keto reductases, as well as to gamma-crystallin, a vertebrate eye lens protein" YDR047W HEM12 0.21 1.1 fifth enzyme in the heme biosynthetic pathway YGL122C NAB2 0.21 1.1 nuclear polyadenylated RNA binding protein YLR065C 0.21 0.9 YGR248W SOL4 0.21 2.4 similar to SOL3 YLR100W ERG27 0.21 2.1 S 3-keto sterol reductase YPL129W TAF14 0.21 1.2 Protein required for actin cytoskeleton assembly or function YKR030W MSG1 0.21 1.0 Multicopy suppressor of gea1-6 YGL187C COX4 0.21 2.6 subunit IV of cytochrome c oxidase YLR050C 0.21 2.6 S C YDR079W PET100 0.21 1.5 cytochrome c oxidase-specific assembly factor YIL079C AIR1 0.21 1.6 arginine methyltransferase-interacting RING finger protein YJR099W YUH1 0.21 0.8 ubiquitin hydrolase YFL027C GYP8 0.21 2.1 GAP for Ypt protein YOR061W CKA2 0.21 0.8 may have a role in regulation and/or execution of the eukaryotic cell cycle YNL208W 0.21 2.1 S YDL142C CRD1 0.21 1.7 Cardiolipin synthase YGL101W 0.21 4.7 Z S C YLL049W 0.21 1.5 YDR540C 0.21 2.3 YDR428C 0.21 1.2 YGR133W PEX4 0.21 1.0 Involved in peroxisome biogenesis YNR017W MAS6 0.21 1.1 23 kDa mitochondrial inner membrane protein YOR094W ARF3 0.21 0.9 GTP-binding ADP-ribosylation factor YNL334C SNO2 0.21 1.7 "SNZ2 proximal ORF, stationary phase induced gene" YPL040C ISM1 0.21 1.5 nuclear encoded mitochondrial isoleucyl-tRNA synthetase YFL060C SNO3 0.21 3.0 S "SNZ3 proximal ORF, stationary phase induced gene family" YNL255C GIS2 0.21 0.8 GIG3 suppressor YER146W LSM5 0.21 1.4 Like Sm-E protein YGR220C MRPL9 0.20 1.7 Mitochondrial ribosomal protein MRPL9 (YmL9) (E. coli L3) (human MRL3) YGL088W 0.20 1.6 YDR377W ATP17 0.20 1.3 Subunit f of mitochondrial ATP synthase. Homologous to bovine subunit f. YGR012W 0.20 1.5 YDR399W HPT1 0.20 1.6 enzyme involved in de novo purine biosynthesis YOR130C ORT1 0.20 2.4 "Mitochondrial integral membrane protein, ornithine transporter" YBR042C 0.20 1.3 YPL029W SUV3 0.20 0.8 putative ATP-dependent helicase YBR084W MIS1 0.20 1.9 mitochondrial C1-tetrahydroflate synthase YKL032C IXR1 0.20 2.8 Z C intrastrand crosslink recognition protein YOL072W THP1 0.20 1.2 YMR281W GPI12 0.20 1.0 N-acetylglucosaminylphosphatidylinositol de-N-acetylase YJL161W 0.20 1.3 YLR209C PNP1 0.20 2.7 S "purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides" YDR529C QCR7 0.20 1.7 ubiquinol-cytochrome c oxidoreductase subunit 7 (14 kDa) YPR020W ATP20 0.20 1.2 Protein associated with mitochondrial ATP Synthase; essential for dimeric state of ATP synthase YLR064W 0.20 1.2 YFR050C PRE4 0.20 1.4 "B-type subunit of proteasome, euk. & archae. multicatalytic proteinase complex likelyinvolved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. eukary: the proteasome is composed of ~24 subunits forming a ring-shaped structure" YJL218W 0.20 2.6 YNL153C GIM3 0.20 0.8 "Prefoldin subunit 4; putative homolog of subunit 4 of bovine prefoldin, a chaperone comprised of six subunits" YPL060W LPE10 0.20 1.2 mitochondrial protein with homology to MRS2 YLR191W PEX13 0.20 0.9 "Pas20p may be the component of peroxisomal protein import machinery that binds Pex5p, the mobile receptor for type I peroxisomal targeting sequence (PTS1)-containing proteins" YMR164C MSS11 0.20 1.3 Multicopy Suppressor of STA10 - 11 YIR001C SGN1 0.20 1.4 contains one RNA recognition (RRM) domain YIL053W RHR2 0.20 1.8 DL-glycerol-3-phosphatase YLR009W RLP24 0.20 1.1 Ribosomal Like Protein 24 YOR391C 0.20 3.5 S YKL218C SRY1 0.20 2.5 Serine Racemase homolog in Yeast YJR085C 0.20 1.5 YBR282W MRPL27 0.20 1.1 essential for mitochondrial function YDL137W ARF2 0.20 0.9 ADP-ribosylation factor 2 YMR114C 0.20 1.1 YOL143C RIB4 0.20 1.0 catalyzes synthesis of immediate precursor to riboflavin YCR063W BUD31 0.20 1.5 YKL192C ACP1 0.20 1.1 mitochondrial acyl carrier protein YPR172W 0.20 1.3 YNL135C FPR1 0.20 1.4 FK506 binding protein; proline rotamase; rapamycin-binding protein YJR112W NNF1 0.20 1.8 C Involved in nuclear function YPL052W 0.20 1.3 YBR242W 0.19 3.1 Z S YPR098C 0.19 1.2 YPL108W 0.19 1.7 YJR096W 0.19 1.2 YJL166W QCR8 0.19 2.3 Ubiquinol cytochrome-c reductase subunit 8 (11 kDa protein) YPR165W RHO1 0.19 1.9 Gtp-binding protein of the rho subfamily of ras-like proteins YIR038C GTT1 0.19 1.8 Glutathione Transferase YPL280W 0.19 1.7 YGL262W 0.19 2.9 YJR157W 0.19 1.4 YER182W 0.19 1.4 YHR100C 0.19 0.8 YLR185W RPL37A 0.19 1.2 Homology to rat L37 YOR163W DDP1 0.19 1.3 Diadenosine and Diphosphoinositol Polyphosphate Phosphohydrolase YLR426W 0.19 0.9 YCL033C 0.19 1.5 YIL136W OM45 0.19 2.0 45-kDa mitochondrial outer membrane protein YOR339C UBC11 0.19 1.2 homolog of ubiquitin carrier protein E2-C YJL189W RPL39 0.19 1.3 Homology to rat L39 YLL053C 0.19 1.3 YJL121C RPE1 0.19 1.0 D-ribulose-5-Phosphate 3-epimerase YER007C-A 0.19 1.1 YBR128C APG14 0.19 1.0 Required for autophagy YGR039W 0.19 1.9 YKL027W 0.19 0.8 YLR364W 0.19 1.1 YDR179W-A 0.19 2.5 YFL017C GNA1 0.19 1.7 involved in UDP-N-acetylglucosamine biosynthesis YKR085C MRPL20 0.19 1.7 22.3 kDa mitochondrial ribosomal large subunit protein YmL20; homologous to L17 of E. coli YDR204W COQ4 0.19 2.4 Involved in ubiquinone biosynthesis. YNL056W 0.19 2.3 S YHR180W 0.19 1.0 YGL103W RPL28 0.19 1.6 "Homology to rat, mouse L27a. May be involved in peptidyl transferase activity." YBR111C YSA1 0.19 1.3 Protein with weak homology to D. melanogaster serendipity protein and X. laevis basis fibroblast growth factor YNR046W 0.19 1.1 YAR008W SEN34 0.18 4.7 Z S C "tRNA splicing endonuclease 34kDa subunit; homologous to the 42-kDa subunit, SEN2; contains active site for 3' splice site cleavage" YBR262C 0.18 1.6 YIL040W APQ12 0.18 0.9 YOL023W IFM1 0.18 1.3 mitochondrial initiation factor 2 YEL039C CYC7 0.18 2.2 iso-2-cytochrome c YBL099W ATP1 0.18 1.4 mitochondrial F1F0-ATPase alpha subunit YNL310C 0.18 1.9 C YDR092W UBC13 0.18 1.6 ubiquitin-conjugating enzyme YCR083W TRX3 0.18 1.6 mitochondrial thioredoxin YIL164C NIT1 0.18 1.6 nitrilase YLR327C 0.18 1.8 YKL071W 0.18 1.6 YPR107C YTH1 0.18 2.0 S Yeast 30kDa Homologue YGR029W ERV1 0.18 1.1 "Protein forms dimers in vivo and in vitro, contains a conserved YPCXXC motif at carboxyl-terminal, binds FAD as a cofactor, and catalyzes the formation of disulfide bonds in protein substrates." YBL036C 0.18 0.9 YOR318C 0.18 0.9 YHR049W FSH1 0.18 1.1 YBL112C 0.18 3.8 S YER012W PRE1 0.18 1.2 Required for mitotic division and sporulation YDL120W YFH1 0.18 1.4 Yeast Frataxin Homologue YJR048W CYC1 0.18 2.5 S iso-1-cytochrome c YMR326C 0.18 1.4 YAR061W 0.18 1.3 YHR059W FYV4 0.18 0.9 Function required for Yeast Viability on toxin exposure YOR286W 0.18 1.7 YLR142W PUT1 0.18 3.7 S proline oxidase YPL227C ALG5 0.17 2.0 UDP-glucose:dolichyl-phosphate glucosyltransferase YEL024W RIP1 0.17 2.6 "oxidizes ubiquinol at center P in the protonmotive Q cycle mechanism, transferring one electron to cytochrome c1 and generating a low-potential ubisemiquinone anion which reduces the low-potential cytochrome b-566 heme group" YMR095C SNO1 0.17 3.2 "SNZ1 proximal ORF, stationary phase induced gene" YMR301C ATM1 0.17 1.0 mitochondrial ABC transporter protein YLR289W GUF1 0.17 0.9 Similar to E. coli elongation factor-type GTP-binding protein LepA YNL154C YCK2 0.17 0.9 membrane-bound casein kinase I homolog YOL010W RCL1 0.17 1.1 protein similar to the RNA 3' terminal phosphate cyclase (RNA 3' terminal phosphate Cyclase-Like) YLR010C TEN1 0.17 1.2 protein involved in Telomeric pathways in association with Stn1 YER163C 0.17 1.8 YOL147C PEX11 0.17 1.8 May promote peroxisomal proliferation by participating in peroxisomal elongation or fission or segregation of peroxisomes to daughter cells YGL029W CGR1 0.17 1.4 Coiled-coil growth-regulated. May contribute to compartmentalization of nucleolar constituents. YDR088C SLU7 0.17 1.6 Involved in 3' splice site choices and acts in concert with Prp18 during the 2nd step of splicing. YLR068W FYV7 0.17 1.3 Function required for Yeast Viability on toxin exposure YOR297C TIM18 0.17 1.2 mitochondrial inner membrane translocase YIL077C 0.17 1.1 YAL049C 0.17 1.8 YMR083W ADH3 0.17 1.8 alcohol dehydrogenase isoenzyme III YKR043C 0.16 1.2 YML078W CPR3 0.16 1.0 cyclophilin-3 (cyclosporin-sensitive proline rotamase-3) YER112W LSM4 0.16 1.0 Like Sm-D3 protein YJR111C 0.16 1.4 YLR305C STT4 0.16 1.1 "functions in the PKC1 protein kinase pathway, in a pathway with STT1 and MSS4" YOL118C 0.16 2.6 YJL180C ATP12 0.16 1.8 essential for assembly of a functional F1-ATPase; binds the alpha subunit of F1-ATPase. YGL080W 0.16 1.2 YDL125C HNT1 0.16 1.2 "Hint homolog, member of the histidine triad superfamily of nucleotide-binding proteins" YOR122C PFY1 0.16 0.8 profilin (actin-binding protein) YBR047W 0.16 1.0 YMR263W SAP30 0.16 1.9 YDR073W SNF11 0.15 1.6 component of SWI/SNF global transcription activator complex YOR253W ARD2 0.15 0.8 YML050W 0.15 1.7 S YIL134W FLX1 0.15 1.2 Nuclear-encoded mitochondrial protein involved in transport of flavine into mitochondria YMR070W MOT3 0.15 1.4 High Copy Suppressor of MOT1-SPT3 synthetic lethality. May have a role in the regulation of membrane-related genes. YPR051W MAK3 0.15 0.9 N-acetyltransferase YMR267W PPA2 0.14 1.5 mitochondrial inorganic pyrophosphatase YNL211C 0.14 0.8 YOL085C 0.13 1.4 YKL200C 1.3 YCR029C 1.4 YFL043C 2.0 YCLX07W 3.4 YKL158W 1.4 YDR134C 1.9 YCR097WB 1.3 YCRX18C 5.7 YCRX15W 0.9 YJL021C 1.2 YER108C 1.4 YCLX06C 1.9 YCLX10C 1.9 YCRX19W 2.2 YCRX21C 0.8 YCRX05W 3.0 S YCR097WA 2.6 YAR074C 1.2 YCLX01W 1.3 YCR029C-A 0.8 YFL035C-B 1.2 YCRX12W 2.3 Z YCL012W 6.0 Z S C YCL026C 2.2 YCRX08W 1.3 YAR040C 2.2 YCRX03C 2.1 YCRX04W 1.8 C YCRX09C 1.3 YCRX16C 1.2 YCR103C 1.6 YCRX06W 1.7 YCRX20C 1.7 YDL134C-A 0.1 YCRX11W 1.2 YCRX07W 1.5 YAR043C 1.5 YCRX01W 0.9 YCR056W 1.6 YCLX11W 1.4 YCR058C 1.6 YCL006C 1.0 YCR070W 1.6 YCLX04W 1.1 YCR074C 1.5 YCLX02C 1.5 YOR240W 1.5 YIL017W 1.0 YOR031W CRS5 1.4 Metallothionein-like protein YCR080W 1.2 YCRX13W 1.1 YCLX03C 0.9 YCLX09W 3.2 S YCLX12W 1.4 YCRX02C 1.0 YCL053C 1.4 YAR037W 1.4 YCL062W 3.6 Z S C YFL035C-A 1.0 YCLX08C 1.1 YCR055C 1.0 YCL013W 5.3 Z S C YCL003W 1.0 YCL021W 1.2 YCLX05C 1.8